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At least 775 records · Page 43Linked to original sources
PubMed1993

[Paratesticular tumor. Liposarcoma of the spermatic cord].

Liposarcoma of the spermatic cord is a rare tumour typically presenting in elderly people. It tends to grow around blood vessels. Most of them have a low level of malignancy and relapses tend to be localized. Metastasis, when present, occur through the haematological route, lymph spread being very unusual. Pre-operative diagnosis is infrequent and overall prognosis is good. The choice treatment is radical orchidectomy, while long-term follow-up of these patients is mandatory. When local relapses become evident, the choice treatment is extensive local excision, followed by optional adjuvant radiotherapy. Chemotherapy has not proven to be effective. This paper reviews the current literature and contributes one case of mixed liposarcoma of the spermatic cord.

Genital Neoplasms, Male↗
PubMedDate not supplied

Complete regression of advanced liposarcoma of the anterior chest wall with interferon-alpha and tumor necrosis factor-alpha.

This paper reports a case of complete regression of a liposarcoma in a 62-year-old Japanese man who, in August 1986, presented with a giant subcutaneous tumor of the right anterior chest wall. Local radiotherapy and conventional chemotherapy were initially performed; however, the tumor did not respond at all. He then received cytokine treatment (interferon-alpha and tumor necrosis factor-alpha). Nineteen months after cytokine treatment, the mass disappeared totally. The patient has been in complete remission for five years without recurrence and with no additional treatment. This suggests that the use of interferon-alpha and tumor necrosis factor-alpha in combination may be an effective and promising modality for liposarcomas which are refractory to the conventional anticancer treatments.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1995

[A case of renal capsular liposarcoma].

A 53-year-old woman was admitted to the Department of Internal Medicine at our hospital with the primary complaint of pyrexia. Abdominal echography and computed tomography (CT) detected a right renal tumor, and the patient was transferred to our department. Angiography revealed a hypovascular tumor. The main nutrient vessels supplying the tumor were the superior and inferior capsular arteries, which arose from the renal artery. A right renal capsular tumor was suspected from these findings, and radical nephrectomy was performed. Histopathological examination revealed a pleomorphic liposarcoma. Therefore, the patient was given 50 Gy of radiation postoperatively. This is the 14th case of a primary liposarcoma of the renal capsule reported in Japan.

Female↗
PubMed1996

Myxoid liposarcoma of the urinary bladder.

We report a case of myxoid liposarcoma of the urinary bladder, that occurred in a 36-year-old woman. We faced the difficulties in reaching the preoperative diagnosis, likewise in determining the extent of the tumor, as the results of the computed tomography differed from the pathologic findings of the tumor. The review of the literature concerning this unusual site for liposarcoma and methods of treatment is also included.

Adult↗
PubMed1996

[Adipose retroperitoneal tumors. Apropos a giant myxoid liposarcoma].

Liposarcomas are the most frequent retroperitoneal tumours, second only to lymphomas. We present a new case of giant retroperitoneal liposarcoma treated in our hospital. A discussion is presented on the most peculiar aspects of this tumour, such us: multicentricity, tendency to local relapse, and need to post-operative (adjuvant) radiotherapy. A review of all nationwide cases over the last few years is included.

Chemotherapy, Adjuvant↗
PubMed1995

Liposarcoma of the vulva: a case report.

BACKGROUND: Vulvar liposarcoma is rare. Three cases have been reported since 1966. Primary sarcomas of the vulva constitute 1-2% of all vulvar malignancies. Because of their location and appearance, they may be easily misdiagnosed as a more benign process. CASE: A 65-year-old, black woman had a vulvar lesion that appeared clinically to be a Bartholin's gland abscess. The lesion was a soft tissue mass, was excised in toto and was sent for pathologic study with a presumed diagnosis of lipoma. The pathology report indicated pleomorphic liposarcoma. CONCLUSION: Only three prior cases of this disease have been reported. The clinician should heighten his or her awareness in a patient with a vulvar mass. Early diagnosis is imperative for a favorable outcome.

Aged↗
PubMed1995

[Liposarcoma of the oral cavity: description of a case and review of the literature].

A case of well differentiated lipoma like and sclerosing liposarcoma in a 66 years old women is reported. The review of literature showed the rare occurrence of this neoplasia in the head and neck region especially in the floor of the mouth. C-T Scans and MRI can be helpful in addressing to the diagnosis of a fot tissue neoplasia, but only microscopic examination of a wide incisional biopsy makes the differential diagnosis from a liposarcoma possible. The elective treatment fundamental to present any relapses, as stressed in literature, is the complete removal of the lesion.

Aged↗
PubMedDate not supplied

Intrathoracic pleomorphic liposarcoma in a child: study of an unusual case.

Primary intrathoracic liposarcoma is an extremely rare neoplasm in the pediatric age group. We report an unusual case of a 3-year-old boy who presented with a large intrathoracic tumor arising from the right chest wall. Biopsy showed a pleomorphic sarcoma with histological, immunohistochemical, and ultrastructural features of pleomorphic liposarcoma. The tumor displayed an aggressive clinical behavior, and the patient continued to have recurrences despite rigorous chemotherapy and radiation treatment. He subsequently died 2 years after the initial diagnosis.

Child, Preschool↗
PubMed1997

Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation.

Dedifferentiated liposarcoma (DDL) has been defined as a tumor composed of well-differentiated liposarcoma (WDL) associated with or progressing to a nonlipogenic, high-grade sarcoma. One might expand this definition of DDL to include low-grade dedifferentiation (LGDD), because tumors with LGDD alone are capable of metastasizing. We studied 20 cases of retroperitoneal WDL with or without LGDD and/or high-grade dedifferentiation (HGDD) to semiquantitate the amount of WDL, LGDD, and HGDD in each case and to correlate the amounts of these components with clinical outcome. For each case, a composite estimate of each of these components was obtained. Thirteen patients (65%) of 20 had an adverse outcome (AO). Within this group, metastatic disease developed in 3 patients, 2 of whom had areas of HGDD (40% and 20%) in their initial excisions, whereas 1 patient had 30% LGDD and 0% HGDD. Of the patients with AOs, 12 (92%) had LGDD areas, 4 (31%) had HGDD areas, and 1 (8%) had pure WDL. Of the seven patients without AOs, three had recurrences, but metastatic disease did not develop in any. All of these seven patients had some element of WDL, five (71%) had LGDD areas, two (29%) had HGDD areas (20% in both cases), and two (29%) had pure WDL. There was no significant difference in clinical outcome between those patients with WDL and those with WDL/LGDD or WDL/LGDD/HGDD. We conclude that recurrences develop in most patients with retroperitoneal WDL and that most of these patients die as a result of local effects of the tumor. Metastases are rare and may occur in patients with tumors with either LGDD, HGDD, or both but do not occur in pure WDL. Neither the amount of LGDD nor HGDD correlates with clinical outcome. LGDD areas, as defined in this study, are commonly seen in de novo retroperitoneal WDLs.

Adult↗
PubMed1997

[Computerized tomography of retroperitoneal liposarcoma].

Besides the malignant fibrous histiocytoma, liposarcoma is one of the most common soft-tissue sarcomas seen in adults. They are most often localized in the lower extremity, followed by sarcomas in the retroperitoneal space which differ from the former in clinical appearance, epidemiology, and prognosis. The prognosis is especially dependent on tumor histology which is mainly classified into four subtypes. The aim of the study was to investigate whether there are specific CT-features for each histologic subgroup, by analyzing the examination of 20 patients. The highest percentage in fat and the biggest tumors were seen with well-differentiated liposarcomas (n = 4), whereas myxoid ones (n = 6) showed the sharpest margins. Round-cell (n = 2) and pleomorphic (n = 5) and pleomorphic (n = 5) types showed mainly soft-tissue attenuation and could not be differentiated, either from each other or from other soft-tissue tumors. A clear identification of the histologic subgroup does not seem to be possible.

Adult↗
PubMed1997

[Liposarcoma of the spermatic cord. Clinical case].

Sarcomas are neoplasms originating from connective tissues of any anatomical region; the sarcoma of spermatic cord is a rare neoplasm with only little more than two hundred cases described in the literature. Rhabdomyosarcomas in childhood and leiomyosarcomas in adults are the most frequent histological types. Liposarcomas, fibrosarcomas and osteosarcomas are less frequent. The spermatic cord liposarcoma originates from the spermatic cord fatty tissue and therefore it consist of adipose cells, fibroblasts and myxomatosus cells; such neoplasms are usually very well differentiated. Diagnosis is suggested by the appearance of a progressively enlarging mass and by echotomography which shows a solid or liquid mass of the spermatic cord. Therapy consists of surgical intervention (orchifunicolectomy) which also allows a correct histological diagnosis. The case of a 56 year-old male who underwent left orchifunicolectomy for a sarcoma of spermatic cord occasionally discovered during surgical repair of a left groin hernia is reported. Six months after the intervention the patient is in good condition and there is no evidence of relapse.

Genital Neoplasms, Male↗
PubMed1997

[A paratesticular myxoid liposarcoma as a simulator of a hernial process. A case report].

OBJECTIVE: To describe a case of paratesticular liposarcoma in a 69-year-old male. The literature is briefly reviewed and the prognostic and therapeutic aspects are discussed. METHODS/RESULTS: The patient was submitted to surgery. Pathological analysis of the surgical specimen disclosed a myxoid liposarcoma with undifferentiated pleomorphic areas. Patient follow up has shown no recurrence or metastasis. CONCLUSIONS: This tumor type develops in scrotal soft tissue, slowly increasing scrotal size, and should be distinguished from inguinoscrotal hernia. Together with physical examination, ultrasonography is generally useful. Treatment is by radical orchiectomy through an inguinal approach; the role of adjuvant therapy remains unclear. It has a good prognosis, with frequent local relapses; metastatic spread is uncommon.

Aged↗
PubMed1998

Pedunculated liposarcoma of the esophagus.

Polypoid tumors of the esophagus present diagnostic and therapeutic problems. Liposarcomas are infrequent among them. We report a recent case. A 73-year-old male patient was seen in May 1995 in the Ear, Nose and Throat (ENT) Department, Clínica Modelo de Morón, with intermittent dysphagia and dyspnoea due to recurrent vomiting. A laryngeal lineal tomography showed a subglottic obstruction due to extrinsic compression. The patient was referred to the Gastroenterology Department, where an upper gastrointestinal (upper GI) series demonstrated mega-esophagus with abundant retained food. Endoscopy showed a large intraluminal mass covered by normal mucosa which arose on the posterior wall. Videofluoroscopy and chest CT diagnosed a probable polypoid lipoma due to its densitometric characteristics. The tumour was resected by left cervicotomy and left esophagotomy. The patient's progress to date is favourable. Pathology studies showed a well-differentiated liposarcoma. According to the literature, the first case was reported in 1983, and ours is only the seventh case in the world to be documented.

Aged↗
PubMed1998

[Liposarcoma of the breast. A case report].

Liposarcoma of the breast is an unfrequent tumor that can be found in 45-55-year-old women, usually with benign clinical and radiological characteristics. We report the case of a 50-year-old patient treated with menopausal hormonal replacement therapy, for whom mammographic screening revealed a solid tumor. Lumpectomy was performed and histology reported liposarcoma of the breast. Two years after surgery alone no relapse was observed. Our case report underlines the possibility of discovering this type of tumor by means of mammographic examination performed during menopausal hormonal replacement therapy. It suggests good prognosis after surgery alone.

Biopsy↗
PubMed1998

[Liposarcoma of the neck].

Liposarcoma is a malignant neoplasm of soft tissue. Its occurrence in the head and neck region is extremely rare. The case of a 26-year-old woman with neck liposarcoma is presented. The clinical manifestation, histopathology, possibility and results of the tumor treatment are described according to the literature.

Adult↗
PubMed1998

[Primary liposarcomas of the mediastinum].

Primary liposarcomas of the mediastinum are rare neoplasms comprising less than 1% of mediastinal tumors. While in early stages often asymptomatic they may grow to an enormous size and then exhibit various clinical symptoms mimicking lung or heart disease by compression of adjacent intrathoracic organs. Intention of surgical treatment is to relieve the symptoms and to establish the histological diagnosis. Surgery alone may be curative in some cases. The role of additional radio- and chemotherapy remains questionable. We report two cases of primary mediastinal liposarcomas that were treated surgically in our institution.

Aged↗
PubMed1998

Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS-CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function.

Human translocation liposarcoma (TLS)-CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) is a fusion oncoprotein found specifically in a malignant tumor of adipose tissue and results from a t(12;16) translocation that fuses the amino-terminal part of TLS to the entire coding region of CHOP. Being that CHOP is a member of the C/EBP transcription factor family, proteins that comprise part of the adipocyte differentiation machinery, we examined whether TLS-CHOP blocked adipocyte differentiation by directly interfering with C/EBP function. Using a single-step retroviral infection protocol, either wild-type or mutant TLS-CHOP were co-expressed along with C/EBPbeta in naïve NIH3T3 cells, and their ability to inhibit C/EBPbeta-driven adipogenesis was determined. TLS-CHOP was extremely effective at blocking adipocyte differentiation when expressed at a level comparable to that observed in human myxoid liposarcoma. This effect of TLS-CHOP required a functional leucine zipper domain and correlated with its ability to heterodimerize with C/EBPbeta and inhibit C/EBPbeta DNA binding and transactivation activity in situ. In contrast, the TLS-CHOP basic region was dispensable, making it unlikely that the inhibitory effect of TLS-CHOP is attributable to unscheduled gene expression resulting from TLS-CHOP's putative transactivation activity. Another adipogenic transcription factor, PPARgamma2, was able to rescue TLS-CHOP-inhibited cells, indicating that TLS-CHOP interferes primarily with C/EBPbeta-driven adipogenesis and not with other requisite events of the adipocyte differentiation program. Together, the results demonstrate that TLS-CHOP blocks adipocyte differentiation by directly preventing C/EBPbeta from binding to and transactivating its target genes. Moreover, they provide strong support for the thesis that a blockade to normal differentiation is an important aspect of the cancer process.

3T3 Cells↗
PubMed2001

Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-kappa B p65-mediated transcription as a coactivator.

In this study, we have demonstrated that translocated in liposarcoma (TLS), also termed FUS, is an interacting molecule of the p65 (RelA) subunit of the transcription factor nuclear factor kappaB (NF-kappaB) using a yeast two-hybrid screen. We confirmed the interaction between TLS and p65 by the pull-down assay in vitro and by a coimmunoprecipitation experiment followed by Western blot of the cultured cell in vivo. TLS was originally identified as part of a fusion protein with CHOP arising from chromosomal translocation in human myxoid liposarcomas. TLS has been shown to be involved in TFIID complex formation and associated with RNA polymerase II. However, the role of TLS in transcriptional regulation has not yet been clearly elucidated. We found that TLS enhanced the NF-kappaB-mediated transactivation induced by physiological stimuli such as tumor necrosis factor alpha, interleukin-1beta, and overexpression of NF-kappaB-inducing kinase. TLS augmented NF-kappaB-dependent promoter activity of the intercellular adhesion molecule-1 gene and interferon-beta gene. These results suggest that TLS acts as a coactivator of NF-kappaB and plays a pivotal role in the NF-kappaB-mediated transactivation.

Cell Line↗