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PubMed1984

[History and sidelights on the forceps].

The author starts by showing that the first forceps were originally designed to handle hot metal in founderies and that the word derived from "formus" (hot) and "capere" (to take). The author, Professor Dumont, tries to trace the history of the development of modern forceps, discussing whether the Arabs or such well known authors of classical works as Roesslin, Raynald, Rueff and Rousset knew of the instrument or whether they just described instruments of destruction. Crainz in 1941 had written an article to discuss whether the early Romans had forceps and came to no firm conclusion. Speert in 1957 said that a live baby had been born earlier than the 17th Century, possibly as early as the 2nd or 3rd century of the Roman empire, i.e. over 300 years before Jesus-Christ, by forceps. The description is given of a bas-relief depicting forceps delivery but no one knows whether the bas-relief is genuine or not. The discovery of the Chamberlen forceps in 1813 at Woodham Mortimer Hall in Essex, England, and the lengthy description of how the Chamberlens kept the secret of the invention of the forceps over several generations is very well described. Then follows the story of Jean Palfyn's "mains de fer" which led later to Levret and his long curved forceps. Returning to England, the authors describes how William Smellie covered his forceps with leather so that the patients should not feel the cold metal or hear the clink of the handles. The author then quotes Dr Slop, who appears in Laurence Sterne's "Tristram Shandy" and who knew the Smellie's forceps. Sacombe was an arch enemy of instrumental delivery. The role of the Dane Saxtorph, and how Antoine Dubois delivered Napoleon's son, the future King of Rome, by forceps, is reviewed. Madame La Chapelle and her work as well as that of Scanzoni, and finally of Simpson who first used anaesthesia after inventing a forceps, continues the history. Great names such as Pajot, Tarnier with his axis-traction forceps and finally Barton, Piper and Kielland with their inventions are all described in this beautiful history of forceps.

Extraction, Obstetrical↗

PubMed1994

Patents and the nurse scholar, Part I: The basic philosophy of intellectual property.

Patenting intellectual property is important for a number of reasons. Health care products are designed to improve the effectiveness and efficiency of care. Without the patent, the property would most likely never enter into the public market for general use by either health care providers or clients. Products such as the specialized IV pole which also accommodates dependent drains (e.g. urinary drainage bags) (Rebar, 1991) or the premature infant pacifier (Engebretson & Wardell, 1991) are valuable assets to patient care. However, without patents to protect them as property, their value in the commercialization process would be nil. Therefore, the public benefits from this system for three reasons: (1) it encourages the inventor to make the invention; (2) the public is given the opportunity to use the invention; (3) the knowledge of the invention is made available to everyone; and (4) often royalties are returned to the institution for further research and development activities.

Clinical Nursing Research↗

PubMed1976

Early bone conduction hearing aid devices.

The concept of bone conduction hearing is old. By the 16th century the conduction of sound by a rod or the staff of a spear was reported by a number of writers; however, these writers considered these phenomena as a curiosity rather than having practical value. In the 17th century, John Bulwer and George Sibscota, both interested in the deaf and their education, applied the bone conduction phenomenon as an aid to defective hearing. Soon, independent reports from Germany, France, and Italy also described bone conduction rod devices as aids to impaired hearing. In 1879, the Audiphone, a hearing fan that operated by bone conduction, was patented. The invention of the Audiphone triggered the development and sale of a number of similar devices that had considerable popularity until the invention of the carbon-electric hearing aid in the early 1900s.

Bone Conduction↗

PubMed1976

Dr Alexander Graham Bell--audiologist and speech therapist.

Alexander Graham Bell is best known for his role in the invention of the telephone. However, he had a lifelong involvement in speech therapy and audiology besides many other medical investigations. He was also awarded an honorary MD degree from Heidelberg University. In this, the 100th anniversary of his invention of the telephone, his life and some of his medical interests are briefly reviewed.

History, 19th Century↗

PubMed2007

Alkaline-cell lysis through in-line static mixer reactor for the production of plasmid DNA for gene therapy.

A state-of-the-art in-line static mixer reactor (ISMR) was invented to lyse E. coli cells and neutralize the cell lysate continuously and efficiently for the extraction of plasmid DNA. It comprised two connected static dynamic mixers, each 0.01 m in diameter and 0.9 m in length, one for lysis and one for neutralization. Cells were lysed using concentrated alkaline with 1% SDS and the lysate was neutralized at feed rates of cell suspension:lysis solution:neutralization solution of 125:250:125, 250:500:250, and 500:1,000:500 mL/min. Distances for the mixtures to reach color homogeneity were dependent on feed rates. The higher the feed rates the shorter the mixing distances and times. However, complete cell lysis and neutralization were independent of color homogeneity. Lysate viscosity and neutralized floc size decreased and floc density increased, as distances and feed rates increased. High plasmid yields were obtained from both lysis and neutralization at feed rate ratios of 125:250:125 and 250:500:250 mL/min within mixing distances < or =0.6 m. Poor mixing performance and plasmid yield were obtained at a high feed rate of 500:1,000: 500 mL/min when residence and reaction times were less than 2 s and from mixing distances > or =0.6 m at all feed rates due to a longer exposure to strong alkali and shear flow. This invention showed excellent performance with scaleable potential for the commercial manufacture of plasmid DNA.

DNA, Superhelical↗

PubMed2005

The early origins and development of the scatterplot.

Of all the graphic forms used today, the scatterplot is arguably the most versatile, polymorphic, and generally useful invention in the history of statistical graphics. Its use by Galton led to the discovery of correlation and regression, and ultimately to much of present multivariate statistics. So, it is perhaps surprising that there is no one widely credited with the invention of this idea. Even more surprising is that there are few contenders for this title, and this question seems not to have been raised before. This article traces some of the developments in the history of this graphical method, the origin of the term scatterplot, the role it has played in the history of science, and some of its modern descendants. We suggest that the origin of this method can be traced to its unique advantage: the possibility to discover regularity in empirical data by smoothing and other graphic annotations to enhance visual perception.

Animals↗

PubMed2003

Innovations and intellectual property: the case of genomic patenting.

In an effort to balance static and dynamic efficiency in the production and use of knowledge, societies institute intellectual property policies. In the United States, the patent system is a well-established mechanism to provide inventors with time-limited protection of new technologies in exchange for disclosure of information about their inventions. Emerging biotechnology, specifically the filing of patents on gene sequences, raises serious questions about whether the patent system is appropriately weighing societal costs and benefits in its grants of intellectual property protection. Gene sequences represent a hybrid case between discrete inventions and more general pieces of information that are useful for many, potentially very different, purposes. This information content in genes makes it possible for a patent on a gene to cover a wide range of possible technological applications and, as a result, be of unknown breadth when issued. This analysis explores the potential effect of these characteristics on future innovation in biotechnology.

Biotechnology↗

PubMed1997

Song development by grey catbirds

What are the relative roles of imitation, improvisation and invention in the development of large song repertoires in species of the songbird family Mimidae? This question was addressed in a laboratory study of the vocal development of young grey catbirds, Dumetella carolinensiscollected from western Massachusetts. Two groups heard a repeated 10-s, tape-tutored segment of catbird song, two other groups heard a repeated 16-min segment and a fifth group heard no tape-tutored songs. One male selected for study from each group developed a large repertoire of seemingly normal songs, and wild males responded strongly to songs of the male that had heard no tape-tutored song. Relying little on precise imitation and largely on improvising or inventing, each male developed a highly unique repertoire. A geographical survey of catbird song revealed little to no evidence of song sharing or microgeographical variation, which is consistent with the idea that imitation plays a relatively minor role in song development. Perhaps simultaneous selection for large repertoires and reduced geographical variation has led to such an emphasis on song individuality and non-imitative developmental processes.

Journal Article↗

PubMed1996

Individual difference variables that predict response to training in phonological awareness.

The cognitive abilities that predicted growth in response to a 12-week training program in phonological awareness were investigated with a sample of 100 kindergarten children. The children were selected from two elementary schools with historically low achievement in reading. Sixty children received training in both analytic and synthetic awareness skills, and 40 children constituted a no-treatment control group. Pretest measures included assessment of phonological awareness, phonological memory and naming rate, letter knowledge, reading and spelling, and general verbal ability. Growth in phonological awareness was assessed during the middle and at the end of the training period. Hierarchical linear modeling was used to estimate individual growth curves in phonological awareness for children in both the treatment and control groups. Initial comparisons between children in the two groups indicated substantial overall training effects in phonological awareness for children in the treatment group. For children in the training group, the model that best predicted growth in analytic awareness included invented spelling and general verbal ability, while growth in synthetic awareness was predicted best by a combination of invented spelling and rapid automatic naming of digits.

Awareness↗

PubMed1998

Biomimicry as a basis for drug discovery.

Selected works are discussed which clearly demonstrate that mimicking various aspects of the process by which natural products evolved is becoming a powerful tool in contemporary drug discovery. Natural products are an established and rich source of drugs. The term "natural product" is often used synonymously with "secondary metabolite." Knowledge of genetics and molecular evolution helps us understand how biosynthesis of many classes of secondary metabolites evolved. One proposed hypothesis is termed "inventive evolution." It invokes duplication of genes, and mutation of the gene copies, among other genetic events. The modified duplicate genes, per se or in conjunction with other genetic events, may give rise to new enzymes, which, in turn, may generate new products, some of which may be selected for. Steps of the inventive evolution can be mimicked in several ways for purpose of drug discovery. For example, libraries of chemical compounds of any imaginable structure may be produced by combinatorial synthesis. Out of these libraries new active compounds can be selected. In another example, genetic system can be manipulated to produce modified natural products ("unnatural natural products"), from which new drugs can be selected. In some instances, similar natural products turn up in species that are not direct descendants of each other. This is presumably due to a horizontal gene transfer. The mechanism of this inter-species gene transfer can be mimicked in therapeutic gene delivery. Mimicking specifics or principles of chemical evolution including experimental and test-tube evolution also provides leads for new drug discovery.

Algorithms↗

PubMed1985

Creativity in biology and in the human mind (manifestation of concepts).

The article is based on the widely held notion that creativity is a phenomenon studied in two branches of the science of life: psychology (in a wide sense) on one side, and evolutionary biology on the other. Therefore, an analysis of creativity of the mind should contribute to the solution of problems in biological evolution, problems which cannot be fully explained by the orthodox assumption of small steps of mutation and selection. This analysis is restricted to three classes of creativity, which are: a) organismal creativity, as exemplified by the creation of organs such as "eye" and "heart". b) mental-scientific creativity, exemplified by Newton's notion of "gravity" between planets and stars. c) mental-technological creativity, exemplified by Gutenberg's invention of "printing by movable types". The analysis of these classes is based on concepts, which are interrelated structurally by means of propositions. Two types of propositions are distinguished: factual ones named "cognita", and hypothetical ones named "hypothetical episodes". A further basis of the analysis is the assumption that creativity consists of several phases, of which incubation and insight are the essential ones. In carrying out the analysis, the writer shows that incubation functions on two or three lines of thought, one of which can be expressed by factual cognita, and the other ones predominantly by hypothetical episodes. Those several lines are integrated by means of logical implication, by which insight into a novel concept is obtained. In a second method of analysis, the several lines of incubation are represented by networks. In this method, the novel concept is obtained by integrating the individual networks into a common structure. It is proved that the methods of analysis described above can be applied to all three classes of creativity definined previously. Drawing conclusions from the analysis, the writer points out that the organismal concepts were manifested in biological evolution many millions of years prior to the appearance of man and his brain on earth. The writer, therefore, argues that a great number of concepts are not a creation of man's mind, but are entities which pre-existed man and were manifested to him. Such concepts may be conceived as forming a time-independent "conceptual universe" external to the "material universe" of galaxies, stars and organisms. Thus, for example, the concept of an "eye" was manifested in biological evolution as the organ "eye" of many organisms. Much later, this concept was manifested to man, when he invented the optical camera.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

PubMed1984

[Patent protection for living matter].

Inventions are patentable according to the German Patent Law (and the European Patent Convention), if they are new, involve an inventive step and are susceptible to industrial application. Living matter and processes performed therewith are likewise patentable.

Animals↗

PubMed1994

Improvisation and authority in illness meaning.

Using the example of psychosomatic diagnosis, I argue that the clinical context has unique epistemological constraints that limit the certainty of diagnosis and so make meaning indeterminate for sufferer and healer. As a result, forms of clinical truth are borrowed from the therapeutic context to create and authorize meanings for ambiguous or ill-defined conditions and inchoate suffering. Diagnostic interpretation is concerned with classification and legitimation through the production of authoritative truth. In contrast, therapeutic interpretation is fundamentally concerned with the pragmatic problem of "how to continue" and hence, with the improvisation of meaning. These different ends give rise to tensions and contradictions in psychosomatic theory and practice. While authority is necessary to provide a structure on which variations of meaning can be improvised, authoritative meanings may also restrict the possibilities for invention by clinician and patient. The goal of patient and physician is to create enough certainty to diminish the threat of the inchoate while preserving enough ambiguity to allow for fresh improvisation. Accounts of illness meaning must recognize the interdependence of normative rigidity and metaphoric invention.

Authoritarianism↗

PubMed1989

On growth and dispersal of population.

In his unpublished Master's thesis of 1921, the young Hotelling invented an ingenious model of population growth and diffusion. The contribution remained widely unknown until Waldo Tobler and Alan Wilson edited it as an article in 1978. Not even then did it trigger any outburst of contributions. Meanwhile, in 1951, Skellam invented the same model for non-human populations. Unlike in economics, it was a great success in ecology. In a recent contribution, Skellam is named Father of Ecological Diffusion and more than 1000 articles on the subject are listed. There were many attempts at solving the equation, but none were quite successful. The Hotelling and Skellam models both assumed a given saturation population that nature could support. In 1985 the present author suggested that an explicit production function be introduced in the Hotelling model, as a man produces his own means of subsistence. Moreover, it was proposed that diffusion be related to spatial differences in per capita productivity, rather than to those in population density. The present contribution is a rejoinder. It is shown that the stationary solutions to the original Hotelling model are periodic and dip into negative populations, whereas this is avoided by the modified model suggested. It can thus be used to show how agglomerative structures may evolve.

Demography↗

PubMed1991

["Scoring"--benefits and pitfalls].

Problems of calculations and predictions on more than two particles moving are known in mathematics and physics since a long time already. However in medicine as there is lack of knowledge about the complexity of the pathophysiological behaviour of "systems" doctors tend to invent scores, scales and indices to make parameters more intelligible to them without concern on underlying interdependencies and redundancies. There is nothing to say against this kind of proceeding as long as the resulting data are not processed statistically. However, since the personal computer was invented there was and especially today is no need to summarize data any longer to gain the degree of understanding, in the contrary, the only data that really count are those that are processed correctly according to statistics, and thus doctors do not have to keep an eye any longer on incomplete intermediate results.

Computer Graphics↗

PubMed1986

History of blood gas analysis. VI. Oximetry.

Oximetry, the measurement of hemoglobin oxygen saturation in either blood or tissue, depends on the Lambert-Beer relationship between light transmission and optical density. Shortly after Bunsen and Kirchhoff invented the spectrometer in 1860, the oxygen transport function of hemoglobin was demonstrated by Stokes and Hoppe-Seyler, who showed color changes produced by aeration of hemoglobin solutions. In 1932 in Göttingen, Germany, Nicolai optically recorded the in vivo oxygen consumption of a hand after circulatory occlusion. Kramer showed that the Lambert-Beer law applied to hemoglobin solutions and approximately to whole blood, and measured saturation by the transmission of red light through unopened arteries. Matthes in Leipzig, Germany, built the first apparatus to measure ear oxygen saturation and introduced a second wavelength (green or infrared) insensitive to saturation to compensate for blood volume and tissue pigments. Millikan built a light-weight ear "oximeter" during World War II to train pilots for military aviation. Wood added a pneumatic cuff to obtain a bloodless zero. Brinkman and Zijlstra in Groningen, The Netherlands, showed that red light reflected from the forehead could be used to measure oxygen saturation. Zijlstra initiated cuvette and catheter reflection oximetry. Instrumentation Laboratory used multiple wavelengths to measure blood carboxyhemoglobin and methemoglobin is cuvette oximeters. Shaw devised an eight-wavelength ear oximeter. Nakajima and co-workers invented the pulse oximeter, which avoids the need for calibration with only two wavelengths by responding only to the pulsatile changes in transmitted red and infrared light. Lübbers developed catheter tip and cuvette fiberoptic sensors for oxygen tension, carbon dioxide tension, and pH.

Colorimetry↗

PubMed2000

Are natural gene sequences patentable?

The title question is answered in the affirmative. The patentability of natural gene sequences is based on general principles of patent law, and depends on novelty, inventive steps and industrial applicability of the subject matter to be patented. Patentability is further confirmed by the particular articles of the European Patent Convention and the recent EC Directive on the legal protection of biotechnological inventions.

Base Sequence↗

PubMed1998

Origin of laparoscopy: coincidence or surgical interdisciplinary thought?

The history of laparoscopy illustrates the interaction between the many areas of medicine and technology; in fact, the development of that technique is a cumulative effort of internists, gynecologists, and surgeons. At the beginning of our century, however, neither group was particularly open to the idea of scholarly exchange. In this respect, an early pioneer of laparoscopy, Georg Kelling (1866-1945) of Dresden and the story surrounding the invention of the laparoscopy are interesting exceptions. Although Kelling regarded himself a surgeon, he devoted a great deal of energy to the development of "nonsurgical" methods of treatment. He spent a great part of his life determining stomach capacity, constructing a semiflexible tube endoscope (straightened after the insertion), and attempting to alleviate gastrointestinal bleeding by means of high-pressure pneumoperitoneum (lufttamponade). To observe the effects of insufflation on abdominal organs, Kelling introduced a cystoscope into the abdominal cavity. In fact, the invention of "celioscopy" or laparoscopy (1901) can be called a synthesis of Kelling's work with insufflation and his fascination with endoscopy.

Germany↗