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PubMedDate not supplied

Awareness of eye donation in an urban population in India.

PURPOSE: Awareness of eye donation and willingness to pledge eyes for donation was assessed in the urban population of Hyderabad, India, where corneal blindness is a significant problem. METHODS: A total of 2522 subjects of all ages, representative of the Hyderabad population, participated in the Andhra Pradesh Eye Disease Study. Subjects >15 years old were interviewed regarding awareness of eye donation and willingness to pledge eyes for donation. RESULTS: Age-gender-adjusted prevalence of awareness of eye donation was 73.8% (95% CI: 66.5-81.0%) but only 1.9% (95% CI: 0.16-3.66%) had pledged eyes. With multivariate analysis, significantly less awareness of eye donation was found in illiterate subjects (OR 0.1; 95% CI: 0.1-0.14), subjects > or =70 years old (OR 0.3; 95% CI: 0.2-0.6), subjects of lower socio-economic status (OR 0.4; 95% CI: 0.3-0.6), females (OR 0.6; 95% CI: 0.5-0.8) and Muslims (OR 0.7; 95% CI: 0.6-0.9). Media was the major source of information about eye donation. Of those aware of eye donation, 44.9% were willing to pledge eyes. Willingness to pledge eyes for donation was significantly lower in Muslims (OR 0.18; 95% CI: 0.13-0.24) than in Hindus and in subjects > or =60years old (OR 0.3; 95% CI: 0.2-0.5). CONCLUSIONS: These data show that although only a few had pledged eyes there is enough potential in this population for obtaining many more corneas for transplantation. The information about distribution and demographic associations of awareness and willingness for eye donation could help in developing strategies to increase procurement of corneas for dealing with corneal blindness.

Adolescent↗
PubMed2004

[Psychological impact of the new digital media].

This review article starts from the hypothesis that the new digital media's impact on people's mental health, which in professional and private everyday life has become increasingly frequent and intense, is widely underestimated. The disturbances associated with media exposure, which have been already described and examined, are presented and discussed, while classifying them in three groups of disorders, namely dissocial, dissociative and impulse control disorders. In a second step, psychotherapeutic and psychiatric applications of the digital media are presented, especially, psychometric and neuropsychological testing, distribution of information and behavioral therapeutic tools. The positive and negative effects of the internet and cyberspace are applied to the multicausal understanding of the genesis and therapy of mental disturbances. Against this background, the opinion is held, that the paradigmatic medialization of the world has to be taken seriously and actively approached as a psycho-ecological factor with psychosocial, psychopathogenic and also neuroplastic effects. Therefore, also a psychiatric approach is needed to establish both research on media-associated disorders including their therapy and the development of quality standards in the therapeutic use of the Internet and Cyberspace.

Antisocial Personality Disorder↗
PubMed2007

Exploring conformational energy landscape of glassy disaccharides by cross polarization magic angle spinning 13C NMR and numerical simulations. I. Methodological aspects.

This article demonstrates the ability of chemical shift surfaces to provide information on distributions of various conformations of disaccharides in the glassy, solid state. The validity of the general method leading to a simulation of inhomogeneous (13)C chemical shift distributions is discussed in detail. In particular, a proper consideration of extrema and saddle points of the chemical shift map correctly accounts for the observed discontinuities in the experimental cross polarization magic angle spinning spectra. Provided that these basic requirements are met, density functional theory/gauge-independent atomic orbital chemical shift maps calculated on relaxed conformations lead to a very satisfactory description of the experimental line shapes. Using amorphous trehalose as a model disaccharide, the simulation unambiguously defines the range of most populated conformations in the glass.

Carbon Radioisotopes↗
PubMed1982

Interregional migration models with source and interaction information.

"Information flows in models of migration are emphasized. In particular, migrants are assumed to react to two types of information about job vacancies. 'Interaction information' may be defined as interpersonal communication between recent migrants and their former neighbors or friends, and 'source information' represents a direct flow of information from employers or agencies to individuals. Models are developed that investigate the effects of various communication rates and information retention levels on vacancy rates and labor-force population trajectories. It is found that attempts by planners to reduce regional inequities in vacancy rates through controlled advertising may be successful, but at the possible cost of increasing temporal fluctuations of regional vacancy rates."

Communication↗
PubMed1989

Modeling the macrodynamics of international migration: determinants of emigration from Cyprus, 1946-85.

"A model is presented of international migration that is based on the concept of a pool of potential emigrants at the origin created by push-pull forces and by the establishment of information feedback between origin and destination. The forces can be economic, political, or both, and are analytically expressed by the 'mediating factor'. The model is macrodynamic in nature and provides both for the main secular component of the migratory flow and for transient components caused by extraordinary events. The model is expressed in a Bernoulli-type differential equation through which quantitative weights can be derived for each of the operating causes. Out-migration from the Republic of Cyprus is used to test the tenets of the model."

Asia↗
PubMed1986

The complete structure of the rat thyroglobulin gene.

We have isolated the entire gene for rat thyroglobulin, the precursor for thyroid hormone biosynthesis. The gene is at least 170,000 base pairs (bp) long; 9000 bp of coding information are distributed in 42 exons of homogeneous size (150-200 bp) except for two exons of 1100 and 620 bp. The sequences coding for two major thyroxine-forming sites are localized in exons 2 and 39. These two sequences do not show any homology either at the DNA or at the protein-sequence level, even though they code for sites highly specialized for the same function. Furthermore, both the 3' and the 5' end of the thyroglobulin structural gene appear to be made of repetitive units, which again do not show any homology. On the basis of these observations, we propose that the thyroglobulin gene arose by shuffling of at least two segments, with different evolutionary histories, each of which already contained introns.

Amino Acid Sequence↗
PubMed2001

Infectious disease surveillance in North Rhine-Westphalia: first steps in the development of an early warning system.

It is often difficult to detect warning signals on infectious disease outbreaks from raw surveillance data. Data need to be used for a timely generation and distribution of information on the current state of infectious diseases. This offers the opportunity to detect outbreaks and to initiate preventive measures. To improve the surveillance system in North Rhine-Westphalia we have introduced an infectious disease barometer, a simple tool based on weekly notification data. The aim of this tool is not to provide in depth data analysis, but to help to detect clusters or outbreaks. This can be the first step in the development of an early warning system and can support epidemiological investigation and policy making.

Communicable Diseases, Emerging↗
PubMed1990

Characteristics of change in Ericksonian hypnotherapy: a cognitive-psychological perspective.

Milton H. Erickson's approach to hypnosis and psychotherapy has established itself as a therapeutic paradigm in recent years. As its popularity grows, however, myths and misconceptions about his approach have also emerged. Some of them claim falsely that Erickson's therapy consists of nothing more than a set of quick, symptom-management formulae. To understand Erickson's hypnotic psychotherapy in a proper context, a systematic review is warranted. In this article I have examined, from a cognitive-psychological perspective, four of the major characteristics of therapeutic change underlying Erickson's work: (a) self-efficacy, (b) spontaneous compliance, (c) cognitive/experiential reorganization, and (d) global distribution of information. Drawing on Erickson's original writing, this paper integrates his published cases into an existing theoretical and empirical framework. Clinical implications are also discussed.

Combined Modality Therapy↗
PubMed2002

HIV/AIDS and care provider attributions: who's to blame?

The discovery of HIV/AIDS prompted a profusion of research focusing on the disease and its causes. Though the bulk of this research emphasizes behavioural risk factors, treatment and disease progression, researcher efforts are beginning to examine the public's attitude toward individuals who are HIV-positive or have developed AIDS. Utilizing Weiner's Attribution Theory, the current study examines the beliefs of social service providers who work directly with individuals affected by HIV/AIDS. Forty-six (28 female and 18 male) HIV/AIDS social service providers from three community-based organizations were asked to read a hypothetical scenario depicting an individual at-risk for HIV/AIDS because of multiple high-risk behaviours. The gender of the target was manipulated and at the conclusion of the scenario participants completed a questionnaire designed to assess attributions. Results of the study show that social service providers who perceive individuals as more responsible for their illness report increased anger, attribute more blame and express less willingness to help those at-risk for HIV/AIDS. This research suggests that despite growing numbers of media campaigns and national distribution of information regarding the disease and its transmission, in general, people continue to stigmatize and place blame on those at-risk.

Adult↗
PubMed1989

AIDS and the press: an analysis of the coverage of AIDS by Zimbabwe newspapers.

An analysis of articles about HIV and AIDS in Zimbabwe newspapers for the period January 1987 to September 1988 reveals several areas of concern. An analysis of coverage before and after a Government campaign designed to increase awareness of issues related to AIDS indicated only a short term increase in press coverage of such issues. Articles were assigned to one of seven content categories: statistics, cure or vaccine, prevention, education and awareness, transmission and risk, counselling and care, and policy and economics. The relative lack of articles on counselling and care and on transmission and risk indicates possible gaps in public awareness of susceptibility to AIDS. There were few articles with a local basis, nor were there any personalized stories. This is likely to encourage feelings of distance and relatively low personal risk. In general, Zimbabwe newspapers show little of the sensationalist and prejudiced accounting of AIDS found in some British press coverage.

Acquired Immunodeficiency Syndrome↗
PubMed1990

The impact and use of written leaflets as a counselling alternative in mass antenatal HIV screening.

Pre-test counselling has been seen as a pre-requisite for HIV screening. As HIV moves into the heterosexual community, the role of HIV screening in ante-natal care has increased. As vertical transmission is the major contributor to perinatal infection HIV screening of pregnant women has become a reality. The pregnant population comprises large numbers, the practical difficulties of routine pre-test counselling and the informational demand from pregnant women themselves has necessitated the provision of ante-natal leaflets about HIV infection and AIDS. A survey of 24 London hospitals revealed only three leaflets in use, two from one hospital and one from an AIDS Charity. A content evaluation of the leaflets revealed varying readability, elements of bias and presentation factors which may all affect the usefulness of such leaflets. An in depth qualitative group on the leaflet with highest readability revealed particular concerns and highlighted the fact that the leaflets could be seen as additions and addendums to counselling but were not sufficient in themselves.

Counseling↗
PubMed2006

Orthotropic properties of cancellous bone modelled as parameterized cellular material.

Analysis of stresses and strains in bone tissues and simulation of their adaptive remodelling require exhaustive information about distribution of constitutive properties of cancellous bone and their relationships to microstructural parameters. Homogenization of "equivalent" trabecular microstructures appears to be an advantageous tool for this task. In this study, parameterized orthotropic constitutive models of cancellous bone are derived from finite element analysis of repeatable microstructure cells. The models, based on a space-filling dodecahedron, are fully three-dimensional and are parameterized with four shape parameters. Variation of the parameters allows to imitate most of typical microstructure patterns observed in real bones, along with a variety of intermediate geometries. Finite element models of cells are generated by a special-purpose structured mesh generator for any arbitrary set of shape parameter values. Static numerical tests are performed for an exhaustive number of parameter value sets (microstructure instances). Coefficients of elastic orthotropic stiffness matrix are determined as tabularized functions of elastic constants versus the shape parameters. Additionally, they are correlated to apparent density and principal fabric tensor values. Comparison of the results with micro-FE data obtained for a large set of cancellous bone specimens proves a good agreement.

Animals↗
PubMed2004

Model parameterization, prior distributions, and the general time-reversible model in Bayesian phylogenetics.

Bayesian phylogenetic methods require the selection of prior probability distributions for all parameters of the model of evolution. These distributions allow one to incorporate prior information into a Bayesian analysis, but even in the absence of meaningful prior information, a prior distribution must be chosen. In such situations, researchers typically seek to choose a prior that will have little effect on the posterior estimates produced by an analysis, allowing the data to dominate. Sometimes a prior that is uniform (assigning equal prior probability density to all points within some range) is chosen for this purpose. In reality, the appropriate prior depends on the parameterization chosen for the model of evolution, a choice that is largely arbitrary. There is an extensive Bayesian literature on appropriate prior choice, and it has long been appreciated that there are parameterizations for which uniform priors can have a strong influence on posterior estimates. We here discuss the relationship between model parameterization and prior specification, using the general time-reversible model of nucleotide evolution as an example. We present Bayesian analyses of 10 simulated data sets obtained using a variety of prior distributions and parameterizations of the general time-reversible model. Uniform priors can produce biased parameter estimates under realistic conditions, and a variety of alternative priors avoid this bias.

Animals↗