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At least 775 records · Page 43Linked to original sources
PubMed1999

William Osler at 150: an overview of a life.

Sir William Osler is one of the most admired and honored physicians in the history of medicine. He influenced the development of medicine in Canada, the United States, and Great Britain, where he held professorships at McGill University, the University of Pennsylvania, Johns Hopkins University, and Oxford University. Through his textbook, The Principles and Practice of Medicine, and other clinical and philosophical writings, he exercised a truly global influence. In this sesquicentennial of his birth, William Osler continues to serve as a model of excellence for the medical profession. This examination of the reasons for his enduring impact reveals a legacy of clinical, scientific, literary, educational, and intraprofessional accomplishments linked to a remarkable personality, and bound together by an extraordinary humanism.

Canada↗
PubMed2000

Vesalius on the variability of the human skull: book I chapter V of De humani corporis fabrica.

Vesalius' short chapter on craniology and the "unnatural" shapes that skulls could take is a uniquely interesting illustration of the young anatomist's position halfway between a traditional belief in a standard or canonical "natural" human anatomy and the host of variations confronted in his day-to-day observation of actual cadavers. His interest in variability is marked in both editions of De humani corporis fabrica (1543, 1555), and it is no coincidence that two of the anatomical features that today bear the great anatomist's name are atypical. In their shape, all of the five skulls that illustrate Chapter 5 of Book I of the Fabrica fall within margins of variability recognized as standard today, but even in Vesalius' own century it was noticed that the sutures in the four "unnatural" skulls do not occur in real life. The article considers the meaning of this unusual departure from his reliance upon observation and includes a translation of Vesalius' craniology chapter from the original Latin, with annotations and two appendices containing his 1555 revisions and clinical addenda.

Anatomy↗
PubMed1982

Eponymy, obscurity, Twitmyer, and Pavlov.

The discovery of the conditioned reflex is generally credited to Ivan P. Pavlov. So closely is Pavlov associated with this phenomenon that it is commonly referred to as the Pavlovian conditioned reflex. Edwin B. Twitmyer independently discovered the conditioned reflex at approximately the same time and reported the finding in 1904 at the meeting of the American Psychological Association. Unlike Pavlov's, Twitmyer's data had little impact on psychology. There have been various hypotheses to explain the failure of the field to recognize Twitmyer's discovery. These explanations are criticized and modified to reflect an emphasis on Twitmyer's and Pavlov's respective social and intellectual contexts.

Animals↗
PubMed1991

Syndrome: le mot de jour.

Syndrome is one of the oldest terms in the medical vocabulary. It has been used as a designation for those disorders that were marked by etiologically nonspecific similar groups of manifestations up to the time of Syndenham. His contention that the terms syndrome and disease were in fact synonymous explains in part infrequent use of syndrome in the literature until the latter part of the 19th century. Redefinition of syndrome early in the 20th century as a disorder characterized by the concurrence of symptoms which are causally related, and further refinement of the definition as a condition marked by a cluster of symptoms occurring together coincidentally, gradually restored the popularity of the term to where syndrome is now one of the most frequently used designations of morbid states in the literature. There are numerous definitions of syndrome currently in use. One which is accepted by most dysmorphologists, geneticists, and some clinicians states that syndrome is an etiologically defined entity of unknown pathogenesis. However, most writers use the term randomly to denote any abnormal condition, whether medical, social, or behavioral, when a more satisfactory designation cannot be found or created, or to emphasize special complexity (syndromic qualities?) of already named diseases, or merely to be amusing. The post-Sydenham custom of naming of syndromes after physicians gave way in the mid-20th century to methods wherein syndrome names incorporate clinical, etiological, genetic, and other significant characteristics. Other methods used in designating syndromes include using the names of the first patient known to be affected, acronyms and abbreviations, personal names of all kinds, and the like.(ABSTRACT TRUNCATED AT 250 WORDS)

Eponyms↗