[Treatment of cardiomyopathies].
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When examining patients with heart failure, it is often impossible to assess the underlying cardiac disease only on the basis of clinical examination, electrocardiogram and chest X-ray. As an additional noninvasive method, echocardiography provides a high level of diagnostic accuracy for heart diseases. Different cardiologic ultrasound methods and procedures, applied in patients with heart failure during a modern echocardiographic routine examination, are shown. Despite an increasing availability of this imaging technology, inappropriate use without clear indication must be avoided. Criteria of indication are discussed, followed by an illustrating case report.
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Echocardiography in veterinary medicine has both enhanced our ability to diagnose and treat cardiac diseases in small animals and added confusion to what we already know. Because we can actually see the heart beating and visualize blood flows within the cardiac chambers as well as measure velocities of blood flows, we have a tool that increases our non-invasive diagnostic abilities. On the other hand, the lines between different heart diseases are not always clear-cut, and the more we learn about heart disease the more we see the shades of distinction between different diseases become blurred. This chapter will look at the main abnormalities we see in veterinary medicine (mitral regurgitation, pericardial disease, and the different feline and canine cardiomyopathies) and will attempt to help the veterinary echocardiographer avoid common problems encountered in acquired heart disease as well as use echocardiographic information to gain a better understanding of the disease process occurring in animals.
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Magnetic resonance imaging (MRI), a relatively new, noninvasive technique, provides comprehensive information on the myocardial anatomy through its excellent contrast resolution, high spatial resolution and intrinsic high contrast between the blood pool and the surrounding soft tissues. Cine MRI possesses an adequately high time resolution for the analysis of the global and regional function of the left ventricle. 31phosphorus magnetic resonance spectroscopy (MRS) is a unique tool for the assessment of alterations of the myocardial high energy phosphate metabolism in the intact, working heart. On the basis of personal data and an overview of the literature, the current relevance and future perspectives of MRI and MRS in the diagnosis of cardiomyopathies are presented.
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Despite success in adults, heart transplantation (HT) is still considered by many as only desperation therapy for children with end-stage heart disease. Thus, of 30 pediatric patients undergoing HT at our center, only seven (23%) patients had not developed pulmonary hypertension with increased pulmonary vascular resistance (PH) or hemodynamic decompensation (HD) requiring inotropic support at the time of transplantation. We have retrospectively reviewed the effect of preoperative PH, HD, and seven other potential risk factors on survival of our pediatric heart transplant recipients. All 30 patients, aged 5 days to 18 years, had New York Heart Association class III or IV symptoms. Twenty had idiopathic cardiomyopathy, nine had congenital lesions, and one infant had a large left ventricular tumor. A univariate and multivariate Cox proportional-hazards analysis was performed examining the effects of nine variables on survival after transplantation: PH, HD, age, need for hospitalization, congenital heart disease, need for surgical pulmonary artery reconstruction, prior stroke, history of cardiac arrest(s), and mechanical ventilator dependence. One-year actuarial survival for the entire series was 66% and was 100% for the seven patients with neither PH nor HD. None of the nine potential risk factors was a statistically significant predictor of risk, yet the combined presence of PH and HD represented a highly significant predictor of mortality (relative risk, 4.08: 1; p less than 0.002). One-year actuarial survival of the 10 patients with this combination was 30% versus 84% of those without the combination.(ABSTRACT TRUNCATED AT 250 WORDS)
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