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Results for “BONE REGENERATION”

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At least 775 records · Page 43Linked to original sources
PubMed2002

The effect of low intensity pulsed ultrasound on regenerate bone in a less-than-rigid biomechanical environment.

The purpose of this study was to investigate effects of low intensity pulsed ultrasound (LIPU) on distraction osteogenesis in a less-than-rigid biomechanical environment in a rabbit model. A less-rigid mini-lengthener was applied and a mid-tibial osteotomy performed in 20 New Zealand White rabbits. After a 7 day latency period, the tibiae were distracted 0.5 mm every 12 hours for 10 days. Ten of the rabbits received LIPU for 20 min/day (ultrasound group) and 10 received sham LIPU (control group) from day 17 until sacrifice on day 37. Radiographs were taken weekly after distraction and the callus area was measured. After sacrifice, dual-energy X-ray absorptiometry (DEXA), torsional testing to failure, and histomorphometry were performed. On radiographs, all the treatment tibiae displayed persistent radiolucencies; however, only one of the control tibiae displayed a radiolucent interzone. Torsional strength of the treatment group was 54% of the contralateral tibia compared to 139% in the control group (p<0.008). Bone density and callus size were not significantly different between the 2 groups; however, the ultrasound group displayed a tendency towards more cartilage and fibrous tissue formation (p<0.16) and less bone (p<0.16) than controls. In a biomechanically unstable environment, LIPU appears to stimulate more cartilage formation in regenerated callus than in controls. This callus is biomechanically inferior to unstimulated callus at the early stage of healing tested. During distraction osteogenesis a sound biomechanical environment is important to achieving anticipated results.

Animals↗
PubMed2004

Evaluation of a poly-l-lactic acid membrane and membrane fixing pin for guided tissue regeneration on bone defects in dogs.

OBJECTIVES: The purpose of the study was to clarify the usefulness of a poly-l-lactic acid and membrane fixing pin, used in combination with guided bone regeneration, on bone defects in dogs. STUDY DESIGN: Osteotomies bone defects were created in 8 beagle dogs. Group I: one defect was covered with test membrane and held by fixing pins. Group II: the other defect was covered test membrane and not held by fixing pins. The control group received no membrane. The dogs were killed after 24 or 36 weeks of healing. Sections were stained and evaluated microscopically. Data were analyzed statistically. RESULTS: The degradation and resorption of test membrane was not observed at 24 weeks but was noted at 36 weeks. After 24 and 36 weeks, most of Group I defects were completely closed with new bone, while in the control defects, only a small amount of new bone was observed at the bottom of the bone defects. After 36 weeks, the percentage of new bone volume (62.2%) in the space beneath the test membrane and membrane fixing pin (Group I) was greater than that without a membrane fixing pin-53.2% (Group II), whereas only 43.9% of the defect area in the control group was filled with new bone. CONCLUSION: The results of this study show that a poly-l-lactic acid membrane and membrane fixing pin permit bone regeneration that can be ensured by excluding surrounding soft tissues from the wound area.

Absorbable Implants↗