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Victimization, substance use, and HIV risk behaviors among gay/bisexual/two-spirit and heterosexual American Indian Men in New York City.

OBJECTIVES: secondary aims included describing condom-use attitudes, beliefs about HIV/AIDS in the Indian community, HIV knowledge, HIV status, and preference for and access to HIV prevention services in this population. METHODS: A survey was mailed to all members of an American Indian community organization in New York City. RESULTS: The 20 men self-identifying as gay, two-spirit, or bisexual (hereafter, "two-spirit") were more likely to report being victimized and engaging in HIV risk behaviors than the 51 heterosexual respondents, although they reported comparable levels of recent substance use. Overall, victimization was associated with lifetime HIV risk behaviors (even after control for sexual orientation) but not with substance use or unsafe sex in the past 12 months. The percentage of HIV infection was surprisingly high (10% of two-spirit men and 6% of heterosexual men). CONCLUSIONS: Two-spirit men are a vulnerable population whose victimization must be understood within an appropriate historical and political context.

Adult↗

Passage of feeding catheters into the pleural space: a radiographic sign of trauma to the pharynx and esophagus in the newborn.

Although rarely recognized, traumatic pharyngeal and cervical esophageal pseudodiverticula are probably not infrequent in newborns who have undergone vigorous oropharyngeal suctioning and endotracheal intubation. This report describes four premature infants with clinically unsuspected retroesophageal false passages incidentally discovered on chest radiographs. Differentiation of pseudodiverticula from spontaneous rupture of the middle or distal esophagus can be achieved by careful inspection of the course of the feeding catheter in frontal and lateral projections and by partial withdrawal of the catheter to permit injection of the retroesophageal false passage with a small volume of water-soluble contrast material.

Catheterization↗

Scrotal migration of ventriculoperitoneal shunts.

Ventriculoperitoneal diversion of cerebrospinal fluid in infants and children with hydrocephalus has become the procedure of choice over the last 15 years. It has replaced ventriculoatrial shunts, resulting in a marked decrease in the complication rate after such procedures. Four cases of migration of the shunt tip through patent processus vaginalis resulting in scrotal hydrocele are presented.

Cerebrospinal Fluid Shunts↗

MR imaging of bone marrow in glycogen storage disease type IB in children and young adults.

OBJECTIVE: Patients with glycogen storage disease type IB have neutropenia and neutrophil dysfunction that predispose them to frequent infections, for which they are given granulocyte colony--stimulating factor. Because neutropenia is a consequence of defects in myeloid maturation, the bone marrow aspirations show hypercellularity due to myeloid hyperplasia. This study evaluated MR imaging of bone marrow in glycogen storage disease type IB with and without granulocyte colony-stimulating factor. CONCLUSION: As confirmed by the histologic results in bone marrow aspirations, abnormal findings on MR images of bone marrow in patients with glycogen storage disease type IB indicate an increased myelopoietic activity, which is augmented by treatment with granulocyte colony-stimulating factor.

Adolescent↗

Comparison of Chemstrip uG, Clinitest, and Diastix urine test methods in diabetic children.

The new urine test, Chemstrip uG, was compared with Clinitest and Diastix methods by pediatric diabetic patients and by health care professionals. With the children testing all urine samples (N = 108), accuracy for Chemstrip uG and Clinitest was similar and superior to that of Diastix. When the children tested specimens containing up to only 2.2% glucose (N = 75), all test methods were shown to have generally similar accuracies. The diabetic children, however, preferred Chemstrip uG (P less than 0.02). It is concluded that Chemstrip uG is a clinically useful and acceptable method for self-monitoring of urine glucose in diabetic children.

Adolescent↗

Overextended gutta-percha and Kloroperka N-O root canal fillings. Radiographic findings after 10-17 years.

A representative sample, 55%, of the patients treated endodontically by undergraduate students in a teaching clinic during the years 1963 to 1969 were reexamined 10-17 years later. Gutta-percha/Kloroperka-NO root fillings (282), classified as having surplus material at the time of treatment, were evaluated in follow-up radiographs. In about 80% of the cases of overfilling, no excess root filling material could be traced at the reexamination. In a few cases only, the appearance of the excess material was nearly identical to that at the time of treatment, whereas the remaining overfillings (18%) showed a reduced size. Among the recorded variables only one seemed to have a major impact on the prognosis--namely, the presence or absence of an apical radiolucency at the time of treatment, indicating that infection was the important factor when failures occurred. Apical overfilling per se had little influence on the long-term healing result as judged radiographically.

Adolescent↗

An optimal period for setting sustained variability levels.

In two experiments, we investigated how explicit reinforcement of highly variable behavior at different points in training affected performance after the requirement was eliminated. Two versions of a computer game, differing in the number of possible solution paths, were used. In each, an optimal period of training for producing sustained high variability was found. Exposure to a high lag requirement shortly after acquisition sustained variability. Rewarding variability at other times did not have a sustained effect. The implications for learning and problem solving are discussed.

Adult↗

Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators.

PGs and leukotrienes (LTs) mediate cardinal signs of inflammation; hence, their enzymes are targets of current anti-inflammatory therapies. Products of arachidonate 15-lipoxygenases (LO) types I and II display both beneficial roles, such as lipoxins (LXs) that stereoselectively signal counterregulation, as well as potential deleterious actions (i.e., nonspecific phospholipid degradation). In this study, we examined transgenic (TG) rabbits overexpressing 15-LO type I and their response to inflammatory challenge. Skin challenges with either LTB(4) or IL-8 showed that 15-LO TG rabbits give markedly reduced neutrophil (PMN) recruitment and plasma leakage at dermal sites with LTB(4). PMN from TG rabbits also exhibited a dramatic reduction in LTB(4)-stimulated granular mobilization that was not evident with peptide chemoattractants. Leukocytes from 15-LO TG rabbits gave enhanced LX production, underscoring differences in lipid mediator profiles compared with non-TG rabbits. Microbe-associated inflammation and leukocyte-mediated bone destruction were assessed by initiating acute periodontitis. 15-LO TG rabbits exhibited markedly reduced bone loss and local inflammation. Because enhanced LX production was associated with an increased anti-inflammatory status of 15-LO TG rabbits, a stable analog of 5S,6R,15S-trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid (LXA(4)) was applied to the gingival crevice subject to periodontitis. Topical application with the 15-epi-16-phenoxy-para-fluoro-LXA(4) stable analog (ATLa) dramatically reduced leukocyte infiltration, ensuing bone loss as well as inflammation. These results indicate that overexpression of 15-LO type I and LXA(4) is associated with dampened PMN-mediated tissue degradation and bone loss, suggesting that enhanced anti-inflammation status is an active process. Moreover, they suggest that LXs can be targets for novel approaches to diseases, e.g., periodontitis and arthritis, where inflammation and bone destruction are features.

Administration, Topical↗

The sonographic appearance of the hemorrhagic ovarian cyst in adolescents.

Pelvic sonography was performed on ten teenaged girls who were proven by surgery to have hemorrhagic ovarian cysts. Pathologically, four were follicular ovarian cysts, while three were corpus luteal cysts, and the exact nature of three was undetermined. At sonography, these masses had variable appearances, ranging from anechoic to moderately echoic with septa and thick walls. All these features are nonspecific and can be encountered in other adnexal masses. The changing sonographic appearance of the hemorrhagic ovarian cyst due to clot lysis is helpful in establishing the diagnosis, and was demonstrated in two cases. These ten cases are discussed, the varied sonographic appearances are described and a review of pertinent literature is included.

Adolescent↗