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PubMed1994

Measuring functional health status in primary care using the COOP-WONCA charts: acceptability, range of scores, construct validity, reliability and sensitivity to change.

BACKGROUND: The COOP-WONCA charts comprise six scales designed to measure functional health status in primary care. AIM: A study was undertaken to describe the acceptability, distribution of chart scores, construct validity, test-retest reliability and sensitivity to change when these charts were used in the United Kingdom. METHOD: For acceptability, distribution of scores and construct validity, data were obtained from 100 consecutive consulting patients aged 16 years and over and 100 non-consulting age-sex matched individuals from one general practice. In order to examine reliability and sensitivity to change, both groups were followed up two weeks later. RESULTS: Regarding acceptability, four patients refused to complete the charts during the initial recruitment of the consulters; 74 out of 100 non-consulters returned the first postal questionnaire. The follow-up questionnaire was returned by 68 out of 100 consulters and 57 out of 74 non-consulters. Overall distributions of scores demonstrated reasonable variation. Regarding construct validity, differences between the consulters and non-consulters were all in the anticipated direction and reached statistical significance for three of the six charts. For reliability, the proportion of non-consulters whose scores were unchanged ranged from 56% to 73%. For those whose scores changed, the differences were small and evenly balanced. For sensitivity to change, the proportion of consulters whose scores altered ranged from 45% to 59% with mean changes all indicating improvements in health. There were larger changes for patients consulting about acute problems than for those with chronic problems. CONCLUSION: It appears that the charts were acceptable, with reasonable distributions of scores and evidence of construct validity. Moderate levels of reliability and sensitivity to change were demonstrated. This study suggests that the COOP-WONCA charts are suitable for measuring functional health status in primary care in the UK.

Adolescent↗
PubMed1994

Long-term safety and clinical acceptability of venlafaxine and imipramine in outpatients with major depression.

The antidepressant efficacy and safety of venlafaxine was shown previously in 6-week, placebo-controlled trials. We evaluated the long-term safety and clinical acceptability of venlafaxine and imipramine in a double-blind, parallel-group, comparative study. Two hundred ninety depressed outpatients were treated with venlafaxine, and an additional 91 received imipramine for as long as clinically necessary, up to 1 year. The total daily dose of each drug could vary from 75 to 225 mg. The Clinical Global Impressions Scale and a therapeutic response rate that was based on Clinical Global Impressions Scale-Improvement and incorporated discontinuation information were used to evaluate efficacy. Safety determinations and patient subjective ratings were used to evaluate safety and clinical acceptability. During the study, the adverse events were generally mild to moderate and most subsided with continued treatment; the most frequent were nausea for venlafaxine and dry mouth for imipramine. The anticholinergic side effect burden was significantly higher in the imipramine group than in the venlafaxine group. Venlafaxine was judged significantly more acceptable than imipramine, on the basis of the subjective ratings by patients. Fewer venlafaxine-treated patients than imipramine-treated patients withdrew because of adverse events and unsatisfactory response. There was a consistent trend in the therapeutic response rates in favor of venlafaxine that reached statistical significance at months 2, 6, and 12. In this long-term study, patient acceptability was greater for venlafaxine than for imipramine, suggesting therapeutic advantages for venlafaxine in the long-term treatment of depression. Additional studies with other active comparators are underway to confirm and extend these encouraging results.

Adult↗
PubMedDate not supplied

Nursing acceptance of a speech-input interface: a preliminary investigation.

Many new technologies are being developed to improve the efficiency and productivity of nursing staffs. User acceptance is a key to the success of these technologies. In this article, the authors present a discussion of nursing acceptance of computer systems, review the basic design issues for creating a speech-input interface, and report preliminary findings of a study of nursing acceptance of a prototype speech-input interface. Results of the study showed that the 19 nursing subjects expressed acceptance of the prototype speech-input interface.

Adult↗
PubMed1994

A comparative evaluation of the percent acceptable end-rounded bristles: Butler G.U.M., Colgate Plus, Crest Complete, and Reach.

Many researchers have concluded that end-rounded toothbrush bristles reduce the potential of soft tissue trauma. Toothbrushes with a rippled-bristle pattern have been shown to more effectively remove dental plaque from interproximal surfaces than flat-trimmed toothbrushes. Unfortunately, many attempts to utilize rippled-bristle toothbrushes are fraught with difficulty due to poor end-rounding of these bristles in the traditional manufacturing process. In this study, the proportion of acceptably end-rounded bristles has been compared for a rippled bristle design toothbrush (Crest Complete), a traditional flat-trimmed brush (Colgate Plus), a bi-level brush (Reach), and a domeshaped brush (Butler G.U.M. 411). Toothbrush bristles were examined using a stereomicroscope by a grader blind to brush type, and bristle end-rounding was evaluated based on the Silverstone and Featherstone scale used previously in the literature. The results were tabulated for the percent of bristles with acceptable grades, summed, and averaged for five random bristles per tuft, five random tufts per brush, for 30 brushes of each type. Bristles in the Crest Complete toothbrush demonstrated 96.5% acceptable end-rounding. These results were significantly different (p = 0.0001) from those found in the other brushes tested: 34.3% (Reach), 16.1% (Colgate Plus), and 14.0% (Butler G.U.M.) acceptable end-rounding was observed. These results demonstrate that the newly designed rippled-bristle brush (Crest Complete) exhibits excellent bristle end-rounding.

Analysis of Variance↗
PubMed1994

[Organization of socially acceptable working hours in nursing].

Three dimensions in the structure of the working hour system of nurses, rendering them socially acceptable, are becoming important: duration of the working day, the time of day which is being worked and the distribution of working hours. The latter two are of particular importance because flexible shift is becoming the dominant pattern in nursing. Six indicators are discussed as criteria for social acceptability: security of employment which includes access to the labour-market, level of income, health, opportunity for social relationships, social participation, and autonomy. Responses of 297 nurses in one General Hospital taking part in a study, were analysed to examine empirically the concept of 'socially acceptable structure of the working hours'. Ideal and factual patterns are considered first. Secondly aspects of autonomy are considered and the way this depends on time, thirdly the criteria used to define 'social acceptability' are examined for validity. Results show firstly the cross contrast between the hospital's expectation and the nurses' wishes with regard to working hours. Furthermore, inspite of the demand for flexibility, staff have very little choice and there is little sign of joint decision making. Thirdly results show that health, interpersonal and social aspects are of special importance and that, correspondingly, in the view of nurses, financial and practical problems are of lesser importance in their every day life.

Humans↗
PubMed1993

Influence of thumb sucking on peer social acceptance in first-grade children.

Chronic thumb sucking in school-age children may reduce peer social acceptance, an important contributor to social development. The influence of thumb sucking on social acceptance was assessed among 40 first-grade children, who were shown four slides of two 7-year-old children (one boy, one girl) in two poses (one thumb sucking, one not). After viewing each slide in their classrooms, the children answered 10 numerically weighted questions related to peer acceptance. To limit the possibility that the children would determine the girl and boy were the same in each pose, the slide presentation was counterbalanced across two sessions 1 week apart. Using a repeated-measures analysis of variance, the authors compared composite scores on each question for both poses. The results indicate that while in the thumb-sucking pose, the children were rated as significantly less intelligent, happy, attractive, likeable, and fun and less desirable as a friend, playmate, seatmate, classmate, and neighbor than when they were in the non-thumb-sucking pose. These findings suggest that the risk of reduced social acceptance should be added to the list of potentially harmful effects of chronic thumb sucking in school-age children.

Analysis of Variance↗
PubMed1995

The impact of mood on time perception, memorization, and acceptance of waiting.

The effects of mood on two cognitive processes, memorization and time perception, were examined. Participants (N = 155) first watched videos that successfully manipulated their mood (happy or sad); then they watched a video simulating a waiting line (Bateson & Hui, 1992; Bosselman & Craik, 1987). A questionnaire was administered to both groups to assess the number of items memorized from the "waiting" video, the estimated waiting time, and the degree of acceptance of waiting time. A series of analyses of variance showed that happy mood enhanced the number of items memorized and the acceptance of waiting but had no significant effect on time estimates. Memorization had no effect on time estimates or on acceptance of waiting; as expected, the longer the perceived waiting time, the less the acceptance of waiting time. A global model based on a system of linear equations (LINEQS) reproduced these results, which are interpreted in terms of both previous studies on mood and time estimate models.

Adaptation, Psychological↗
PubMedDate not supplied

Creatinine clearance in continuous peritoneal dialysis: dialysis dose required for a minimal acceptable level.

OBJECTIVES: To identify the most advantageous formula for estimating creatinine clearance (CCr) and to establish a dose of dialysis that will ensure minimal acceptable levels of creatinine clearance in patients on continuous peritoneal dialysis (CPD). DESIGN: Analysis of all CCr studies performed in CPD patients over 40 months. SETTING: All four dialysis units following CPD patients in one city. One dialysis unit is government-owned, one is university-affiliated, and two are community based. PARTICIPANTS: One hundred and ninety-four patients representing almost the entire CPD population in Albuquerque. INTERVENTIONS: Creatinine and urea clearance studies were performed in 24-hour urine and drained dialysate samples. Creatinine clearance (peritoneal plus urinary) was normalized to either 1.73 m2 body surface area (CCr) or body water estimated by the Watson formulas (KT/VCr). CCr and KT/VCr were either corrected by averaging urinary creatinine and urea clearances or were not corrected. Two dialysis units were designated as the training set (92 patients, 143 clearance studies) and the other two units as the validation set (102 patients, 181 clearance studies). MAIN OUTCOME MEASURES: Minimal acceptable creatinine clearance levels were determined in the training set by computing the creatinine clearance value corresponding to 1.70 weekly KT/V urea by linear regression. Logistic regression models predicting low creatinine clearance were developed in the training set and were tested in the validation set. RESULTS: The following weekly creatinine clearance values corresponded to 1.70 KT/V urea: corrected CCr 52.0 L/1.73 m2, uncorrected CCr 54.4 L/1.73 m2, corrected KT/VCr 1.46, uncorrected KT/VCr 1.53. Logistic regression identified as predictors of low creatinine clearance low daily urine volume (UV) and low daily dialysate drain volume/body water (DV/V) for all four creatinine clearance formulas, plus low/low-average peritoneal solute transport (only for uncorrected CCr) and serum creatinine (for both KT/VCr formulas). In the validation set, the predictive models produced an area under the receiver operating characteristic (ROC) curve between 0.835 and 0.919 indicating very good predictive accuracy. For corrected CCr and anuria, the regression model produced a minimal normalized drain volume (DV/V) value consistent with minimal acceptable CCr equal to 0.305 L/L per 24 hours. This DV/V cutoff detected low corrected CCR in validation set anuric subjects (n = 55) with a sensitivity of 85% and a specificity of 71%. For uncorrected CCR and anuria, DV/V cutoffs were 0.273 L/L per 24 hours (high/high-average peritoneal solute transport) and 0.420 L/L per 24 hours (low/low-average transport). Sensitivity and specificity of these cutoffs in validation set anuric subjects were 87% and 85%, plus 86% and 33%, respectively. CONCLUSIONS: The uncorrected CCr appears to be the most advantageous creatinine clearance formula in CPD, because it allows the use of peritoneal solute transport type in the calculation of the minimal required normalized drain volume. The minimal acceptable uncorrected CCr is 54.4 L/1.73 m2 weekly. To achieve this uncorrected CCr in anuria, the required minimal normalized drain volume is 0.273 L per liter of body water daily if peritoneal solute transport is high or high-average and around 0.420 L per liter of body water daily if peritoneal solute transport is low or low-average. The required total daily drain volume is computed by multiplying the required normalized drain volume by body water.

Biological Transport↗
PubMed1997

[Editing of articles accepted for publication by the Nederlands Tijdschrift voor Geneeskunde].

The Nederlands Tijdschrift voor Geneeskunde has been publishing medical science in Dutch for 140 years. To bridge the gap between the specialist science and the general medical reader several sections in the accepted papers have to be clarified, simplified and shortened by post acceptance editing. The style and language of the authors is treated with respect. Changes are made if the article does not comply with internationally accepted rules on scientific reporting, if the article can not be understood using currently authoritative general and medical books of reference, and if its language does not comply with generally accepted Dutch rules for grammar and spelling.

Netherlands↗
PubMed1998

[Nutritive value and acceptability of chinchilla's meat].

(Eriomys lanigera y brevicaudata) Food value and acceptability of chinchilla's meat with different thermic treatments were studied. Chinchilla's in captivity of the Province of Jujuy were used. They were divided into three groups: raw and treated with dry and wet heat and the following analysis were carried out: moisture, protein, ether extract, ashes, iron (A.O.A.C.), cholesterol (enzymatic method), Net Protein Ratio (NPR), Digestibility and acceptability tests were also done. Moisture content of raw chinchilla's meat was 68.24 g/100 g and the meat treated with wet and dry heat had moisture of 65.09 g and 62.49 g/100 g respectively. Protein percentage of raw chinchilla's meat was 20.03 g/100 g, no significant differences were observed in the meat thermally treated. The same tendency was observed concerning the ether extract content (11.26; 12.00 and 12.92 g/100 g for raw meat and the one treated with wet and dry heat respectively). No difference was observed among the three types of meat as far as the ash content is concerned. The mg of iron in raw meat were higher (13.76 mg/100 g) than in thermally treated meat (12.43 and 12.37 mg/100 g for wet and dry heated respectively). NPR and digestibility of thermally treated meat were 5.26 and 5.65; 96.75 and 96.84 (for wet and dry heated meat respectively); both were similar to and higher than casein. The acceptability of chinchilla's meat treated with wet heat (94%) was higher than that treated with dry heat (90%). It can be concluded that chinchilla's meat thermally treated has both good food value and acceptability.

Animals↗
PubMed1986

Women's acceptance of a preterm birth prevention program.

A major modification in French national perinatal policy was proposed in 1970. Its primary aim was to reduce preterm births, and a specific program has been progressively applied to all pregnant women in France since 1971. Because the policy was introduced at a national level, it was possible to use a district hospital in Haguenau (northeastern France) as an observation site for measuring the effects of the change. A longitudinal study was begun in 1971 and continued for 12 years, during which time a total of 16,004 singleton pregnancies were followed. This article focuses on acceptance by the pregnant women in Haguenau in response to the new prenatal care proposals. A major reduction in preterm births is demonstrated, and the relationship between acceptance and observed changes in preterm birth is discussed. Certain time-related patterns were observed: it took time for the policy modification to be measurable; while the outcomes showed general improvement, results were closely related to the patient's social status; there were significant time-lag differences between social class groups with regard to acceptance of specific interventions.

Birth Weight↗
PubMed1981

Acceptability of the contraceptive vaginal ring by rural and urban population in two Latin American countries.

A study of the field acceptability of the Contraceptive Vaginal Ring (CVR) was carried out in rural, small town and urban slum clinics in four locations, two in Brazil and two in the Dominican Republic (D.R.) The CVR was offered as a new method in the clinics and described as similar to the pill but placed in the vagina for three weeks each month with a one-week rest interval. Follow-up surveys were carried out in the four locations at the end of the experimental period. Three, eight, nine and 12.5% of the total acceptors in each of the 4 locations chose the CVR. The acceptance rate fell after the first five months but recovered during the second year. The acceptance rate was much higher in three rual clinics where the nurses themselves used the ring. The follow-up surveys showed that the fact that the ring is placed and kept in the vagina without removal for a prolonged period was the most important attribute of the method and played a large role in women's reactions to it. Anticipated use-related problems were the most prominent reason given by pill users for not choosing the ring, however ease of use was named as the "most killed" characteristic by 55% of ring users. Women tended to remove the ring for intercours and washed it frequently, often with detergents, thus illustrating their concern with "cleanliness" of an object kept within a body cavity for long periods of time.

Brazil↗
PubMed1999

Lea's Shield contraceptive device: pilot study of its short-term patient acceptability and aspects of use.

OBJECTIVE: To assess the short term patient acceptability and aspects of use of the Lea's Shield(R). DESIGN: Observational study. Ten women were each invited to use the Lea's Shield on 10 occasions and to report their observations and experiences on structured questionnaires after each use. Thus, data on a maximum of 100 uses would become available for analysis. Answers were recorded on numerical scales and in descriptive terms. On conclusion of their study participation, patients and their partners were required to document their overall experience with the product. SETTING AND SUBJECTS: Women aged 18 to 40 years, self-selected from clients attending the Margaret Pyke Family Planning Centre. They had to be in a stable monogamous relationship, gynaecologically healthy, and willing to continue their use of oral contraceptives, IUD, or injectable. MAIN OUTCOME MEASURE: Ability to use the method without formal teaching, assessed after vaginal examination by the investigator at end of first visit. User satisfaction, as expressed in structured questionnaires and by premature withdrawal from trial. RESULTS: Ten women used Lea's Shield on a total of 70 occasions, of which 46(66 per cent) were associated with sexual intercourse. Five subjects withdrew from the trial prematurely on account of discomfort to either or both partners (four), and recurrent cystitis (one). At the enrolment visit, all but one woman inserted the device correctly without formal teaching, but there was considerable inter-patient variation in their responses concerning ease of insertion/removal, and comfort during subsequent uses. CONCLUSIONS: These preliminary observations suggest that the Lea's Shield may be acceptable to a highly select minority of women. However, much more research is required to permit a reliable assessment of its acceptability to the wider public. The product's potential for causing pain and discomfort also needs further exploration.

Adolescent↗
PubMed1981

Trend in vasectomy acceptance: 1974-1981.

It is often heard in Thai population seminars and workshops that Thai men are resistent to vasectomy. There are claims that due to traditional fears of vasectomy or an unwillingness to play a role in family planning most Thai men will not accept vasectomy services even if they are offered nearby. This assumption may be wrong. The Research and Evaluation Unit of the Family Health Division has graphed a new acceptance of vasectomy by month service January, 1974-June, 1981. The graph also plots important events that should be related to vasectomy acceptance. Indeed it appears that when extra effort is made, such as a demonstration mobile team, private sector reimbursement, short-term campaigns and the deployment of mobile teams, willing and waiting acceptors are there. The fact that "extra effort" is required with vasectomy is probably more the result of a general reluctance to undergo the procedure than rather fear or hard-core resistance.

Asia↗
PubMedDate not supplied

Evaluation of safety, efficacy, and acceptability of NORPLANT implants in Sri Lanka.

This paper presents findings based on a one-year pre-introductory clinical investigation concerning safety, efficacy, and acceptability of the new contraceptive NORPLANT implants in Sri Lanka. The study is based on 400 acceptors of the implants at two clinics in Sri Lanka. Acceptors' mean age was 27 years, mean number of children was about two, and average educational attainment was eight years. Nearly half of the acceptors did not want to have another child. Follow-up was conducted at one, three, six, and twelve months. The one-year termination rate due to medical problems was very low, and the one-year life-table pregnancy rate was 0.5. Menstrual pattern disruption was the most frequently reported complaint with the implants. Amenorrhea increased in the first three months of use, and intermenstrual bleeding was common among those menstruating. In spite of these changes and some significant variations between the acceptors in the two study center, the overall degree of satisfaction with the implants was very high. The features most important to the acceptability of the implants were low risk of pregnancy, the long duration of action, and the convenience of use. The results of the study suggest that NORPLANT implants are safe, effective, and highly acceptable to Sri Lankan women.

Adolescent↗
PubMed1977

Inguinal herniorrhaphy under local anesthesia. A prospective study of 100 consecutive patients with emphasis of perioperative morbidity and patient acceptance.

For various reasons, repair of inguinal hernias under local anesthesia is not well accepted. The purpose of this study is to evaluate the effectiveness of local anesthesia in inguinal hernia repairs. One hundred consecutive inguinal herniorrhaphies are reported. The selection of patients, surgical technique, and incidence of intraoperative and postoperative complications are reported. Patient acceptance and their immediate postoperative course are also described. The study demonstrates that inguinal hernias can be easily repaired under local anesthesia, complications are minimal, and patient acceptance, excellent. We strongly recommend thath this form of anesthesia be used in the "routine" repair of inguinal hernias in cooperative patients.

Adult↗
PubMed2026

Perceptions of Pharmacogenomic Testing Among People With Treatment Resistant Depression: Legitimization as a Facilitator of Acceptance.

Pharmacogenomic testing for psychiatric medications has been proposed as both an early intervention to optimize treatment response, and for use among patients who have tried multiple medications without symptom remission. Therefore, this testing may be particularly salient to the subset of individuals with major depressive disorder for whom depression has been labeled as "treatment resistant". Understanding the impact of this diagnostic label on illness identity and attitudes towards new therapies is important as genomic technology expands and rates of depression increase. We sought to explore perceptions and attitudes towards pharmacogenomic testing among individuals who had received a diagnosis of treatment resistant depression. We conducted a qualitative study with a constructivist orientation. Participants were recruited from a larger genomic research study and interviewed by phone or video call. We took an inductive approach to coding guided by reflexive thematic analysis. Themes were then organized into a relational framework following principles of interpretive description. Twelve individuals were interviewed. Key themes included internalized acceptance/hopelessness, and external validation/frustration, which were cyclically interconnected. These themes were situated within a larger framework illustrating the ways that illness identity and modifying factors such as relief of guilt, social support, pharmacogenomic testing and depressive symptoms can either facilitate acceptance and validation or contribute to feelings of hopelessness and frustration. Though participants expressed some skepticism around its effectiveness, pharmacogenomic testing may contribute to the shift towards acceptance and validation by legitimizing individuals' experiences with lack of treatment response. Genetic counselors and other healthcare providers should be aware of the complex balance between hope and frustration underlying conversations around pharmacogenomic testing, and factors that are more likely to foster self-acceptance.

Humans↗
PubMed1996

[Patient acceptance of patient-controlled intranasal analgesia (PCINA)].

UNLABELLED: Patient-controlled intravenous analgesia (i.v.-PCA) represents the gold standard in the management of acute postoperative pain. However, in many countries i.v.-PCA is rarely used. Recent clinical studies demonstrated that intranasal fentanyl titration provides a rapid and safe form and pain management. In the present study we investigated patients' acceptance and assessment of patient-controlled intranasal analgesia (PCINA) and compared it to intravenous PCA and the customarily prescribed pain therapy. MATERIAL AND METHODS: After approval by the local ethics committee and written informed consent, 79 ASA physical status I or II patients were investigated on the first postoperative day following orthopaedic surgery. The patients were allocated either to the PCINA group (a maximum of 0.025 mg fentanyl over 6 min), to the i.v.-PCA group (0.025 mg fentanyl bolus, lockout interval 6 min) or to a group of patients who received the customarily prescribed pain management. Following the 8-h investigation period, the patients were questioned regarding their satisfaction with the pain therapy using a 6-point rating scale (ranging from 1 = very good to 6 = not acceptable). The patients were furthermore asked to name the advantages and disadvantages of their pain management. RESULTS: Three patients in the i.v.-PCA group had to be excluded due to pain at the injection site and one patient in the PCINA group because of a surgical complication. Seventy-five patients were finally included, 25 patients per group. No statistically significant intergroup differences regarding age, weight, height and initial pain intensity (evaluated by a 101-point numeric rating scale) were demonstrated. The patients' satisfaction with the mode of pain management was significantly higher in the PCINA (median "good") and in the i.v.-PCA group (median "good") than in the group who received the customarily prescribed pain management (median "satisfactory"). This difference was statistically significant (P = 0.0001). No statistically significant difference was demonstrated between the PCINA and i.v.-PCA groups. The patients in the PCINA and in the i.v.-PCA group stated as main advantages the rapid onset of action and good pain relief (n = 25 and n = 25, respectively), as well as their independence from the doctor or nurse (n = 12 and n = 13). The main disadvantages were pain on injection in the i.v.-PCA group and too frequent fentanyl administrations in the PCINA group (n = 6). DISCUSSION: The results demonstrate that the patients' satisfaction with PCINA is comparable to that with i.v.-PCA. Both PCINA and i.v.-PCA were assessed as superior to the customarily prescribed pain management (P = 0.0001). Patients' acceptance of a given form of pain management is mainly related to its efficiency. However, side effects such as pain on injection with i.v.-PCA, or frequent opioid administration with PCINA, must be considered when assessing a method of pain control. Patients' global assessment includes both efficiency and side effects. PCINA represents an interesting alternative non-invasive method for postoperative pain management.

Administration, Intranasal↗