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[Biological and genetic properties of a polyploid-forming mutant of the Venezuelan equine encephalomyelitis virus].

Some genetic and biological properties of the multiploid -forming mutant of Venezuelan equine encephalomyelitis virus as well as of standard and multiploid virions isolated from its population were analysed. The mutant steadily retained the capacity for formation of multiploid virions comprising up to 20% of the population both in passages in CEF culture and in the progeny of multiploid and standard virions. Owing to this, the concentration of multiploid virions in the population of this mutant remains at a constant level. Formation of multiploid virions compensates for the temperature-sensitive defect inherent in the standard virions which is associated with later stages of virus replication.

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PubMed1981

Evaluation and comparative studies of inactivated rabies vaccines obtained in the heterologous diploid and polyploid cells (HAK, BHK and VERO).

This study is concerned with the following characteristics of the vaccines: 1.) protecting power, 2.) rabies antigens and 3.) major polypeptide components. This study was performed on supernatants of tissue cultures and on concentrated and purified vaccines. Moreover, some cellular and serum contaminants, especially the proteins produced by BHK cells, as well as minor rabies proteins, were analysed in the viral solutions. Thus, it appears that all three types of vaccines have a similar protecting power (Number of 50% protective doses/micrograms viral protein).

Animals↗