Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “multimodal data”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 757 records · Page 42Linked to original sources
PubMedDate not supplied

Therapeutics of aggression in children.

This paper examines the phenomenology, aetiology and therapeutics of childhood aggression that arises as part of a disruptive behaviour disorder. Phenomenology is discussed with an emphasis on treatment implications. Reviewed studies show that aggressive behaviour exhibits both episodicity and considerable individual stability. Aetiological theories are reviewed with emphasis on the interplay between biological and socio-environmental factors. Both factors are centrally involved in the development and treatment of aggression. A review of double-blind, placebo-controlled medication studies is presented. A computer-based, literature search using Medline and PsychInfo was conducted to locate all potentially relevant articles published in the past 20 years. It was found that there are various treatments available for reducing paediatric aggression including psychotherapeutic and psychopharmacological treatments. There are data to support the use of psychostimulants, lithium and antipsychotics, while data for other agents are only beginning to accumulate. Various pharmacological treatments can reduce aggression in children. However, given the role of both biological and social factors in the development of aggression, multimodal treatment may ultimately provide maximal benefits.

Aggression↗
PubMedDate not supplied

Medical image informatics infrastructure design and applications.

Picture archiving and communication systems (PACS) is a system integration of multimodality images and health information systems designed for improving the operation of a radiology department. As it evolves, PACS becomes a hospital image document management system with a voluminous image and related data file repository. A medical image informatics infrastructure can be designed to take advantage of existing data, providing PACS with add-on value for health care service, research, and education. A medical image informatics infrastructure (MIII) consists of the following components: medical images and associated data (including PACS database), image processing, data/knowledge base management, visualization, graphic user interface, communication networking, and application oriented software. This paper describes these components and their logical connection, and illustrates some applications based on the concept of the MIII.

Age Determination by Skeleton↗
PubMed2004

[ Effects of electromagnetic fields generated by mobile phones on the nervous system].

The authors present some data on the effects of electromagnetic fields (EMF) generated by mobile phones on the nervous system. The main attention was paid to the usefulness of some neurophysiological methods, such as electroencephalography (EEG), multimodality evoked potentials (MEP), and event related potentials (ERP) in the evaluation of the bioelectrical activity of the brain. The majority of the cited articles underline the difficulties in the evaluation of adverse effects of EMF generated by mobile phones, which can result from their nonspecific influence on biological structures.

Cell Phone↗
PubMed1999

[Standards, options and recommendations (SOR) for clinical care of malignant thymoma. Groupe de Travail SOR].

CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of the French Cancer Centres (FNCLCC), the 20 French Cancer Centres and specialists from French Public Universities, General Hospitals and Private Clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and outcome for cancer patients. The methodology is based on literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery. OBJECTIVES: To develop clinical practice guidelines according to the definitions of Standards, Options and Recommendations for the clinical care of malignant thymoma in adult. METHODS: Data have been identified by literature search using Medline (december 1998) and the expert groups personal reference lists. Once the guidelines were defined, the document was submitted for review to national and international independent reviewers, and to the medical committees of the 20 French Cancer Centres. RESULTS: The main recommendations for malignant thymoma management are that: 1) the clinical diagnosis is based on appropriate clinical and radiological findings; 2) the final diagnosis is pathological and made from a biopsy, except in cases of well-encapsulated tumors which are completely resected. The biopsy, via anterior mediastinostomy, should be performed by the surgeon who will subsequently perform the definitive surgery; 3) surgical resection must be complete including thymus and perithymic fat and performed by an experienced surgeon; 4) the therapeutic strategy for malignant thymoma is based on the three current staging systems and involves surgery with radiotherapy given if the capsule is invaded or penetrated. Radiotherapy should be given in experienced centres. Inclusion of patients in prospective clinical trials is recommended in order to determine the usefulness of neoadjuvant chemotherapy and multimodality approaches; 5) treatment of metastatic malignant thymoma is based on chemotherapy. Secondary surgery may be performed with the aim of achieving complete resection. Inclusion in clinical trials is recommended; 6) at the present time, there are no clear data on which to base guidelines for timing and duration of follow-up studies in this condition. Because of late recurrence, follow-up should be long.

Adult↗
PubMed2003

Multimodal ultrasound assessment of cerebral hemodynamics in a patient with a diffuse cerebral angiomatosis.

Recent newly developed ultrasound (US) techniques extend our ability to study the cerebral hemodynamics in patients with arteriovenous malformations (AVM) beyond the conventional cerebral blood flow velocity (CBFV) analysis. We present US data of global cerebral blood flow (CBF) and global cerebral circulation time (CCT) in a patient with a unique bihemispherial diffuse cerebral angiomatosis and compare them with 10 age-matched controls. In addition, the estimation of an US-derived global cerebral blood volume (CBV) is proposed. Duplex sonographic CBF analysis revealed 2620 mL/min in the patient and 754 +/- 93 mL/min in controls. Doppler sonographic CCT was 2.9 s and 6.3 +/- 1.5 s and CBV 126 mL and 79 +/- 19 mL, respectively. US allows a simple, minimal invasive bedside analysis of several global hemodynamic parameters that might provide valuable additional information in patients with diffusely altered cerebral hemodynamics.

Adult↗
PubMed2006

Towards multimodal atlases of the human brain.

Atlases of the human brain have an important impact on neuroscience. The emergence of ever more sophisticated imaging techniques, brain mapping methods and analytical strategies has the potential to revolutionize the concept of the brain atlas. Atlases can now combine data describing multiple aspects of brain structure or function at different scales from different subjects, yielding a truly integrative and comprehensive description of this organ. These integrative approaches have provided significant impetus for the human brain mapping initiatives, and have important applications in health and disease.

Anatomy, Artistic↗
PubMed1986

A multimodal system for reconstruction and quantification of neurologic structures.

The utility of computers and computer graphics as aids in the study of nervous system architecture is growing. However, modern histologic, immunocytologic and biochemical methods for revealing the underlying microarchitecture and macroarchitecture of the nervous system yield data formats requiring disparate computer acquisition, analysis and display approaches, capable of spanning many orders of magnitude of scale. This paper describes the Image Graphics Laboratory data acquisition, processing and display system, whose various components and programs may be used singly or in concert to enable definition of various tissue properties at different levels of resolution and integration. Examples are given of the system's use in light microscopic two-dimensional and three-dimensional reconstructions, autoradiographic reconstructions, reconstructions from projected images, reconstructions of impregnated cells (e.g., whole neurons) and peripheral nerve image analysis.

Animals↗
PubMed1999

A reduction in the AAPM TG-36 reported peripheral dose distributions with tertiary multileaf collimation. American Association of Physicists in Medicine Task Group 36.

PURPOSE: The American Association of Physicists in Medicine Task Group 36 (AAPM TG-36) data can be used to estimate peripheral dose (PD) distributions outside the primary radiation field. However, the report data apply to linear accelerators not equipped with tertiary multileaf collimators (MLCs). Peripheral dose distributions consist of internal scatter, collimation scatter, transmission through collimation, head leakage, and room scatter. Tertiary MLCs may significantly reduce the PD due to a reduction in collimation scatter, transmission through collimation, and head leakage. Measurements were performed on a multimodality linear accelerator, equipped with a tertiary MLC, to determine PD distributions as a function of energy, field size, distance from the primary radiation field edge, MLC position, and collimator orientation. METHODS AND MATERIALS: Measurements were made using an ionization chamber embedded in a 20 x 40 x 120-cm3 water-equivalent plastic phantom with the secondary collimator and MLC settings of 10 x 10, 15 x 15, 20 x 20, 25 x 25 cm2, and with the MLC fully retracted. Data were taken along the longitudinal axis of the machine for 6 and 18 MV photons. Peripheral dose distributions were evaluated with the collimator set to 180 and 90 degrees. Rotation of the collimator allowed measurements parallel and orthogonal to the direction of motion of the MLC. RESULTS: For both photon energies, peripheral doses measured on a MLC machine were lower than the TG-36 data. When the collimator is rotated by 90 degrees, placing the lower jaws and the MLC leaves along the plane of interest, PD was reduced by as much as a factor of three compared with PDs measured with the MLC fully retracted and the collimator rotated to 180 degrees. PDs measured with the MLC fully retracted and collimator rotated to 180 degrees were comparable to the TG-36 data. Measured PDs were lower when the MLC was used to shape the field than when the MLC was fully retracted. CONCLUSION: A strategic orientation of the collimator with a tertiary MLC can reduce PD distributions by more than a factor of two. This decrease significantly lessens or eliminates the need for external lead shielding to reduce the critical organ dose. This method can be used even when Lipowitz metal blocking (such as for mantle fields) is used, with the MLC leaves oriented along the longitudinal plane.

Particle Accelerators↗
PubMed2003

A multivariate, spatiotemporal analysis of electromagnetic time-frequency data of recognition memory.

Electromagnetic indices of "fast" (above 12 Hz) oscillating brain activity are much more likely to be considerably attenuated by time-averaging across multiple trials than "slow" (below 12 Hz) oscillating brain activity. To the extent that both types of oscillations represent the activity of temporally and topographically separable neural populations, time averaging can cause a loss of brain activity information that is important both conceptually and for multimodal integration with hemodynamic techniques. To address this issue for recognition memory, simultaneous electroencephalography (EEG) and whole-head magnetoencephalography (MEG) recordings of explicit word recognition from 11 healthy subjects were analyzed in two different ways. First, the time course of neural oscillations ranging from theta (4.5 Hz) to gamma (42 Hz) frequencies were identified using single-trial continuous wavelet transforms. Second, traditional analyses of amplitude variations of time-averaged EEG and MEG signals, event-related potentials (ERPs), and fields (ERFs) were performed and submitted to distributed source analyses. To identify data patterns that covaried with the difference between correctly recognized studied (old) words and correctly rejected nonstudied (new) words, a multivariate statistical tool, partial least squares (PLS), was applied to both types of analyses. The results show that ERPs and ERFs are mainly displaying those neural indices of recognition memory that oscillate in the theta (4.5-7.5 Hz), alpha (8-11.5), and to some extent in the beta1 (12-19.5 Hz) frequency range. The sources of the ERPs/ERFs were in good agreement with the topography of theta/alpha/beta 1 oscillations in being confined to the anterior temporal lobe at 400 ms and being distributed across temporal, parietal, and occipital areas between 500 and 700 ms. Gamma oscillations covaried either positively or negatively with theta/alpha/beta1 oscillations. A positive covariance, for instance, was detected over left anterior temporal sensors as early as 200-350 ms and is compatible with studies in rodents showing that gamma and theta oscillations emerge together out of the interaction of the hippocampus and the entorhinal and perirhinal cortices. Fast beta oscillations (20-29.5 Hz), on the other hand, did not strongly covary with slow oscillations and were likely to arise from neural populations not adequately represented in ERPs/ERFs. In summary, by providing a more comprehensive description of electromagnetic signals, time-frequency data are of potential benefit for integrating electrophysiological and hemodynamic indices of brain activity and also for integrating human and animal electrophysiology.

Adolescent↗
PubMed2001

[Physical and methodological aspects of multimodality imaging and principles of treatment planning in 3D conformal radiotherapy].

The recent evolutions of the imaging modalities, the dose calculation models, the linear accelerators and the portal imaging permit to improve the quality of the conformal radiation therapy treatment planning. With DICOM protocols, the acquired imaging data coming from different modalities are treated by performant image fusion algorithms and yield more precise target volumes and organs at risk. The transformation of the clinical target volumes (CTV) to planning target volumes (PTV) can be realised using advanced probabilistic techniques based on clinical experience. The treatment plans evaluation is based on the dose volume histograms. Their precision and clinical relevance are improved by the multi-modality imaging and the advanced dose calculation models. The introduction of the inverse planning systems permitting to realise modulated intensity radiation therapy generates highly conformal dose distributions. All the previously cited complex techniques require the application of rigorous quality assurance programs.

Dose Fractionation, Radiation↗
PubMed1996

[Results of radiotherapy in recurrences of soft tissue sarcomas].

PURPOSE: Published data for radiotherapy in soft tissue sarcomas refer in most of the cases to the use of irradiation for primary tumors. Experiences of radiotherapy in local recurrences are limited. The own treatment results of a multimodal treatment approach in a large number of patients will be analyzed for local tumor control rates, survival rates, side effects and prognostic factors and will be compared to the literature. PATIENTS AND METHODS: At the University Hospital Hamburg-Eppendorf a total of 98 patients with local recurrences of soft tissue sarcomas were irradiated between 1980 and 1993. The median age of the patients was 55 years. There was a large variety of different histologies. Grading was evaluable in 95 cases: G1 24 patients, G2 21 patients and G3 50 patients. Localisation was dominated by the extremities with 64.3%. Recurrences were reclassified: 21 patients had rT1-tumors and 77 patients had rT2-tumors. Twelve cases showed lymph node metastases and 9 patients distant metastases. Generally treatment included surgery and postoperative irradiation. R-classification showed R0 in 25, R1 in 20 and R2 in 48 cases. Neutrontherapy was prefered in 57 cases and neutron- and photontherapy in 22 cases. Local tumor control rates and survival rates were calculated using the Kaplan-Meier method. Side effects were scored using the RTOG/EORTC scoring system. Univariate and multivariate analyses were applied to evaluate prognostic factors. RESULTS: Local tumor control rates at 5 years were 56.4%, for G1 75.2%, G2 52.5%, G3 47.1%, rT1 66.0%, rT2 53.6%, R0 63.4%, R1 42.3% and R2 53.2%, N0 61.1% vs. N1 31.7%. Survival rates at 5 years were 45.2%, for G1 64.8%, G2 66.9%, G3 25.0%, rT1 60.0%, rT2 41.5%, R0 64.2%, R1 49.3% and R2 32.7%. Acute side effects were scored as grade 1 and grade 2. The rate of grade 3 and 4 late effects was about 6%. Lymph node status was a significant factor for local control. Grade, residual tumor status, type of irradiation and the applied neutron dose were significant factors for survival. CONCLUSIONS: Nowadays no standard treatment exists for local recurrences of soft tissue sarcomas. Treatment should be interdisciplinary. Local recurrences should be avoided by the consequent use of surgery and radiotherapy. It is important that local recurrences should be detected early. Neutrontherapy may bring advantages for local control of recurrences with macroscopic tumor residuals.

Adolescent↗
PubMed1987

Fear-potentiated startle using an auditory conditioned stimulus: effect of lesions of the amygdala.

The effect of lesions of the amygdala on fear-potentiated startle using an auditory conditioned stimulus (CS) was evaluated, after replicating and extending previous findings that a tone is an effective CS for fear-potentiated startle. Rats received 10 tone-shock pairings on 2 successive days. At 24-48 hr following training, they received bilateral electrolytic lesions of the central nucleus of the amygdala or sham operations, and then were tested for fear-potentiated startle 4-5 days later. Lesions of the amygdala impaired fear-potentiated startle using an auditory CS, consistent with the previous findings using a visual CS. These data indicate that the effect of lesions of the amygdala on fear-potentiated startle is not specific to one sensory modality, consistent with the hypotheses that the amygdala is involved in processing multimodal information related to conditioned fear, or is part of an output pathway for motor and autonomic expressions of conditioned fear.

Acoustic Stimulation↗
PubMed2006

Subclavicular recurrence of breast cancer: does surgery play a role?

Occasionally, breast cancer relapses in the subclavicular region. In patients with failed multimodal treatment, or in those who develop an isolated recurrence, surgical resection may be useful to remove all macroscopically evident diseases. However, the procedure may be technically demanding and there are no published data regarding its benefits. The aim of the present study was to evaluate the feasibility and safety of subclavicular resection in breast cancer and provide indications as to whether it can contribute to disease control. We used a transpectoral approach to surgically remove isolated breast cancer recurrence in the subclavicular region in seven consecutive patients presenting over 2 years; in the eighth case a transmanubrial approach was necessary. We found that the surgical approach proposed is feasible and safe, with a 75% rate of complete resection; however, the series was characterised by a high rate of local and distant relapse. We conclude that the technique may be useful, in selected cases, for palliation only.

Adult↗
PubMed2001

Improving operative performance using a laparoscopic hernia simulator.

BACKGROUND: Traditionally, the acquisition of surgical skill has occurred entirely in the operating room. To meet the expanding challenges of cost containment and patient safety, novel methods of surgical training utilizing ex-vivo workstations are being developed. The purpose of our study was to evaluate the impact of a laparoscopic training curriculum on surgical residents' operative performance. METHODS: Twenty-one surgery residents completed baseline laparoscopic total extraperitoneal (TEP) hernia repairs. Operative performance was evaluated using a validated global assessment tool. Each resident was then randomized to a control group or a trained group. A CD ROM, video, and simulator were used for training. At the end of the study, each resident's operative performance was again evaluated. RESULTS: Improvement was significantly greater in the trained group in five of the eight individual global assessment areas as well as the composite score (P <0.05). Questionnaire data suggested that training resulted in improved understanding of the TEP hernia repair (P = 0.01) and an increased willingness to offer the operation to patients with nonrecurrent unilateral hernias (P = 0.02). CONCLUSIONS: A multimodality laparoscopic TEP hernia curriculum improves residents' knowledge of the TEP hernia repair and comfort in performing the procedure, and may also improve actual operative performance.

Clinical Competence↗
PubMed1990

Mechanism of O-antigen distribution in lipopolysaccharide.

O-antigen units are nonuniformly distributed among lipid A-core molecules in lipopolysaccharide (LPS) from gram-negative bacteria, as revealed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate; the actual distribution patterns are complex, multimodal, and strain specific. Although the basic biochemical steps involved in synthesis and polymerization of O-antigen monomers and their subsequent attachment to lipid A-core are known, the mechanism by which specific multimodal distribution patterns are attained in mature LPS has not been previously considered theoretically or experimentally. We have developed probability equations which completely describe O-antigen distribution among lipid A-core molecules in terms of the probability of finding a nascent polymer (O antigen linked to carrier lipid) of length k (Tk) and the probability that a nascent polymer of length k will be extended to k + 1 by polymerase (pk) or transferred to lipid A-core by ligase (qk). These equations were used to show that multimodal distribution patterns in mature LPS cannot be produced if all pk are equal to p and all qk are equal to q, conditions which indicate a lack of selectivity of polymerase and ligase, respectively, for nascent O-antigen chain lengths. A completely stochastic model (pk = p, qk = q) of O-antigen polymerization and transfer to lipid A-core was also inconsistent with observed effects of mutations which resulted in partial inhibition of O-antigen monomer synthesis, lipid A-core synthesis, or ligase activity. The simplest explanation compatible with experimental observations is that polymerase or ligase, or perhaps both, have specificity for certain O-antigen chain lengths during biosynthesis of LPS. Our mathematical model indicates selectively probably was associated with the polymerase reaction. Although one may argue for a multimodal distribution pattern based on a kinetic mechanism i.e., varying reaction parameters in space or in time during cell growth, such a model requires complex sensory and regulatory mechanisms to explain the mutant data and mechanisms for sequestering specific components of LPS biosynthesis to explain the distribution pattern in normal cells. We favor the simple alternative of enzyme specificity and present generalized equations which should be useful in analysis of other analogous biochemical systems.

Antigens, Bacterial↗
PubMed1978

Inert gas a-A differences: a direct reflection of V/Q distribution.

A computer model was developed to study the relationship between ventilation-to-perfusion (V/Q) mismatch and the development of inert gas arterial-to-alveolar partial pressure differences (a-A differences). Increasing inhomogeneity of V/Q ratio is revealed directly as an increase in the a-A difference of each gas. The quantitative relationships between the Q vs. V/Q distribution and the fractional a-A difference solubility plot (a-A difference plot) were studied and described. These studies demonstrated that for log normally distributed V/Q ratios, the area under the a-A difference plot is linearly related to the log variance of the V/Q distribution and can be estimated directly from the values obtained from six gases. The maximum a-A difference occurs for a gas whose solubility is numerically equal to the mean V/Q. The effects of departure from log normality and multimodality are discussed. We conclude from these studies that quantitative information regarding the degree of inhomogeneity of V/Q for log normal distribution is available from direct calculations of inert gas retention and excretion data. Qualitative information is also available indicating the departure from log normality and the region toward which the distribution is skewed.

Biophysical Phenomena↗
PubMed2004

ERP evidence for cross-modal audiovisual effects of endogenous spatial attention within hemifields.

Previous ERP studies have uncovered cross-modal interactions in endogenous spatial attention. Directing attention to one side to judge stimuli from one particular modality can modulate early modality-specific ERP components not only for that modality, but also for other currently irrelevant modalities. However, past studies could not determine whether the spatial focus of attention in the task-irrelevant secondary modality was similar to the primary modality, or was instead diffuse across one hemifield. Here, auditory or visual stimuli could appear at any one of four locations (two on each side). In different blocks, subjects judged stimuli at only one of these four locations, for an auditory (Experiment 1) or visual (Experiment 2) task. Early attentional modulations of visual and auditory ERPs were found for stimuli at the currently relevant location, compared with those at the irrelevant location within the same hemifield, thus demonstrating within-hemifield tuning of spatial attention. Crucially, this was found not only for the currently relevant modality, but also for the currently irrelevant modality. Moreover, these within-hemifield attention effects were statistically equivalent regardless of the task relevance of the modality, for both the auditory and visual ERP data. These results demonstrate that within-hemifield spatial attention for one task-relevant modality can transfer cross-modally to a task-irrelevant modality, consistent with spatial selection at a multimodal level of representation.

Acoustic Stimulation↗
PubMed2006

Pharmacological treatment options for panic disorder in children and adolescents.

Although panic disorder usually emerges in early to middle adulthood, adults with panic disorder often retrospectively report that their panic symptoms began in childhood or early adolescence. The majority of these juvenile cases are being misdiagnosed, and/or do not come to clinical attention. Awareness of early-onset panic disorder, as well as a more precise definition of early signs and possible clinical subtypes, can favour timely diagnosis and treatment, reduce clinical impairment and improve the prognosis of these patients. In the context of a multimodal approach, pharmacological treatment can be helpful. This review focuses on the empirical evidence of pharmacotherapy in early-onset panic disorder, including selective serotonin re-uptake inhibitors, benzodiazepines and tricyclics. The data supporting efficacy are still limited, and no controlled studies are available. Practical guidelines for the management of these patients are provided, including treatment of the most frequent psychiatric comorbidities.

Adolescent↗