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PubMed1999

Assessing and enhancing medical students' computer skills: a two-year experience.

In 1984, the Association of American Medical Colleges (AAMC) issued recommendations for the reform of medical education. One recommendation was that information sciences be incorporated into the medical curriculum. In fall 1996, a survey was conducted to learn more about computer use by medical students at the Rockford regional site of the University of Illinois at Chicago College of Medicine. The purpose of the survey was to gather information not only about computer skills, but also about overall comfort level in using computers and about expectations for enhancing computer skills while attending medical school. Over a two year period, 208 students representing four classes received this survey in their e-mail. Non-respondents received a follow-up print copy in their student mailboxes. Results, based on a 60% response rate, showed a majority of Rockford students entered medical school with good skills in using e-mail and word processing, but many lacked the skills necessary to search the medical literature or to use computer-assisted instructional programs. Overall, 80% of students expected to learn more about computers while attending medical school. Results contributed to an increased effort to integrate computer applications into the medical curriculum and to use computers as a means of communicating with students.

Computer Communication Networks↗
PubMed2004

Unitary vs multiple semantics: PET studies of word and picture processing.

In this paper we examine a central issue in cognitive neuroscience: are there separate conceptual representations associated with different input modalities (e.g., Paivio, 1971, 1986; Warrington & Shallice, 1984) or do inputs from different modalities converge on to the same set of representations (e.g., Caramazza, Hillis, Rapp, & Romani, 1990; Lambon Ralph, Graham, Patterson, & Hodges, 1999; Rapp, Hillis, & Caramazza, 1993)? We present an analysis of four PET studies (three semantic categorisation tasks and one lexical decision task), two of which employ words as stimuli and two of which employ pictures. Using conjunction analyses, we found robust semantic activation, common to both input modalities in anterior and medial aspects of the left fusiform gyrus, left parahippocampal and perirhinal cortices, and left inferior frontal gyrus (BA 47). There were modality-specific activations in both temporal poles (words) and occipitotemporal cortices (pictures). We propose that the temporal poles are involved in processing both words and pictures, but their engagement might be primarily determined by the level of specificity at which an object is processed. Activation in posterior temporal regions associated with picture processing most likely reflects intermediate, pre-semantic stages of visual processing. Our data are most consistent with a hierarchically structured, unitary system of semantic representations for both verbal and visual modalities, subserved by anterior regions of the inferior temporal cortex.

Adult↗
PubMed2005

Sequential processing in hemispheric word recognition: the impact of initial letter discriminability on the OUP naming effect.

The cerebral hemispheres have been proposed to engage different word recognition strategies: the left hemisphere implementing a parallel, and the right hemisphere, a sequential, analysis. To investigate this notion, we asked participants to name words with an early or late orthographic uniqueness point (OUP), presented horizontally to their left (LVF), right (RVF), or both fields of vision (BVF). Consistent with past foveal research, Experiment 1 produced a robust facilitatory effect of early OUP for RVF/BVF presentations, indicating the presence of sequential processes in lexical retrieval. The effect was absent for LVF trials, which we argue results from the disadvantaged position of initial letters of words presented in the LVF. To test this proposition, Experiment 2 assessed the discriminability of various letter positions in the visual fields using a bar-probe task. The obtained error functions highlighted the poor discriminability of initial letters in the LVF and latter letters in the RVF. To confirm that this asymmetry in initial letter acuity was responsible for the absent OUP effect for LVF presentations, Experiment 3 replicated Experiment 1 using vertical stimulus presentations. Results indicated a marked facilitatory effect of early OUP across visual fields, supporting our contention that the lack of OUP effect for LVF presentations in Experiment 1 resulted from poor discriminability of the initial letters. These findings confirm the presence of sequential processes in both left and right hemisphere word recognition, casting doubt on parallel models of word processing.

Adult↗
PubMed2000

Visual semantic features are activated during the processing of concrete words: event-related potential evidence for perceptual semantic priming.

There has been conflicting evidence to date regarding the existence of non-strategic semantic priming based on semantic similarity, and in particular on visual-perceptual semantic features (e.g., button-coin: words refer to objects with the same global shape). Both event-related potential (ERP) and reaction time (RT) measures were employed to investigate visual-perceptual semantic priming in a word-pair lexical decision task designed to minimise the contribution of conscious strategic processing. While no RT priming effect was observed, a robust priming effect was obtained on the N400 component of the ERP. This result shows that semantic priming, as indexed by the N400 component, can be supported by nonassociative visual-perceptual semantic relations. The data are consistent with perceptual form information being accessed during the processing of concrete words, and provide support for models of semantic representation which incorporate semantic features and form information.

Adult↗
PubMed1989

A dissociative word-frequency X levels-of-processing interaction in episodic recognition and lexical decision tasks.

The effects of levels-of-processing and word frequency were directly compared in three different memory tests. In the episodic recognition test, the subjects decided whether or not a word or a pronounceable nonword had been previously studied. In the two lexical decision tests with either pronounceable or unpronounceable nonwords as distractors, the subjects decided whether a test item was a word or a nonword. There were four main results: (1) in all three tests, reaction times (RTs) in response to studied words were faster if they had received semantic rather than rhyme processing during study; (2) in the episodic recognition test, RTs were faster for low- than for high-frequency words; in both lexical decision tests, RTs were faster for high- than for low-frequency words, though less so when the nonword distractors were unpronounceable; (3) prior study facilitated lexical decisions more in response to low- than to high-frequency words, thereby attenuating the word-frequency effect, but more so when the nonword distractors were pronounceable; (4) in the lexical decision test with pronounceable nonword distractors, relative to prior rhyme processing, prior semantic processing facilitated performance more for high- than for low-frequency words, whereas the opposite was the case in the episodic recognition test. Discussion focused on the relationship of these results to current views of the mechanisms by which (1) word frequency and depth of processing affect performance in implicit and explicit memory tests, and (2) repetition priming attenuates word-frequency effects for lexical decisions.

Adult↗
PubMed2005

Processing of disyllabic compound words in Chinese aphasia: evidence for the processing limitations account.

The current study addresses the debate between so-called 'structural' and 'processing limitation' accounts of aphasia, i.e., whether language impairments reflect the 'loss' of linguistic knowledge or its representations, or instead reflect a limitation in processing resources. Confrontation-naming task and category-judgment tasks were used to examine and compare the performance of non-fluent and fluent aphasics on different compound types of nouns and verbs. We demonstrate that aphasic patients' performance is modulated by the canonicity of the particular compound type, a result that holds true even for the category in which patients show a 'selective category deficit.' These findings weigh against the 'loss' of linguistic representations as the underlying cause of noun-verb deficits, instead supporting a 'processing limitations' approach.

Adult↗
PubMed1984

A Melanoma Registry based on a computer-run word and data processing system.

A Melanoma Register, previously organised on a filing card system, has been largely transferred to a computer which utilises both word and data processing programs. This transfer has revolutionised not only the analytical potential of the material, but the follow up of all patients, both old and new. The system is applicable to many other tumours and diseases.

Computers↗
PubMed2005

Lexical processing of ambiguous words: dominance or associative strength?

Four experiments examined the role of meaning frequency (dominance) and associative strength (measured by associative norms) in the processing of ambiguous words in isolation. Participants made lexical decisions to targets words that were associates of the more frequent (dominant) or less frequent (subordinate) meaning of a homograph prime. The first two experiments investigated the role of associative strength at long SOAs (Stimulus Onset Asynchrony) (750 ms.), showing that meaning is facilitated by the targets' associative strength and not by their dominance. The last two experiments traced the role associative strength at short SOAs (250 ms), showing that the manipulation of the associative strength has no effect in the semantic priming. The conclusions are: on the one hand, semantic priming for homographs is due to associative strength manipulations at long SOAs. On the other hand, the manipulation of the associative strength has no effect when automatic processes (short SOAs) are engaged for homographs.

Association Learning↗
PubMed2004

Unilateral brain damage effects on processing homonymous and polysemous words.

Using an auditory semantic priming paradigm, the present study investigated the abilities of left-hemisphere-damaged (LHD) non-fluent aphasic, right-hemisphere-damaged (RHD) and normal control individuals to access, out of context, the multiple meanings of three types of ambiguous words, namely homonyms (e.g., "punch"), metonymies (e.g., "rabbit"), and metaphors (e.g., "star"). In addition, the study tested certain predictions of the "suppression deficit" and "coarse semantic coding" hypotheses that have been proposed to account for the linguistic deficits typically observed after RH damage. Homonymous, metonymous, and metaphorical words were used as primes followed after a short (100 ms) or a long (1000 ms) inter-stimulus interval (ISI) by dominant-meaning-related, subordinate-meaning-related or unrelated target words. No significant group effects were found, and for both ISIs, dominant- and subordinate-related targets were facilitated relative to unrelated control targets for the homonymy and metonymy conditions. In contrast, for the metaphor condition, only targets related to the dominant meaning were facilitated. These findings provide only partial support for the "suppression deficit" hypothesis and no support for the "coarse semantic coding" hypothesis (as interpreted herein) indicating that patients with focal LH or RH damage can access the multiple meanings of ambiguous words and exhibit processing abilities comparable to those of older normal control subjects, at least at the single-word level.

Adult↗
PubMed2004

"I can write seven but I can't say it": a case of domain-specific phonological output deficit for numbers.

While it is established that numbers represent a category-specific semantic domain being dissociable from other semantic domains, it is a debated issue whether the category-specific dissociability persists at a level of lexical processing or whether words and number words are processed by the same lexical mechanisms. In most of the documented cases of brain damage, lexical processing of words and number words was equally spared or impaired. Here, we describe the case of a patient who after recovering from his naming disorders, showed a selective deficit in the spoken production of numbers with spared number writing and number comprehension abilities. After having ruled out alternative interpretations, we can conclude that these results indicate that words and numbers are not only categorically organised at the semantic level but that they are also processed by different lexical mechanisms. In addition, the results argue in favour of the existence of different modality-specific output lexicons for the written and spoken production of numerals.

Cerebral Cortex↗
PubMed2005

Neural mechanisms underlying the processing of Chinese words: an fMRI study.

The present study employed functional magnetic resonance imaging (fMRI) to investigate the neural mechanisms underlying orthographic, phonological and semantic processing of single character Chinese words. Twelve right-handed native Chinese speakers participated in the study. Three fundamental linguistic tasks including orthographic judgment, phonological matching and semantic association task were used. Our results demonstrated robust activation in the left posterior inferior temporal cortex (BA 37) for all three tasks. While the phonological matching task produced left-lateralized activation in the inferior frontal and parietal regions, semantic association task showed considerable bilateral activation in the inferior frontal and occipito-parietal regions. Direct comparison between phonological matching and semantic association task yielded semantic related activation in the anterior portion of the left inferior frontal gyrus (BA 47) and the right inferior frontal region (Broca's homology; BA 45). Behaviorally, there was no difference in response time between phonological matching and semantic association task. Our findings suggested that differential neural pathways were involved in the processing of meaning and sound of single-character Chinese words. The present study provided systemic information of the neural substrates underlying the processing of different components of Chinese language.

Adult↗
PubMed2004

Selective processing of food words during insulin-induced hypoglycemia in healthy humans.

RATIONALE: Hypoglycemia leads to undernutrition of the brain. Favoring selective processing of food stimuli would be an adaptive cognitive strategy. However, hypoglycemia is known to impair several aspects of cognitive function, and it is unknown whether selective cognitive processing of food stimuli occurs during insulin-induced hypoglycemia. METHODS: In a single-blind repeated measures design, healthy young adults (n=12, six female, mean age 28 years; mean body mass index 22.5 kg/m(2)) performed a standard Stroop word-color test, as well as a variant with food words designed to detect selective processing of food cues. Two sessions were scheduled with a 4-week interval. In each session, a hyperinsulinemic clamp method produced a normoglycemic (plasma glucose: 4.7 mmol/l) period, followed on 1 day by a hypoglycemic (2.7 mmol/l) testing period, and on the other day a second normoglycemic testing period (counterbalanced order). RESULTS: Color naming verbal reaction time (RT) increased during hypoglycemia (P<0.0001). The extent of the Stroop cognitive interference was independent of plasma glucose level. The key finding is that RT for food words increased more than for non-food control words (P<0.004), and this effect was not predicted by hunger ratings. CONCLUSIONS: Our data provide new evidence that during hypoglycemia, attention is directed selectively to food-relevant stimuli. The results are discussed in terms of adaptation.

Adaptation, Physiological↗
PubMed1978

Depth of processing and retention of words by alcoholic Korsakoff patients.

The relationship between the depth to which a word is initially processed and its eventual probability of being recognized was investigated with amnesic (alcoholic Korsakoff) patients. Several variations of Craik and Tulving's paradigm designed to asses this relationship were used. basically, this procedure insures analysis of particular features of a word by the nature of the question the subject must answer about the word during its initial presentation. Decision-time measures demonstrated that Korsakoff patients could answer the query nearly as rapidly as normals, but the patients failed to demonstrate a normal increase in recognition as a function of the depth of analysis demanded by the query (Experiments 1--2). However, when the test procedure was extremely simplified (Experiment 3) by presenting only a small number of to-be-recognized words, the Korsakoff patients did demonstrate the normal "pattern" of recognition. It was concluded that under the appropriate circumstances, Korsakoff patients' recognition memory can be improved by instructions to analyze the more sophisticated (semantic) features of verbal information.

Adult↗
PubMed1993

Semantic process in kana word reading: activation studies with positron emission tomography.

Regional cerebral blood flow was measured by positron emission tomography to study changes during Japanese kana word or kana non-word reading tasks. The main cortical activation was observed bilaterally in the lateral and medial occipital gyri, and the left posterior inferior temporal area in both kana word and kana non-word tasks. In addition, the kana word task activated the right posterior inferior temporal area. Comparison of the mean regional cerebral blood flow increases revealed that the kana word task activated the left posterior inferior temporal area more than the kana non-word task, suggesting the role of the semantic process as well as the morphological one in this area.

Adolescent↗
PubMedDate not supplied

Phonotactics and syllable stress: implications for the processing of spoken nonsense words.

Two experiments using bisyllabic CVCCVC nonsense words that varied in phonotactic probability and stress placement were conducted to examine the influences of phonotactic and metrical information on spoken word recognition. Experiment 1 examined participants' intuitions about the phonological "goodness" of nonsense words. Experiment 2 examined processing times for the same stimuli in a speeded auditory repetition task. The results of both studies provide further evidence that the phonotactic configuration and stress placement of spoken stimuli have important implications for the representation and processing of spoken words.

Humans↗
PubMed2002

Central bottleneck influences on the processing stages of word production.

Does producing a word slow performance of a concurrent, unrelated task? In 2 experiments, 108 participants named pictures and discriminated tones. In Experiment 1, pictures were named after cloze sentences; the durations of the word-production stages of lemma and phonological word-form selection were manipulated with high- and low-constraint cloze sentences and high- and low-frequency-name pictures, respectively. In Experiment 2, pictures were presented with simultaneous distractor words; the durations of lemma and phoneme selection were manipulated with conceptually and phonologically related distractors. All manipulations, except the phoneme-selection manipulation, delayed tone-discrimination responses as much as picture-naming responses. These results suggest that early word-production stages--lemma and phonological word-form selection--are subject to a central processing bottleneck, whereas the later stage--phoneme selection--is not.

Adult↗
PubMed1996

Orthographic processing in visual word recognition: a multiple read-out model.

A model of orthographic processing is described that postulates read-out from different information dimensions, determined by variable response criteria set on these dimensions. Performance in a perceptual identification task is simulated as the percentage of trials on which a noisy criterion set on the dimension of single word detector activity is reached. Two additional criteria set on the dimensions of total lexical activity and time from stimulus onset are hypothesized to be operational in the lexical decision task. These additional criteria flexibly adjust to changes in stimulus material and task demands, thus accounting for strategic influences on performance in this task. The model unifies results obtained in response-limited and data-limited paradigms and helps resolve a number of inconsistencies in the experimental literature that cannot be accommodated by other current models of visual word recognition.

Adult↗