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PubMed1989

Complete denture retention. Part I: Physical analysis of the mechanism. Hysteresis of the solid-liquid contact angle.

Analysis of physical forces involved in the mechanism of denture retention clearly shows that the hysteresis of the liquid-solid contact angle governs the viscoelastic response of the system dislodgment. This result is in contradiction to the most commonly admitted view according to which perfect wettability is necessary to obtain good retention and implies the existence of the high advancing contact angle of saliva on a prosthetic material.

Capillary Action↗
PubMed1990

An evaluation of the surface characteristics of a facial prosthetic elastomer. Part I: Review of the literature on the surface characteristics of dental materials with maxillofacial prosthetic application.

Silicone elastomers are used to construct a wide variety of maxillofacial prostheses and appliances. These applications dictate that an elastomer-tissue interface is present. The behavior of this interface will vary according to the method of retention of the prosthesis, the nature of the tissue surface, and whether the prosthesis is externally applied or occupies an intratissue location. Understanding the behavior of the silicone-tissue interface is consequently important. Part I of this series of three articles is a review of the literature on the surface characteristics of dental materials with maxillofacial prosthetic application. The review considers surface texture, indentation hardness, wettability, and reaction of tissues to surface texture of restorative materials.

Dental Materials↗
PubMed1990

Properties of a new polyether urethane dimethacrylate photoinitiated elastomeric impression material.

The photoinitiated impression material is supplied premixed as a light-bodied material in a light-tight plastic syringe and as a heavy-bodied material in a tube. The impression material has excellent physical, mechanical, and clinical qualities with noteworthy long working times, short setting times, dimensional stability, accuracy, high tear strength, good wettability, biocompatibility, and ease of cold disinfection without loss of quality. The impression material is also compatible with gypsum and silver or copper metallizing baths. Accurate casts can be obtained by means of either a double-impression technique or a double-mix technique.

Biocompatible Materials↗
PubMed1991

Detail reproduction of soft tissue: a comparison of impression materials.

The extent to which an impression material reproduces detail is influenced by factors such as viscosity, wettability, handling properties, and voids. This clinical study compared the ability of several impression materials to register soft tissue without creating voids and produce detailed gypsum casts. Thirty impressions of the hard palate of a single subject were made by use of a custom-cast metal framework serving as an impression tray. Six impression materials commonly used in clinical practice were tested. Die stone casts made from the impressions were evaluated and ranked by five judges. Polyether and hydrophilic addition silicone were judged best in terms of detail reproduction and zinc oxide-eugenol and polysulfide low-viscosity materials were judged worst in this regard. Impression voids were minimized with low-viscosity polysulfide and zinc oxide-eugenol when compared with addition silicones (low and medium viscosities).

Calcium Sulfate↗
PubMed1991

Transfer of NO2 through pulmonary epithelial lining fluid.

Absorption of inhaled NO2 across the pulmonary gas/tissue interface is principally governed by chemical reaction(s) rather than by physical solubility. While the kinetics of NO2 transfer into reactant-containing aqueous solutions appear to be bulk phase independent, it is unclear whether unreacted NO2 diffuses appreciably through the epithelial lining fluid (ELF) to cellular compartments. We avoided the difficulties associated with directly quantifying NO2 dissolved in biological fluids by indirectly determining the potential for NO2 penetration to underlying tissues. An in vitro system was developed which horizontally suspended a wettable, gas permeable, fibrous material between two gas chambers. Aqueous substrates were applied to the sieve material and NO2 (10.9 ppm) was introduced into one chamber and sampled for in the other. O2 served as a tracer gas. We determined the influence of ELF, a model biochemical (reduced glutathione; GSH), and PO4 buffer (control) on NO2 transfer as evaluated by "breakthrough time." (A) Both O2 and NO2 rapidly diffused through the sieve material when dry. Under PO4 wetted conditions, O2 continued to penetrate rapidly but NO2 transfer was slightly inhibited relative to O2. (B) Addition of GSH (1 mM) significantly prolonged NO2 breakthrough time. Increasing initial [GSH] resulted in concomitant prolongation of NO2 breakthrough time. (C) We observed a direct correlation between oxidation of sieve GSH and NO2 breakthrough. (D) Freshly harvested rat ELF inhibited NO2 transfer in a concentration-dependent manner similar to GSH. These data suggest that in the presence of reactant solutes, unreacted NO2 does not penetrate through the ELF layer. Reactive absorption must, therefore, occur primarily within the ELF compartment so that reaction products which induce subsequent toxicity are generated as a result of the initial uptake interactions.

Animals↗
PubMed1990

Relationship between contact angles of die stone on elastomeric impression materials and voids in stone casts.

Poor wettability of elastomeric impression materials results in surface defects on stone casts. This study examined the relationship between contact angles of die stone and voids in casts produced from five medium-viscosity impression materials. Contact angles of a die stone material formed against impression specimens made from polyether, addition and condensation silicones were measured by reflex microscope. The contact angle values achieved on the hydrophilic addition silicones were significantly higher than the polyether but lower than other silicone materials. Contact angle values correlated with the number of voids found at margins and line angles of stone casts but not with those on smooth surfaces.

Dental Impression Materials↗
PubMed1983

Gas-to-liquid permeation in silicon-containing, crosslinked, glassy copolymers of methyl methacrylate.

Copolymers of methyl methacrylate with disiloxane derivatives have been proposed as biomaterials for contact lens applications. Although glassy, these copolymers exhibit high oxygen permeability and adequate wettability so that they can be used for manufacture of hard, extended wear lenses. Crosslinked copolymers of poly(methylmethacrylate-co-1,3-bis(methacryloxymethyl) -1,1,3,3-tetramethyl-disiloxane), P(MMA-co-BMTDS), containing from 0.085 to 0.53 mole fraction of BMTDS were prepared and tested for oxygen permeation using a novel apparatus which simulates the atmosphere/lens/cornea conditions. The gas-to-liquid dissolved oxygen permeability, P gd1 was determined and it was found to increase with BMTDS content. Permeability values for P(MMA-co-BMTDS) at 34 degrees C were significantly higher than for pure homopolymer PMMA, although these copolymers were glassy at this temperature. The increased oxygen permeation was attributed to increased oxygen solubility in the copolymers due to the presence of the -Si-O-bonds.

Biocompatible Materials↗
PubMed1986

Coating of two polyether-polyurethanes and polyethylene with a heparin-poly-(vinyl alcohol) hydrogel.

Two polyether-polyurethane elastomers (Pellethane and Biomer) and polyethylene were coated with a heparin-poly(vinyl alcohol) hydrogel. The requisite surface modification in preparation for coating consisted of glow discharge cleaning and acid treatment for the polyether-polyurethanes and glow discharge cleaning and chromic acid oxidation for polyethylene. The chemical modifications increased surface wettability. Surface analysis by attenuated total reflectance Fourier transform infrared spectroscopy indicated that the acid treatment caused hydrolysis of the polyether segments of Pellethane and Biomer. Prolonged partial thromboplastin times were observed on the coated films. The results of toluidine blue assay of heparin in the solution in which the coated films were immersed for a long time suggested that heparin was covalently bound in the coating. Such coating techniques extend the usefulness of the heparin-poly(vinyl alcohol) hydrogel to a number of medically important substrate materials.

Biocompatible Materials↗
PubMed1986

Residual formaldehyde in steam-formaldehyde sterilized materials.

The amounts of residual formaldehyde and paraformaldehyde present in polymeric materials after steam-formaldehyde sterilization in a commercial sterilizer were determined. Appreciable amounts of residue were detected in ethylene-vinyl alcohol copolymer (EVOH), polyamide-6 (PA-6) and natural rubber (NR). These polymers all have a relatively low contact angle with water which indicated that the wettability of a material is an important parameter in determining amount of residue. The residue present in EVOH and in PA-6,6 filter material appeared to be toxic in the HFL-test (a screening test for acute toxicity). This indicated that a more thorough investigation into the possible toxicological consequences of the use of some steam-formaldehyde sterilized materials is necessary.

Biocompatible Materials↗
PubMed1987

Polyethylene/hydrophilic polymer blends for biomedical applications.

Polyethylene blends with poly(2-hydroxyethyl methacrylate) [poly(HEMA)] or poly(2,3-dihydroxypropyl methacrylate) [poly(DHPMA)] were prepared by swelling polyethylene with HEMA or 2,3-epoxypropyl methacrylate (EPMA) and by polymerization of the respective monomers. Poly(EPMA) in blends was hydrolysed to poly(DHPMA) with acetic acid. The blends had similar surface and bulk compositions. Swelling with water and surface wettability were proportional to the content of the hydrophilic component; at the same content the polyethylene/poly(DHPMA) blends appeared more hydrophilic than those of polyethylene/poly(HEMA). Thrombus formation in contact with blood examined ex vivo and in vivo was considerably slower on the blends than on unmodified polyethylene. The tests indicated optima in composition; the best biological response was achieved with the blends containing about 14% poly(HEMA) or 16% poly(DHPMA).

Animals↗
PubMed1989

Adhesion and spreading of cultured endothelial cells on modified and unmodified poly (ethylene terephthalate): a morphological study.

The in vitro adhesion and spreading of human endothelial cells (HEC) on hydrophobic poly(ethylene terephthalate) (PETP) and moderately wettable tissue culture poly(ethylene terephthalate) (TCPETP) were studied with light microscopy and electron microscopy. Numbers of HEC adhering on TCPETP were always higher than those found on PETP. When cells were seeded in the presence of serum, extensive cell spreading on both PETP and TCPETP was observed after the first 30 min. Thereafter, spread cells appeared to withdraw from the PETP surface, resulting in irregularly shaped cells. Complete cell spreading occurred on TCPETP. Complete cell spreading also occurred on PETP and TCPETP when HEC had first been seeded from phosphate buffer solution and serum was supplied after 30 min. Furthermore, HEC spread on both PETP and TCPETP when the surfaces were precoated with protein(s), which promotes cell adhesion. However, when plasma was used for the coating, spread cells did not proliferate in a monolayer pattern. This study shows that TCPETP is, in general, a better surface for adhesion and proliferation of HEC than is PETP, suggesting that vascular prostheses with a TCPETP-like surface will perform better in vivo than prostheses made of PETP.

Blood↗
PubMed1990

Silicone rubber-hydrogel composites as polymeric biomaterials. II. Hydrophilicity and permeability to water-soluble low-molecular-weight compounds.

The surface and transport properties of water-swollen silicone rubber-hydrogel composites were investigated. Surface wettability of these materials, composed of a polysiloxane matrix and the hydrogel phase consisting of very fine particles of lightly cross-linked poly(2-hydroxyethylmethacrylate), increased markedly with increasing content of the hydrogel phase. For composite materials containing a lightly cross-linked 2-hydroxyethylmethacrylate (HEMA)-methacrylic acid (MAA) copolymer and polymethacrylic acid (PMAA) as the hydrogel phase, permeability to water-soluble organic compounds and drugs were measured. The permeability varied within a broad range depending on the composition and content of the hydrogel phase. High permeation rates could be obtained while still retaining relatively fair mechanical properties. Relationships between the composition of silicone rubber-hydrogel composites, their structure and the permeation coefficients of the individual permeates are discussed.

Biocompatible Materials↗
PubMed1990

Platelet deposition studies on copolyether urethanes modified with poly(ethylene oxide).

Pellethane 2363 80A films and tubings were chemically modified and the effect of these modifications on platelet deposition was studied. Grafting of high molecular weight poly(ethylene oxide) and graft polymerization of methoxy poly(ethylene glycol) 400 methacrylate resulted in surfaces with a good water wettability. The increased hydrophilicity of these modified surfaces could be demonstrated by contact angle measurements. The platelet deposition was investigated with tubings in a capillary flow system, using different types of perfusates. Platelet deposition from a buffer-containing perfusate on surfaces modified with either high molecular weight poly(ethylene oxide) or methoxy poly(ethylene glycol) 400 methacrylate was almost absent and less than on Pellethane 2363 80A. Using a citrated plasma-containing perfusate the amount of deposited platelets on Pellethane 2363 80A modified with high molecular weight poly(ethylene oxide) was low and about the same as on unmodified surfaces. However, a marked reduced platelet deposition compared to unmodified Pellethane 2363 80A was found when the platelets were activated by Ca2+ ionophore. The improved blood compatibility of the modified Pellethane 2363 80A tubings obviously indicates the favourable effect of the presence of grafted PEO on the surface.

Biocompatible Materials↗
PubMed1991

Boundary lubrication and maxillofacial prosthetic polydimethylsiloxanes.

Polydimethylsiloxanes exhibit hydrophobic behaviour and poor wettability. These features impose some problems with the clinical performance of the material when used for the construction of intraoral and extraoral facial prostheses. Surface active agents were added to modify the surface energy of the polydimethylsiloxane and contact angle measurements were carried out to observe wetting characteristics. Five siloxane-alkene oxide block copolymers, one organosilicon quaternary ammonium chloride and an epoxyalkyl silane ester were used as surfactants. The best surfactant in terms of permanency and contact angle lowering achieved a value of 24 degrees when added at 10% level compared with 57 degrees for the unmodified silicone. The fairly high viscosity, combined with a comb-like structure, together with the high hydroxyl number of 75 provided the correct balance of permanence and wetting characteristics.

Dimethylpolysiloxanes↗
PubMed1991

Cell adhesion and growth on polymer surfaces with hydroxyl groups prepared by water vapour plasma treatment.

Various polymer surfaces--polyethylene, polypropylene, polystyrene, polyethylene terephthalate and poly(methyl methacrylate)--were modified by water vapour plasma discharge treatment. The plasma-treated polymer surfaces were characterized by water contact angle measurement and electron spectroscopy for chemical analysis. It was observed that by the water vapour plasma treatment, the wettability of the polymer surfaces increases largely and almost all functional groups produced on the surfaces are hydroxyl groups. The interactions of Chinese hamster ovary cells with the polymer surfaces having hydroxyl groups by plasma treatment were investigated. The cells adhered and grown on the polymer surfaces were counted using a haemocytometer and photographed with an inverted microscope with a camera attached. The water vapour plasma-treated polymers showed good adhesion, spreading and growth properties on the surfaces with high hydroxyl group density. We confirmed that the water vapour plasma treatment is a simple and effective method to produce hydroxyl groups on the polymer surfaces, which probably have a positive effect on cell adherence.

Animals↗
PubMed1994

Differential surface binding of albumin, immunoglobulin G and fibrinogen.

Protein-protein interactions, as well as the nature of the surface, significantly affect the activity of a specific protein towards a defined surface. Indications are that protein-protein associations may affect antibody detectability, but in some cases this is the result of altered antigenic accessibility rather than physical removal of the molecule. The antibody binding patterns are also quite variable over an entire methyl-silanol wettability gradient on silicon, suggesting that the surface itself is affecting protein-protein and protein-protein-surface associations. Ellipsometric studies were carried out on the gradients which were incubated in single; binary and tertiary physiological concentration solutions of human albumin, immunoglobulin G (IgG) and fibrinogen. The ellipsometric-antibody detectability of the proteins on such surfaces were found to be variable, depending upon the location on the gradient and the order and combination in which the proteins were presented to the surface. Radiolabelled proteins were studied on discrete regions of these gradients. Competitive effects of albumin were found to be inhibitory (negative) with respect to IgG adsorption on hydrophobic surfaces, while enhancing IgG deposition on hydrophilic surfaces (positive). Scanning force microscopy in the so-called tapping mode indicates that proteins, particularly IgG, organize themselves differently with respect to surfaces, depending upon the nature of the surface and the presence of other proteins.

Animals↗
PubMed1994

Titanium with different oxides: in vitro studies of protein adsorption and contact activation.

Adsorption of albumin (HSA) and fibrinogen (Fib) from human blood plasma onto titanium surfaces with varying oxide properties was studied with an enzyme-linked immunosorbent assay. The intrinsic activation of blood coagulation (contact activation) was studied in vitro using a kallikrein-sensitive substrate. The sample surfaces were characterized with Fourier transform Raman spectroscopy. Auger electron spectroscopy and atomic force microscopy. Low Fib and high HSA adsorption was observed for all titanium samples except for the radio frequency plasma-treated and water-incubated samples, which adsorbed significantly lower amounts of both. Oxide thickness and carbon contamination showed no influence on protein adsorption or contact activation. Smooth samples with a surface roughness (Rrms) < 1 nm showed some correlation between surface wettability and adsorption of Fib and HSA, whereas rough surfaces (Rrms > 5 nm) did not. To varying degrees, all titanium surfaces indicated activation of the intrinsic pathway of coagulation as determined by their kallikrein formation in plasma.

Adsorption↗
PubMed1994

Cell behaviour on polymer surfaces with different functional groups.

Surfaces with differently chargeable functional groups were prepared on low density polyethylene sheets by corona discharge treatment, followed by graft copolymerization of acrylic acid (-COOH, negatively chargeable) and a subsequent substitution reaction of carboxylic acid groups to hydroxyl (-CH2OH, neutral) or amide (-CONH2, neutral) groups. The amide groups grafted on the surface were further converted to amine groups (-CH2NH2, positively chargeable). The prepared surfaces were characterized by measuring the water contact angle, electron spectroscopy for chemical analysis and Fourier-transform infrared spectroscopy in the attenuated total reflectance mode. It was observed that the wettability of the different functional group-grafted surfaces largely increases compared with the control surface but is not much affected by the kind of functional groups grafted. The interaction of Chinese hamster ovary cells with the functional group-grafted surfaces was investigated. The cells adhered and grown on the surfaces were counted using an electronic cell counter and observed by a scanning electron microscope. The surface grafted with amine groups was best for cell adhesion, spreading and growth probably owing to the positively chargeable character in aqueous cell culture medium. For surfaces grafted with neutral functional groups, the surface grafted with hydroxyl groups showed better cell spreading than that grafted with amide groups.

Alcohols↗