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At least 757 records · Page 42Linked to original sources
PubMed1985

Iliac artery aneurysm in Behçet's disease: a case report.

Today, Behcet's disease is known as a multisystem disorder. Eye lesions, mouth and genital aphthous lesions, and skin lesions are accepted as major lesions. The disease also attacks the locomotor system, central nervous system, gastrointestinal system and also arteries and veins. According to available data, some 30% of the patients have vascular lesions; mostly thrombosis of the veins. Arterial thromboses have been rarely reported; and only a few number of arterial aneurysms are noted. Here we present an iliac artery aneurysm in a case of Behcet's disease.

Adult↗
PubMed2005

Vascular ossification-calcification in metabolic syndrome, type 2 diabetes mellitus, chronic kidney disease, and calciphylaxis-calcific uremic arteriolopathy: the emerging role of sodium thiosulfate.

BACKGROUND: Vascular calcification is associated with metabolic syndrome, diabetes, hypertension, atherosclerosis, chronic kidney disease, and end stage renal disease. Each of the above contributes to an accelerated and premature demise primarily due to cardiovascular disease. The above conditions are associated with multiple metabolic toxicities resulting in an increase in reactive oxygen species to the arterial vessel wall, which results in a response to injury wound healing (remodeling). The endothelium seems to be at the very center of these disease processes, acting as the first line of defense against these multiple metabolic toxicities and the first to encounter their damaging effects to the arterial vessel wall. RESULTS: The pathobiomolecular mechanisms of vascular calcification are presented in order to provide the clinician-researcher a database of knowledge to assist in the clinical management of these high-risk patients and examine newer therapies. Calciphylaxis is associated with medial arteriolar vascular calcification and results in ischemic subcutaneous necrosis with vulnerable skin ulcerations and high mortality. Recently, this clinical syndrome (once thought to be rare) is presenting with increasing frequency. Consequently, newer therapeutic modalities need to be explored. Intravenous sodium thiosulfate is currently used as an antidote for the treatment of cyanide poisoning and prevention of toxicities of cisplatin cancer therapies. It is used as a food and medicinal preservative and topically used as an antifungal medication. CONCLUSION: A discussion of sodium thiosulfate's dual role as a potent antioxidant and chelator of calcium is presented in order to better understand its role as an emerging novel therapy for the clinical syndrome of calciphylaxis and its complications.

Animals↗
PubMed1979

Pathology of Kawasaki disease: II. Distribution and incidence of the vascular lesions.

Histopathology, distribution and incidence of vascular changes were studied in tissues obtained at autopsy on thirty-seven children. Elastic and musculoelastic arteries showed a high incidence of arteritic changes, however the degree of the lesions was in general mild to moderate with the exception of the iliac artery, which revealed severe changes and a necrotizing panarteritis which was often accompanied with an aneurysm formation. A high incidence of arteritic changes, of which main histological feature was necrotizing panarteritis, was seen in extravisceral middle sized arteries. The coronary artery in particular was involved in each case and most had an accompanying aneurysm, some of which had ruptured. Intravisceral small sized arteries showed a relatively low incidence of arteritic changes and the degree of inflamation was in general mild. Phlebitis was present in over half the number of patients. The degree of lesions was mild in the small veins and mild to moderate in the large veins. Vascular lesions in Kawasaki disease should be termed systemic vasculitis rather than a systemic arteritis. There was a correlation between the caliber of involved vessels and the degree of vascular lesions. According to the histopathology, distribution and incidence of angitis, Kawasaki disease does resemble infantile periarteritis nodosa with the exception of the different manner of the coronary and iliac involvement.

Aorta↗
PubMed2004

Human saphenous vein and coronary bypass surgery: ultrastructural aspects of conventional and "no-touch" vein graft preparations.

Coronary artery bypass graft surgery (CABG) is routinely used to restore blood flow to diseased cardiac muscle due to coronary artery disease. The patency of conventional grafts decreases with time, which is due to thrombosis and formation of neointima. A primary cause of graft failure is the mechanical damage inflicted to the graft during harvesting, including removal of surrounding tissue accompanied by high pressure saline distension to overcome vasospasm (both causing considerable mechanical trauma). The aim of this study was to compare the ultrastructural features of human saphenous vein (SV) grafts harvested conventionally and grafts prepared using an atraumatic 'no-touch' harvesting technique introduced by Souza (1996). The results of this study showed a better preservation of the lumenal endothelium and medial vascular smooth muscle (SM) in 'no-touch' versus conventional grafts. A 'fast' (within 30 min) response of SM cells to conventional harvesting was noted where features of both SM cell division and apoptosis were observed. It is concluded that the 'preserved' nature of the 'no-touch' aortocoronary SV grafts renders them less susceptible to thrombotic and atherosclerotic factors than grafts harvested conventionally. These features are suggested to contribute to the improved early patency rate described using the no-touch technique of SV harvesting.

Aged↗
PubMed2006

Uncommon presentation of Behçet's syndrome: aortic aneurysm and dissection due to Behçet's syndrome.

Aneurysm and dissections localized to the ascending aorta are usually encountered in patients with atherosclerosis and hypertension. Behçet's syndrome is a rare vasculitic syndrome occasionally responsible for inflammation in small to large vessels. Aneurysm formation and dissection in the ascending aorta due to Behcet's disease is an even rarer presentation of this vasculitis that will be discussed in conjunction with a case presentation.

Aortic Dissection↗
PubMed1992

Branches of the internal thoracic artery of rats supplying the heart, the sinus regions and the brachiocephalic veins.

Branches of the internal thoracic artery (ITA) of rats which supply the heart, the sinus regions (see Terminology 1) and the brachiocephalic veins, were macroscopically studied. Two major branches of the ITA, the pericardiacophrenic artery and the descending ramus of the bronchoesophageal artery, were found supplying branches to these central portions of the cardiovascular system (see Table 1). They constituted, together with the ordinal coronary arteries, a system of dual blood supply to the heart as reported by Grant & Regnier (1926), Halpern et al. (1953, 1954) and Hebel & Stromberg (1986). This finding also supports a proposal of Grant & Regnier (1926) that the rat ITA emits cardiac branches which should be classified on the vertebrate scale to the caudal or extracoronary artery. Branches of the ITA to the heart, the sinus regions and to the brachicephalic veins were found to be classified into 2 major groups depending on their choice of entrance--arterial portal and venous porta; the latter was further divided into 3 subgroups depending on their selection of the (lateral or pulmonary or esophageal) mesocardium for traveling to the venous porta (see Table 2).

Animals↗