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Results for “SPASMOLYTICS”

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At least 757 records · Page 42Linked to original sources
PubMed1978

Bronchial spasmolytic action of terbutaline and fenoterol compared with that of ipratropium bromide in the anaesthetized dog.

Continuous recordings of heart rate, respiration rate, minute volume and bronchial resistance were made over a period of altogether three hours in spontaneously breathing dogs anaesthetized with chloralose. At hourly intervals, before and 1 and 2 hr after the administration of bronchodilators, bronchial spasm was induced by inhalation of an acetylcholine solution. Two beta2-stimulants, terbutaline and fenoterol, were administered by inhalation in doses of 0.5, 0.16 and 0.05 mg/kg and 0.1, 0.3 and 0.01 mg/kg respectively. For comparison, an atropine derivative, ipratropium bromide, was also given by the same route in doses of 0.04 and 0.01 mg/kg. Controls received normal saline. Terbutaline and fenoterol caused an increase in heart rate, respiration rate and minute volume. Acetylcholine-induced bronchial spasm was inhibited to the extent of 10--70% for 2 hr after the administration of terbutaline, and by 15--70% after fenoterol. The acetylcholine antagonist ipratropium bromide caused only transient changes in heart rate, respiration rate and minute volume. Acetylcholine-induced bronchial spasm was inhibited by 95% and 80% for 2 hr after doses of 0.04 and 0.01 mg/kg, respectively. Fenoterol had a slightly greater central stimulant effect than terbutaline; ipratropium bromide displayed no stimulant activity.

Acetylcholine↗
PubMed2006

[Functional state of kidneys and upper urogenital tract in patients with intraligamentary ovarian cysts in pre and postoperative periods during the treatment with spasmolytics].

25 patients with different types of intraligamentary ovarian cysts were observed. The main diagnostic method of the patients with intraligamentary cysts was ultrasound Dopplerometry of arteries iliaca interna, uterine and renalis using the following indicators: pulsatory index, resistance index, maximal blood speed. Determination of these indicators was conducted before operation, on 10 and 30 days after operation. In post-operation period we found that in the side free from the tumor's development, all doppleromethric indices were substantially normalised.

Adult↗