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At least 757 records · Page 42Linked to original sources
PubMed2006

[A high sensitivity optical multichannel analyzer].

Noise sources of the CCD as the photoelectric detection device in an optical multichannel analyzer (OMA) were analyzed, and noise suppression methods were discussed. A high sensitivity OMA was developed successfully on the basis of the noise suppression techniques, and the 7th spectral lines of Balmer series of hydrogen and deuterium were resolved clearly by the OMA. Its sensitivity was enhanced by one order of magnitude, compared with those reported in the literatures. This OMA also showed high resolution, high precision and good reliability in the authors' experiments.

English Abstract↗
PubMed2002

Feasibility study of a fiber-optic system for invasive blood pressure measurements.

A comparative study was conducted to evaluate the feasibility of a fiber-optic sensor in invasive blood pressure measurements. Static and wide-bandwidth stimuli were offered to the fiber-optic, Millar, Baxter, and Sentron devices to measure static transfer function and transient response. Animal experiments focused on offset drift, dynamic accuracy, and electromagnetic sensitivity. Compared to the Millar, Sentron, and Baxter devices, the fiber-optic sensor had a near-identical static transfer function. Gain and offset errors were < 3.4% and < 0.25%, respectively. Hysteresis nonlinearity was < 0.1%. The dynamic accuracy of the fiber-optic system matched that of the Millar and Sentron systems. Time delay was < 1 msec. Maximum rate of change was > 30,000 mm Hg/sec and bandwidth was 0-150 Hz minimum. Offset drift was 0.6 +/- 0.03 mm Hg. Application of diathermy highlighted the fiber-optic sensor's excellent electromagnetic disturbance rejection. The fiber-optic system appears to be a reliable, high-fidelity pressure monitor in demanding clinical environments.

Animals↗
PubMed2005

Synthesis of MFI zeolite films on optical fibers for detection of chemical vapors.

We report the development of a novel zeolite-incorporated optical fiber sensor and demonstrate its capability for in situ detection of chemical vapors. The sensor comprises a polycrystalline silicalite thin film grown upon the cleaved end face of a standard single-mode optical fiber. The sensor device operates by measuring the optical reflectivity of the zeolite crystals, which changes reversibly in response to the amount of chemical vapor adsorbed in its crystalline microporous structure. The sensor has been successfully demonstrated for measuring the concentration of isopropanol vapor in mixtures with nitrogen gas.

2-Propanol↗
PubMed2003

Optical bio-sniffer for ethanol vapor using an oxygen-sensitive optical fiber.

An optical bio-sniffer for ethanol was constructed by immobilizing alcohol oxidase (AOD) onto a tip of a fiber optic oxygen sensor with a tube-ring, using an oxygen sensitive ruthenium organic complex (excitation, 470 nm; fluorescent, 600 nm). A reaction unit for circulating buffer solution was applied to the tip of the device. After the experiment in the liquid phase, the sniffer-device was applied for gas analysis using a gas flow measurement system with a gas generator. The optical device was applied to detect the oxygen consumption induced by AOD enzymatic reaction with alcohol application. The sensor in the liquid phase was used to measure ethanol solution from 0.50 to 9.09 mmol/l. Then, the bio-sniffer was calibrated against ethanol vapor from 0.71 to 51.49 ppm with good gas-selectivity based on the AOD substrate specificity. The bio-sniffer with the reaction unit was also used to monitor the concentration change of gaseous ethanol by rinsing and cleaning the fiber tip and the enzyme membrane with buffer solution.

Alcohol Oxidoreductases↗
PubMed2005

All-optical multichannel 2R regeneration in a fiber-based device.

We propose the design of an all-optical 2R regenerator capable of handling multiple wavelength-division-multiplexed channels simultaneously. It extends the known concept of off-center filtering of self-phase-modulation-broadened signal spectra. The novel feature of the proposed device is a dispersion map that strongly suppresses interchannel impairments. The map employs several sections of nonlinear fiber with high normal dispersion, separated by dispersion compensators with spectrally periodic group delay. The results of our numerical simulations indicate the feasibility of such a multichannel regenerator.

Journal Article↗
PubMed2006

Spectrometric determination of the refractive index of optical wave guiding materials used in lab-on-a-chip applications.

The design and optimization of light-based analytical devices often require optical characterization of materials involved in their construction. With the aim of benefiting lab-on-a-chip applications, a transmission spectrometric method for determining refractive indices, n, of transparent solids is presented here. Angular dependence of the reflection coefficient between material-air interfaces constitutes the basis of the procedure. Firstly, the method is studied via simulation, using a theoretical algorithm that describes the light propagation through the sample slide, to assess the potentially attainable accuracy. Simulations also serve to specify the angles at which measurements should be taken. Secondly, a visible light source and an optical fiber spectrometer are used to perform measurements on three commonly used materials in optical lab-on-a-chip devices. A nonlinear regression subroutine fits experimental data to the proposed theoretical model and is used to obtain n. Because the attainable precision using this method of refractive index determination is dictated by the uncertainty in the transmission measurements, the precision (with 95% confidence) for mechanically rigid samples, namely glass and poly(methyl methacrylate) (PMMA), is higher than those estimated for the elastomer sample (in-house-molded poly(dimethylsiloxane) (PDMS)). At wavelengths with the highest signal-to-noise ratio for the spectrometer setup, the estimated refractive indices were 1.43+/-0.05 (580 nm) for PDMS, 1.54+/-0.02 (546 nm) for glass, and 1.485+/-0.005 (656 nm) for PMMA. Accurate refractive index estimations with an average precision equal to 0.01 refractive index units (RIU) were obtained for PMMA and glass samples, and an average precision of 0.09 RIU for the PDMS molded slide between 550 and 750 nm was obtained.

Combinatorial Chemistry Techniques↗
PubMed2000

[Devic disease: a rare cause of retrobulbar optic neuritis: a case report].

A case of 58-year-old woman with recurrent retrobulbar optic neuritis (ron) and transverse myelitis is presented. The patient was admitted to the opthalmology unit because of acute right retrobulbar optic neuritis. In 1997 she complained of left retrobulbar optic neuritis. One year later transverse myelitis of thoracic spine with spastic paraparesis occurred. MRI examination showed T2 hyperintensive focus in the thoracic spine (Th8-Th9, probably demyelinisation). Nowadays MRI examination of the optic nerves and brain showed demyelinisation focus in the right optic nerve. There was no pathological changes in the brain. The diagnosis of Devic disease was established. Treatment with intravenous methyloprednisolon was administered with slight improvement. The pathology and clinical course of Devic disease are discussed.

Anti-Inflammatory Agents↗
PubMed1991

Practical use of optical cards in medical care.

This paper reports excellent results with respect to application of optical cards in medical care, based on improvements in the technology for encoding optical cards and devices used to increase read-write speed, and also reports the issuance of the first Japanese standards for the data format of optical cards.

Information Storage and Retrieval↗
PubMed2003

Design and demonstration of a switching engine for a binary true-time-delay device that uses a white cell.

Optical true-time-delay devices based on the White cell can be divided into two general types: polynomial cells, in which the number of delays that can be obtained is related to the number of times m that a beam bounces in the cell raised to some power, and exponential cells, in which the number of delays is proportional to some number raised to the power of m. In exponential cells, the topic to be addressed, the spatial light modulator switches between a delay element and a null path on each bounce. We describe an improved design of this switching engine, which contains a liquid-crystal switch and a White cell. We examine astigmatism and corrections for it and present a specific design.

Journal Article↗
PubMed2001

Optical resonant ultrasound spectroscopy for fluid properties measurement.

The properties of fluids are studied using unusually small containment spherical resonators. Proper identification of resonant fluid signatures allows determination of pressure and density of the internal gas with great accuracy using an appropriate equation of state (EOS). Low noise and high sensitivity detection of vibration are critical parameters to characterizing the contained gas when its pressure approaches 1 atm or less. The benefits of using spherical resonators to determine fluid properties are discussed, and some example calculations of sound speed are presented. In addition to measuring fluids, a comparative experimental approach is taken to explore and, eventually, to optimize vibration detection. In the experiments, two detection methods, a contact piezoelectric transducer (PZT) device and a non-contact optical device, are compared simultaneously and quantitatively. This is done in a unique manner without change in vibration coupling to the sample between tests. A commercially available resonant ultrasound spectroscopy system is used as the contact system, while another commercial device (used as the non-contact vibration detector) combined with the same excitation source (used in the contact system) comprises the other system. The non-contact detector is an optical interferometric receiver that provides adaptation to optically rough surfaces and high sensitivity to acoustic displacements through optical interference in photorefractive GaAs. Both vibration detection systems are compared with particular emphasis on displacement sensitivity, frequency response, and noise level. Furthermore, the results from comparing detection modalities are presented, and their effects on fluid properties measurement are discussed.

Journal Article↗
PubMed2003

FliMax, a novel stimulus device for panoramic and highspeed presentation of behaviourally generated optic flow.

A high-speed panoramic visual stimulation device is introduced which is suitable to analyse visual interneurons during stimulation with rapid image displacements as experienced by fast moving animals. The responses of an identified motion sensitive neuron in the visual system of the blowfly to behaviourally generated image sequences are very complex and hard to predict from the established input circuitry of the neuron. This finding suggests that the computational significance of visual interneurons can only be assessed if they are characterised not only by conventional stimuli as are often used for systems analysis, but also by behaviourally relevant input.

Animals↗
PubMed2007

Study of on-line monitoring of lactate based on optical fibre sensor and in-channel mixing mechanism.

A PDMS-based microfluidic device with integrated optical fibres was developed for online monitoring of lactate. The detection is based on the optical adsorption of the colour solution formed by in-channel mixing of sample and reagent solutions. Computational Fluid Dynamics (CFD) simulation and kinetic study of the colour development were conducted to determine the minimum channel length and optimum residential time for homogenous mixing and maximum optical adsorption respectively. The system was proved to be able to detect lactate with good linearity (R(2)=0.98), response time of about 130 s and estimated limitation of detection (LOD) of 0.52 mM (about 47 mg/L), which is sufficient for a general online lactate detection. Due to the miniaturization of sensing system and micro-scale mixing, higher detection sensitivity (0.15 V/mM) can be realized than the mixing in lab-scale equipments (0.08 V/mM).

Dimethylpolysiloxanes↗
PubMed2001

Three-dimensional time-resolved optical tomography of a conical breast phantom.

A 32-channel time-resolved imaging device for medical optical tomography has been employed to evaluate a scheme for imaging the human female breast. The fully automated instrument and the reconstruction procedure have been tested on a conical phantom with tissue-equivalent optical properties. The imaging protocol has been designed to obviate compression of the breast and the need for coupling fluids. Images are generated from experimental data with an iterative reconstruction algorithm that employs a three-dimensional (3D) finite-element diffusion-based forward model. Embedded regions with twice the background optical properties are revealed in separate 3D absorption and scattering images of the phantom. The implications for 3D time-resolved optical tomography of the breast are discussed.

Journal Article↗
PubMed2004

Electrochemical modulation of remote fluorescence imaging at an ordered opto-electrochemical nanoaperture array.

An array of nanometer-sized apertures capable of electrochemically modulating the fluorescence of a model analyte is presented. The device, which combines near-field optical methods and ultramicroelectrode properties in an array format, is based on an etched coherent optical fiber bundle. Indeed, the fabrication steps produced an ordered array where each optical nanoaperture is surrounded by a ring-shaped gold nanoelectrode. The chronoamperometric behavior of the array shows stable diffusion-limited quasi-steady-state response. The model analyte, tris(2,2'-bipyridine) ruthenium, emits fluorescence in the Ru(II) state, but not in the oxidized Ru(III) state. Fluorescence is excited by visible light exiting from each nanoaperture since light is confined to the tip apex by the gold coating. A fraction of the isotropically emitted luminescence is collected by the same nanoaperture, transmitted by the corresponding fiber core and eventually detected by a charge-coupled device (CCD) camera. The array format provides a fluorescence image resolved at the nanometric scale which covers a large micrometric area. Therefore the high-density array plays a bridging role between these two fundamental scales. We established that the opto-electrochemical nanoapertures are optically independent. Fluorescence of the sample collected by each nanoaperture is modulated by changing the potential of the nanoring electrodes. Reversible electrochemical switching of remote fluorescence imaging is performed through the opto-electrochemical nanoaperture array itself. Eventually this ordered structure of nanometer light sources which are electrochemically manipulated provides promising photonic or electro-optical devices for various future applications. For example, such an array has potential in the development of a combined SNOM-electrochemical nanoprobe array to image a real sample concomitantly at the nanometer and micrometer scale.

Journal Article↗
PubMed2004

Optic nerve changes following posterior insertion of glaucoma drainage device in rabbit model.

OBJECTIVE: To study the histopathological changes in the optic nerve following posterior insertion of a glaucoma drainage device. METHODS: The Ahmed glaucoma valve (AGV) (model no. S-3) was inserted 10 to 12 mm behind the limbus in the superotemporal quadrant of the rabbit eye. One eye of six albino New Zealand rabbits was randomly assigned to the AGV group. At the end of two months, the enucleated eyes were examined histologically for optic nerve changes. RESULTS: The fibrous capsule around the endplates involved the optic nerve in all eyes in the AGV group. The endplate was found to be either in contact (4 eyes) or within 1 mm from the optic nerve (2 eyes) in all six eyes. Histopathological examination of the optic nerves in the AGV group with optic nerve contact exhibited microglial loss, astrocyte clustering, and fibrillary changes. The two eyes in which the end-plate was within 1mm (but no physical contact) with the optic nerve showed only early vacuolization of the astrocytes. No such changes were noticed in the control eyes. CONCLUSIONS: The rabbit model demonstrates the potential for optic nerve damage when the AGV end-plate is inserted within 1 mm of the optic nerve.

Animals↗
PubMed2005

Fiber-optic tunable multiwavelength variable attenuator and routing module designs that use bulk acousto-optics.

A compact fiber-coupled bulk acousto-optical multiwavelength variable optical attenuator module design that uses a retroreflective double-pass geometry within a single bulk acousto-optic tunable filter device is presented. The proposed attenuator module demonstrates a high 17-dB notch dynamic range at a low 100-mW drive power and uses a single bulk collinear-interaction acousto-optic tunable-filter device. Experiments show a low (<1.8-dB) fiber-to-fiber insertion loss with a fast 34-micros speed within a wide 1520-1640-nm agile multinotch band. The basic broadband attenuator module design is extended to allow for efficient architectures for routing modules such as agile drop filters, analog hitless tap filters, and digital add-drop switches.

Journal Article↗
PubMed2005

Scanning near-field optical microscopy as a tool for the characterization of multimode interference devices.

We report the scanning near-field optical microscopy (SNOM) characterization of a 4 x 4 multimode interference (MMI) device working at a wavelength of 1.55 microm and designed for astronomical signal recombination. A comprehensive analysis of the mapped propagating field is presented. We compare SNOM measurements with beam-propagation-method simulations and thus are able to determine the MMI structure's refractive-index contrast and show that the measured value is higher than the expected value. Further investigation allows us to demonstrate that good care must be taken with the refractive-index profile used in simulation when one deals with low-index contrast structures. We show evidence that a step-index contrast is not suitable for adequate simulation of our structure and present a model that permits good agreement between measured and simulated propagating fields.

Journal Article↗