Reaction of various skin wounds in the rat to collagen sponge dressing.
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The permeation properties of dressings to gases are important to the healing processes. It is necessary that dressings are permeable to water vapour, oxygen and carbon dioxide. A series of commercially available dressings have been assessed in vitro in respect of their permeability characteristics to these gases.
The effects of a Polyethylene oxide hydrogel dressing and a co-polymer starch hydrogel dressing upon the rate of re-epithelization were evaluated in a study using Yorkshire pigs. The polyethylene oxide hydrogel dressing significantly promoted re-epithelization by 44% as compared to untreated control wounds, while the copolymer starch hydrogel dressing significantly promoted epidermal healing by 24%. A possible mechanism of action is presented for the quicker healing induced by these dressings.
The socio-medical importance of venous leg ulcers is clear, considering that 2% of adults are suffering from. Hospitalization-time is twice as long than the average. The ratio female: male is about 2-3:1. 90% are venous leg ulcers. There is agreement to treat venous leg ulcers by compressive dressings basically. External local therapy can optimize the wound-healing. Contact dermatitis in about 80% of patients demand the use of 'inert' dressings, i.e. polyurethane foam dressings (e.g. Lyomousse).
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