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At least 757 records · Page 42Linked to original sources
PubMed2003

Preoperative detection of pancreatic insulinomas on multiphasic helical CT.

OBJECTIVE: The objective was to analyze enhancement characteristics of insulinomas and to determine the ability of multiphase CT to localize these tumors. MATERIALS AND METHODS: Prospective interpretations of multiphase helical CT scans were reviewed in 30 patients who had insulinomas resected over a 5-year period. CT scans were retrospectively reviewed to determine enhancement characteristics, tumor conspicuity in each phase of enhancement, and potential causes for false-negative findings. RESULTS: Sixty-three percent (19/30) of tumors were identified on CT prospectively. An additional six tumors were visualized in retrospect, allowing characterization of 25 (83%) of 30 tumors. Most tumors were hyperdense on at least one phase (n = 19), three tumors were hypoattenuating, and three were isodense and pedunculated. Insulinomas were most conspicuous on the early phase in 15 patients and in the portal venous phase in three. All tumors that underwent pancreatic phase imaging were seen (13/13), whereas three of 18 arterial and six of 25 portal venous phase findings were inconclusive for tumor. In the six examinations with false-negative findings in which the tumor could be seen in retrospect, two tumors were isodense and pedunculated, three were in close proximity to vessels, and one had a cystic appearance. CONCLUSION: Multiphasic CT has a moderate sensitivity in the detection of insulinomas. Most tumors are more conspicuous on the earlier phases of enhancement. The pancreatic phase may be more useful than the arterial phase. Potential sources of false-negative results include tumors adjacent to vessels, pedunculated morphology, or nonhyperattenuating lesions.

Adult↗
PubMed1997

Sleep characteristics of Japanese working men who score alexithymic on the Toronto Alexithymia Scale.

This study examined the relationship of sleep characteristics including insomnia with scores on alexithymia in a sample of 171 Japanese working men. Levels of nonrestorative sleep and daytime sleepiness reported on a sleep questionnaire were significantly associated with scores on Depression and Confusion on the Profile of Mood States for Japanese men who had a high mean score on the Toronto Alexithymia Scale.

Adaptation, Psychological↗
PubMed1987

Clinching the diagnosis: using the biochemical profile.

The biochemical profile is an important extension of clinical evaluation and should include widely applicable tests for this purpose. Interpretation of results requires a proper understanding of what constitutes normality and abnormality and a knowledge of how changes may occur. The pathologist has a major responsibility in advising on interpretation in different clinical situations. This requires a familiarity with artefactual and drug-induced changes and a thorough knowledge of the pathophysiology of disease processes.

Algorithms↗
PubMed1984

Blood pressure and other risk factors in healthy middle-aged men in relation to self-reported first-degree family history of hypertension.

In a questionnaire-assessed first-degree family history of hypertension obtained in a sizable subsample of middle-aged male attenders to a multiphasic health screening programme in Malmö, the actual blood pressure distributions and other risk factors are compared in the different heredity groups. Both mean values and frequencies of borderline and hypertensive levels of the systolic and diastolic blood pressures were significantly higher in groups with a family history of hypertension in particular biparental, than in those without. Reported paternal hypertension was less frequent than reported maternal hypertension but resembled more the biparental history group in terms of the recorded blood pressure levels. Several biochemical and physiological variables were compared between the groups, but there were no differences in associated risk factors, including blood lipids, except for higher serum urate in the biparental history group than in the others. Only part of the overrepresentation of increased blood pressure levels that was present appeared to be of the genuine idiopathic variety of hypertension, and the genotype for this disorder did not appear to be associated with other risk factors for hypertension in the population.

Blood Pressure↗
PubMed1990

Changes in drinking behavior: demographic, psychosocial, and biomedical factors.

Demographic, psychosocial, and biomedical variables were collected from 12,371 ambulatory persons who had an initial multiphasic health examination in 1978 or 1979 and a second examination 5 years later in 1983 or 1984. Subgroups of this cohort who had substantially increased and decreased their drinking were compared with persons who continued to drink at baseline rates. A balanced model of demographic, psychosocial, and biomedical variables had the capacity to differentiate persons who had substantially increased their drinking; fewer variables--primarily psychosocial--differentiated persons who had greatly decreased their drinking.

Adult↗
PubMedDate not supplied

The long-term quality control and clinical data evaluation of individuals in AMHTS.

A new aspect of clinical data evaluation has been revealed by our recent research on the membership of AMHTS--long-term quality control (LTQC). The state of LTQC is evaluated by the distribution of mu, where mu is (mean minus micro 0) square root n minus/sigma 0, n is the number of the samples taken each day, mean is the mean of each day's samples, and sigma 0 and micro 0 are population deviation. Correction methods have been developed to obtain reasonable correction factors against the long-term analytic errors, and they have been implemented as an on-line, real-time subsystem of the AMHTS information system. The correction of LTQC errors has enabled us to observe an individual's health dynamics accurately, which allows us to pursue detection methods of diseases, such as cancer, in terms of a homeostatic disorder.

Blood Chemical Analysis↗
PubMedDate not supplied

Periodically repeated multi-phasic health tests--a unique data source for detecting subject-specific normal ranges.

When a comprehensive health check-up is repeated for the purpose of health control, the individual clinical data should be evaluated carefully by a proper normal range, which must be specific to each subject, if early detection of disease is a goal. The Perfect Liberty Health Control System, a health plan run on a membership basis, has been giving its periodic multi-phasic health tests to all of the 24 000 + members biannually since 1970. Studies concerning health parameter dynamics have been made on the data obtained and these are important to the new challenging field of clinical laboratory examinations. Other helpful aspects of this punctually repeated AMHTS (Automated Multi-phasic Health Testing) on a lifetime membership basis are also presented, such as cancer detection accuracy, protection from unnecessary X-ray exposure during examinations and a new form of physician's examination supported by current laboratory-data preview.

Adult↗