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[A case of retroperitoneal liposarcoma].

A 77 year-old woman presented with the chief complaint of a mass in the right upper quadrant. The examination on admission including IVP, echography, Ga scintigraphy, barium enema, CT scan, and angiography revealed that the right kidney and ascending colon were displaced by the mass. Under the diagnosis of retroperitoneal tumor, operation was carried out. Most of the mass was resected with the right kidney. The pathological diagnosis of the resected tumor revealed well differentiated liposarcoma. Convalescence was uneventful and the patient has been well and free from disease for 14 months. Based on our experience and the review of the pertinent literature in English and Japanese, we emphasize the importance of definite surgery and close follow up, as liposarcoma is frequently recurrent.

Aged↗

[Surgical therapy of liposarcoma].

The clinical course of 17 patients with liposarcoma was followed from 6 months to 20 years. Local recurrence was seen in 11 patients, metastases in 3. Survival was 1 year in one case up to 18 years in another. There was a close correlation of survival and histological findings. There was also a distinct influence of primary surgical therapy on local recurrence rate. In our opinion, the extent of excision of the primary tumor is most important in the treatment of liposarcoma.

Adult↗

[Computed x-ray tomography of abdominal lipoma and liposarcoma in adults. Apropos of 9 cases].

CT scans were performed in 9 patients with fatty tumors of the abdomen: 2 lipomas and 7 liposarcoma. Of primary retroperitoneal origin, five tumors had extended intraperitoneally. Scanning images typical for each type of tumor are described: lipomas are very hypodense and well circumscribed, with thin intratumoral septa; liposarcomas are less hypodense and contain thick septa which may coalesce and form large nodules. Scanner imaging provides precise data on tumor extension and allows early detection of recurrences of these fatty tumors.

Abdominal Neoplasms↗

[Liposarcoma of the gallbladder and the peritoneum. A case report].

We report a case of a male patient who was cholecystectomized at the age of 79. We diagnosed an intramural myxoid liposarcoma of the gall bladder without signs of metastasis. Two years later at autopsy we found a diffuse spread of the same type of tumour on mesentery, omentum maius, parietal and visceral peritoneum. The unusual primary site of the tumour is pointed out referring to literature, the question of primary multicentric liposarcoma resp. diffuse peritoneal metastases is discussed.

Aged↗

Liposarcoma of the foot: a case report.

A 56-year-old black, apparently healthy female presented with a rapidly growing mass on the medial aspect of her left hallux. The mass was seen on x-ray examination, and did not appear locally invasive. Excision revealed the mass to be a well differentiated liposarcoma, and after further consultation, the left hallux was amputated. Although the incidence of differentiated liposarcoma in the foot is rare, the preceding case should reiterate to all the need for closer investigation of soft tissue masses which may appear in the foot. Prompt excision of malignant tumors results in a good prognosis for the patients, whereas misdiagnosis based on the apparently benign appearance may lead to unnecessary delay and a less fortuitous prognosis for the patient.

Female↗

Cytopathology, including transmission and scanning electron microscopy, of pleomorphic liposarcomas in pleural fluids.

Liposarcoma cells in pleural fluid from two patients with metastatic pleomorphic liposarcoma are described. The major diagnostic feature of such specimens, perceivable by light microscopy, is the presence of solitary, pleomorphic giant cells with cytoplasmic vacuoles. In some cells, transmission electron microscopy revealed numerous cytoplasmic lipidic droplets. With scanning electron microscopy, the cellular surfaces were markedly pleomorphic, with ruffles, blebs and long, thin processes.

Adult↗

Liposarcoma of the breast. A case report.

Two cases are reported of liposarcoma of the breast, the first in a 62, and the second in a 60-year-old woman, respectively. The tumours were of the poorly differentiated, pleomorphic type and predominantly myxoid type, respectively. Liposarcoma of the breast is extremely rare, and including the present two cases, only 32 patients suffering from the condition have been described. It is difficult to make any prognosis owing to the small number of cases reported. Patient No. 1 in the present work, died 14 months postoperatively, owing to widespread metastatic tumour tissue infiltration of the spine, liver, as well as, the lungs; No. 2 lived for 17 years without signs of recurrence, until she died of carcinoma of the opposite breast.

Breast↗

[Role of radiation therapy in the combined treatment of soft tissue liposarcomas].

The end results of surgical and combination (radiation + surgery) treatment of 85 patients with liposarcoma are compared. The 5-year survival rate following combination therapy proved to be much higher than after surgery (84 and 53.4%, respectively). Application of radiation improves the results for treatment of all histological types of tumor, polymorphocellular liposarcoma included. Indications of standard and concentrated dose-fractionated radiation should be determined by the size of tumor.

Adult↗

[Liposarcoma in adults. Prognostic factors in a series of 84 cases (author's transl)].

A retrospective study of 84 patients with liposarcoma treated at the Gustave Roussy Institute between 1956 and 1978 has elicited a number of factors which influence the prognosis, namely: (1) the site of the initial tumour: patients with liposarcoma of the head, trunk and extremities have a better survival rate than those with retroperitoneal tumours or tumours of the pelvic and pectoral girdles; (2) the histological type: differentiated forms have a brighter prognosis than undifferentiated forms; (3) the size of the tumour: tumours of less than 10 cm in diameter have a more favourable prognosis than larger tumours; and (4) the patient's age, which in fact correlates with the histological type. Local recurrences are common but do not seem to worsen the prognosis. The only curative treatment is surgery, but radiotherapy reduces the risk of local recurrences and chemotherapy may be considered in cases with poor prognosis.

Adult↗

[Combination of surgical therapy and interventional radiology in a recurrent myxoid liposarcoma with a 37-year history].

Extreme long-term survivals of low grade liposarcomas are rare. The authors present a case of a 75 year old man with a 37 year history of recurrent myxoid liposarcoma. The tumor dynamics are obviously related to the histology subtype. The clinical and radiological findings of the sixth tumor recurrence are discussed. The combination therapy of surgical tumor reduction and interventional radiology with implantation of endovascular prostheses for iliaco-femoral vein compression due to tumor recurrence is described.

Abdominal Neoplasms↗

[Glottic liposarcoma: a first case in the national literature].

Liposarcoma is a tumour of mesenchymal origin. Only between 3-8 percent of the total amount of cases are localized in the head and neck. Laryngeal sitting is an extremely rare occurrence. The AA. inform about the case princeps published in the national literature. It deals with an 83-years-old woman presenting a polypoid tumor on the left vocal cord. The diagnosis could be confirmed through immunochemistry which verified the positivity of the proliferative cellularity for vimentine and protein S-100, immunophenotype consistent with liposarcoma. 36 months later the patient, alive, remains tumor-free.

Aged↗

[Well-differentiated liposarcoma of the spermatic cord with dedifferentiation].

We report a case of well-differentiated liposarcoma with dedifferentiation of spermatic cord in a 73-year-old-man. Treatment was by orchiectomy without retroperitoneal lymph node dissection or adjuvant therapy. The patient has survived 10 months with no evidence of recurrence. Liposarcoma localized to the spermatic cord is rare; less than 70 cases have been previously reported. The literature is reviewed with special emphasis on the clinical significance of the dedifferentiation phenomenon.

Aged↗

[A case of renal liposarcoma].

A-48-year-old male was admitted to our hospital with a right renal tumor. He received radical nephrectomy immediately. Histological examination of surgical specimen revealed renal liposarcoma, which consisted of mixed type of pleomorphic and well differentiated subtypes. Multiple tumorous lesions were scattered in the renal parenchyma. He has been alive without disease for 2 years and 7 months after surgery. Only 23 cases of renal liposarcoma have been reported in Japan.

Humans↗

Surgical management of primary retroperitoneal liposarcomas.

During a 21-year period (1970-1991), 7 patients with primary retroperitoneal liposarcomas were treated surgically in our department. All the tumours were excised completely, and in 2 patients an additional nephrectomy was performed. Postoperatively 4 patients had adjuvant radiotherapy. Two other patients received adjuvant chemotherapy. Both of them had to be reoperated, because of a local recurrence 12 and 9 months after their first operation. There was one death on the first postoperative day, and 4 patients died 1 1/2-2 years after the initial operation. Two patients are still alive 34 and 22 months after their first operation with recurrent disease. Adjuvant therapy proved to be ineffective on the survival of our patients. The prognosis of retroperitoneal liposarcomas continues to be poor and the primary treatment has to be aggressive with complete resection of the tumor.

Aged↗

Retropharyngeal liposarcoma.

We report a case of a large inhomogeneous tumor confined to the retropharyngeal space, visualised by CT and MRI, which proved to be a liposarcoma. Liposarcoma in the head and neck region is a very rare condition and a retropharyngeal location has only been described once previously.

Adult↗

[A surgical case of liposarcoma in the chest wall within the thoracic cavity of a young patient].

A 21-year-old man presented to our hospital on June 7, 1990, asymptomatic but with an abnormal shadow in his chest roentgenogram. A well-demarcated tumorous shadow was seen in the left hilum of the lung in the frontal view of the chest X-ray, and adjacent to the posterior chest wall in the lateral view. A percutaneous needle biopsy was performed, and since there were no malignant findings, the tumor was left untreated for future examinations. However, since the tumor was observed to be enlarging gradually in subsequent chest X-rays, it was resected surgically on June 18, 1991. The tumor was fist-sized and its surface smooth, and was protruding into the thoracic cavity. At surgery, the tumor was separated from the chest wall. The tumor, weighing 170 grams, was diagnosed pathologically as a liposarcoma (myxoid type). It was confirmed that there was no infiltration into the surrounding tissue and that total resection had been performed. There are few reports of liposarcomas within the thoracic cavity developing in the extra-mediastinal chest wall. As our case is the second in Japan occurring in a young patient, we present it here together with a review of the literature.

Adult↗