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The development of a collaborative medical modelling service: organisational and technical considerations.

We describe the steps, problems, pitfalls and modifications in the development of a collaborative medical modelling service for a general hospital in the United Kingdom. We emphasise the value of having as much control as possible in the hands of clinicians so that the maximum relevant information can be obtained at minimum cost. Three-dimensional imaging, modelling and planning are now essential parts of any reconstructive surgery unit and must be adapted to make them as user friendly as possible for clinicians.

Computer-Aided Design↗

The concept of 'developing the brain': a new natural science for learning and education.

From the viewpoint of biology, learning and education can be defined as the processes of forming neuronal connections in response to external environmental stimuli, and of controlling or adding appropriate stimuli, respectively. Learning and education can thus be studied as a new field of natural sciences with the entire human life span as its subject, thus including various problems such as fetal environment, childcare, language acquisition, general/special education, and rehabilitation. Non-invasive imaging of higher-order brain functions in humans will clarify the brain's developmental processes, and will provide various evidence for learning sciences. This new approach is called 'developing the brain' or 'brain science and education'. The origin of the concept and its present state are described and its future prospects are briefly analyzed.

Brain↗

Neuroeconomics--from neural systems to economic behaviour.

Neuroeconomics is a new and highly interdisciplinary field. Drawing from theories and methodologies employed in both economics and neuroscience, it aims at understanding the neural systems supporting and affecting economically relevant behaviour in real-life situations. Although incomplete, the evidence is beginning to clarify with the possibility that neuroeconomic methodology might eventually trace whole processes of economically relevant behaviour. This paper accompanies the author's ConNEcs 2004 keynote speech on applications of neuroeconomic research.

Behavioral Sciences↗

Editorial.

Explore the source record for details and available documents.

Animals↗

Comparing classifications of death in the Mode Selection Trial: agreement and disagreement among site investigators and a clinical events committee.

Clinical events committees (CECs) are the current standard for endpoint adjudication in clinical trials. However, little data exist with which to compare CEC and site investigator determinations or to evaluate internal agreement among CEC members. Using data from the Mode Selection Trial in Sinus Node Dysfunction (MOST), we analyzed classifications of death in order to compare internal agreement among CEC physician reviewers and agreement between the CEC and site investigators. Death was classified at 2 levels: by major cause (cardiac, noncardiac, or unknown) and by minor subclassification of the major classifications. Reviewer agreement was tabulated at the major and minor levels, and standard and weighted kappa statistics were calculated. Disagreement at both levels was also determined. Individual decision-making was tabulated in terms of frequency in classifying death as unknown. All 404 deaths were classified by the CEC. Site investigators determined major classifications in 382 cases and minor classification in 379 cases. The CEC and the site investigators disagreed in classifying 41 cases (10.7%) at the major level and 117 (30.9%) at the minor level. CEC reviewers disagreed internally at the major level in 64 cases (15.8%), at the minor level in 63 cases (15.6%), and at any level in 127 cases (31.4%) (kappa = 0.60, 95% confidence interval (CI) [0.55, 0.66]; weighted kappa = 0.66, 95% CI [0.62, 0.75]). In resolving internal disagreements, the full CEC agreed with 1 of 2 CEC reviewers in 85.9% of cases. Disagreements occurred between site investigators and CEC reviewers in classifying deaths. Endpoint determination and decision-making varied among individual CEC reviewers, but second-tier reviews by the full CEC resolved all disagreements. These findings support continued use of CECs for endpoint adjudication in clinical trials.

Cause of Death↗

NIMR awaits the final verdict.

Is translational research enhanced by the proximity of research institutes to hospitals? For scientists at the UK's National Institute of Medical Research, which is facing relocation from London's outskirts to its center, the question is no longer academic.

Academies and Institutes↗

Neuroscience and architecture: seeking common ground.

As these paired Commentaries discuss, neuroscientists and architects are just beginning to collaborate, each bringing what they know about their respective fields to the task of improving the environment of research buildings and laboratories.

Architecture↗

The neonate with congenital heart disease: what the cardiac surgeon needs to know from the neonatologist and the cardiologist.

To plan and accomplish a successful operation for a neonate with congenital heart disease, the cardiac surgeon requires a complete anatomic description of the cardiovascular malformation. For optimum outcome, this information must be supplemented by a complete report of the prenatal and postnatal course of the newborn as well as by a thorough summary of any noncardiac congenital or acquired abnormalities. In the most favorable circumstance, the neonate arrives in the operating room completely diagnosed, fully resuscitated, well nourished, and with appropriate monitoring devices in place. Unique perioperative considerations attach to each cardiac anomaly and are briefly reviewed, and the importance of continuity of care for the patient and family is emphasized.

Cardiology↗

Interdisciplinary teamwork in a school-based health center.

The goal of school-based health centers (SBHCs) is to provide culturally competent primary, preventive, and mental health care services for students who otherwise may not have access to care. Often, an SBHC is the primary health care provider for students because many adolescents are uninsured or lack access to other health care service providers. At other times, the SBHC works in collaboration with primary care providers and other health professionals to provide health care services for students and their families. Complex health and social problems and changes in professional practice make it impossible to serve clients effectively without collaborating with professionals from other disciplines. One process used in SBHCs to assure that students' needs and concerns are addressed is an interdisciplinary case review (ICR). The ICR is a method of evaluating complex cases with members of the health care team to ensure that the physical and mental health and social needs of students are meeting or exceeding the standard of care.

Adolescent↗

Collaborating with key school partners: triumphs and challenges.

Problems that affect the health and well-being of the nation's children and youth are becoming increasingly complex and interrelated, requiring the joint efforts of education, health, and social service systems. School-based health centers (SBHCs) provide a bridge between these disciplines. Professionals who staff SBHCs routinely interface with key partners within their host schools. This article provides lessons from the field, exploring the intricacies of the collaborative process from the perspective of 17 nurse practitioners working in an SBHC in Cook County, Illinois.

Adolescent↗

Evaluation of school-based health center programs and services: the whys and hows of demonstrating program effectiveness.

Evaluation and dissemination of the outcomes of school-based health center (SBHC) services is essential for the continual growth and funding of SBHCs in the United States. Since their inception, SBHCs have been practice sites for nurse practitioners and have used interdisciplinary teams to provide care for underserved school-aged children. Early research and evaluation focused on describing the types of services and the quality of care provided. Supporters of SBHCs were anxious to demonstrate that the care provided was "as good as" care delivered in traditional primary care practices. Documentation of program impacts, such as changes in population health indicators or improved academic achievement, has been more elusive. Current evaluation priorities outlined by the National Assembly on School-Based Health Care include evaluation of mental health services using a new online tool; assessing productivity of SBHC staff; measuring quality; and attempts to link SBHC care with improved academic outcomes.

Adolescent↗

Establishing a clinical cardiac MRI service.

After several years of research development cardiovascular MRI has evolved into a widely accepted clinical tool. It offers important diagnostic and prognostic information for a variety of clinical indications, which include ischaemic heart disease, cardiomyopathies, valvular dysfunction and congenital heart disorders. It is a safe non-invasive technique that employs a variety of imaging sequences optimized for temporal or spatial resolution, tissue-specific contrast, flow quantification or angiography. Cardiac MRI offers specific advantages over conventional imaging techniques for a significant number of patients. The demand for cardiac MRI studies from cardiothoracic surgeons, cardiologists and other referrers is likely to continue to rise with pressure for more widespread local service provision. Setting up a cardiac MRI service requires careful consideration regarding funding issues and how it will be integrated with existing service provision. The purchase of cardiac phased array coils, monitoring equipment and software upgrades must also be considered, as well as the training needs of those involved. The choice of appropriate imaging protocols will be guided by operator experience, clinical indication and equipment capability, and is likely to evolve as the service develops. Post-processing and offline analysis form a significant part of the time taken to report studies and an efficient method of providing quantitative reports is an important requirement. Collaboration between radiologists and cardiologists is needed to develop a successful service and multi-disciplinary meetings are key component of this. This review will explore these issues from our perspective of a new clinical cardiac MRI service operating over its first year in a teaching hospital imaging department.

Cardiovascular Diseases↗