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At least 757 records · Page 42Linked to original sources
PubMedDate not supplied

[Circadian and seasonal characteristics of the reaction of the liver to the administration of bilignost].

It has been shown in experiments on female rats that there are circadian and seasonal modulations in the liver reaction to bilignost administration. The most copious bile secretion was observed in the morning and evening hours in summer and in the evening hours in winter. The minimal liver sensitivity to bilignost was found in the summer group animals. It is suggested that rhythmic activity of the hypothalamohypophyseal-adrenal system underlies the changes in liver sensitivity to bilignost.

Animals↗
PubMedDate not supplied

[Pharmacokinetics of bilignost in the normal liver and in experimental pathology].

In the first approximation the process of distribution of the radiographic contrast agent bilignost may be formalized with the aid of a linear two-compartmental model, while generally, with the aid of a non-linear many-compartmental perfusion model of the pharmacokinetics. Pharmacokinetic analysis of experimental data has shown that the decreased content of bilignost in the liver during acute carbon tetrachloride poisoning is largely determined by the impairment of radiographic contrast agent absorption by the liver.

Acute Disease↗
PubMedDate not supplied

[New information on the biotransport of the x-ray contrast substance, bilignost, in the hepatocyte].

Electron microscopic studies on rats have shown that promptly (30 sec--5 min) after administration to the portal vein, bilignost progresses diffusely, through the cell membrane, from Disse's space and intercellular slits to the hepatocytic cytoplasm. It is accumulated by the cytoplasm and subcellular organellas and then is rapidly eliminated from the cells to bile capillaries.

Animals↗
PubMed1980

[Quality of roentgenological visualization and tolerance of various intravenous cholegraphic contrast media (author's transl)].

The recently introduced intravenous cholegraphic contrast media produce a greater diagnostic yield in radiological routine thanks to improved roentgenological contrasting. Whereas the percentage share of roentgenologically clearly assessable cases is about 75 % when using Biligrafin, this percentage is much higher with the more recent contrast media, especially Biliscopin, namely, up to 88 %. These new contrast media are also superior in respect of tolerance, since they produce fewer side effects. While side effects must be expected in about 28 % of the cases when injecting Biligrafin, the side effect quota is about 10 % only with Biliscopin or Endomirabil. If the contrast medium is infused instead of injected, the quota of side effect drops to 2.3 % with Biliscopin or 3.9 % with Endomirabil. Slight and medium side effects have definitely decreased with the more recent contrast media. The slower and more continually the contrast medium is administered, the fewer are the side effects observed; this becomes particularly noticeable in the case of long-term infusions. However, the likelihood of severe incidents caused by the contrast medium, remains unchanged at about 1 % of the examined patients, even with the more recently introduced contrast media.

Cholangiography↗
PubMed1981

A double-blind comparison of meglumine iotroxate (Biliscopin) and meglumine iodoxamate (Cholovue).

A double-blind comparison of two recently introduced cholangiocholecystographic agents was carried out in 80 patients. Both agents proved to be equally effective in opacifying the gall-bladder and the bile ducts. The visualization of the bile ducts after cholecystectomy was slightly better after meglumine iotroxate administration. Both agents showed evidence of hepatic toxicity in mild or moderate degree. However, there were 3 cases in which adverse hepatotoxic reactions t meglumine iodoxamate have been observed. Careful observation of patients receiving this drug is advised.

Chemical and Drug Induced Liver Injury↗
PubMed1982

[Practice-oriented method of cholangiography].

The authors present their methodology of cholegraphy which was tested in practical routine work under in most cases examination conditions of an outpatient department with orientation to optimized relations between expense, risk and utility. The peculiarities of the methodical and tactical procedure are described in detail. A radiological representation of the biliary system should be performed only when there is no possibility to sonography and when there are discrepancies between its result and clinical picture, respectively. The oral cholegraphy is regarded as basis examination. When it has a negative result and when there is a congruity to the clinical findings (especially confirmation of the symptom colic) a surgical intervention seems to be justified. The intravasal application of a contrast remedy should in the interest of the patient be performed per infusionem, in order to keep the risk in justifiable limits. For the same reason a very strong indication is necessary. It is primarily used in disturbances of the enteral resorption, after cholecystectomy as well as in certain blood-chemical changes which suggest a severe disturbance of the hepatobiliary system. Secondarily it is used as second examination for further clarification of the picture of the disease. Here the decision must be rendered subject to the situation in the individual case, since in a series of pathological conditions a reduction of the quantity of the contrast remedy becomes necessary.

Administration, Oral↗
PubMedDate not supplied

[Reaction between x-ray contrast media and dyes and hepatocyte plasma membranes].

It has been shown in experiments in vitro that the hepatotrophic organic anions, the radiographic contrast agent (RCA) bilignost used in cholecystography and Bengal pink, have an affinity, unlike the urographic RCA triombrin and renotrophic dye indigo-carmine, for the plasmatic membranes (PM) of liver cells. Hydrophobic interaction has been ascertained to be of primary importance in the course of Bengal pink binding to PM of hepatocytes. PM has a higher capacity for binding Bengal pink as compared to that of lysosomal and microsomal membranes of liver cells. The binding capacity of uterine and renal PM is about 2.5 and 3 times less, respectively than that of liver PM, that is accounted for by differences in the number of binding sites on the membranes with a similar affinity for the dye. The results obtained indicate that PM of liver cells carry specific binding sites responsible for recognition and selective absorption of the hepatotrophic organic anions.

Animals↗