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ECHO virus type 30 meningitis in Edinburgh.

Fifty-five patients with ECHO virus type 30 meningitis were admitted to the Infectious Diseases Unit, Edinburgh City Hospital between August and December 1980. There was a preponderance of males and patients aged 10-15 years. The peak admission rate was about two weeks earlier than that recorded for Scotland as a whole. Helpful diagnostic findings were headache, fever, photophobia, vomiting and nuchal rigidity but not Kernig's sign. Only one patient had a rash. The majority of patients were admitted within 48 hours of the onset of symptoms. The CSF pleiocytosis was high and tended to be polymorphonuclear in type. CSF glucose concentrations were all normal. There were no serious sequelae. The considerable morbidity reported after leaving hospital emphasises the importance of adequate convalescence.

Adolescent↗

Laparoscopic nephrectomy: a review of 16 cases.

Laparoscopic nephrectomy is a new procedure in which the entire kidney is removed via an endoscopic technique using a surgical sack entrapment method in combination with a recently developed high-speed 10-mm electrical tissue morcellator. Since June 25, 1990, this procedure has been successfully accomplished in 16 consecutive patients. The average operating room time was 5.6 h. Two patients received a blood transfusion (one and three units, respectively). The average hospital stay was 4.6 days, and convalescence was completed within an average of 12 days. We believe the methods developed for laparoscopic nephrectomy will allow surgeons in other disciplines to broaden their indications for laparoscopic surgery as the entrapment sack and morcellator can potentially be applied to the removal of many other solid intraabdominal and pelvic tissues.

Adolescent↗

Transvenous catheter ablation of a posteroseptal accessory pathway in a patient with coexistent posteroseptal and right-sided accessory pathways.

Transvenous catheter ablation techniques have recently been used successfully in blocking posteroseptal accessory pathways in patients with Wolff-Parkinson-White syndrome (WPWS). We report the case of a patient in the People's Republic of China who had WPWS and posteroseptal and right anterolateral accessory pathways, and who had failed to respond to conventional antiarrhythmic drug therapy. The posteroseptal accessory pathway was ablated successfully. During 23 months of follow-up there were no complications; this led us to conclude that this technique can be used to achieve successful long-term ablation of this accessory pathway. This technique obviates the need for drug therapy and direct surgical ablation; it offers, as well, the advantages of shorter hospitalization, lower cost, a much shorter convalescence, and less discomfort to the patient.

Journal Article↗

[Laparoscopic cholecystectomy--benefit or risk?].

A comparing observation between 600 patients with laparoscopic cholecystectomy and 921 conventionally operated patients reveals that while achieving the same standard of results, the laparoscopic cholecystectomy does not lead to an increased rate of complications. With the operating time slightly prolonged, there is quick freedom from pain, short hospitalization and a short period of convalescence. Thus the laparoscopic cholecystectomy appears to meet the standard of conventional cholecystectomy despite higher demands regarding personnel and materials. It is not only characterized by being better accepted by the patient, but also seems to represent an adequate therapy for symptomatic cholelithiasis from the economic point of view.

Adolescent↗

[Concentration of the beta-chemokine CCL5 (RANTES) in cerebrospinal fluid in patients with tick-borne encephalitis].

BACKGROUND AND PURPOSE: In tick-borne encephalitis (TBE), perivascular infiltrates are formed within the central nervous system (CNS) and are accompanied by pleocytosis with a predominance of T CD4+ lymphocytes in cerebrospinal fluid (CSF). Factors responsible for leukocyte flow into CNS in TBE have not been investigated. We evaluated the concentration of the chemotactic factor for lymphocytes, chemokine CCL5 (RANTES, Regulated upon Activation, Normal T cell Expressed and Secreted) in CSF and serum of patients with TBE and assessed its correlation with CSF pleocytosis. MATERIAL AND METHODS: Group I consisted of 10 patients with TBE virus infection presenting as meningitis; group II included 11 patients with TBE presenting as encephalomeningitis or myeloencephalomeningitis. The control group consisted of 8 patients, in whom neuroinfection and infection with TBE virus was excluded. The concentration of CCL5 was measured by ELISA in CSF and serum samples taken within 24 hours after hospitalization (examination 1) and in the convalescence period, on average after 16 days (examination 2). RESULTS: Mean CCL5 concentration in serum did not differ between the groups, while in CSF it was significantly increased in group I (64.3+/-75.5 pg/ml in examination 1 and 44.4+/-39.5 pg/ml in examination 2) and in group II (38.4+/-17.0 pg/ml in examination 1 and 48.8+/-24.7 pg/ml in examination 2) in comparison with controls (3.7+/-5.3 pg/ml). There was no significant difference regarding CCL5 concentration between groups I and II and between the examination 1 and 2. There was no correlation between the concentration of CCL5 and CSF parameters. CONCLUSIONS: The concentration of CCL5 is increased in CSF, but not in serum of patients with TBE. This increase does not depend on the clinical form of the disease and is sustained after the disappearance of the symptoms of acute infection. Further studies are necessary to determine the source of CCL5, and its role in the pathogenesis of TBE and its sequelae.

Adult↗

[Lipid evaluation in cerebral infarction in its early phase and in the 4th month. Practical consequences].

Plasma lipid values studied in 30 subjects with stroke at days 1, 2 and 4 of the early phase indicated a significant decrease in total cholesterol, HDL-cholesterol and apolipoprotein A1 from day 1 to 4. However, there was no significant difference between values at day 1 and during the 4th month of convalescence. Since some patients admitted to hospital are never followed up later in a hospital environment, it would seem advisable, for practical purposes, to perform plasma lipid analysis on the first day of admission.

Adult↗

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