Japanese experience with clinical trials of fast neutrons.
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The data are obtained indicating that it is possible to increase the cytogenetic effects of 6 MeV neutrons by the additional effect of hyperthermia and caffeine. A combination of gamma rays and neutrons produced a superadditive effect, in estimating the level of chromosome aberrations in human lymphocytes, and in radiation practice when estimating the degree of tumor regression. It is suggested that a different mechanism is involved in the formation of chromosome aberrations after the combined effect of gamma and neutron radiation.
Neutron therapy started in Orleans in January 1981, after a period of radiobiological investigations [5,6]. Up to December 1984, 437 patients have been irradiated with neutron beams produced by 34 MeV protons on beryllium.
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