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At least 757 records · Page 42Linked to original sources
PubMed2006

Giant cardiac fibroma.

A 29-year-old woman who presented with persistent ventricular premature beat during her delivery was referred to us. Her cardiac echocardiography showed a giant tumor located in the posterior wall of the left ventricle. She had no symptoms of heart failure. Partial resection of the mass was safely conducted using cardiopulmonary bypass. The histopathologic finding was fibroma. She has been doing well 6 years after operation. Periodic echocardiography has showed no growth in this tumor.

Adult↗
PubMed2006

An unusual mucinous osteoma with features of an ossifying fibroma in the nasal cavity of a horse.

A 4-month-old Warm-blooded colt presented with facial distorsion and an abnormal respiratory noise of 2 weeks' duration. A proliferative mass was found endoscopically and by computer tomography. Clinical differential diagnosis included cyst formation of the concha, malformation and neoplasia. Euthanasia was followed by post-mortem examination, which revealed a well-circumscribed, semi-solid, jelly like structure, measuring 14.5 x 9.0 x 12.0 cm, in the left posterior nasal cavity extending into the left frontal and maxillary sinus. Histologically, the mass consisted of trabeculae of woven bone, focal lamellar bone and fibroblast proliferation within a moderate fibro-vascular stroma. Abundant mucin production was noted within areas of fibroblastic differentiation. Some areas contained irregularly shaped spicules of osteoid rimmed by osteoblasts, randomly distributed within a moderately vascularized, fibro-osseous stroma. On the basis of the histopathological features, a nasal mucinous osteoma with focal ossifying fibroma-like structures was diagnosed.

Animals↗
PubMed2004

Ossifying fibroma of the jugum sphenoidale.

We report a rare case of an eight year old boy with an ossifying fibroma of the jugum sphenoidale who presented with rapid onset bilateral blindness. This benign tumour was initially debulked and required re-operation with decompression of both optic nerves due to progressive visual deterioration. Post-operatively, there was good visual recovery in the left eye, but visual acuity in the right eye remained at <1/60. A 17 years follow period is described, in which there has been no clinical or radiological evidence of tumour recurrence.

Bone Neoplasms↗
PubMed2006

Spinal chondromyxoid fibroma of C2.

Chondromyxoid fibroma of bone (CMF) is a rare benign primary bone neoplasm accounting for less than 0.5% of all primary bone neoplasms. The spine is an uncommon site for this tumour, with forty-two cases reported in the modern English literature. They have clinical features similar to CMF arising at other sites. Local recurrence is well documented. We report an incidentally discovered lytic lesion of the C2 vertebra. The patient underwent stereotactic CT guided trans-oral curettage of the lesion with iliac bone graft and anterior fusion of C2 and C3. Microscopic examination of the surgical specimen demonstrated CMF. This is the second reported case of this rare tumour in this location. We review the literature and the unique radiological and pathological features and management of spinal CMF. Local recurrence of spinal CMF and its management is also discussed in light of the five previously reported cases of local spinal recurrence.

Adolescent↗
PubMed2003

Cardiac fibroma in an infant: single ventricle palliation as a bridge to heart transplantation.

A prenatal echocardiogram revealed a large right ventricular mass. Following birth, there was obstruction to pulmonary blood flow and cyanosis. The tumor's size and location prevented resection. The patient underwent "single ventricle palliation," including placement of a systemic-to-pulmonary shunt as a newborn. This palliation served as a successful bridge to heart transplantation at 7 months of age. Pathologic examination revealed cardiac fibroma.

Cardiac Surgical Procedures↗
PubMed1999

Left ventricular fibroma masquerading as postinfarction myocardial rupture.

A large left ventricular fibroma was encountered perioperatively for what was presumed to be a sealed ventricular rupture after thrombolytic therapy for an acute myocardial infarction. We review the pertinent literature concerning the diagnosis of ventricular rupture and this rare benign tumor of the heart.

Adult↗
PubMedDate not supplied

Cytogenetic characterization of a fibroma and three haemangiopericytomas in domestic dogs.

Cytogenetic evaluation of tumour cells taken from an 11-year-old mixed breed birth with a fibroma, showed trisomy 1 (2n = 79) and often the presence of a third copy of chromosome 4. In a 13-year-old mixed breed Boxer bitch with a haemangiopericytoma, trisomy 9 (2n = 79) was present. In contrast, another haemangiopericytoma (in a 15-year-old rough-haired Dachshund bitch) showed a deleted chromosome 1, several centric fusions and trisomy 2. Trisomy 2 and trisomy 29 were detected in a third haemangiopericytoma from an 11-year-old rough-haired Dachshund bitch.

Animals↗
PubMed1992

Testicular fibroma.

A testicular fibroma in a 67-year-old man is reported. The tumor presented with expansive growth and myxoid areas. Atypias were absent. Differential diagnosis was made with immunohistochemical techniques that are useful for the diagnosis of nonspecialized gonadal stromal tumors. The origin of the tumor was probably in the interstitial or peritubular myofibroblasts.

Aged↗
PubMed1995

Myxoma virus and Shope fibroma virus encode dual-specificity tyrosine/serine phosphatases which are essential for virus viability.

Sequence analysis of the genomes of the Leporipoxviruses myxoma virus and Shope fibroma virus (SFV) led to the discovery of open reading frames homologous to the vaccinia H1L gene encoding a soluble protein phosphatase with dual tyrosine/serine specificity. These viral phosphatase genes were subsequently localized to the myxoma BamHI-I fragment and the SFV BamHI-M fragment, and the resulting encoded proteins were designated I1L and M1L, respectively. The localization and orientation of the myxoma I1L and SFV M1L open reading frames within the well conserved central core of the viral genomes closely mirror that of the Orthopoxviruses vaccinia virus and variola virus. The myxoma I1L and SFV M1L phosphatases each contain the conserved tyrosine phosphatase signature sequence motif, (I/V)HCXAGXXR(S/T)G, including the active site cysteine, found previously to be essential for phosphotyrosine dephosphorylation. The vaccinia H1L phosphatase was originally shown to have the ability to dephosphorylate phosphotyrosyl and phosphoseryl residues in vitro. To assess whether this is a common feature of poxvirus phosphatases, myxoma I1L was expressed as a GST-fusion protein, purified, and shown to dephosphorylate substrates containing tyrosine and serine phosphorylated residues, in a similar fashion to vaccinia H1L. A myxoma I1L variant, in which the active site cysteine 110 was mutated to serine, was expressed in a parallel fashion to the wild-type I1L protein and found to be completely deficient in its ability to dephosphorylate both phosphotyrosine and phosphoserine amino acids. In an attempt to ascertain the biological requirement for the myxoma I1L phosphatase, we constructed a recombinant myxoma virus containing a disrupted I1L open reading frame. This I1L mutant virus was able to successfully propagate in tissue culture only in the presence of a wild-type complementing gene, and pure virus clones containing only the disrupted allele were not viable. Thus, we conclude that the myxoma I1L dual specificity phosphatase is an essential factor for virus viability.

Amino Acid Sequence↗
PubMed1983

Histopathology of corneal leukoma and fibroma in the ACL syndrome.

Corneal tissues of four persons and a buccal fibroma from one of these persons with ACL syndrome, an autosomal dominant disorder, were evaluated clinically and microscopically. The corneal lesions appeared as a gray epithelial infiltrate over the cornea, destroying Bowman's membrane. Light and electron microscopic images of both types of lesions showed abnormal accumulation of granular mucopolysaccharide material and extensive aberrant orientation of collagen fibers. The authors postulate that the mucopolysaccharide accumulation is involved in the pathogenesis of the syndrome.

Acromegaly↗
PubMed1985

Multifocal nonosteogenic fibroma: report of a case with ultrastructural findings.

The case of a patient in whom multiple nonosteogenic fibromas developed is reported. This condition is very unusual and must be differentiated not only from the multiple lesions that occur in association with well-known entities but also from some occasionally multifocal bone tumors. The lesion is characterized by proliferations of spindle cells disposed in storiform patterns, with numerous scattered multinucleated giant cells. Ultrastructural study revealed that the basic cell of this lesion had fine structural features of both fibroblast and myofibroblast cells.

Adolescent↗
PubMed1998

Calcifying aponeurotic fibroma: a clinicopathologic study of 22 cases arising in uncommon sites.

Calcifying aponeurotic fibroma is a rare soft tissue tumor that primarily occurs in children and adolescents and has a strong predilection for the distal portion of the extremities, especially the hands and feet. This report describes 22 previously unpublished cases arising in uncommon sites. Fifteen patients were male, and seven were female (age range, 2 to 43 years; median age, 9 years). The process typically presented as a painless mass and was present from 2 weeks to 11 years before resection. Sites of involvement were the back (n=8), knee region (n=5), thigh (n=3), forearm (n=3), elbow (n=2), and arm, not otherwise specified (n=1). The lesions were often adherent to dense fibrous connective tissue (eg, tendon, fascia, or periosteum) and ranged from 1.0 to 5.0 cm in maximum dimension. The process typically had an irregular contour and a firm, fibrous consistency. Sometimes minute foci with a calcific appearance were evident grossly. Microscopic examination showed spindled fibroblasts with a fascicular growth pattern and scattered epithelioid cells bordering chondroid foci with or without mineralization. Immunoreactivity was present for vimentin (six of six), muscle-specific actin (three of six), smooth muscle actin (three of six), CD99 (five of five), CD34 (one of six), CD57 (one of six, trace), EMA (two of six, trace), S100 protein (five of six), CD68 (five of five), and progesterone receptor (one of six). The tumors were managed by local excision (n=20), incomplete local excision (n=1) and biopsy only (n=1). Follow-up information was available for 10 patients with a median follow-up interval of 94 months. Five patients (50%) developed one or more recurrences. Familiarity with this entity should help to avoid confusion with other processes, including infantile and extraabdominal fibromatoses, a chondroma of soft parts, and a fibrous hamartoma of infancy.

Adolescent↗
PubMed1998

The multidisciplinary management of psammomatoid ossifying fibroma of the orbit.

OBJECTIVE: To discuss the multidisciplinary management of psammomatoid ossifying fibroma (POF) of the orbit and to clarify the clinicopathologic terminology. DESIGN: The authors present a cohort of cases of POF involving the frontal and ethmoid sinuses and the orbit and discuss the nomenclature and literature. PARTICIPANTS: Three patients with POF and their treatment are discussed. INTERVENTION: Patients were worked up and treated by a multidisciplinary team using imaging studies and histopathologic analysis. Reconstruction, if necessary, was carried out at the time of excision or in a second-stage procedure. MAIN OUTCOME MEASURES: In each case, the lesion was completely excised and has not recurred. RESULTS: The diagnosis of POF was made in each case, and the patient underwent successful resection of the tumor. CONCLUSION: The authors' experience suggests that a multidisciplinary approach, including a radiologist, pathologist, neurosurgeon, otolaryngologist, craniofacial surgeon, and orbital specialist, may be useful in the evaluation and management of these lesions.

Adolescent↗
PubMed2002

Sublabial approach to sinonasal juvenile ossifying fibroma.

Juvenile ossifying fibroma is a rare, unusual fibro-osseous benign tumor of the craniofacial region. It is a progressively growing tumor and has to be removed completely to prevent recurrence. A radical surgery is not advisable in a pediatric patient. Here we describe the sublabial approach for excision of this tumor that allows the complete removal of the tumor without compromising with the aesthetic looks of the patient.

Bone Neoplasms↗
PubMed1989

Sclerotic fibromas of the skin.

Eleven cases of a peculiar, hyalinized, hypocellular dermal fibroma are reported. The lesions are characterized by epidermal atrophy, a whorled appearance of sclerotic collagen bundles separated by clefts containing mucin, and sharp demarcation of the lesions from the surrounding normal skin. They are small white or flesh-colored waxy papules. Multiple lesions of this type have been reported in the multiple hamartoma syndrome (Cowden's disease). We believe that the solitary lesions of these eleven patients who did not have Cowden's disease represent an unrecognized form of the same fibrous hamartoma that occurs in Cowden's disease.

Adult↗