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[Colposcopic picture of blood vessels in the early stages of cervix cancer].

A case of carcinoma in situ with the beginning of invasion is presented. In contradistinction to the changes characteristic of such cases, in this case branching vessels completely typical of a normal transformation zone were found. This suggests only adaptive vascular hypertrophy without vascular neoplasia, in spite of the cancerous changes in the epithelium in situ.

Carcinoma in Situ↗

[The value of double contrast colon imaging in inadequate colposcopic diagnosis].

PURPOSE: Prospective evaluation of colon double-contrast enemas in patients with incomplete colonoscopy during routine examination. MATERIALS AND METHODS: From 1. February 1993 through 31. January 1994 we prospectively evaluated all patients undergoing a double-contrast barium enema following incomplete colonoscopy in the endoscopy unit of the Department of Surgery of the University Hospital Marburg. The examination was carried out using the typical double-contrast technique at least 24 h after colonoscopy. The results of the barium enema were correlated with the findings at colonoscopy with regard to completion of the diagnostic procedure and additional pathological findings. RESULTS: Of 448 colonoscopies 168 remained incomplete. Sixty patients underwent an additional double-contrast study of the colon. In 43 patients this study was sufficient to complete the diagnostic procedure. Unknown pathological diagnoses were found in 11 patients. In 2 patients an adenocarcinoma and in 9 patients polypoid lesions were detected. CONCLUSION: After incomplete colonoscopy a double-contrast barium enema should be performed to complete the diagnostic examination of the whole colon and to reveal unknown additional pathological findings.

Adenocarcinoma↗

Abnormal Papanicolaou smears and colposcopic follow-up among American Indian and Alaska Native women in the Pacific northwest.

BACKGROUND: Mortality that is due to cervical cancer among American Indian and Alaska Native women in the Pacific Northwest exceeds that among women of other races. Nevertheless, little information is available regarding the prevalence and follow-up of abnormal Papanicolaou smears among American Indian and Alaska Native women in the region. METHODS: We conducted a retrospective review of medical records of American Indian and Alaska Native women seen at 12 Indian Health Service and tribally operated clinics in Washington, Oregon, and Idaho who had an abnormal Papanicolaou smear in 1992. RESULTS: Of 4547 Papanicolaou smear results reviewed, 280 (6.2 percent) had an abnormal result (dysplasia or carcinoma in situ). Of the recommended colposcopies, 167 of 224 (75 percent) were completed. Women with high-grade squamous intraepithelial lesions were more likely to obtain recommended colposcopy than were women with low-grade squamous intraepithelial lesions. Women treated at clinics that referred patients to outside providers for colposcopy were more likely to have colposcopy than were those who were offered the procedure on site. CONCLUSIONS: The proportion of Pacific Northwest American Indian and Alaska Native women in Indian Health Service and tribal clinics with abnormal Papanicolaou smears and the proportion who receive colposcopy are similar to those in other populations. The higher rate of cervical cancer mortality among American Indian and Alaska Native women could be due to failure to screen high-risk women. Cytologic screening rates, methods to improve adherence to colposcopy recommendations, and the contribution of other factors to the cause of cervical cancer mortality need to be characterized in this population.

Alaska↗

[Anogenital papillomavirus lesions in humans with or without HIV infection. Comparison of colposcopic, histopathological and virological results].

Anal and genital lesions caused by human papilloma virus (HPV) may be associated with severe dysplasia and cancer, chiefly in cases of "high risk" HPV types 16, 18, 31, 35, 51. The frequency of HPV infections and the severity of genital cancers seem to be increased in patients with human immunodeficiency virus (HIV) infection. PATIENTS AND METHOD. The distribution of different HPV types was compared with the anatomical and clinical features of the lesions in two populations, one HIV+ (n = 40) and the other HIV- (n = 48), who had anal and genital lesions. The HPV DNA was determined by molecular hybridization in situ, using biotinylated probes which recognized HPV types 6/11, 16/8 and 31/35/51 on 99 lesions. RESULTS. HIV+ subjects differed from HIV- subjects in that a higher proportion of them had anal lesions (50 p. 100 vs 10 p. 100) and condyloma latum (80 p. 100 vs 50 p. 100). Koilocytosis without dysplasia was more often found in HIV- subjects (12.5 p. 100 vs 55 p. 100). Conversely, dysplasia was more frequent among the lesions of HIV+ subjects: grade I 39.5 p. 100 vs 17.5 p. 100; grade II 25 p. 100 vs 4 p. 100; grade III 12.5 p. 100 vs 0 p. 100. Koilocytosis was preferentially associated with condyloma acuminatum. In HIV+ subjects the DNA of HPV, detected in 73 p. 100 of the lesions, was "high risk" HPV DNA in 86 p. 100 of the cases, whereas in HIV- subjects 51 p. 100 of the samples were positive in hybridization, and 61.5 p. 100 had "low risk" HPV DNA. In subjects of all groups "high risk" HPV was found in dysplastic lesions. CONCLUSION. HIV seropositive subjects show an imbalanced distribution of HPV with predominance of "high risk" HPV. This suggests that immunodepression encourages infection by this oncogenic virus, thereby contributing to the frequency of cancer in HIV+ subjects.

AIDS-Related Opportunistic Infections↗

Colposcopic examination of the vagina.

Examination of the vagina must include assessment of the minor vestibular glands and urethral meatus. Vaginal mucosal lesions related to papillomavirus infection and neoplasia are best discovered by the use of acetic acid wash followed by the application of Monsel's solution.

Adult↗

[Clinical and colposcopic aspects of bacterial vaginosis].

Bacterial vaginosis is characterized by an uniform, malodorous, white-grey discharge. The presenting symptom is generally the unpleasant smell of the vaginal discharge, particularly following the menses or intercourse. Other functional signs, such as pruritus, dysuria and dyspareunia are rare. Inflammatory signs are frequent, and can be revealed by colposcopy with the Lugol test: this shows punctuate colpitis with small regular points corresponding histologically to an inflammatory focus in the connective tissue. The term "vaginitis" is avoided because of the absence of polymorphonuclear cells in the vaginal discharge, despite the presence of inflammation. Bacterial vaginosis has been held responsible for prematurity, small birthweight and post-partum infection. Nonetheless, Gardnerella vaginalis and Mobiluncus spp can be recovered from the vaginal flora of women with no signs of inflammation.

Animals↗

[Value of endocervical curettage in colposcopic diagnosis of cervix diseases].

The present study was undertaken to determine the credibility of endocervical curettage as a part of evaluation of patients with abnormal Pap smears. A series of 108 patients were carefully examined with colposcopy, ectocervical biopsies and endocervical curettage, and all of them underwent cervical conization following diagnostic study. The histologic diagnosis results between endocervical curettage and cervical cone was compared. The estimate was 85% for sensitivity, 35% for specificity, 62% for positive predictive value and 65% for negative predictive value of cervical curettage. The observations suggest that endocervical curettage credibility is poor and we need to asses the outpatient evaluation and treatment carefully.

Adenocarcinoma↗

A comparison of techniques to assess cervicovaginal irritation and evaluation of the variability between two observers.

BACKGROUND: Colposcopy is used to evaluate effects of new vaginal products on cervicovaginal epithelium as part of the US Food and Drug Administration-mandated product approval process, yet few aspects of its use have been investigated. OBJECTIVES: To determine the effect of the colposcopic examination itself on the number and type of findings seen, to compare colposcopy with the AviScope hand-held device and the naked eye and to compare the findings reported by two examiners during a single visit. STUDY DESIGN: Fourteen healthy women volunteered for five paired examinations in random order: (1) naked eye inspection plus colposcopy done twice by a single examiner; (2) naked eye inspection plus AviScope examination, then naked eye inspection plus colposcopy by a single examiner; (3) Examination 2 repeated with the order of device reversed; (4) naked eye inspection plus colposcopy done by two examiners; (5) Examination 4 repeated with the order of examiner reversed. The colposcopic examinations were done per published standards but were limited to the areas visible without manipulation of the speculum. RESULTS: Length of colposcopic examination averaged 7 min. The number of colposcopic findings found when the examination was done twice by the same clinician was not statistically different (p = 0.12), suggesting that the examination itself did not induce findings. More findings were seen using magnification than naked eye. A similar number of findings were seen by AviScope compared to the colposcope (p = 0.99), but clinically significant findings were "undercalled" or "overcalled" by the AviScope. A weighted kappa score of the "worst" colposcopic finding was 0.32 (SE 0.10, p = 0.00), indicating moderate agreement between examiners. CONCLUSIONS: The colposcopic examination is not burdensome nor does it induce findings. If naked eye observation were used alone in practice, these data suggest that half the colposcopically detected findings would be missed. Using the naked eye observation for screening would minimally reduce the number of magnified observations carried out. For detecting epithelial changes, the colposcope seems to be the most sensitive technique, followed by the AviScope.

Adult↗