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[Current medical technologies in the treatment of cholelithiasis].

AIM: Assessment of different approaches to treatment of cholelithiasis (CL). MATERIALS AND METHODS: 245 CL patients were given a long-term treatment with ursosan, laser lithotripsy and combined modalities. RESULTS: Ursosan promoted dissolving of the stones in 56% of the patients. Laser lithotripsy destroyed the stones in 74 from 91 patients. Ursosan and laser lithotripsy eliminated the concrements in 59 of 67 patients. CONCLUSION: Efficacy of laser lithotripsy in CL depends on valid selection of the patients. The combined therapy of CL is preferable in patients who reject operative intervention and in those with severe somatic complications.

Adult↗

[Interdisciplinary guidelines: cholelithiasis].

Quality management in internal medicine and surgery is especially difficult because of the magnitude of these two subjects. Between the years 1994 and 1996, the German scientific societies of internal medicine developed the manual "Rationelle Diagnostik und Therapie in der Inneren Medizin". The cooperation of colleagues was most helpful when the interests of several internal branches were involved. An even greater challenge is the development of interdisciplinary internal and surgical guidelines, which are presented here for cholelithiasis.

Cholecystectomy↗

Lithogenecity of bile in the pathogenesis of cholelithiasis.

The authors have made a review of the present literature relating to lithogenic bile as the main pathogenic factor in the creation of cholelithiasis. Lithogenic bile is formed in result of complex biochemical reactions taking place in bile under physiological conditions, as well as in pathology of the liver and the biliary tract. Significant clinical implications result from the analysis.

Bile↗

[Pyloric stenosis - a complication of cholelithiasis. (Case of gallstone perforation into the duodenal bulb)].

Pressure-necrosis followed by stone perforation is ralatively rare among the complications of cholelithiasis. There is always a danger of a stenosis in the gastro-intestinal tract. Report of a case of perforation of a gallstone into the duodenal bulb producing few signs but the clinical picture of pyloric stenosis. Symptoms, signs and differential diagnosis are discussed on the basis of the literature.

Aged↗

[Cholelithiasis in chronic Chageas' disease patients].

The studies on the occurrence of biliary lithiasis in patients with chronic Chagas' disease have shown conflicting results. Aiming at contributing to a better understanding of the topic was assessed, by ultrasonographic scan, the frequency of Colelithiasis in chagasic patients with different anatomo-clinical forms of the disease. A total of 128 patients were studied, 85 males (mean age: 53 +/- 13 years) and 43 females (mean age: 53 +/_ 10 years) nineteen males and 18 females had the cardiac form ; 32 males and 19 females the digestive form; 20 males and 3 females the cardiac and digestive forms simultaneously; and 14 males and 3 females the indeterminate form. Controls were a series of 1139 individuals without Chagas' disease, 716 males and 423 females (mean age 46 +/_ 14 years for both sexes), who were submitted to postmortem examination. The frequency of cholelithiasis in chagasic males (14.1%) was significantly higher than in the controls (6%); by subgroup, it was significantly higher in the individuals with the cardiac and cardiac-digestive form (26.3% and 20% respectively), but not in those with the digestive form (9.4%). The frequency of colelithiasis was also significantly higher in chagasic females in the total (42%) and in the cardiac (50%) and digestive (31.6%) forms, when compared to the control group (14%). Male and female chronic chagasic patients have an increased frequency of colelithiasis, and therefore the preoccupation about this finding should not be restricted to the digestive form of the disease, as previous studies on this subject have suggested.

Adult↗

[Cholecystectomy from mini-approach with the elements of open laparoscopic technique in surgical treatment of cholelithiasis].

The experience and the technique of cholecystectomy from mini-approach with elements of open laparascopic technique (MSE) in 102 patients with choledocholithiasis and calculous cholecystitis is descubed. In 99 cases the operation was carried out for chronic calculous cholecystitis, in 3 cases--for acute calculous cholecystitis. The patients were aged from 23 to 76 years (mean age 59.3 +/- 3.4 years). The average length of the incision in performing MSE made up 4.1 +/- 0.3 cm. Mean duration of the operation 42.4 +/- 5.3 min. In 5 cases (4.9%) intraoperative cholangiography was performed. The possibility to avoid the use of narcotic analgetics in postoperative period in patients who underwent MSE is demonstrated. Postoperative period made up 3.8 days. Social and cost-effect aspects of different modes of surgical treatment of patients with cholelithiasis are considered. The study of quality of life index makes it possible to come to conclusion about quicker return of the patients who underwent MSE to their habitual social and intellectual activities, practically complete absence of the influence of negative factors of conventional treatment (pains, dyspepsial, cosmetic defects) higher appreciation of their health conditions, well being, which manifests in higher quality of life in operated patients.

Adult↗

[Diagnostic usefulness of magnetic resonance cholangiopancreatography (MRCP) in comparison with retrograde cholangiopancreatography (ERCP) for cholelithiasis].

PURPOSE: To elucidate MRCP diagnostic usefulness compared to ERCP. PATIENTS, METHODS: 29 MRCP performed patients diagnosed by ERCP were studied. RESULTS: MRCP showed 92%, 67% sensitivity and 73%, 100% specificity in choledocholithiasis (CBD) and cholecystolithiasis (GB), respectively. MRCP revealed 4.0 false positive and 1.5 false negative in CBD and GB, respectively. MRCP could detect 22 stones out of 33 in CBD and 13 out of 42 in GB. As for the maximal diameter, MRCP depicted 31% for less than 5 mm and 100% for over 6 mm in CBD. In GB, 7% for less than 5 mm, 83% for 6-10 mm and 100% for over 11 mm. CONCLUSION: Although the depection of tiny stone is limited, MRCP is a useful diagnostic tool for cholelithiasis, especially choledocholithiasis.

Adult↗

[Pre- and post-operative changes in serum levels of glycocholic acid and 3,5,3'-triiodothyronine and their clinical significance in patients with cholelithiasis].

Pre- and post-operative changes of serum glycine-conjugated cholic acid (CG) and 3,5,3'-triiodothyronine (T3) levels were observed in twenty-two patients with cholelithiasis. The increase of the levels of serum CG varied with the patients; the highest levels were seen in patients with cirrhosis. After operation, the levels of serum CG and T3 were decreased significantly in patients without cirrhosis. There was positive correlation between serum CG and T3 (r = 0.4667, P < 0.01). It is indicated that the lowering of serum CG after operation may be related to the lowering of serum T3; the significant increase of serum CG level is useful to the diagnosis of liver cirrhosis, which is more sensitive than Type B ultrasonography or routine examination of liver function.

Adult↗

Congenital web of the common bile duct in association with cholelithiasis.

Congenital web formations are extremely rare anomalies of the extrahepatic biliary tree. The age at presentation and the clinical symptomatology of these anomalies depend on the grade of the biliary obstruction. We report a case of a common bile duct septum in association with cholelithiasis in a 30-year-old woman. The diagnosis was made on preoperative magnetic resonance cholangiopancreatography (MRCP) and confirmed with intraoperative cholangiography. Because all known causes of acquired web formation were excluded, a congenital origin of the web was assumed. The patient was treated with a hepaticoduodenostomy above the level of the septum. The embryological aspects of this rare anomaly are described.

Adult↗

[A patient complaining of right hypochondralgia with back pain. Aortic dissection or cholelithiasis?].

A 70-year-old woman with a past history of cholecystolithiasis was admitted to a local clinic because of right hypochondralgia with back pain. Since physical examination revealed Murphy's sign, this patient was diagnosed as acute cholecystitis. The ultrasonographic examination of the gallbladder showed a stone of the cystic duct with no definitive wall thickening. CT scan revealed dissection of the abdominal aorta. She was then referred to our hospital for further examinations. She was observed in the cardiac care unit to determine whether the aneurysm and cholecystitis were in an acute or chronic state. Blood examinations and enhanced CT scan showed that her clinical symptoms originated not from cholelithiasis but from acute closing aortic dissection, Stanford classification type B. Close cooperation with a highly developed medical facility is essential when diagnosing elderly patients with symptoms open to a variety of interpretation.

Acute Disease↗

[Correction of lipid metabolism in rabbits with experimental cholelithiasis].

The effect of 16-20% medicinal preparation "Equalen" on some parameters of lipid metabolism in female rabbits with cholelithiasis induced by 40% clamp of common bile duct was investigated. The total course of Equalen administration for 90-120 days included daily oral administration of Equalen for 7 days followed by 3-4 day interval. The optimal dose was 1.5 ml per day (the effective range of doses varied from 1.2 to 2.0 ml). Such treatment resulted in disappearance of large and medium sized cholesterol formations from gallbladder, normalization of lipid metabolism in organs of hepatoenteric system and lipid composition of bile.

Animals↗

[The parameters of physico-chemical properties of bile and urine in the diagnosis of pancreatitis associated with cholelithiasis].

Specific electrical conductance (SEC) of the hepatic bile in 94 patients with cholelithiasis and concomitant pancreatitis was increased (p < 0.001) and depended on the degree of cholestasis and the morpho-functional state of the liver. The value of SEC of the intraoperative bile higher than 193 S/m is taken for a criterion of the diagnostics of biliary pancreatitis. The electrical conductance of urine during the first 4 days of observation decreased in patients with acute pancreatitis (p < 0.05), impaired carbohydrate metabolism and concomitant renal dysfunction. The value of SEC of urine lower than 238 S/m corresponds to acute pancreatitis. The investigation of physico-chemical indices of biological liquids in patients with a pathology of the pancreato-biliary system allows to objectively control the course of the disease and to correct the treatment methods.

Adult↗

[Level of circulating immune complexes in patients with complicated cholelithiasis].

In 165 patients with the different forms of cholelithiasis, a level of the circulating immune complexes (CIC) was measured in the blood serum and bile from the common bile duct at the postoperative period. In associated purulent-resorptive and cholemic intoxication, the CIC level in the blood serum and bile increases. This, in turns, enhances the likelihood of the development of purulent-septic complications at the postoperative period, and requires performance of target immunocorrection.

Acute Disease↗

[Selection of prognostic criteria for external respiration function during surgical treatment of progressive cholelithiasis].

Studying risk factors of developing damage and complication of cardio-respiratory system it was established that indices of external respiration system function such as respiratory minute volume, general oxygen uptake are reliable in forecasting consequences of surgical treatment of cholelithiasis. Availability of inspection and calculation methods makes it possible to recommend these indices to fully implement in Health Care to control treatment quality in patients with acute surgical diseases.

Cholecystectomy↗

[The relationship between the C589T polymorphism of IL-4 gene and cholelithiasis].

OBJECTIVE: To investigate the relationship between IL-4 gene polymorphism and cholelithiasis in Chinese population. METHODS: Polymerase chain reaction combined with restriction enzyme digestion was used to detect the polymorphism of IL-4 gene in 81 cholecystolithiasis, 41 patients with biliary duct stone. RESULTS: There were no significant differences of the IL-4 gene polymorphism genotypes and alleles between 81 cholecystolithiasis patients (CC11.1%, CT34.6%, TT54.3%; C28.4.7%, T71.6%). There were significant differences of the IL-4 gene polymorphism genotypes and alleles between 41 patients with biliary duct stone (CC48.8%, CT36.6%, TT14.6%; C67.1%, T32.9%). CONCLUSIONS: The C589T polymorphism of IL-4 gene was not associated with cholecystolithiasis patients in Chinese, but was related to patients with biliary duct stone in Chinese.

Adult↗