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At least 757 records · Page 42Linked to original sources
PubMed1995

Evoked otoacoustic emissions and electrocochleography in a patient with multiple sclerosis.

A 24-year-old woman with multiple sclerosis had right-sided hearing impairment with tinnitus. She underwent electrocochleography (ECochG) and examination of evoked otoacoustic emissions (EOAEs) to assess cochlear function. An acoustic probe to measure EOAEs was inserted into the external ear canal. The ECochG action potential and cochlear microphonics were recorded by a transtympanic needle electrode technique. Both fast and slow components of EOAEs appeared in either the period of deteriorated hearing acuity or when it was improved. They showed normal detection thresholds and input-output curves during both periods. Cochlear microphonics with almost normal detection thresholds and input-output functions were obtained during the period of deteriorated hearing acuity. Action potential (N1) input-output curves during relapse with hearing loss were notably lower in amplitude and longer in latency than those obtained at the time hearing impairment showed improvement. The EOAE and ECochG findings suggested that this patient had almost normal cochlear function, and we assumed from the magnetic resonance imaging and auditory brain stem response findings as well as the ECochG that the hearing impairment was caused by dysfunction of auditory pathways in the brain stem, including structures that contribute to generation of the N1 potential of the ECochG.

Adult↗
PubMed2006

Development of functional synaptic connections in the auditory system visualized with optical recording: afferent-evoked activity is present from early stages.

A comprehensive survey of auditory network formation was performed in the brain stem of the chicken embryo using voltage-sensitive dye recording. Intact medulla/brain stem preparations with the auditory branch of the eighth nerve attached were dissected from 5.5- to 8-day chicken embryos, and responses evoked by nerve stimulation were recorded optically. In the medulla of 7- and 8-day embryos, we identified four response areas, corresponding to ipsilateral Nucleus magnocellularis (NM) and Nucleus angularis (NA), which receive the auditory afferents, and ipsi- and contralateral Nucleus laminaris (NL), which receive projections from NM. The optical responses consisted of a fast spikelike signal followed by a long-lasting slow signal, which reflected the sodium-dependent action potential and glutamatergic excitatory postsynaptic potential (EPSP), respectively. In NM, NA, and NL, the EPSP-related slow optical signals were detected from some 6-day and all 7- and 8-day preparations, indicating that functional synaptic connectivity in these nuclei arises by the 7-day stage. In the pons of 7- and 8-day embryos, we identified two additional response areas, which evidently correspond to ipsi- and contralateral Nucleus lemnisci lateralis (NLL), the higher-order nuclei of the auditory pathway. Furthermore, we detected optical responses from the contralateral cerebellum, which possibly correspond to transient projections observed only during embryogenesis. The present study demonstrates that functional auditory circuits are established in the chicken embryo at stages earlier than previously reported. We discuss the possible role of afferent-evoked activity with reference to auditory neural network formation.

Action Potentials↗
PubMed2004

Effects of exposure of the ear to GSM microwaves: in vivo and in vitro experimental studies.

The effects of mobile phone (GSM) microwaves on the ears of guinea pigs were investigated in two in vivo experiments and one in vitro experiment. In the first experiment, three groups of eight guinea pigs had their left ear exposed for 1 h/day, 5 days/week, for 2 months, to GSM microwaves (900 MHz. GSM modulated) at specific absorption rates (SARs) of 1, 2 and 4 W/kg respectively, and a fourth group was sham-exposed. Distortion-product otoacoustic emissions (DPOAEs) were measured for each ear before exposure, at the end of the 2-month exposure period, and 2 months later. In the second experiment, the same protocol was applied to eight sham-exposed and 16 exposed guinea pigs at 4W/kg, but the auditory brainstem response (ABR) thresholds were monitored. Repeated-measures ANOVA showed no difference in DPOAE amplitudes or in ABR thresholds between the exposed and non-exposed ears and between the sham-exposed and exposed groups In the course of the second experiment, acute effects were also investigated by measuring once, in all animals, ABR thresholds just before and just after the 1-h exposure: no statistically significant difference was observed. In vitro, the two organs of Corti (OCs) of newborn rats (n=15) were isolated and placed in culture. For each animal, one OC was exposed for 24-48 h to 1 W/kg GSM microwaves, and the other was sham-exposed. After 2-3 days of culture, all OCs were observed under light microscopy. They all appeared normal to naive observers at this stage of development. These results provided no evidence that microwave radiation, at the levels produced by mobile phones, caused damage to the inner ear or the auditory pathways in our experimental animals.

Analysis of Variance↗
PubMed2006

Posttraining lesions of the auditory thalamus, but not cortex, disrupt the inhibition of fear conditioned to an auditory stimulus.

The purpose of this study was to examine the effects of lesions within the auditory system in an effort to disrupt the processing of the noise stimulus conditioned to inhibit fear. To accomplish this, three experiments were conducted in which rats were first given feature-negative discrimination training in which a noise was conditioned to inhibit fear to a light that signals danger. Following training, rats were given lesions of the medial geniculate body (MGB), auditory thalamus (ADT), or auditory cortex (CTX). Next, rats were tested for the ability to inhibit fear in the presence of the noise safety signal. The results of these experiments indicated that bilateral lesions of ADT disrupted the ability of the noise inhibitor to inhibit fear. In contrast, lesions largely restricted to the MGB or CTX did not disrupt the inhibition of fear. Along with past studies, these results suggest that an auditory pathway(s), which includes projections from the tectum to the ADT, is used to detect the safety properties previously conditioned to an auditory stimulus.

Acoustic Stimulation↗
PubMed1977

Clinical and pathologic correlates of brain stem auditory response abnormalities.

Short-latency auditory evoked responses were recorded in over 100 neurologic patients. Abnormalities of each response component were correlated with postmortem or radiologic localization of different brain stem lesions. These findings suggested that waves I-VII largely reflect activity at the following levels of the auditory pathway: acoustic nerve (I), pontomedullary junction (II), caudal pons (III), rostral pons or midbrain (IV), midbrain (V), thalamus (VI), and thalamus or auditory radiation (VII). When this information was applied prospectively to the evaluation of brain stem dysfunction, response abnormalities proved useful in detecting and localizing certain lesions not revealed by other tests. Serial recordings provided information about the evolution of brain stem lesions and their response to therapy.

Adult↗
PubMed2000

Development of afferent patterns in the inferior colliculus of the rat: projection from the dorsal nucleus of the lateral lemniscus.

The inferior colliculus (IC) receives a variety of layered afferent projections. The purpose of the present study was to determine the development of the projection from the dorsal nucleus of the lateral lemniscus (DNLL) to the IC in rat prior to the onset of hearing (postnatal day 12/13). Lipophilic carbocyanine dye, DiI (1, 1'-dioctodecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate), was used to trace the crossed inhibitory projection of DNLL in a developmental series of rat embryos and pups between ages embryonic day 15 (E15) and postnatal day 12 (P12). Dye-coated pins were positioned in paraformaldehyde-fixed brains either unilaterally in DNLL (embryonic cases), or in the commissure of Probst where DNLL fibers cross the midline (postnatal cases). By E15, pioneer fibers have left DNLL and crossed the midline. A few fibers have nearly reached the contralateral IC by E19. At birth (E22 = P0), the projection has invaded ventromedial, high-frequency layers of the IC. The vast majority of DNLL axons parallel the presumptive IC layers by P4, and by P8 the projection has segregated into a pattern of bands (afferent dense) and interband (afferent sparse) spaces that encompasses the entire frequency axis of the IC. Adult-like patches, regions along afferent bands that exhibit the heaviest labeling, develop by P12. These results indicate that some mature projection patterns are in place prior to the onset of hearing. Such findings suggest that evoked activity may not be required for the initial organization of patterned projections in the ascending auditory pathway.

Animals↗
PubMed1998

Neurodegenerative changes in the guinea pig brainstem after intratympanic injection of gentamicin.

Gentamicin (4%) was injected intratympanically into the middle ear of guinea pigs and the effects on the brainstem evaluated 28 days later by immunohistochemistry with an antibody against glial fibrillary acidic protein to detect astrocytes, and by cytochrome oxidase staining to detect metabolic activity. Astrocytes were observed in the cochlear nucleus indicating the possible presence of anterograde degeneration. Deficiencies in the intensity of cytochrome oxidase staining up to the level of the superior olivary complex indicated the presence of abnormal metabolic activity. Both of these observations support the conclusion that a single intratympanic injection of gentamicin may lead to neuronal degeneration along the central auditory pathway.

Animals↗
PubMedDate not supplied

[Efferent neurons of the auditory center in the midbrain of the frog Rana ridibunda].

Individual cells which produce projections from the torus semicircularis in the frog have been visualized after injection of horseradish peroxidase (HRP) to various thalamic and isthmal areas. Labeled toral cells were observed if HRP had been injected to the posterodorsal areas of the thalamus or to the isthmal areas where lateral lemniscus fibers and cells of the premature lateral lemniscal nucleus are situated. Medium and large size cells in the rostrolateral torus semicircularis were mainly labeled. Thalamic injections of the HRP produced more labeled cells in the lateral part of the magnocellular nucleus, whereas isthmal injections produced labeled cells mainly in the lateral part of the laminar nucleus. A few HRP containing cells were observed in the principal nucleus of the torus. Specificity of the neuronal organisation of the auditory pathway in amphibians is discussed.

Animals↗
PubMed1983

Noise-induced degeneration in the brain and representation of inner and outer hair cells.

Noise that destroys receptor cells in the chinchilla cochlea also results in degeneration of axonal endings in the brain from the cochlear nerve fibers and the auditory pathways ascending to the superior olivary complex and inferior colliculus. The patterns of degeneration provide experimental evidence for differential representation of inner and outer hair cells and their functions.

Animals↗
PubMed1999

Development of GABA, glycine, and their receptors in the auditory brainstem of gerbil: a light and electron microscopic study.

Inhibitory synaptic transmission is known to play an important role during the maturation of central auditory pathways. While there is a lot of information on the modulatory role of glycine (Gly) on the postsynaptic target nuclei in the developing auditory brain stem, such a role for gamma-aminobutyric acid (GABA) in the lateral superior olive (LSO) of neonatal gerbil has been only recently reported (Kotak and Sanes [1997] Soc Neurosci Abst 23:1549; Kotak et al. [1998] J Neurosci 18:4646-4655). Here we present further immunohistochemical findings and the first ultrastructural evidence documenting a significant decrease in the postsynaptic localization of the beta2,3 subunit of the GABA(A) receptor from postnatal day (P)4 to P14 in the LSO of gerbil and the shift in the location of most of the staining from dendritic to astroglial over the same time course. There was a concomitant increase in staining for the Gly receptor (GlyR) anchoring protein, gephyrin. At the same time, GABA and Gly did not show a significant change in their staining pattern, suggesting that the transmitter levels are not particularly indicative of the inhibitory function in the neonatal gerbil LSO, but their receptors on the postsynaptic cells are. The observations of the present study suggest that the early GABAergic inhibition may be important in establishing appropriate synaptic contacts in the LSO of gerbil.

Animals↗
PubMed2002

Brainstem auditory response in the reserpinized rat.

The brainstem auditory evoked potential (BAEP) is a brief, low-level response that reflexes the brainstem transmission of auditory signals. The presence of catecholamines (CA) has been reported in cochlea and auditory pathway. However, the role of CA in the BAEP pattern is unknown. Five Wistar rats were anesthetized with pentobarbital (50 mg/kg; i.p.), in order to record BAEP using one active needle electrode placed on vertex. The common and ground electrodes were located on the opposite ear. Auditory stimuli consisted of alternated loudspeaker clicks given at 70 cm in front of the animal's head. After that a basal record was taken, reserpine (10 mg/kg, i.p.) was injected and BAEP was recorded every 15 min for 75 min. Results showed that reserpine increased latency in waves III, IV and V. These results suggest that dopamine and norepinephrine are involved in the electrical transmission at the superior olivary complex, lateral lemniscus and inferior colliculus levels.

Animals↗
PubMed1998

Speech sound perception and learning: biologic bases.

Historically, auditory research has focused predominantly on how relatively simple acoustic signals are represented in the neuronal responses of the auditory periphery. However, in order to understand the neurophysiology underlying speech perception, the ultimate objective is to discover how speech sounds are represented in the central auditory system and to relate that representation to the perception of speech as a meaningful acoustic signal. This paper reviews three areas pertaining to the central auditory representation of speech: (1) the differences in neural representation of speech sounds at different levels of the auditory system, (2) the relation between the representation of sound in the auditory pathway and the perception/misperception of speech, and (3) the plasticity of speech-sound neural representation and speech perception.

Auditory Pathways↗
PubMed1996

Brainstem auditory evoked potentials in individuals exposed to long-term low concentrations of toluene.

Brainstem auditory evoked potentials (BAEPs) were examined in 49 workers employed in a printing press, who were occupationally exposed to low concentrations of toluene for an average of 20.3 years, and in 59 subjects in a control group. In the group of exposed workers, a significant decrease was found in all wave amplitudes examined, a significant prolongation of P1 wave latency, and an increased interval of interpeak latencies (P3-P5), indicating that the extramedullary and high medullary part of the auditory pathway are biologically most frequently affected by chronic exposure to low concentrations of toluene. The level of exposure to toluene in both groups was evaluated by defining the concentration of toluene in peripheral blood and the concentration of hippuric acid and ortho-cresol in urine.

Adult↗
PubMed1984

The maturation of the auditory brainstem response compared to peripheral nerve conduction velocity in preterm and full-term infants.

The maturation of the auditory brainstem response in preterm and full-term infants is compared with that of nerve conduction velocity. There is a linear relationship between wave I latency, the peripheral component of the response, and nerve conduction velocity, but the negative correlation is not high. A poor negative correlation exists between the I-V interval, an index of brainstem transmission, and nerve conduction velocity. The factors governing the maturation of central transmission along the auditory pathway in the brainstem are not related to myelination of peripheral nerves. Abnormal nerve conduction velocities are not related to any particular abnormal brainstem response in a stable external environment.

Auditory Pathways↗
PubMed1978

Central auditory testing with peripheral hearing loss.

Seventy subjects with sensorineural hearing losses participated in this study. The goal of the study was to examine the effect of peripheral hearing loss on auditory tasks that are used to assess dysfunction within the central auditory pathways. Each subject received a central auditory processing (CAP) test battery that consisted of: (1) a dichotic sentence listening task; (2) a monosyllabic filtered word task; (3) a spondaic word binaural fusion task; and (4) a rapidly alternating speech task. All of these tasks were affected by certain degrees/configurations of sensorineural hearing loss, with the monosyllabic filtered word task being the most seriously affected. From the results of this study, it was concluded that while the CAP test battery can be administered to certain persons with sensorineural hearing losses, all results must be interpreted with caution and in view of the basic audiological assessment.

Adolescent↗
PubMed2001

Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with the central auditory nervous system.

TWIK-related acid-sensitive K(+) (TASK) channels contribute to setting the resting potential of mammalian neurons and have recently been defined as molecular targets for extracellular protons and volatile anesthetics. We have isolated a novel member of this subfamily, hTASK-5, from a human genomic library and mapped it to chromosomal region 20q12-20q13. hTASK-5 did not functionally express in Xenopus oocytes, whereas chimeric TASK-5/TASK-3 constructs containing the region between M1 and M3 of TASK-3 produced K(+) selective currents. To better correlate TASK subunits with native K(+) currents in neurons the precise cellular distribution of all TASK family members was elucidated in rat brain. A comprehensive in situ hybridization analysis revealed that both TASK-1 and TASK-3 transcripts are most strongly expressed in many neurons likely to be cholinergic, serotonergic, or noradrenergic. In contrast, TASK-5 expression is found in olfactory bulb mitral cells and Purkinje cells, but predominantly associated with the central auditory pathway. Thus, TASK-5 K(+) channels, possibly in conjunction with auxiliary proteins, may play a role in the transmission of temporal information in the auditory system.

Amino Acid Sequence↗
PubMed1993

Early monaural occlusion alters the neural map of interaural level differences in the inferior colliculus of the barn owl.

Monaural occlusion during early life causes adaptive changes in the tuning of units in the owl's optic tectum to interaural level differences (ILD) that tend to align the auditory with the visual map of space. We investigated whether these changes could be due to experience-dependent plasticity occurring in the auditory pathway prior to the optic tectum. Units were recorded in the external nucleus of the inferior colliculus (ICx), which is a major source of auditory input to the optic tectum. The tuning of ICx units to ILD was measured in normal barn owls and in barn owls raised with one ear occluded. ILD tuning at each recording site was measured with dichotic noise bursts, presented at a constant average binaural level, 20 dB above threshold. The best ILD at each site was defined as the midpoint of the range of ILD values which elicited more than 50% of the maximum response. A physiological map of ILD was found in the ICx of normal owls: best ILDs changed systematically from right-ear-greater to left-ear-greater as the electrode progressed from dorsal to ventral. Best ILDs ranged from 13 dB right-ear-greater to 15 dB left-ear-greater and progressed at an average rate of 12 dB/mm. The representations of ILD were similar on both sides of the brain. In the ICx of owls raised with one ear occluded, the map of ILD was shifted in the adaptive direction: ILD tuning was shifted towards values favoring the non-occluded ear (the direction that would restore a normal space map). The average magnitude of the shift was on the order of 8-10 dB in each of 4 owls. In one owl, the mean shift in ILD tuning was almost identical on both sides of the brain. In another owl, the mean shift was much larger on the side ipsilateral to the occlusion than on the contralateral side. In both cases, the mean shifts measured in each ICx were comparable to the mean shifts measured in the optic tectum on the same sides of the brain. Thus, the adjustments in ILD tuning that have been observed in the optic tectum in response to monaural occlusion are almost entirely due to adaptive mechanisms that operate at or before the level of the ICx.

Acoustic Stimulation↗
PubMed1994

Inhibition of discharge in inferior colliculus, AII cortex and Ep cortex after presentations of click stimuli.

A temporally related reduction of discharge in response to 70-dB clicks was identified in secondary auditory (AII) cortex (48-56 ms after click), posterior ectosylvian (Ep) cortex (40-56 ms after click) and inferior colliculus (IC) (56-76 ms after click). Units in primary auditory (AI) cortex, dorsal cochlear nucleus (DCN) and ventral cochlear nucleus (VCN) did not demonstrate a significant reduction of discharge at comparable periods. Neurons of AI cortex showed increased activity 36-40 ms after click. The timing of the periods of inhibited discharge in AII, Ep and IC, taken with the earlier activation of AI, supported the hypothesis of an inhibitory auditory pathway emanating from AI, affecting secondary auditory cortical regions and IC.

Acoustic Stimulation↗