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Anterior innervation of the proximal tibiofibular joint.

Mucoid cysts compressing the common peroneal nerve have been reported. Whether these cysts are schwannoma or are synovial in nature is the subject of controversy in the medical literature. To contribute to this debate, the present study was designed to detail the anterior innervation of the proximal tibiofibular joint. We dissected 10 knees of five fresh cadavers after staining the tibiofibular joint under fluoroscopic guidance. Through a lateral approach near the fibular head, the common peroneal nerve was isolated then dissected distally to determine whether it or its branches ramified over the proximal tibiofibular joint. In all 10 legs, only one collateral branch was observed on the common peroneal nerve proximal to its terminal division. This collateral sent a branch to the proximal tibiofibular joint before penetrating the tibialis anterior muscle. The articular branch coursed in a superior and posterior direction approximately 1 cm to attain the tibiofibular joint. In no specimen did the deep or superficial peroneal nerves send a twig to the tibiofibular joint. This study confirms and clarifies prior descriptions of the innervation of the anterior aspect of the proximal tibiofibular joint. It clarifies the mechanisms of compression of the common peroneal nerve by synovial cysts that originate from the proximal tibiofibular joint and provides anatomical landmarks that should facilitate complete resection of these cysts.

Cadaver↗

Characteristics of distribution and configuration of intracranial arachnoid membranes.

An understanding of the microsurgical anatomy of the arachnoid membranes and the subarachnoid cisterns is important in minimally invasive neurosurgery. But the topography of the arachnoid membranes has not been completely elucidated. The description of the distribution and the configuration of the intracranial arachnoid membranes is still a subject of controversy. In order to clarify this we examined eight Han Chinese adult human cadavers under an operating microscope. The dissections were performed with microsurgical instruments and techniques without staining of the intracranial structures nor injection of colored material into blood vessels. Twenty seven arachnoid membranes were identified. They were named according to their locations and attachment. They were divided into three groups: basal, convex and trabecular arachnoid membranes. They varied greatly in appearances and configurations. They were single-leaf structured except Liliequist's membrane, the chiasmatic membrane and the cerebellar precentral membrane. They were distributed extensively and unevenly and crisscrossed in the cranial cavity. The more complexly and intricately the blood vessels or the nerves converged or branched within the subarachnoid space, the more luxuriant and complex the arachnoid membranes and trabeculae were. The areas where the arachnoid membranes crowded most thickly in the subarachnoid space included the regions around the bifurcation of the internal carotid artery, the area around the hypothalamus, the interpeduncular cistern, the arachnoidal sheaths of the oculomotor nerve, the quadrigeminal cistern and the cisterna magna. Almost all the cranial nerves were encased by their own arachnoidal sheaths when they crossed the cisterns. The arachnoid membranes and trabeculae must be dissected or incised sharply during the operations. Thorough knowledge of the anatomy of the intracranial arachnoid membranes is valuable to take full advantage of the natural anatomic landmarks and interfaces formed by them during surgery.

Adult↗

Microsurgical anatomy of intralaryngeal distribution of the inferior laryngeal nerve.

The functional results of a partial laryngeal surgery or a laryngeal reinnervation depend on the precise knowledge of the intra laryngeal anatomy of the inferior laryngeal nerve (ILN). Ten human larynges without known laryngeal disorders were obtained from human cadavers for ILN microdissection. Intra laryngeal ILN branching patterns were determined bilaterally. The lengths of the vertical, genu and oblique segments of the anterior division of ILN and the distance between the nerve within the paraglottic space and the cricothyroid articulation (CTA) were measured with a digital microcaliper. The mean lengths of the vertical, genu and oblique segments were 10.82, 5.89 and 9.29 mm, respectively. The mean distance between the nerve in the paraglottic space and the CTA was 11.20 mm. Key anatomical landmarks of the abductor division (vertical and genu segments of ILN) were the lateral border of posterior cricoarytenoid (PCA) muscle and the superior ligament of the CTA. The two-branch pattern for the lateral border of the PCA muscle has been the most frequent (50%). A branch of interarytenoid muscle (IA) originated from the genu segment. One or two branches for the PCA muscle has been identified in 75% of cases from the IA neural plexus on the front side of PCA muscle. The adductor division for the thyroarytenoid muscle and the lateral cricoarytenoid muscle was the oblique segment of the nerve. We conclude that abductor and adductor divisions of intra laryngeal ILN can be readily identified and the knowledge of key landmarks allows preservation of the ILN during partial surgery of the larynx and possibly selective muscle reinnervation.

Cadaver↗

The value of magnetic resonance imaging in the diagnosis of orbital floor fractures.

The value of MRI in the diagnosis of acute orbital floor fractures has not been clearly defined. We therefore compared MR findings with CT findings in patients with orbital trauma. In 30 patients with isolated orbital trauma both coronal CT and coronal MRI were used to examine the orbits and the adjacent paranasal sinuses. Visualization of anatomical landmarks, the kind and extent of traumatic lesions, as well as artifacts were scored. The scores were compared using the Wilcoxon matched-pairs signed-rank test. Interexamination agreement between the two methods was calculated using a kappa analysis. All examinations had diagnostic quality: 30 fractures of the orbital floor (9 right and 21 left orbital floor fractures) were identified. In addition, CT showed fractures of the medial orbital wall in 19 patients (63.3%), of the lateral wall in 10 patients (33.3%), of the zygomatic arch in 2 patients (6.7%), and of the maxillary sinus in 4 patients (13.3%). Soft tissue herniation was shown in 13 patients (inferior rectus muscle twice, orbital fat in 11 cases). Magnetic resonance imaging demonstrated soft tissue herniation in 21 patients: muscle in 4, orbital fat in 17 cases. Magnetic resonance imaging is able to demonstrate orbital floor fractures as sensitively as CT, but CT is superior to MRI in showing small and associated fractures; therefore, CT remains in orbital fractures the imaging modality of choice. Magnetic resonance imaging is superior to CT in showing soft tissue herniations; therefore, MRI may have a role as an adjunct to CT if soft tissue entrapment remains unclear.

Adolescent↗

Direct detector radiography versus dual reading computed radiography: feasibility of dose reduction in chest radiography.

The image quality of dual-reading computed radiography and dose-reduced direct radiography of the chest was compared in a clinical setting. The study group consisted of 50 patients that underwent three posteroanterior chest radiographs within minutes, one image obtained with a dual read-out computed radiography system (CR; Fuji 5501) at regular dose and two images with a flat panel direct detector unit (DR; Diagnost, Philips). The DR images were obtained with the same and with 50% of the dose used for the CR images. Images were evaluated in a blinded side-by-side comparison. Eight radiologists ranked the visually perceivable difference in image quality using a three-point scale. Then, three radiologists scored the visibility of anatomic landmarks in low and high attenuation areas and image noise. Statistical analysis was based on Friedman tests and Wilcoxon rank sum tests at a significance level of P<0.05. DR was judged superior to CR for the delineation of structures in high attenuation areas of the mediastinum even when obtained with 50% less dose (P<0.001). The visibility of most pulmonary structures was judged equivalent with both techniques, regardless of acquisition dose and speed level. Scores for image noise were lower for DR compared with CR, with the exception of DR obtained at a reduced dose. Thus, in this clinical preference study, DR was equivalent or even superior to the most modern dual read-out CR, even when obtained with 50% dose. A further dose reduction does not appear to be feasible for DR without significant loss of image quality.

Adult↗

A new technique for localization of hepatic tumors that are poorly visible with CT fluoroscopy.

The purpose of this study was to report a new technique for localization of hepatic tumors that are poorly visible with CT fluoroscopy. Forty-three hepatocellular carcinomas were not visible with CT fluoroscopy. A 22-gauge Chiba end-hole needle was inserted in the approximate location of a lesion estimated on the basis of anatomical landmarks demonstrated on both previous MR and CT images. We injected 3 ml of a mixture of nonionic contrast material and saline solution. Following the first injection, contrast solution filled the hepatic lesion in 29 of 43 cases. In 8 of 43 cases, contrast solution was distributed in the normal surrounding liver. In 7 of these 8 cases, repositioning allowed us to adjust the needle in the tumor. In the other 6 of 43 cases, contrast solution spread within capsule or pseudocapsule (pattern 3). In all 6 cases, repositioning allowed to adjust the needle in the tumor. This new technique allows an accurate localization of hepatic tumors that are poorly visible with CT fluoroscopy.

Adult↗

Local staging of rectal cancer: the current role of MRI.

With the advent of powerful gradient coil systems and high-resolution surface coils, magnetic resonance imaging (MRI) has recently extended its role in the staging of rectal cancer. MRI is superior to endorectal ultrasound, the most widely used staging modality in patients with rectal tumors, in that it visualizes not only the intestinal wall but also the surrounding pelvic anatomy. The crucial advantage of MRI is not that it enables exact T-staging but precise evaluation of the topographic relationship of a tumor to the mesorectal fascia. This fascia is the most important anatomic landmark for the feasibility of total mesorectal excision, which has evolved into the standard operative procedure for the resection of cancer located in the middle or lower third of the rectum. MRI is currently the only imaging modality that is highly accurate in predicting whether or not it is likely that a tumor-free margin can be achieved and thus provides important information for planning of an effective therapeutic strategy, especially in patients with advanced rectal cancer.

Contrast Media↗

Endoscopic surgery for hypothalamic hamartomas causing medically refractory gelastic epilepsy.

INTRODUCTION: There is increasing evidence that removal or disconnection of hypothalamic hamartomas can lead to seizure control and improvement in behavior. The purpose of this study is to report our experiences with endoscopic removal of these hamartomas. METHODS: This is a prospective review of the early outcome of 44 patients undergoing endoscopic resection utilizing frameless stereotaxis and a micromanipulator. RESULTS: All patients had normal-sized ventricles. Complete removal was possible in 14 patients, 13 of whom were seizure free at follow-up. Four patients suffered complications that have persisted for more than 3 months: One had significant hemiparesis and three had persistent difficulties with short-term memory. Postoperatively, no patient suffered a permanent hormonal deficiency. In one patient who had undergone a previous attempt at transcallosal resection, the procedure was abandoned because of the lack of internal anatomic landmarks. In a second patient, insufficient mass could be removed due to the size of the lesion and the distorted anatomy. Consequently, 1 week later, the patient underwent a transcallosal approach. CONCLUSION: In appropriately selected patients, sessile hypothalamic hamartomas can be removed completely or they can be completely disconnected from the hypothalamus with an acceptable risk. At least a year after surgery is needed to evaluate the efficacy of the procedure in terms of control of seizures and improvements in behavior and emotional ability.

Adolescent↗

[Computer assisted radiological diagnostics of arthritic joint alterations].

Computer assisted diagnosis (CAD) schemes are currently used in the field of musculoskeletal diseases to quantitatively assess vertebral fractures, joint space narrowing, andr erosion. Most systems work semi-automatically, i.e. they are operator dependent in the selection of anatomical landmarks. Fully automatic programs are currently under development. Some CAD products have already been successfully used in clinical trials.

Absorptiometry, Photon↗

Simplified MRI sequences for postoperative control of hamstring anterior cruciate ligament reconstruction.

INTRODUCTION: Usually, standard radiographs are used for postoperative quality follow-up after ACL reconstruction. However, with the use of hamstring grafts and bioabsorbable implants, accurate assessment of the tunnel and implant position is impossible. The graft and its relation to anatomical landmarks cannot be evaluated directly. MRI is an alternative to radiography, permitting direct graft visualization and 3-dimensional assessment of the tunnel position, but it is expensive and time consuming for routine use. The aim of this study was to develop a simplified MRI protocol and to evaluate it for routine postoperative quality follow-up after ACL reconstruction. MATERIALS AND METHODS: Various scanning protocols were tested in a series of 105 patients and evaluated for image sharpness, clarity of the structures, susceptibility to artefacts, applicability regarding precise analysis of graft and tunnel position, and time consumption. One simplified specific scan protocol was then defined and applied in a series of 60 consecutive patients after hamstring ACL replacement. The position of the femoral and tibial tunnels was measured in the sagittal, coronal and axial sections and classified according to Harner (femoral) and Stäubli (tibial). Impingement of the graft in the intercondylar roof was analysed according to Howell. The position of the bioabsorbable interference screws was assessed. RESULTS: Scan protocol: T2-weighted gradient-echo sequences (GRE) with TR 246 ms, TE 11 ms, flip angle 25 degrees, 2 mm sections and a 256 x 256 matrix yielded the best image quality of tendon grafts and bone tunnels with tolerable time consumption (average scanning time per patient 1 min 40 s). Altogether 8-16 sections were obtained for every patient. Tunnel placement: 46/60 (77%) of the femoral tunnels were in zone 4, 13/60 (21%) at the border of zones 3 to 4, 1/60 (2%) in zone 3 in the sagittal plane (Harner). The femoral tunnels in the axial plane were at 10:30 o'clock in 32/60 (53%), at 11:00 o'clock at 24/60 (40%) and at 10:00 o'clock in 4/60 (4%) patients. The mean distance of the anterior border of the tibial tunnel from the anterior cortex was 39% (+/- 4.9%) related to the total sagittal diameter of the tibia. There was no graft impingement. The position of the interference screws was anterior to the grafts in all cases. CONCLUSION: Simplified MRI sequences can be used for postoperative quality follow-up after ACL replacement and are an alternative to standard radiographs giving more specific and precise information regarding tunnel position and screw placement. Analyzing the bone tunnels in a series of 60 patients demonstrated that correct assessment of tunnel placement after arthroscopic ACL reconstruction is feasible using this simplified MRI technique.

Absorbable Implants↗

Does scapular elevation accompany glenohumeral abduction in healthy subjects?

INTRODUCTION: Although it is used in clinical practice, there are no data concerning scapular elevation during glenohumeral abduction. MATERIALS AND METHODS: Scapular elevation of 30 healthy volunteers in supine and sitting positions were measured at 90-180 deg of glenohumeral abduction by two examiners. In addition, radiographs of the ten subjects were taken in supine position at 0-180 deg of glenohumeral abduction, and the scapular elevation measurements were repeated. Also, the movements of five anatomical landmarks (acromioclavicular joint, center of glenoid cavity, scapular notch, angulus superior and inferior) were measured with regard to transverse and vertical axes. RESULTS: The values obtained for scapular elevation during 90, 120, 150, and 180 deg of glenohumeral abduction were (mean and SD) 26.63 and 3.96, 31.77 and 4.36, 35.97 and 5.15, 40.10 and 5.18 deg, respectively. There were no significant differences with regard to side, gender, and position of the subject. No correlation was found between the clinical and radiological measurements. Movements of certain points did not reveal progressive upward motion. CONCLUSION: There is no scapular elevation but rather rotation during glenohumeral joint abduction. Normal values given in the present study can be used in clinical examinations.

Acromioclavicular Joint↗

The cartilage of the tibiofibular joint: a source for autologous osteochondral grafts without damaging weight-bearing joint surfaces.

Within the past few years, autologous osteochondral transplantation has become an established procedure in the therapy of articular cartilage defects of the knee. One significant disadvantage of this technique is the harvesting of grafts from the weight-bearing area. The tibiofibular articulation is less loaded. The purpose of this study was to evaluate the question of whether this joint is suitable as a donor site for osteochondral grafts. Ten fresh human knees were dissected to perform histology, immunohistochemistry, and thickness measurement of the tibiofibular cartilage. Favourable approaches and establishing of anatomical landmarks were investigated in 44 fixed tibiofibular joints. In knee extension, the shortest distance between the joint cleft and common fibular nerve was measured. A total of 389 bone specimens was analysed morphometrically (cartilage area, orientation of the joint line, signs of arthrosis). Histological and immunohistochemical examination showed hyaline cartilage and type II collagen. The area of cartilage amounted to 3.58 cm(2) (mean) at the tibia and at the fibula with a thickness of 1.6 mm (mean). The joint line is mainly orientated perpendicular to an axis course from craniomedioventral to caudolaterodorsal. Depending on the available instruments, two approaches are possible: from anteromedial or from posterolateral. The mean distance to the common fibular nerve was 19.5 mm. Signs of arthrosis were found in 1 of 10 fresh knee specimens and in 11.4% of the bone specimens. Transplantation into three patients showed no intra- or postoperative complications and a rapid and uneventful recovery. The proximal tibiofibular joint is an excellent donor site for autologous osteochondral grafts.

Aged↗

Laryngo-tracheal profile: a new method for assessing laryngo-tracheal stenoses.

We present the clinical application of a new method for objective assessment of both grade and length of laryngo-tracheal stenoses (LTS) on a CT-based skeletonization algorithm, called laryngo-tracheal profile (LTP). Extraction of the laryngo-tracheal tract (LTT)-medial axis was performed after S-CT scanning. Orthogonal to the medial axis, the LTT cross-profile was computed, and the length and degree of LTS were presented as line charts. Clinical application of this newly developed method is demonstrated on three patients who had to undergo preoperative assessment before surgical treatment of tracheal stenoses. LTP provides an objective method of assessment of both the length and degree of tracheal stenoses in precise correlation to defined anatomical landmarks. This method provides important additive information for preoperative evaluation as well as for monitoring of therapeutical success. Current methods used so far are able to evaluate the severity of LTS, but do not provide exact quantitative assessment of complex LTS. Especially in CT-scans of strong curved passages, where an overestimation of the cross-sectional area results by an oblique cut of the tubular structure, LTP may overcome this problem by a simple post processing skeletonization algorithm.

Adult↗

Vertical displacement of stereotaxic target in the cat brain after burr hole production of the skull.

In order to observe the postoperative vertical displacement caused by various open functional stereotaxic procedures in the coordinate of brain target, we produced a similar surgical procedure in 14 cats. On preoperative computed tomography (CT) scans, certain well defined brain structures (the cortical surface of the brain and the floor of the third ventricle) were chosen as anatomical landmarks and their relationship to the skull were determined with the cat in a prone position. Thereafter, a burr hole was opened on the right side of the skull of each animal and a small dural incision was made. All animals were re-examined with CT scanning using the same technique and the distances to the skull were determined. There was a cortical descent in postoperative coronal CT images (range 1.2-3.6, mean 2.1 mm). On the other hand, the vertical coordinate of the floor of the third ventricle was found to be lower than it had been preoperatively, with an average of 0.6 mm lower (range -1.2(-)+0.3 mm). These results indicate that there was a good correlation between the degree of cortical descent and displacement of the vertical coordinate of the floor of the third ventricle (r = 0.70 and r = 0.69, respectively; P < 0.01). Our results also suggest that thalamic targets can be calculated by compensatory adjustment of the vertical coordinate by an additional distance of about half of the vertical descent. However, further experimental and clinical studies will be needed to determine the validity of this result in human beings.

Animals↗

Bolus location at the initiation of the pharyngeal stage of swallowing in healthy older adults.

This study characterized the vertical position of the bolus head at the onset of the pharyngeal swallow in healthy older adults. Lateral-view videofluoroscopic (VF) images were obtained from ten healthy volunteers (age-71.6 +/- 7.5 years, mean+/- SD) as they swallowed 5-cc thin liquid barium aliquots. For each swallow, the bolus head and several anatomic landmarks were digitally recorded from the image in which pharyngeal swallow-related hyoid bone elevation began. Vertical distance between the bolus head and the intersection of the tongue base and mandibular ramus (TMI) was computed. Bolus head position at swallow onset ranged from 47.4-mm above to 34.9-mm below the TMI (2.2 +/- 14.4-mm, mean +/- SD). Although the bolus head was below the level of the TMI for the majority of swallows, neither penetration nor aspiration occurred. For individual subjects, mean bolus head position ranged from 25.8 +/- 5.0-mm above to 15.5 +/- 6.5-mm below the TMI. Whereas five of ten subjects initiated the pharyngeal swallow with the bolus head consistently above or consistently below the TMI, five subjects initiated swallowing with the bolus head either above or below the TMI across trials. Older adults commonly initiate thin-liquid swallows with the bolus head well below the TMI without associated penetration or aspiration. Thus, bolus position alone does not differentiate between normal and pathologic swallowing within the healthy elderly. Bolus position at pharyngeal swallow onset can vary substantially from trial to trial within an individual, suggesting that the triggering of swallowing depends on multiple influences.

Aged↗

A prospective endoscopic study of retropubic vascular anatomy in 121 patients undergoing endoscopic extraperitoneal inguinal hernioplasty.

BACKGROUND: A sound knowledge of retropubic pelvic vascular anatomy is pivotal to the successful performance of endoscopic total extraperitoneal (TEP) inguinal hernioplasty. The objective of the current study was to evaluate the incidence and anatomy of iliopubic and aberrant obturator vessels. METHODS: Between July 2001 and March 2002, a prospective endoscopic evaluation of retropubic vascular anatomy was performed on patients who underwent TEP. Endoscopic photographs of the vasculature overlying the superior pubic ramus in the recruited patients were captured on a computer. RESULTS: The retropubic vascular anatomy of 121 patients, who underwent either unilateral (n = 100) or bilateral (n = 21) TEP was examined. The iliopubic artery and vein were invariably present in every patient, and traversed along the iliopubic tract toward the pubic symphysis. The aberrant obturator artery was present in 31 pelvic halves, giving an overall incidence of 22%. The aberrant obturator vein existed between the external iliac and obturator venous system in 27% (n = 38) of the 141 pelvic halves examined. The overall incidence of corona mortis, in the form of either an aberrant obturator vein or artery, was 40% (n = 56). CONCLUSIONS: Iliopubic vein and artery are universal findings in every patient. Both aberrant obturator artery and vein cross the superior pubic rami, and are therefore susceptible to injuries during dissection of the Bogros space and stapling of the mesh onto Cooper's ligament. Awareness of these aberrant vessels will help to reduce bleeding and subsequent morbidity. Tracing along the aberrant vessel can easily identify the obturator foramen, which is an anatomic landmark that indicates an adequate inferior dissection of the preperitoneal space.

Aged↗

A prospective randomized trial of different laparoscopic gastric banding techniques for morbid obesity.

BACKGROUND: Slippage of the stomach is the most common postoperative complication after laparoscopic adjustable silicone gastric banding (LASGB) for morbid obesity. Retrogastric placement (RGP) of the band through the lesser sac can cause posterior slippage Incomplete suturing often is responsible for anterior slippage. A randomized prospective study was constructed to determine whether laparoscopic esophagogastric placement (EGP) is associated with a lower incidence of postoperative slippage and pouch dilation than RGP. METHODS: Morbid obese patients presenting for LASGB were randomized to undergo either an EGP (n = 50) or an RGP (n = 51). Patients were blinded to which procedure they underwent, and follow-up date were obtained by a blinded independent investigator. Standardized clinical and radiologic controls were used to assess pouch enlargement and slippage. RESULTS: Operating time was similar for the two procedures (54.5 min for EGP vs 58 min for RGP). There was no significant difference in postoperative weight loss (34 kg after EGP vs 37 kg after RGP within 12 months), esophagus dilation, or postoperative quality of life. There were two postoperative slippages and one pouch dilation in the RGP group and no postoperative complication in the EGP group. CONCLUSIONS: The placement of a LAP-BAND adjustable gastric banding system by the EGP technique is safe and results in a lower frequency of postoperative complications than its placement by the RGP technique. Clear anatomic landmarks are a benefit to education and to the learning curve for LASGB.

Adolescent↗

Laparoscopic inguinal hernia repair: lessons learned after 1224 consecutive cases.

BACKGROUND: Despite numerous attempts to improve the techniques used for hernia repair, current published series show that recurrence rates are as high as 5-20%. The complexity of inguinal anatomy, combined with multiple potential areas of weakness, has contributed to the difficulty in preventing recurrences. However, the laparoscopic approach to inguinal herniorrhaphy has allowed clear visualization of all preperitoneal fascial planes and anatomic landmarks, as well as the hernia defect(s) and the peritoneal reflection. In the course of our performance of a series of 1,224 laparoscopic inguinal hernia repairs, we have developed a total extraperitoneal approach that yields excellent results with a low initial recurrence rate. Herein we describe our experience. METHODS: After our initial 300 transabdominal preperitoneal (TAPP) hernia repairs, which resulted in six recurrences, two bowel injuries, one bladder injury, and six cutaneous nerve injuries, the total extraperitoneal approach (TEP) was adopted. RESULTS: The first 300 TEP repairs resulted in one recurrence, two bowel injuries, one bladder injury, and two cutaneous nerve injuries. All major complications occurred in patients who had had previous lower abdominal surgery. In the last 624 TEP herniorrhaphies we implemented some modifications to the technique, especially for patients with previous lower abdominal surgery. In this group we recorded one bladder injury, no cutaneous nerve injuries, and one recurrence. CONCLUSIONS: The total extraperitoneal approach for laparoscopic herniorrhaphy allows for a safe and effective repair with low rates of complication and recurrence. A thorough knowledge of the anatomy of the extraperitoneal space and especially the two- and three-dimensional inguinal anatomy of this space contributed greatly to the evolution of our technique.

Adolescent↗