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PubMedDate not supplied

The visual map in the corpus callosum of the cat.

The corpus callosum conveys all the fibers that connect areas 17 and 18 in the 2 cerebral hemispheres of the cat. The purpose of the present study was to ascertain the organization of the visual field map described by these fibers in the corpus callosum. This was achieved by injecting anterograde and retrograde pathway tracers at known locations in the callosally connected zones of areas 17 and 18. The positions of the injection sites were varied systematically to include all visual field elevations represented along the marginal and posterolateral gyri. Overall, the results show (1) that callosal fibers projecting between the 2 marginal gyri, where the lower visual fields are represented, pass through the body of the corpus callosum; (2) that fibers connecting the junction of the marginal and posterolateral gyri in the 2 hemispheres, where central fields are represented, pass through the dorsal splenium of the corpus callosum; and (3) that fibers passing between the ventral portions of the 2 posterolateral gyri, where upper fields are represented, pass through posterior and ventral splenium. In addition, the density of visual fibers in the splenium is greater than in the body of the corpus callosum. Within the overall pattern, a finer arrangement exists, and it was possible, by comparison with the cortical visual field maps, to describe a map of visual field elevations in the corpus callosum. In this map, the representations of the different visual field elevations are not a simple reflection of the map in the cortex. The map of the lower fields contained in the body is spread out, whereas the map of the central and upper fields in the splenium is highly compressed. The high degree with which observations can be reproduced in different cats indicates that the map is stereotyped from one animal to another.

Animals↗
PubMed2006

LONI visualization environment.

Over the past decade, the use of informatics to solve complex neuroscientific problems has increased dramatically. Many of these research endeavors involve examining large amounts of imaging, behavioral, genetic, neurobiological, and neuropsychiatric data. Superimposing, processing, visualizing, or interpreting such a complex cohort of datasets frequently becomes a challenge. We developed a new software environment that allows investigators to integrate multimodal imaging data, hierarchical brain ontology systems, on-line genetic and phylogenic databases, and 3D virtual data reconstruction models. The Laboratory of Neuro Imaging visualization environment (LONI Viz) consists of the following components: a sectional viewer for imaging data, an interactive 3D display for surface and volume rendering of imaging data, a brain ontology viewer, and an external database query system. The synchronization of all components according to stereotaxic coordinates, region name, hierarchical ontology, and genetic labels is achieved via a comprehensive BrainMapper functionality, which directly maps between position, structure name, database, and functional connectivity information. This environment is freely available, portable, and extensible, and may prove very useful for neurobiologists, neurogenetisists, brain mappers, and for other clinical, pedagogical, and research endeavors.

Brain Mapping↗
PubMed1991

Relationship of intrinsic connections to forelimb movement representations in monkey motor cortex: a correlative anatomic and physiological study.

1. Intracortical microstimulation (ICMS) and horseradish peroxidase (HRP) histochemistry were combined to examine the relationship between intrinsic connections and intracortical microstimulation sites eliciting evoked movements in the forelimb representation of adult macaque monkey motor cortex. 2. The distribution of sites from which stimulation-evoked movements about individual forelimb joints were elicited under anesthesia varied considerably among animals. Identical movements could often be elicited from multiple, noncontiguous sites. 3. After single, small extracellular HRP injections at sites from which thumb movement was evoked, small groups of retrogradely labeled cells and dense patches of axon terminations were found scattered across a wide area of the forelimb representation. Terminal patches were discontinuous and arose from horizontal, intracortical axons. 4. Correlating the HRP labeling with the physiologically defined movement maps revealed a profuse set of intrinsic, bidirectional connections that connect digit representations and representations of movements about the wrist, elbow, and shoulder. 5. HRP injections placed in the forelimb representation close to the physiologically defined face representation resulted in virtually no retrogradely labeled cells or terminal fiber labeling that crossed into the face representation. A patch of anterolaterally placed label that was present may be the dissociated rostrolateral arm area of other authors. 6. Taken together, these data suggest that extensive, horizontally oriented, intrinsic axon collaterals provide inputs to many different forelimb movement representations and may be recruited during complex movements to coordinate the activity of motor cortical zones whose predominant output is to forelimb muscle groups acting synchronously.

Animals↗
PubMed2001

Analysis of the activity-deprived zebrafish mutant macho reveals an essential requirement of neuronal activity for the development of a fine-grained visuotopic map.

The formation of a retinotopic map is thought to involve an activity-independent molecular phase for early steps of both axon pathfinding and projection and a later phase in which cross talk between retinal ganglion cells (RGCs) and tectal neurons modifies and refines the neuronal connections. We report that the maturation of the retinotopic map in the zebrafish tectum involves activity-dependent processes. Zebrafish larvae mutant for the gene macho (mao) lack neuronal activity in RGCs and also display an enlarged retinotectal projection field but no significant increase in single axon length. This morphological defect can be phenocopied by raising larvae under TTX-induced neural impulse blockade. The effect of activity deprivation is dependent on the developmental stage. The projection phenotype in mao as well as in the TTX-treated larvae develops between 4 and 6 d post-fertilization (dpf), after complete tectal coverage is first achieved. Electrophysiological recordings of RGCs in wild-type and mao zebrafish larvae reveal a temporally regulated reduction of sodium current in the mutant between 5 and 6 dpf. This coincides with the time of the axonal projection shifting on the tectum to compensate for the disparate growth patterns of the retina and the tectum. Our genetic and physiological analyses suggest a model in which neuronal activity in RGCs is needed for the establishment of morphological plasticity.

Animals↗
PubMed1994

ESTRACE--1: a stethoscope for functional checking of electrostimulators and low cost body surface mapping system.

In a project on the mapping of body surface potentials evoked by implanted spinal cord stimulators and transcutaneous electrostimulators, a simple device was developed for use in polyclinical practice for easy checking of the function of these stimulators. The device is an electrical stethoscope and consists of an instrumentation amplifier, bandpass filter, a distortion circuit and a headphone. In vivo measurements demonstrate the generation of an amplitude-dependent tone by the distortion circuit. The apparatus is in many aspects similar to a stethoscope: simple to understand and a practical tool for a fast Go/No-Go test. The device can be optionally connected with a PC and enables body surface mapping documentation within a few minutes.

Adult↗
PubMed2004

Visual areas in the lateral temporal cortex of the ferret (Mustela putorius).

Using systematic electrophysiological mapping, architectonics and the global pattern of interhemispheric connectivity, we have identified three visual areas in the lateral most part of the posterior suprasylvian gyrus. The most posterior and largest area we call area 20a and anterior to this we defined a smaller area, area 20b. These areas lie lateral to the visual areas 18, 19 and 21 and posterior to a third, but incompletely defined, visual area, area PS. Areas 20a and 20b, emphasize the representation of the upper hemifield. Their interhemispheric connections conform to the so called 'midline rule' in that they are abundant in regions representing central portions of the visual field, scarce or absent elsewhere. These areas are probably homologous to the homonymous areas of the cat and might be indicative of a Bauplan from which the temporal areas of primates may have evolved.

Animals↗
PubMed2002

TBE foci in Switzerland.

To give information about the situation in Switzerland and especially in the canton Thurgau. Tick-borne encephalitis (TBE) in Switzerland has to be reported to official bodies, such as the Cantonal Office of Health and the Swiss Federal Office of Public Health. The registered cases are published weekly in the Bulletin of the Swiss Federal Office of Public Health. A map with geographical sites of infection has been published by the Swiss Federal Office of Public Health from time to time. In addition we collect epidemiological data in our diagnostic setting servicing part of eastern Switzerland. The situation of every patient diagnosed in our laboratory is followed up by a questionnaire. Some data derive from an epidemiological study conducted by Baumberger et al. (1996) and from another study conducted in the principality of Liechtenstein (Krech et al., 1992). The data of a more recent publication are also included (Schwanda et al., 2000). More historical data are taken from Krech (1980). Recently, the global positioning system (GPS) connected to a laptop computer containing a geographical map on CD-ROM was used for better determination of possible TBE microfoci. TBE is endemic in areas of northern Switzerland and the principality of Liechtenstein. The number of reported new infections in Switzerland per year ranges between 60 and 120 cases, most of them with neurological manifestations. This represents an incidence of 0.5-1.5 per 100,000 inhabitants per year. In the last 10 years a prominent increase of the number of reported cases occurred in Switzerland, namely from 30-70 cases per year to 60-120 cases per year. This increase was mainly caused by the emergence of TBE in the cantons of Thurgau, Aargau and St. Gallen, all localised in the north-eastern part of Switzerland. The canton Thurgau became the most dangerous region in Switzerland for TBE during the last ten years. Besides the known endemic areas of the regions of Schaffhausen, Thun and Biel-Ins, a number of additional foci have been detected during the last 20 years. These are situated, for instance, around the lake of Zurich or in the region of Chur. In the canton Thurgau, new cases could be located east of the formerly known foci. Besides the larger epidemic areas known there are several TBE virus microfoci in Switzerland and more microfoci are still recognized. Despite active vaccination of persons at risk the incidence of reported TBE cases has increased during the last 20 years, now being between 60 and 120 cases per year, some of them with a severe and prolonged course. No TBE foci have been recognized in western und southern Switzerland so far. From our observations we have got the impression that real new TBE foci are emerging in some regions of eastern Switzerland.

Animals↗
PubMed1993

The dynamics of sparse random networks.

Recurrent neural networks with full symmetric connectivity have been extensively studied as associative memories and pattern recognition devices. However, there is considerable evidence that sparse, asymmetrically connected, mainly excitatory networks with broadly directed inhibition are more consistent with biological reality. In this paper, we use the technique of return maps to study the dynamics of random networks with sparse, asymmetric connectivity and nonspecific inhibition. These networks show three qualitatively different kinds of behavior: fixed points, cycles of low period, and extremely long cycles verging on aperiodicity. Using statistical arguments, we relate these behaviors to network parameters and present empirical evidence for the accuracy of this statistical model. The model, in turn, leads to methods for controlling the level of activity in networks. Studying random, untrained networks provides an understanding of the intrinsic dynamics of these systems. Such dynamics could provide a substrate for the much more complex behavior shown when synaptic modification is allowed.

Animals↗
PubMed2024

A research synthesis of humans, animals, and environmental compartments exposed to PFAS: A systematic evidence map and bibliometric analysis of secondary literature.

BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are a class of widely used anthropogenic chemicals. Concerns regarding their persistence and potential adverse effects have led to multiple secondary research publications. Here, we aim to assess the resulting evidence base in the systematic secondary literature by examining research gaps, evaluating the quality of reviews, and exploring interdisciplinary connections. METHODS: This study employed a systematic evidence-mapping approach to assess the secondary literature on the biological, environmental, and medical aspects of exposure to 35 fluorinated compounds. The inclusion criteria encompassed systematic reviews published in peer-reviewed journals, pre-prints, and theses. Comprehensive searches across electronic databases and grey literature identified relevant reviews. Data extraction and synthesis involved mapping literature content and narrative descriptions. We employed a modified version of the AMSTAR2 checklist to evaluate the methodological rigour of the reviews. A bibliometric data analysis uncovered patterns and trends in the academic literature. A research protocol for this study was previously pre-registered (osf.io/2tpn8) and published (Vendl et al., Environment International 158 (2022) 106973). The database is freely accessible through the interactive and user-friendly web application of this systematic evidence map at https://hi-this-is-lorenzo.shinyapps.io/PFAS_SEM_Shiny_App/. RESULTS: Our map includes a total of 175 systematic reviews. Over the years, there has been a steady increase in the annual number of publications, with a notable surge in 2021. Most reviews focused on human exposure, whereas environmental and animal-related reviews were fewer and often lacked a rigorous systematic approach to literature search and screening. Review outcomes were predominantly associated with human health, particularly with reproductive and children's developmental health. Animal reviews primarily focused on studies conducted in controlled laboratory settings, and wildlife reviews were characterised by an over-representation of birds and fish species. Recent reviews increasingly incorporated quantitative synthesis methodologies. The methodological strengths of the reviews included detailed descriptions of study selection processes and disclosure of potential conflicts of interest. However, weaknesses were observed in the critical lack of detail in reporting methods. A bibliometric analysis revealed that the most productive authors collaborate within their own country, leading to limited and clustered international collaborations. CONCLUSIONS: In this overview of the available systematic secondary literature, we map literature content, assess reviews' methodological quality, highlight data gaps, and draw research network clusters. We aim to facilitate literature reviews, guide future research initiatives, and enhance opportunities for cross-country collaboration. Furthermore, we discuss how this systematic evidence map and its publicly available database benefit scientists, regulatory agencies, and other stakeholders by providing access to current systematic secondary literature on PFAS exposure.

Bibliometrics↗
PubMed1984

Fine-structure analyses of lipid-protein and protein-protein interactions of gag protein p19 of the avian sarcoma and leukemia viruses by cyanogen bromide mapping.

In avian sarcoma and leukemia viruses, the gag protein p19 functions structurally as a matrix protein, connecting internal components with the viral envelope. We have used a combination of in situ cross-linking and peptide mapping to localize within p19 the regions responsible for two major interactions in this complex, p19 with lipid and p19 with p19. Lipid-protein cross-links were localized near the amino terminus within the first 35 amino acids of the polypeptide. Homotypic protein-protein disulfide bridges were found to originate from near the carboxy terminus of p19, from cysteine residues at amino acids 111 and 153. These results suggest that p19 is divided into domains with distinct functions. The peptide maps constructed for p19, and for the related proteins p23 in avian sarcoma and leukemia viruses and p19 beta in recombinant avian sarcoma viruses, should serve as useful tools for other types of studies involving these proteins.

Amino Acids↗
PubMed2001

Quantitative architecture distinguishes prefrontal cortical systems in the rhesus monkey.

The prefrontal cortex encompasses a large and heterogeneous set of areas, whose borders have been variously mapped in different architectonic studies. Differences in cortical maps present a formidable problem in comparing data across studies and in constructing databanks on the connections and functional attributes of cortical areas. Here we used quantitative approaches to cortical mapping to investigate (i) if architectonic areas of the prefrontal cortex in adult rhesus monkeys have unique profiles and (ii) if groups of architectonic areas belonging to distinct cortical types, ranging from agranular to eulaminate, have similar features. In addition, we used multidimensional analyses to see if, and how, prefrontal areas form clusters when multiple features are considered simultaneously. We used quantitative unbiased sampling procedures to estimate the areal and laminar density of neurons, glia and neurons positive for the calcium binding proteins parvalbumin (PV), calbindin (CB) and calretinin (CR) among 21 prefrontal areas or subdivisions of areas. Neuronal density varied among the prefrontal cortices (range: 38 569 +/- 4078 to 58 708 +/- 2327 neurons/mm(3)); it was lowest in caudal orbitofrontal and medial areas (OPAll, OPro, 13, 24a, 32, M25) and highest in lateral prefrontal areas (subdivisions of areas 46 and 8). Neurons positive for PV were most prevalent in lateral prefrontal areas and least prevalent in caudal orbitofrontal and medial pre-frontal areas, whereas the opposite trend was noted for neurons that expressed CB. Neurons positive for CR did not show regional differences, and the density of glia showed small variations among prefrontal cortices. The differences among areas, along with differences in the thickness of individual areas and layers, were used to establish a quantitative profile for each area. The results showed that differences in the density of neurons, and the preponderance of neurons positive for PV and CB, were related to different architectonic types of areas found within the prefrontal cortex. Conventional as well as multiparameter statistical analyses distinguished at one extreme the agranular and dysgranular (limbic) cortices, which were characterized by prominent deep layers (V-VI), the lowest neuronal density, the highest ratio of glia/neurons, and the lowest density of PV and the highest for CB. At the other extreme, lateral eulaminate cortices were characterized by the highest density of neurons, a prominent granular layer IV, denser supragranular (II-III) than infragranular (V-VI) layers, and a balanced distribution of neurons positive for PV and CB. The results provide insights into potentially different rates of development or maturation of limbic and eulaminate prefrontal areas, and their differential vulnerability in neurological and psychiatric diseases. The quantitative methods used provide an objective approach to construct maps, address differences in nomenclature across studies, establish homologies in different species and provide a baseline to identify changes in pathologic conditions.

Animals↗
PubMed1975

Gene transfer in Drosophila melanogaster: cytological alterations in the salivary chromosomes of transformed stocks.

Cytological abnormalities are observed in salivary chromosomes of stocks of Drosophila melanogaster possessing DNA-induced, v+ transformations mapping either at 1-0.0 or 1-33.0. In initial studies, the untransformed control stock and six transformed stocks were assigned code numbers prior to cytological examination. Salivary chromosome regions 1B9 10--C 2-3 and 10A1 2--10B1-2 were carefully examined in each of the coded stocks. (Band 1B11 is tentatively identified as the site of the suppressor-of-sable locus at 1-0.0 and band 10A1 is the site of the vermilion locus at 1-33.0.) When cytological studies were complete each of the stocks was identified. In every transformed stock examined, anomalies had been scored in association with the chromosome region corresponding to the map position of the DNA-induced alteration. In the control stock, anomalies were observed at neither position. -- Approximately 10-15% of the nuclei in transformed stocks exhibit significant departure from normality in the pertinent chromosome region. The perturbations range from minor alterations of banding pattern to apparent pieces of extra chromatin in the most extreme cases. In stocks with v+ transformations mapping at 1-33.0, apparent extra chromatin is observed with frequencies varying from 0.05 to 0.02. In these cases the abnormal structures are associated with salivary band 10A1-2, forming a band-like structure, frequently an almost perfect doublet (open or closed), often lying in an abnormal position, and with fine chromatin threads connecting to the chromosomal doublet. In stocks with v+ transformations mapping at 1-0.0, apparent extra chromatin is observed with a frequency of about 0.001. These abnormal structures are frequently thread-like, lying to the side or off the tip of the chromosome, with compact regions which sometimes resemble chromomeres, and with fine threads connecting to the chromosomal 1B11 region.

Animals↗
PubMed2006

Anatomical correlates of the functional organization in the human occipitotemporal cortex.

The connectivity between functionally distinct areas in the human brain is unknown because of the limitations posed by current postmortem anatomical labeling techniques. Diffusion tensor imaging (DTI) has previously been used to define large white matter tracts based on well-known anatomical landmarks in the living human brain. In the present study, we used DTI coupled with functional magnetic resonance imaging (fMRI) to assess neuronal connections between human striate and functionally defined extrastriate ventral cortical areas. Functional areas were identified with conventional fMRI mapping procedures and then used as seeding points in a DTI analysis to ascertain connectivity patterns between cortical areas, thus yielding the pattern of connections between human occipitoventral visual areas in vivo.

Adult↗
PubMed1984

A digital timing and display unit for intraoperative mapping of cardiac arrhythmias.

An inexpensive display and timing unit incorporating a multichannel signal delay has been developed for mapping the heart during electrophysiological surgery. It provides a continuous digital readout of the time relationships between 3 intracardiac electrograms and the surface electrocardiogram. The electrograms are displayed on a storage oscilloscope with an automatic erase facility. This unit is used to locate accessory atrioventricular connections in the Wolff-Parkinson-White syndrome, to map ventricular tachycardias and to locate the bundle of His. The design has been refined during 5 years of use in over 200 operative procedures.

Arrhythmias, Cardiac↗
PubMed1977

[Precordial ST segment elevation mapping: a new method for a technically easier recording (author's transl)].

Precordial ST segment maps are currently recorded using a 35 electrode blanket connected to an electrocardiograph through a switch box. Problems in adjustment to patients' chests and artifacts are frequently encountered. Other techniques using a single suction electrode placed on different reference points are time wasting. The authors suggest the use of 35 self-adhesive electrodes (3M "Red Dot" chloride free gel pediatric electrodes--cat N. 2243) connected by a press button to a multichannel EKG recorder. This technique prevents artifacts, assures constant arrangement of the electrodes, is suitable for different thoracic structures and does not need any additional device. The authors consider that such a practical method should make precordial ST mapping a more widespread clinical procedure.

Coronary Disease↗
PubMed1990

A lattice theory approach to the structure of mental models.

Lattice theory is proposed to provide a formalism for the knowledge base used as a mental model by the operator of a complex system. The ordering relation 'greater than or equal to' is interpreted as 'is caused by', and the lattice becomes a representation of the operator's causal hypotheses about the system. A given system can be thought of causally in different ways (purposes, mechanics, physical form, etc.). Each gives rise to a separate lattice. These are related to each other and to an objective description of the structure and function of the physical system by homomorphic mappings. Errors arise when nodes on the mental lattices are not connected in the same way as the physical system lattice; when the latter changes so that the mental lattice no longer provides an accurate map, even as a homomorphism; or when inverse one-to-many mapping gives rise to ambiguities. Some suggestions are made about the design of displays and decision aids to reduce error.

Decision Making↗
PubMed1996

Electrophysiological mapping of fast excitatory synaptic inputs to morphologically and chemically characterized myenteric neurons of guinea-pig small intestine.

Neurons within the myenteric plexus of the guinea-pig ileum were impaled using conventional intracellular electrodes. Points of stimulation within the surrounding ganglia and connectives which gave rise to fast excitatory synaptic potentials were mapped using a movable monopolar stimulating electrode. Cells were then injected with the intracellular marker, biocytin, and processed for multiple label immunohistochemistry to reveal their morphologies, chemical contents and, hence, their functional classes. Of 65 neurons belonging to the S electrophysiological class, 53 received fast excitatory synaptic inputs from stimulation at sites at least 2 mm away in a directly circumferential direction. These inputs almost certainly arise from stimulation of the circumferentially-directed axons of the Dogiel type II/AH-neurons, which are thought to be intrinsic sensory neurons. The majority of cells which projected anally and were immunoreactive for nitric oxide synthase (19/25), all neurons which ramified in the tertiary plexus and were identified as longitudinal muscle motor neurons (6/6) and all neurons identified as excitatory motor neurons innervating the circular muscle (12/12) received inputs from these circumferentially-directed pathways. However only one of six descending filamentous interneurons impaled received such inputs, suggesting they may be differentially innervated. The conduction velocities of circumferentially-directed axons giving rise to fast excitatory post synaptic potentials were estimated to be 0.41 +/- 0.10 m/s (mean +/- standard deviation, n = 21). The conduction velocities estimated for longitudinally-directed pathways were 0.55 +/- 0.25 m/s (n = 29). Thus, the majority of myenteric neurons receive fast excitatory synaptic input from putative intrinsic sensory neurons which project circumferentially around the intestine.

Animals↗
PubMed2001

Changes in aortic rotational flow during cardiopulmonary bypass studied by transesophageal echocardiography and magnetic resonance velocity imaging: a potential mechanism for atheroembolism during cardiopulmonary bypass.

The human aorta is a curved conduit with a complex three-dimensional geometry. The curvature influences axial velocity distribution and introduces transverse velocity components. Rotational flow in the aorta can be demonstrated during normal pulsatile flow using transesophageal echocardiography. Cardiopulmonary bypass may affect the pattern of rotational flow in the aorta and thus influence the generation of atheroemboli. We investigated rotational flow in the descending aorta using color flow mapping and pulse-wave Doppler on transesophageal echocardiography before and during cardiopulmonary bypass. We correlated our findings with magnetic resonance velocity imaging in a model of a human aortic arch connected to a cardiopulmonary bypass circuit. Before cardiopulmonary bypass, rotational flow in the descending aorta was seen in 37 of 40 patients (93%). In the majority of these patients, rotational flow was in the clockwise direction during systole, looking in the direction of flow (30 of 37 patients, 81%, P < 0.01 vs counterclockwise rotation). During cardiopulmonary bypass, there were almost equal numbers of patients with clockwise (18 patients) and counterclockwise rotation (19 patients). Forty-seven percent of patients with clockwise rotation before cardiopulmonary bypass developed reversal in the direction of rotation to counterclockwise during cardiopulmonary bypass. Twenty-nine percent of patients with counterclockwise rotation developed reversal of the direction of rotation during cardiopulmonary bypass. The transverse velocity component increased during cardiopulmonary bypass regardless of the direction of rotation. We also demonstrated clockwise rotation in the descending aorta of a human aortic arch model connected to a cardiopulmonary bypass circuit using magnetic resonance velocity mapping. Before cardiopulmonary bypass, rotation was predominantly clockwise, while during cardiopulmonary bypass, there was no preferred direction of rotation. The geometry of the aorta, which is fairly constant in all patients, imposes handedness to aortic flow before cardiopulmonary bypass. However, during cardiopulmonary bypass, other extrinsic factors such as aortic cannula orientation may influence the direction of rotation. The change in direction of rotational flow and increase in its transverse velocity component during cardiopulmonary bypass may have implications for atheroembolism and arterial branch perfusion during extended periods of non-pulsatile flow.

Aorta↗