Benefits of fluoride toothpaste.
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Dentinal hypersensitivity is a common dental problem without a satisfactory solution. Most therapies have focused on either trying to block the stimulation of dentinal nerves or on sealing open dentinal tubules. This study evaluated, in a double blind clinical trial, the effect of Enamelon, a dentifrice containing sodium fluoride, calcium salts and phosphate salts (calcium separated from the phosphate and fluoride by a plastic divider in the tube to prevent interaction) on dentinal hypersensitivity over an 8-week period. A conventional OTC dentifrice containing NaF without calcium and phosphate enhancement served as the control. A third dentifrice, containing sodium monofluorophosphate enhanced by calcium and phosphate salts, was also tested. Based upon subjective anecdotal information, net numbers of sensitive teeth which became non-sensitive, and a logit analysis of the change in the proportion of sensitive teeth over the study time period, Enamelon was the most effective product, and the OTC control the least effective.
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After 7 years unsupervised use of a Na2FPO3 paste the number of new DMF-surfaces was 36 to 38% lower than in the control group. The caries-inhibiting effect is statistically significant (P less than 0.001). Separate consideration of the first molar reduced caries of the other teeth to 40--42%.
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A clinical double blind trial on 98 volunteers was undertaken with the aid of the SB Index to show the effects on the gum of a tooth paste containing detergents. It resulted in a significant increase of the SBI after 6 weeks of a tooth paste with a high content of surface active substances. With the light microscope changes are demonstrable in the Stratum spinosum which could be identified electron-microscopically as a strong increase of bundles of filament in the cytoplasm. The contradiction between clinical and morphological findings is explained by the assumption that the greatincrease in filament bundles leads to a lowering of the adaptability of the epithelium and consequently to increased tendency to bleed, especially in response to mechanical irritation.
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