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Problems in lymphoma management: special sites of presentation.

The staging and treatment of the common presentations of malignant lymphoma are readily familiar to experienced medical oncologists and hematologists. However, because of their rarity and variable and unusual behavior, certain special sites of lymphoma present a major challenge even to experienced clinicians. This article focuses on five such special sites of presentation: the eye, paranasal sinuses, central nervous system (CNS), testicle, and stomach. In each case, an appreciation of the usual histologic types, unique mode of metastatic spread, special patterns of resistance to systemic treatment, and, in the stomach, the remarkable association with a causative organism, Helicobacter pylori, is needed to optimize management. Only if these special characteristics are understood can the clinician plan a multiphase treatment course that offers each patient the best chance of disease control or cure.

Central Nervous System Neoplasms↗

Patients' outcomes: intrahospital transportation and monitoring of critically ill patients by a specially trained ICU nursing staff.

BACKGROUND: Intrahospital transportation of critically ill patients can contribute to patients' morbidity and mortality. OBJECTIVE: To determine adverse outcomes associated with intrahospital transportation of critically ill patients by a specially trained nursing transport team. METHODS: Monitoring and intervention data were collected for 237 instances of transportation of patients between a hospital's ICUs and radiology suites. These results were compared with the results of national studies on complication rates associated with intrahospital transportation of patients. RESULTS: The patients moved by the specially trained transport team has a 15.5% overall complication rate, with 10.2% minor, 2.5% moderate (compensated for with medications), and 2.8% severe complications that did not respond to intervention. No medications of therapies were delayed, and only 2 patients (0.8%) had decompensation that required the examinations to be aborted. Reported national complication rates for intrahospital transportation of patients are as high as 75%; the complications include adverse events such as delayed administration of medications, significant changes in vital signs, dislodgment of artificial airways and i.v. catheters, and cardiopulmonary arrest. CONCLUSION: Use of a specially trained ICU transport team can substantially reduce the rate of adverse outcomes generated by the transportation of critically ill patients for specialized radiological procedures.

Adolescent↗

Improving state Medicaid contracts and plan practices for children with special needs.

The rapid transition of state Medicaid beneficiaries into fully capitated managed care plans requires a special focus on children with chronic or disabling conditions, who often depend on numerous pediatric physicians and other specialty services for health care and related services. Because managed care arrangements for this population are growing in popularity nationwide, it is important that states craft managed care contracts to address the unique needs of children with complex physical, developmental, and mental health problems. Based on the research reported in this article, in-depth interviews with state Medicaid agency staff, interviews with medical directors and administrators of managed care plans serving Medicaid recipients, and input from experts in pediatrics and managed care, a set of recommendations is made for tailoring managed care contracts to meet the needs of this vulnerable group of children. Six contracting elements that should be adopted by state Medicaid agencies include (1) clarifying the specificity of pediatric benefits, (2) defining appropriate pediatric provider capacity requirements, (3) developing a medical necessity standard specific to children, (4) identifying pediatric quality-of-care measures, (5) setting appropriate pediatric capitation rates, and (6) creating incentives for high-quality pediatric care. Nine approaches that should be adopted by managed care practices interested in providing high-quality care for children with special needs also are identified. These include (1) ensuring that assigned primary care providers have appropriate training and experience, (2) offering support systems for primary care practices, (3) providing specialty consultation for primary care providers, (4) establishing arrangements for the comanagement of primary and specialty pediatric services, (5) arranging for comprehensive care coordination, (6) establishing flexible service authorization policies, (7) implementing provider profiling systems that adjust for pediatric case mix, (8) creating financial incentives for serving children with special needs, and (9) encouraging family involvement in plan operations. Implementing these changes to managed care contracting could have a major impact on the quality and comprehensiveness of health care received by children with special needs. Successful implementation, however, requires strong support from both state Medicaid agencies and the managed care plans dedicated to serving this population.

Child↗

[ROLE AND EVOLUTION OF A SPECIALIZED SCIENCE LIBRARY].

This paper deals with the present position of a specialized scientific library, the increase in the number of such libraries, and their development in conjunction with that of the institutes and laboratories to which they belong. It describes the danger for these libraries of too great expansion and the need to restrict themselves to a well-defined area. The different categories of specialized scientific libraries are reviewed, as well as the role of each of these categories vis-à-vis overburdened university libraries. There is an account of the assistance given [by specialized scientific libraries] to university libraries now and in the near future.

Forecasting↗

Influence of specialization on the management and outcome of patients with pancreatic cancer.

BACKGROUND: Cancer care is increasingly specialized. Relationships between pancreatic cancer care, mortality and patterns of clinical practice among the full spectrum of patients, including those with irresectable tumours, are not well understood. METHODS: A cohort of 782 patients diagnosed prospectively with pancreatic cancer in 29 acute hospitals in England and Wales over 1 year were followed for 2-3 years. The effects of doctors' and hospitals' specialization, indicated by annual patient volumes, on operative mortality rates, survival times, and test and treatment provision were studied. Multiple logistic and Cox regression models were used to control for prognostic factors and treatments, providing adjusted odds and hazard ratios associated with a higher volume of ten patients annually. RESULTS: Patients managed by higher-volume hospitals survived significantly longer (hazard ratio 0.88 (95 per cent confidence interval (c.i.) 0.83 to 0.93); P < 0.001). They were more likely to undergo cytological examination (odds ratio (OR) 1.21 (95 per cent c.i. 1.01 to 1.35)), resection (OR 1.44 (1.17 to 1.79)) and biliary stenting (OR 1.17 (1.02 to 1.34)), and were less likely to have bypass surgery (OR 0.66 (0.55 to 0.78)). Patients of higher-volume doctors were more likely to undergo endoscopic retrograde cholangiopancreatography (OR 1.59 (1.19 to 2.11)), percutaneous transhepatic cholangiography (OR 1.50 (1.12 to 2.00)), laparoscopy (OR 1.81 (1.07 to 3.06)), resection (OR 1.84 (1.29 to 2.61)) and bypass surgery (1.71 (1.25 to 2.33)). CONCLUSION: Specialization appears to improve survival and to promote more thorough investigation.

Clinical Competence↗

Evidence of the effect of 'specialization' on the management, surgical outcome and survival from colorectal cancer in Wessex.

BACKGROUND: A prospective audit of the management of colorectal cancer was established to investigate factors associated with variation in survival observed within the former Wessex region (population three million). METHODS: Some 5173 patients (4562 surgically treated) with colorectal cancer diagnosed between 1991 and 1994 were followed for 5 years. Details of referral, diagnosis, surgical treatment, postoperative complications and outcomes were collected. The association between surgical outcomes and survival and both case volume and specialization (defined to include membership of the Association of Coloproctology of Great Britain and Ireland) was explored, accounting for variables with prognostic significance. RESULTS: There was a statistically significant association between high-volume operators (more than 50 operations per year) and specialization. The greatest benefit was observed with respect to specialists versus non-specialists, in terms of a lower postoperative mortality rate (odds ratio 0.67 (95 per cent confidence interval (c.i. 0.53 to 0.84)), lower anastomotic leak rates (odds ratio 0.46 (c.i. 0.31 to 0.66)), higher local recurrence-free survival (hazard ratio 0.56 (0.44 to 0.71)) and better long-term survival (hazard ratio 0.76 (c.i. 0.71 to 0.83)). CONCLUSION: There is a stronger association between surgical specialization in coloproctology and beneficial outcome than with high-volume caseloads. This is not entirely accounted for by case-mix or patient population, and is seen following colonic and rectal surgery and among patients with advanced disease.

Adolescent↗

Mental hygiene of the special schools teachers in Kerman, Iran.

The goal of this research is to identify and study the mental hygiene and its related factors (individual, family, organizational) in the Kerman special schools teachers. 266 teachers of the special schools of the cities of the province Kerman were chosen as the research sample. The necessary data were obtained by "questionnaire" which its validity and reliability were determined. The statistical analysis of the research findings (by Spearman coefficient test) Man-Whithey and Kruskal wallis tests showed that there was a positive and meaningful relationship between "Level of education", "service of record" "the number of the members of teacher's family", "income", "dwelling-place", "economic power", "acceptance of the teacher's job in their family", "leadership style", "suitable educational possibilities", "suitable educational space", "job satisfaction" with the mental hygiene of the teachers. The results of the research also showed that the Kerman special schools teachers enjoyed a "relatively desirable" mental hygiene.

Adult↗

Social validation of decelerative (punishment) procedures by special educators of severely handicapped students.

Ratings on the acceptability, intrusiveness, restrictiveness, and efficacy of 18 commonly used interventions for decelerating behaviors were obtained from 58 special educators of students with severe handicaps. Results indicated that consensually high and low mean ratings were obtained for restrictiveness, intrusiveness, and acceptability. Ratings of efficacy, however, were generally neither consensually high nor low, and demonstrated lower variability across the 18 interventions, and lower reliability across raters than did ratings on the other three dimensions. Additionally, ratings of restrictiveness were negatively correlated with ratings of acceptability, ratings of intrusiveness and restrictiveness were positively correlated, and ratings of acceptability and efficacy were positively correlated. We interpreted these results as suggesting that: (a) special educators may not be certain of the efficacy of interventions they use, despite previously reported use in classrooms, and (b) the constructs of restrictiveness and intrusiveness may not have discriminant validity at present. Implications for ongoing training for special educators were discussed.

Attitude↗

Greek medical students' career choices indicate strong tendency towards specialization and training abroad.

The aim of the study was to investigate the career choices, location preferences and criteria among medical students in Greece. We applied a questionnaire-based analysis using a sample of 591 students of four out of seven Greek Medical Schools. The sample included students of all academic years. The vast majority of students wish to specialize (97.6%), while general practice gathered a very low percentage (1.7%). The scientific challenge (61.4%) and interaction with patients (60.6%) seem to be the major influencing factors for most of the students' specialty preferences, whilst less common variables influencing career choice are the high demand/supply ratio for certain health services (40.4%), the income potential (31.4%), the active tempo (26.2%) and prestige (15%). 70.3% of those asked consider the possibility of specializing abroad. The low concern of Greek medical students for general practice reveals today's drastic deficiency in Greek primary health care. Such a situation will escalate, unless targeted strategies to produce more general practitioners are adopted. Furthermore, the results reflect a lower education and organizing level urging students to specialize abroad. The National Health System (NHS) should be reformed towards a rationalistic distribution of the medical specialties and medical workforce.

Adult↗

Subgroups and Special Populations in Heart Failure Clinical Trials: Insights From the HFC-ARC Expert Consensus Panel.

In the evolving landscape of heart failure (HF) management, the identification and analysis of subgroups and special populations within clinical trials are crucial for enhancing clinical decision-making, guiding further research, and understanding heterogeneity in study outcomes. This expert consensus document results from the collaborative efforts of the Heart Failure Collaboratory and the Heart Failure Collaboratory Academic Research Consortium, which brought together stakeholders from academia, industry, the U.S. Food and Drug Administration, and patient representatives. The purpose of this assembly was to propose standardized definitions and critical endpoint considerations essential for shaping the design and conduct of clinical trials for drugs and devices in the field of HF. In this context, we propose definitions and endpoints for specific subgroups and special populations in the spectrum of HF. We enhanced the precision, efficacy, and applicability of clinical research and promote more "personalized" approaches to interpretation of clinical trials. Furthermore, we explore the burgeoning field of gene therapy as a promising avenue for addressing the genetic basis of certain cardiomyopathies within these specialized patient groups. We focus especially on methodological considerations for subgroup analyses in large-scale trials, highlighting the importance of proper interpretation of subgroups and best practices for identifying heterogeneity suggestive of differential treatment effects, including when these analyses should be considered hypothesis-generating and requiring subsequent validation. We advocate for a methodical approach to clinical trial design, one that prioritizes the strategic identification of subgroups and employs appropriate statistical methodologies to ensure the reliability and clinical relevance of findings. Through this lens, we envision a pathway toward more personalized and effective treatments for HF, ultimately aiming to improve patient outcomes by leveraging the insights garnered from meticulously designed and comprehensively analyzed clinical trials.

Humans↗

Specialized beds program: diversification options in skilled nursing facilities.

Serving patients in the SNF who need specialized, highly skilled care demands strong commitment, intensive planning, cooperative research, and continuous reassessment and evaluation. Specialty care programs are necessary to provide viable alternatives to acute care hospitalization for patients who need long term care. Health care organizations should continue their cooperative efforts to ensure the appropriate and cost effective use of services. Based on CCM's successful history of operating special care programs, providers should be encouraged to become leaders in developing specialized care alternatives. The appropriate use of long term care as well as acute care settings is in the best interest of patients, communities, and the health care industry itself.

Cost Control↗

The effects of biological and social risk factors on special education placement: birth weight and maternal education as an example.

The effects of birth weight (BW) and maternal education (ME) on special education placement at age 10 were studied. Epidemiologic methods quantified risk to the individual and to the population using an electronically linked, county-wide database of birth and school records. A dose-response relationship was found between BW and ME. High ME may serve as a buffer for children with a biological risk for developmental delays. A clinically important finding was that children born with very low BW to mothers with low ME were at a high level of individual risk for receiving special education services. However, such children accounted for a small number of the overall cases. The largest percentage of children receiving special education services had the single risk factor of low ME. From a public policy standpoint, children born to mothers with low levels of education are an important group to target for early intervention.

Adolescent↗

The full-frame approach: a new response to marginalized women left behind by specialized services.

Increasing emphasis on specialization in social and mental health services leaves these systems largely unable to attend to marginalized women's complex needs, despite new models designed to ameliorate specialization's impact. In this article, the authors describe how inattention to these women's contexts leaves them ill-served and leaves programs struggling. The authors articulate a new framework of principles and practices that privileges context and community, and describe two programs that use this "Full-Frame Approach." The authors contend that systemic recognition of full-frame programs as a strategic counterbalance to specialization is a vital component of helping marginalized people and communities move to new levels of health and cohesion.

Community Mental Health Services↗

Variations in sick-listing practice among male and female physicians of different specialities based on case vignettes.

OBJECTIVE: To analyse the influence on sick-listing of speciality and sex of the prescribing doctor and of patients' way of presenting their problem. DESIGN: A sample of 360 general practitioners (GPs), 180 psychiatrists and 180 orthopaedic surgeons were presented case vignettes and asked to fill in a sick certificate for each case. The cases were chosen to reflect common causes of sick-listing in Sweden. The vignettes for each case were presented in three versions with uniform biomedical information plus a variation in the patient's attitude to sick-listing. SETTING: Swedish general practice and hospital physicians. MAIN OUTCOME MEASURES: Proportion of cases not being sick-listed and costs for the period certified. RESULTS: The most important factor affecting sick-listing was the patient's attitude to sick-listing. Patients wishing sick-listing were sick-listed to a greater extent than those who were reluctant. In addition, GPs sick-listed more than orthopaedic surgeons and less than psychiatrists. Female doctors sick-listed more than male doctors, irrespective of speciality and patient attitude. CONCLUSION: Sick-listing is influenced by the physician's speciality and sex. Doctors are strongly influenced by how the patients present their problem.

Female↗

Comparing quality of care for sexually transmitted diseases in specialized and general clinics.

OBJECTIVE: The objective of this study was to compare quality of care for patients with sexually transmitted diseases (STDs) in specialized vs. general clinics. METHODS: The authors conducted a retrospective chart review evaluating compliance with a set of STD-related process of care quality indicators for adult patients seen in six Los Angeles County clinics (two STD specialized clinics and four general medical clinics). RESULTS: Thirty-two quality indicators were selected using a modified Delphi process. From March 1, 1996, to June 31, 1996, there were 205 STD-related visits to the two specialized STD clinics and 373 STD-related visits to the four general medical clinics. For patients with "classic" STDs (those for which sexual contact is the primary means of transmission), STD clinics achieved greater compliance than general medical clinics on 14 quality indicators, while general medical clinics achieved greater compliance on 4 indicators. CONCLUSION: STD clinics provide better overall STD care than general medical clinics. Possible explanations include differences in clinician experience with STD patients and greater use of standardized protocol sheets.

Adult↗

Shaping institution-based specialism: early twentieth-century economic organization of medicine.

This paper focuses on structural development of institution-based medical specialism in the USA in the first third of the twentieth century. It examines organizational ideas of key reformers and specialty leaders and it examines corresponding characteristics of the institutions they built. The structural characteristics which they incorporated into medical care embodied forms of economic organization of the time. Leaders (variously) explained their reform activities in terms of scientific, professional, and/or economic development of medicine. The first section describes a form of specialization within academic medical centres as a vertical functional division of labour which divided medical work into procedures performed by a range of personnel. This division of labour and its required management changed the work of doctors and nurses and required a multiplication of 'auxiliary' hospital staff, as shown in the second section. The final section demonstrates how the departmental structure within academic medical centres provided a necessary institutional framework for vertical specialism. The literature has emphasized the fact that an industrial model was only partly implemented in medical care at the time. Nevertheless, the (industrial) characteristics identified had a significant impact on fundamental structures of twentieth-century medicine.

Economics↗

Mapping medical specialization in Paris in the nineteenth and twentieth centuries.

This paper seeks to provide a systemic perspective on the development of medical specialization in France. Making use of information in medical directories of the period, it offers a quantitative analysis of developing specialization in Paris and the major provincial cities from 1880 to 1935. The first section examines the size and scope of the different specialties in 1884, 1905, 1920, and 1935. The second section analyses evolving patterns of linkage among specialties through the cases of multiple identification which occurred. The final part looks at the relative élitist character of specialties as measured by official hospital and faculty posts and membership in the Academy of Medicine. The conclusion suggests how these quantitative results might orient future research on specialization.

France↗

Power, knowledge, and the discourse of specialization in nursing.

The characterization of specialization in nursing varies across different time periods, contexts, persons, groups, and institutions. Therefore, it may be viewed as a discourse. The expression of this discourse is subject to contextual influences and social interests. For example, its perceived congruence or antagonism to other major discourses, such as specialization, medicine, and nursing, will impact on its expression and legitimization. This article explores the discourse of specialization in nursing, especially as it is expressed in the Australian and North American context, and focuses on the power and knowledge issues that relate to, and constitute, the discourse.

Australia↗