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PubMed1989

Myelination and remyelination in the central nervous system by transplanted oligodendrocytes using the shiverer model. Discussion on the remyelinating cell population in adult mammals.

In the early sixties, remyelination was first observed in animal models of demyelination and described a few years later in multiple sclerosis. The spontaneous remyelination process is now well documented. Remyelination by transplantation of myelin-forming cells has been attempted. Transplanted Schwann cells can myelinate a central nervous system lesion but the remyelination is limited to the area of implantation. Oligodendrocytes or precursor cells are much more invasive and have been shown to migrate from the implantation site to the lesion at a distance of several millimeters. Thus, remyelination by transplantation of myelin-forming cells is possible at least in animal models, the oligodendrocytes being more efficient.

Animals↗
PubMed1991

Shiverer jimpy double mutant mice. V. Correlation of genotype and myelin proteins.

We have reexamined the levels of myelin basic protein (MBP) and proteolipid protein (PLP) in the brains of mice bred to carry both the shi/shi and jp/Y hypomyelination defects. The genotype of each putative double mutant was confirmed by direct DNA analysis: shi/shi by Southern blot analysis, and jp/Y by restriction enzyme analysis of polymerase chain reaction-amplified fragments. MBP and PLP levels were assessed by immunoblotting. All putative double mutants were found to be shi/shi. However, examination of the PLP locus revealed both jp and wild-type genotypes, the latter produced by an expected crossover. Animals proven to be shi/shi*jp/Y had no detectable MBP or PLP; those proven to be shi/shi*+/Y (the crossover) had no MBP but had PLP. These results differ from an earlier report of both MBP and PLP in the brains of presumed shi*jp animals.

Animals↗
PubMed1987

Shiverer jimpy double mutant mice. III. Comparison of shimld*jpmsd and shi*jp phenotypes demonstrates dissimilar interactions of allelic mutations.

Double mutant mice, which are of the genotype shimld/shimld*jpmsd/Y and therefore express both the shimld and jpmsd mutations, have a CNS myelin protein composition which resembles shimld/shimld alone but not jpmsd/Y alone. The double mutant CNS white matter morphology shows much less myelin and major dense line than either shimld/shimld or jpmsd/Y, but has other features which resemble jpmsd/Y but not shimld/shimld. In contrast, the parallel double mutant shi/shi*jp/Y, which expresses the alleles shi and jp rather than shimld and jpmsd, has already been shown to have biochemical and morphological phenotypes which are consistent with each other, both being intermediate between shi/shi and jp/Y and therefore suggesting partial reciprocal intergenic suppression (Brain Research, 374 (1986) 45-53 and 54-62). To assist in explaining the apparent inconsistencies between the biochemical and morphological phenotypes of the shimld/shimld*jpmsd/Y double mutant and between interactions of allelic mutations at the shi and jp loci, a hypothesis of multiple primary gene functions at these two loci is proposed.

Animals↗