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PubMed2003

Quantitative and qualitative documentation of early literacy instruction.

Quantitative and qualitative procedures were used in this pilot study to develop and evaluate the effectiveness of a language and literacy instruction model for meeting the needs of children with impairments, delays, and differences in regular Head Start classrooms. Although the project addresses a variety of literacy domains, this article focuses on rhyming and letter naming. In the instruction model, children were exposed to motivating examples of rhyme and letter targets in different activity structures embedded across the curriculum. A crossover design compared two classrooms of children trained on letter and rhyme targets in a different order. Results of an analysis of variance revealed a significant Condition (rhyme first vs. letter first) x Task (rhyme generation vs. letter generation) x Time (Posttest 1 vs. Posttest 2) interaction. At the first posttest, children in the rhyme-first condition performed better than those in the letter-first condition on rhyme generation, whereas children in the letter first condition performed better on letter generation. At the second posttest, after the groups had experienced instruction in both areas, the children performed comparably on both tasks. In addition to the quantitative analyses, qualitative analyses were also conducted. A qualitative examination of children's participation revealed their affective involvement and engagement in instructional activities. Changes in the children's awareness of their capacity to rhyme and changes in their displayed abilities to participate in rhyming activities were also documented.

Child, Preschool↗
PubMed1998

Educational support programme for gynaecological cancer patients and their families.

In order to improve psychosocial support for gynaecological cancer patients and their families a project with educational and supportive group programmes was started. This article presents an evaluation of the project. The study group consisted of those patients and next-of-kin who wished to participate in the educational support group programmes (n = 36 + 8). Patients from distant parts of the catchment area who were not able to participate constituted the controls (n = 25). A graded Likert-like questionnaire and a short profile of mood state (POMS) were completed before and after intervention. Patients who actively chose to participate differed from the unselected control group even prior to educational intervention. In certain issues their perceived knowledge about cancer was inferior to that of the controls and they felt more confused and angry than the control group (p < = 0.05). After intervention, the patients in the interventional group reported a significantly improved level of knowledge about cancer than the controls (p < 0.001, group by time interaction). The qualitative section of the evaluation revealed that the most positive experiences coupled with participation were the information and knowledge received and the mutual understanding experienced together with the other group members.

Adult↗
PubMed2004

Experience from the first ACT programme in Denmark. II. Severe mental illness. A register diagnosis.

Community psychiatry in Denmark has been criticized because of drop-outs of the patients with severe mental illness. In order to deal with these problems, the first Assertive Community Treatment (ACT) project in Denmark was started in the Tønder region on 1 May 2001. Before starting the clinical study, an epidemiological analysis of severe mental illness was performed. Severe mental illness was defined from register data on the basis of psychosis and high use of psychiatric services. Data concerning drop-out (inactive during a period), death and address were obtained. The point prevalence rate of severe mental illness on 31 December 2000 in Sønderjylland (SJ) county was 1.31/1000. The rate of inactive patients was 0.28/1000. The rates were distributed inhomogeneously between regions. In a 4-year cohort, half of the patients were inactive at least once. The Tønder and Aabenraa regions had homogeneous patterns. In conclusion, the register diagnosis is a target group for ACT. The register diagnosis and the status active/inactive may be used as an unbiased effect parameter.

Adult↗
PubMed2003

A computer-based model for the regulation of mitogen activated protein kinase (MAPK) activation.

Computer simulations and mathematical modeling of biological processes are becoming increasingly popular, and yet the complexity of the biochemical systems or the differences between experimental setups make it very difficult to establish a standard formula for these modeling projects. Before we can start using computer-based models for predictions or targeted experiment designs, it is very important to establish a reliable model on which those predictions can be based and experimentally tested. Here we attempt to present a computer model for the mitogen-activated protein kinase (MAPK) signaling cascade which is consistent with previously published experimental results. In this study we have focused our attention to a generic MAPK ERK (extracellular signal-regulated kinase) pathway activated by epidermal growth factor (EGF) in an attempt to understand how receptors may achieve different activation kinetics of the MAPK signaling. We successfully show that the level of receptor expression is one key determinant in this regulation, and that the binding affinity of the active receptor to adaptor proteins can have a small but albeit direct effect on the downstream activation.

Animals↗
PubMedDate not supplied

The origin and topography of long-range intrinsic projections in cat visual cortex: a developmental study.

We investigated the morphological features of long range intrinsically projecting neurons and their pattern of axonal arborization in cat area 17 at different stages of postnatal development. In one set of experiments intracortically projecting cells were retrogradely labeled in vivo with rhodamine latex beads and then visualized by in vitro filling with Lucifer yellow. In another approach, intracortical fibers including the cells of origin were labeled postmortem in fixed brains with the lipophilic carbocyanine dye Dil. The results of this study indicate that the long-range intrinsic circuitry of the primary visual cortex develops in three major steps. The first step consists of the development of unclustered long-range axons in the two outer compartments of the cerebral cortex, layer I and the subplate. These early connections could serve as a scaffold for the organization of the tangential architecture of the neocortex as they originate from cells that are the first to receive synaptic input from extrinsic afferents. The second step consists of the outgrowth of horizontal axon collaterals originating from cells located in layers II-VI. During the first 2-3 weeks these connections still differ from those in the adult because they span shorter distances, originate more often from neurons with morphological features of nonpyramidal cells, and lack the precise clustering of the mature connections. The third step consists of a selection process that leads to the elimination of axon terminals from locations between the clusters of tangentially projecting neurons. This selection starts at the end of the second postnatal week and, hence, overlaps in time with the still proceeding elongation of axons and continues beyond the end of the fourth postnatal week when axon length has reached its maximal extent. This refinement process enhances the specificity of long-range connections and is probably influenced by visual experience.

Animals↗
PubMed2006

MBGD: a platform for microbial comparative genomics based on the automated construction of orthologous groups.

The microbial genome database for comparative analysis (MBGD) is a comprehensive platform for microbial comparative genomics. The central function of MBGD is to create orthologous groups among multiple genomes from precomputed all-against-all similarity relationships using the DomClust algorithm. The database now contains >300 published genomes and the number continues to grow. For researchers who are interested in ongoing genome projects, we have now started a new service called 'My MBGD,' which allows users to add their own genome sequences to MBGD for the purpose of identifying orthologs among both the new and the existing genomes. Furthermore, in order to make available the rapidly accumulating information on closely related genome sequences, we enhanced the interface for pairwise genome comparisons using the CGAT interface, which allows users to see nucleotide sequence alignments of non-coding as well as coding regions. MBGD is available at http://mbgd.genome.ad.jp/.

Algorithms↗
PubMed1997

Genetic testing for familial hypercholesterolaemia: practical and ethical issues.

Coronary artery disease (CAD) has a strong genetic component, but is also greatly influenced by environmental factors such as diet and smoking, and disorders such as diabetes mellitus and hypertension. This interaction makes prediction of CAD risk generally difficult. However, in familial hypercholesterolaemia (FH), risk of early CAD is considerably increased by the mutation of a single gene, and genetic testing may be appropriate. We summarize current knowledge concerning DNA-based tests in the identification and management of FH, and propose specific recommendations for genetic testing and further research. The major value of DNA tests for FH is in genetic tracing programs to identify and treat affected individuals. DNA testing is appropriate for: (a) diagnosis of FH when physical signs or family history are equivocal or absent (important given the increased risk of CAD associated with FH compared to other hypercholesterolaemias); (b) detection of a mutation causing FH in immediate family members (particularly children) where there is a family history of premature CAD. A positive DNA-based test for a mutation is especially useful in children, in whom plasma lipid levels may not be diagnostic. Current clinical practice is to test relatives for raised cholesterol. Testing for mutation carriers in distant relatives, although feasible, is not currently recommended. Research projects should now be started to address two issues: (i) whether genetic tests for FH better predict clinical outcome than does measurement of plasma lipid levels; (ii) whether genetic testing for FH confers overall benefit both to the patient and their relatives, and to the NHS. Answers to these questions will guide the subsequent development and implementation of genetic tests for CAD risk in general, if and when the considerably more complex genetic causes of CAD are identified.

Adult↗
PubMed2006

Official dosimetry with personal electronic dosemeters--the framework in Germany.

In Germany, personal electronic dosemeters (AEPDs) are presently applied mainly for operational radiation protection monitoring particularly in nuclear power engineering companies, large hospitals and research centres. This is done in addition to the official dosimetry of record. Therefore, frequently, double monitoring occurs-officially and operationally. A crucial advantage of AEPDs compared with passive dosemeters is the ability to adapt the monitoring period to the working time in controlled areas and to allow an immediate readout of the dose after leaving the controlled area, e.g. a job-related monitoring is possible by correlating the readout dose with the job performed. Germany started a general research project, consisting of two parts, for an optimised implementation of personal electronic dosemeters into official dosimetry. The use of AEPDs as official dosemeters depends on an approval by Federal and Federal State ('Länder') authorities as an official dosimetry system, which has to comply with special requirements ensuring that the legal requirements are fulfilled. The formulation of these special requirements is in the focus of part one of the research project, supervised by the Federal Office for Radiation Protection (BfS) and performed by the Gesellschaft für Anlagen- und Reaktorsicherheit (GRS) mbH. As a result of part one, a framework was developed which is the basis for a future technical implementation project. Part one is described in the paper, while part two is still to be initiated and will deal with the implementation and testing phase of the introduction of personal electronic dosemeters as official dosemeters.

Electronics↗
PubMed1998

Implementing a strategy for improving care: lessons from studying those age 80 and older in a health system.

This article describes some potential solutions to the many practical barriers that arise when trying to improve clinical care in everyday practice. A useful mnemonic for incorporating measurement into daily work is called GAPS--setting Goals, Assessing the current processes, Planning a new approach, and Starting it. The 80+ Project represents a foundation of information and offers promise to create durable, productive interactions for elderly individuals and their health care providers.

Aged↗
PubMed1996

Establishing a framework for research: the example of needs assessment.

This paper explains the early planning stage of a study commissioned by the English National Board which will investigate the changing educational needs of community nurses with regard to needs assessment and quality of care in the context of the NHS and Community Care Act 1990. Two focus groups, comprising 22 participants altogether, generated data which were used to augment and clarify issues explored in an initial literature review. Some of the methodological issues are explained. Traditional community nursing approaches to needs assessment appeared to value process and integration, while the new legislation emphasizes the separateness of assessment; there is a danger that it may be seen as a single event. The consumer views were both supportive and critical about each of the approaches; some important insights were gained, and a confident basis from which to launch the study identified. The approach offers one possible way to clarify the starting point of a project when carrying out a standard literature review seems insufficient. This may occur with under-researched or rapidly changing phenomena, or if a field of interest is the subject of multiple interpretations or lack of consensus.

Community Health Nursing↗
PubMed1992

Dying back type axonal degeneration of sensory nerve terminals in muscle spindles of the gracile axonal dystrophy (GAD) mutant mouse.

A disorder of the gracile axonal dystrophy (GAD) mutant mouse is characterized by a neuromuscular disease with sensory ataxia (detectable 30 days after birth) and paresis of the hindlimbs (detectable at 80 days). In the sensory ataxia stage, histological study of the primary sensory system shows that, in addition to the lesions in the central nervous system, peripherally projecting axons have also started to degenerate at their distal ends in muscle spindles. Although the structure of Ia fibre endings appear normal until 15 days after birth, initial changes in the annulo-spiral structure are detected around the 20th day by a degeneration of the terminal axons. Degeneration then progressed proximally and the secondary endings also start to degenerate. Neuron cell bodies located in the dorsal root ganglia are morphologically intact until the later stages. Chronological studies indicate that, although axonal degeneration progresses throughout life, it is accentuated during the rapid somatic growth period. Around 50 days of age, transient regeneration takes place at axonal endings when somatic growth has attained a plateau. Such primary sensory endings tend to be restored by fine, multiple axons which gain access to the intrafusal fibres through the original endoneurial tubes. Ultrastructural observations at the fully affected stage show intrafusal muscle fibres lying scattered within spindles due to loss of the fine network of inner capsule layers and an almost complete loss of sensory endings from the surface of intrafusal muscle fibres. These results indicate that this mutant mouse is a useful model for naturally occurring 'dying back' type axonal degeneration or 'central and peripheral distal axonopathies', and would provide significant information about the complete evolution of the pathological processes involved.

Animals↗
PubMedDate not supplied

Getting nursing research going in a community hospital with limited resources.

In today's rapidly changing healthcare environment, validating nursing practice is more important than ever. Research findings can be used to improve the quality of care, demonstrate cost-effectiveness, and confirm the need for professional nursing practice. Even with limited resources, research activities can become an integral part of your nursing practice. Assess your current assets, then start with a feasible project you feel strongly committed to. Work to develop your skills, support, and resources as you create a research-friendly environment. The greatest reward will be knowing you are providing the best nursing care possible.

Clinical Nursing Research↗
PubMed2004

The development of professional guidelines on the law and ethics of male circumcision.

This paper does not attempt to lay out the arguments relating to male circumcision for non-medical reasons. Rather, the aim is to focus more on the process and the problems of a professional body (in this case the British Medical Association (BMA)) attempting to produce any consensus guidelines for its members on an issue which clearly polarises doctors as much as it divides society as a whole. The legal and ethical considerations of male circumcision are inevitably touched upon here but are not the central issue. In 2003, the BMA published professional guidance on this subject. Some thought this a pointless exercise; others saw it as an initiative which simply failed to go far enough. Reservations centred on the fact that the BMA's guidance--like that of the statutory body, the General Medical Council--explored the issues without either firmly rejecting or accepting non-therapeutic male circumcision. Was it then a fruitless project or a brave start to grasping the nettle?

Circumcision, Male↗
PubMed2006

Gene identification and analysis of transcripts differentially regulated in fracture healing by EST sequencing in the domestic sheep.

BACKGROUND: The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance of the sheep, relatively little research has been performed into sheep genetics, and DNA sequences are available for only a small number of sheep genes. RESULTS: In this work we have sequenced over 47 thousand expressed sequence tags (ESTs) from libraries developed from healing bone in a sheep model of fracture healing. These ESTs were clustered with the previously available 10 thousand sheep ESTs to a total of 19087 contigs with an average length of 603 nucleotides. We used the newly identified sequences to develop RT-PCR assays for 78 sheep genes and measured differential expression during the course of fracture healing between days 7 and 42 postfracture. All genes showed significant shifts at one or more time points. 23 of the genes were differentially expressed between postfracture days 7 and 10, which could reflect an important role for these genes for the initiation of osteogenesis. CONCLUSION: The sequences we have identified in this work are a valuable resource for future studies on musculoskeletal healing and regeneration using sheep and represent an important head-start for genomic sequencing projects for Ovis aries, with partial or complete sequences being made available for over 5,800 previously unsequenced sheep genes.

Animals↗
PubMed2000

Growth hormone therapy of Turner syndrome: the impact of age of estrogen replacement on final height. Genentech, Inc., Collaborative Study Group.

Clinical trials of recombinant human GH therapy in Turner syndrome that began more than a decade ago show that GH accelerates the linear growth rate. Several studies indicate that final height is also improved, although the magnitude of the increase has been debated. The age at which feminization is induced could be an important factor in determining the patient's ultimate growth response. To test this, 60 patients from a large (n = 117), previously unreported, clinical trial of GH treatment were randomly assigned to begin conjugated estrogens at either 12 or 15 yr of age. The 60 patients were all less than 11 yr of age at entry (mean, 9.5 yr) and received 0.375 mg/kg x week of GH for nearly 6 yr on a daily or three times weekly regimen. Height gain was calculated by comparing the study patients' final or near final heights to their pretreatment projected heights as well as to those of a separate set of age-matched, historical control patients. Patients in whom estrogen treatment was delayed until age 15 yr gained an average of 8.4 +/- 4.3 cm over their projected height, whereas those starting estrogen at 12 yr gained only 5.1 +/- 3.6 cm, on the average (P < 0.01). Analysis of the interval data showed that growth was stimulated for approximately 2 yr after estrogen initiation, but then declined in association with bone age advancement. Patients who were older than 11 yr at entry (n = 57) all initiated estrogen 1 yr after beginning GH and showed a mean gain in adult height of 4.7 cm, similar to those given estrogen at age 12 yr. Multivariate analysis revealed that the number of years of GH therapy before estrogen treatment was a strong factor in predicting height gained, indicating that the timing of estrogen introduction is an important determinant of final height in this cohort of GH-treated patients with Turner syndrome matched for baseline age and other characteristics.

Adolescent↗
PubMed2005

The iPath telemedicine platform.

An early, point-to-point telepathology system at the University of Basel developed into an open-source, Internet-based platform for telemedicine in 2001. The Internet Pathology Suite (iPath) is a Web-based telepathology platform that permits the online presentation and discussion of cases within user groups. It also allows realtime telemicroscopy across firewalls. After four years, the telepathology network has over 700 active users. More than 6,300 cases with a total of about 39,000 images have been diagnosed. The diagnostic workload of all these cases is not exclusively handled by the Department of Pathology in Basel, but by a growing number of independent groups who also use the server simply as a case repository. What started as a small project for hospitals in Switzerland has become a global network.

Communication↗
PubMed2006

[Phylogenomics--an attractive avenue to reconstruct "tree of life"].

The successive start-up of genome project in recent years has far-reaching impact on present phylogenetic studies. A new synthesized discipline--"Phylogenomics", combing genomics with phylogenetics together, is emerging, and becomes an attractive avenue to reconstruct "Tree of Life". In the review, the conception and analytic method of phylogenomics are summarized. The potential problems are also suggested.

Animals↗
PubMed2006

Good ecological status in a heavily urbanised river: is it feasible?

In Germany, a national instructions sheet, BWK M3, sets out how the impact of sewer system discharges on receiving water bodies is to be analysed. When applying the simplified assessment procedure defined therein and relying on traditional measures only, it becomes evident that in heavily urbanised rivers a large number of retention facilities would be needed to improve the hydraulic and qualitative conditions. However, the associated economics make the feasibility of such an immission-based approach to river restoration doubtful. In response, the Bergisch Rheinischer Wasserverband and the Ruhrverband started a common research project to find out whether and how the Rinderbach River, a heavily modified water body in terms of morphology and flow dynamics, could achieve the good ecological status required under the European Water Framework Directive. The focus of the survey was on the elaboration of an inventory, the identification of potentially attainable ecological objectives, and the discussion of measures with regard to their benefits and feasibility. The results obtained clearly show that it is possible to achieve good ecological status in already heavily urbanised rivers by making use of all existing natural potential within the river basin. They also demonstrated that a good interactive co-operation of experts in the fields of biology, urban drainage and hydraulics is indispensable.

Conservation of Natural Resources↗