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[Lesions of the distal segment of the large intestine in Reiter's disease].

Altogether 23 male patients with Reiter's disease (RD) were followed-up in an arid zone. An interstitial syndrome was diagnosed in addition to the urethro-oculo-synovial syndrome. In one group (14 patients) RD followed acute enterocolitis (dysentery in 3 cases and 9 cases of unknown etiology). Halprovias were found in 5 patients, colon lesion in 12 patients. In the other group (9 patients) halprovias were found in 4 patients. The signs of enterocolitis, pathological microbial flora in the stool and changes in the colon mucosa were absent. An assumption was made of pathogenetic relationship of the urethro-oculo-synovial and intestinal syndromes in RD. A more serious RD course was noted in this combination of syndromes.

Adolescent↗

Change in the extent of colonic involvement in ulcerative colitis: a colonoscopic study.

The change over time in the extent of colonic involvement in ulcerative colitis has, to date, been assessed only by radiological means. To study this issue further, we examined, with repeated colonoscopies, 31 patients with ulcerative colitis. Serial biopsies were taken every 5 cm from the most proximal area reached by the colonoscope down to rectum. The endoscopic and histological extents were evaluated, and the severity of the inflammatory process was graded. Clinical scoring also was performed at the time of both colonoscopies. A change of extent was found in 77% of the patients endoscopically, and in 58% histologically, during a mean follow-up period of 17 months. Extension and regression were demonstrated in the same number of patients. In 61% of 62 procedures, there was complete agreement between colonoscopic and histological extents. The histological extent exceeded the colonoscopic extent in 28% of the procedures. We have the impression that change in the disease extent is a frequent event, and may be a part of the natural history of ulcerative colitis, rather than the exception.

Adult↗

[Ileo-rectal anastomoses].

Ileorectal anastomosis is a classical method for re-establishing continuity after total colectomy. It is usually immediate and terminoterminal, but if local circumstances or emergency considerations demand it is carried out secondarily using mechanical sutures. The effects of colic suppression are rapidly compensated and the minimal functional sequelae are compatible with a normal life. Any change in intestinal rhythm or flow suggests organic alteration of the anastomosis or of the under- or overlying intestine. Ileorectal anastomosis is indicated whenever rectal resection is not obligatory. If this is not the case (polyadenomastosis-ulcerative coloproctitis) ileoanal anastomosis with reservoir currently allows definitive ileostomy to be avoided.

Adenoma↗

[Pseudomembranous rectocolitis].

The following conclusions were drawn from a study of 15 cases of pseudo-membranous coloproctitis (PMCP): PMCP was seen in subjects of both sexes and all ages. The causative agent was found in all antibiotic classes. Clinical signs comprised constant diarrhea, fever, abdominal pain, toxic shock and, more rarely, pseudo-occlusive, pseudo-perforative surgical evidence. Diagnosis involved visualization of pseudo-membranes by endoscopy. Lesions were most frequent in the left colon and increased in severity towards the distal end. Three stages were distinguished by histological examination: superficial necrosis of the mucous membranes, interruption of glands, complete necrosis of the mucous membrane. Without preparation the abdomen did not provide specific information; nor did barium enema which revealed lesions that were frequently diffuse but more marked in the left colon. Conventional coprocultures did not provide diagnostic information. Only a more sophisticated technique will be capable of detecting the pathogen currently considered to be the cause of PMCP: Clostridium difficile. The course of the disorder is generally satisfactory under medical treatment (parenteral feeding, vancomycin) but may sometimes call for surgery.

Cholestyramine Resin↗

Early radiation-induced proctosigmoiditis responds to magnesium therapy.

A group of 10 patients with cervical carcinoma with early radiation-induced proctosigmoiditis and low serum Mg levels was treated with low residue diet and antidiarrheals. The diarrhea cleared within a period of 2-6 weeks. A second group of 10 patients with hypomagnesemia was treated with intravenous infusion of Mg sulfate for 3 consecutive days. The diarrhea disappeared by the end of treatment, paralleling normalization of serum Mg levels.

Colitis↗