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At least 739 records · Page 41Linked to original sources
PubMed1991

[Cardiomyocyte in valvular cardiopathies. Comparative morphometry of myofibrils and mitochondria. Functional correlations].

Twenty-four endomyocardial biopsies performed during surgical correction of valvulopathies were compared with ventricular function. Patients were divided into three groups: group I without anomalies of ventricular function, group II with a slight decrease of the ventricular ejection fraction, group III with a low ventricular ejection fraction. Morphometric analysis was carried out using electron microscopic photographs and an image analyser. The results were correlated with those of functional studies. In patients of the second group, the small number of mitochondria with respect to the increased myofibrillary area seemed to indicate mitochondrial dysfunction. In patients of the third group, alterations of myocontractility expressed a myofibrillary deficiency unable to be corrected by the multiplication and the increased exchange areas of mitochondria.

Heart Valve Diseases↗
PubMed1990

[Myofibril degeneration of heart muscle: histologic picture and pathophysiologic significance].

Mechanical trauma to the heart induces a rhythmical transverse banding of adjacent myocytes. This finding is due to hypercontraction (true contraction bands) and it is different from the cross band type myofibrillar degeneration (MFD) which is characterized by disseminated foci of irregular transverse banding. This latter type is mainly found after temporary myocardial ischemia, in cases of reanimation using catecholamines and defibrillation as well as in severe brain trauma. Both types of cross banding can be identified in hematoxylin and eosin or in azan stains; a much better visualization is obtained using the PTAH or the Luxol Fast Blue (LBF) method. Moreover, LFB, giving a selective blue staining of the damaged cells, allows the identification of the recently described diffuse type MFD. Well developed contraction bands may indicate the vitality of a heart trauma, yet a supravital occurrence seems to be possible. MFD, diffuse or cross band type, clearly correlates with high blood catecholamine levels at the time of death.

Cardiomyopathies↗
PubMed1990

[Myofibril degeneration of heart muscle: diagnostic value of selected forensic pathology case material].

Information on the incidence of myofibrillary degeneration (MFD) was obtained by investigating the hearts of seven groups of cases with different forensic diagnosis using luxol fast blue as a staining method. The following diagnostic groups were examined: acute morphine intoxication, acute carbon monoxide intoxication, hanging, strangling by hand and/or ligature, drowning, acute hemorrhagic shock and sudden infant death syndrome. MFD positive cases were found in all diagnostic groups, but the morphologic expression of MFD as well the number of cases per group differed: The phenomenon of cytoplasmatic banding could be observed in nearly all cases of hanging, strangling and acute hemorrhagic shock; the phenomenon of diffuse cytoplasmatic staining in most cases of drowning. The diagnostic importance is discussed.

Adult↗