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PubMed1984

Serum concentrations of vitamin D metabolites in maternal and umbilical cord blood of Libyan and Norwegian women.

The serum concentrations of the vitamin D metabolites 25-hydroxyvitamin D (25-OHD), 1,25-dihydroxyvitamin D (1,25-(OH)2D) and 24,25-dihydroxyvitamin D (24,25-(OH)2D), and vitamin D binding protein, calcium, phosphate and alkaline phosphatase were determined in 19 grand multiparous Libyan women at delivery, and in the umbilical cord blood of 14 of their babies. The results were compared with similarly collected data from 22 vitamin D-supplemented Norwegian mother-infant pairs. The median 25-OHD and 24,25-(OH)2D concentrations were significantly lower for the Libyan group (maternal 25-OHD: 34 vs 112 nmol/l; cord 25-OHD: 20 vs 76 nmol/l; maternal 24,25-(OH)2D: 0.6 vs 4.1 nmol/l; cord 24,25-(OH)2D: 0.4 vs 2.7 nmol/l, P less than 0.001 for all differences). In both groups the 25-OHD and 24,25-(OH)2D levels in maternal as well as in cord blood were closely associated (P less than 0.001). The median 1,25-(OH)2D level was similar for the two maternal groups (198 vs 194 pmol/l), but slightly lower for the Libyan than for the Norwegian cord samples (80 vs 93 pmol/l, P = 0.04). A calculated free 1,25-(OH)2D concentration (not bound to vitamin D binding protein) did not differ between the two maternal or cord groups. Calcium and phosphate concentrations were similar for the respective maternal and cord samples, while the median alkaline phosphatase level of cord blood was slightly higher for the Libyan group (P = 0.04). The results suggest that calcium and phosphate homoeostasis of pregnant women and their fetuses can be maintained despite wide variations in vitamin D supply and numerous repeated pregnancies.(ABSTRACT TRUNCATED AT 250 WORDS)

25-Hydroxyvitamin D 2↗
PubMed1983

Six years mortality statistics in a Libyan paediatric hospital.

During the six year period from 1975 to 1980, at Al-Fatch Paediatric Hospital 35,488 sick children under 12 years of age were admitted for inpatient treatment; 3 009 had a fatal outcome. The mortality rate per 1000 admissions and discharges respectively, was 54.9 and 52.1 in 1975; and 135.6 and 119.4 in 1980. The age specific mortality rate per thousand discharges was 219.4 for infants, 32.8 for 1 to 4 years, 21.7 for 5 to 9 years, 25.7 for 10 to 12 years of age. Although the overall mortality rate was almost equal for boys and girls, it was higher for boys below 1 year or over 10 years, and higher for girls between 1 to 9 years of age. The proportion of deaths and admissions was more during winter the season from September to January and during the summer season from May to July. More than 80% of those who recovered were admitted with acute respiratory infection, gastroenteritis, meningitis, diseases of urinary system, acute poisoning and symptoms or ill-defined conditions; whereas, more than 70% of expired cases were admitted with prematurity, gastroenteritis, septicaemia, acute respiratory diseases and congenital malformations. The case fatality in 1980 was 84.5% for septicaemia, 55.5% for prematurity, 41.7% for congenital malformations, 18.9% for malnutrition and 16.1% for diseases of nervous system.

Age Factors↗
PubMed1983

Hematologic values and prevalence of anaemia in Libyan school children.

The hematologic values and prevalence of anemia in Libyan school children 6-19 yrs of age were investigated. The mean values of boys followed the normal pattern of rise with age. In girls, the mean values increased with age until age 15 yrs, and subsequently declined. The prevalence of low hemoglobin and of low hematocrit values was 3.2% and 11.3% respectively. The highest prevalence of low hemoglobin in boys and in girls was 4.6% (13-15 yrs) and 6.2% (16-19 yrs) respectively. The highest prevalence of low hematocrit was observed in age group 6-9 yrs in both sexes (boys 17.0%, girls 20.2%). Rates of prevalence of anaemia in Libyan school children were compared with those in Bahrain, Oman and USA.

Adolescent↗