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At least 739 records · Page 41Linked to original sources
PubMed1987

[Analysis of liposarcoma].

Liposarcoma is one of the most common soft tissue sarcomas, ranking with rhabdomyosarcoma and malignant fibrous histiocytoma. We have treated 47 cases of liposarcoma, comprising 35 males and 12 females ranging in age from 22 to 86 years, with a median age of 56 years. The most common site of primary tumor was the thigh, the most common primary tumor stage by the UICC classification was T2, and the most common histological subtype by the WHO classification was myxoid type. Xerography, CT and angiography are useful forms of examination for diagnosis before surgery. Naked eye findings of the tumor often show a lobular or nodular growth pattern. Surgical therapy for the primary tumor, especially curative wide resection (by the method of Kawaguchi, et al.) is most effective for preventing local recurrence. Radiotherapy is not as effective as for rhabdomyosarcoma and chemotherapy should be applied for occult micro-metastases. Ten of the 47 cases died due to distant metastases and the 5 year survival rate was 76.2%.

Adult↗
PubMed1987

[A case of retroperitoneal liposarcoma].

A case of retroperitoneal liposarcoma is reported. A 42-year-old woman was admitted to our hospital with the complaint of a palpable mass in her left abdomen. Intravenous pyelography, barium enema and an ultrasonogram revealed a huge left abdominal tumor. At operation, a huge yellow-brownish tumor found in the retroperitoneal space, was completely removed. The tumor was 32 x 24 x 12 cm and weighed 4,075 g. Histologically, it was a myxoid liposarcoma. Three courses of adjuvant chemotherapy (cis-platin) were administered. The postoperative course was uneventful and the patient has been free of disease for 16 months.

Adult↗
PubMedDate not supplied

The human int-1 gene is located at chromosome region 12q12-12q13 and is not rearranged in myxoid liposarcoma with t(12;16) (q13;p11).

The mouse cellular oncogene int-1 is often transcriptionally activated as a consequence of nearby proviral insertions in mouse mammary tumors. A highly conserved sequence has been found in the human genome, called int-1 gene, the role of which in human tumors is not known. By somatic hybrids, the human int-1 gene has been assigned to the segment 12q14-12pter. Using a genomic DNA clone containing the fourth exon of the human int-1 gene we have mapped the human int-1 gene to 12q12-12q13. To determine whether this gene, which is located close to the 12q13 breakpoint associated with myxoid liposarcoma, is rearranged in these tumors, we have performed Southern blot analysis of DNA from myxoid liposarcomas carrying the translocation t(12;16) (q13;p11). In the two tumors investigated, the translocation does not disrupt the int-1 gene.

Chromosome Mapping↗
PubMed1988

Primary mesenteric liposarcoma.

Primary mesenteric liposarcomas (PMLs) are rare neoplasms, with a review of the English literature revealing only 10 cases. This paper describes an additional case of PML, and collates the currently documented cases, thus creating the framework for delineating the profile of this neoplasm. It is a tumor of adults that has characteristic clinicopathological and radiological features. In contradistinction from the retroperitoneal liposarcoma, the PML is eminently resectable, and requires aggressive surgical management.

Aged↗
PubMed1988

[Lipoblastic liposarcoma of the lung. Ultrastructural study of a case].

A case of fatal lipoblastic pulmonary liposarcoma in a 20 year-old female is reported. A thoracotomy was performed but failed to yield the pathological diagnosis. This diagnosis was obtained by ultrastructural study of a cerebral metastasis. To our knowledge, only seven cases of pulmonary liposarcoma have been previously described in the literature and the lipoblastic aspect was never mentioned.

Adult↗
PubMedDate not supplied

Liposarcoma in a Canada goose (Branta canadensis).

A multicentric liposarcoma was identified in various skeletal muscles of a mature Canada goose. The light and electron microscopic appearance of the tumor is discussed in relation to the appearance of liposarcoma in other species.

Animals↗
PubMedDate not supplied

[Liposarcoma of the spermatic cord (presentation of a case)].

Liposarcoma of the spermatic cord is a rare tumour, usually well differentiated, that generally resembles a lipoma and undergoes a slow, progressive enlargement. Most patients with liposarcoma do not experience any recurrence after local excision. Due to the rare occurrence of this tumour it seems appropriate to document one case that came to our observation in recent years.

Genital Neoplasms, Male↗
PubMed1986

[Prolonged survival in retroperitoneal liposarcoma. Apropos of a case with 27 years' survival. Prognostic value of the histological type and role of repeat surgery].

The authors report a case of differentiated myxoid liposarcoma with a survival of 27 years as a result of repeated resections. They emphasise the value of a precise study of the histological type and grade: well differentiated and/or myxoid forms of liposarcomas appear to have a more favourable long term prognosis. This prognosis justifies repeated operations. The post-operative follow-up by computed tomography ensures earlier detection of recurrences. The time of re-operation depends on the volume of the tumour, the rate of growth, the possibilities of resection and the request for relief by the patient.

Female↗
PubMed1986

Myxoid liposarcoma of the right atrium. A case report.

A case of primary liposarcoma of the right atrium is presented. Liposarcomas of the heart are extremely uncommon, only 3 previous cases having been reported in the English-language literature. The tumour must be differentiated from other polypoid cardiac tumours, particularly cardiac myxomas.

Aged↗
PubMed1986

[Well-differentiated liposarcoma of the submandibular region. Case report and literature review].

Liposarcoma of the head and neck are seen only occasionally. In particular manifestations of this tumour in the submandibular region or the floor of the mouth are very rare. The pathohistological features and the clinical picture of these tumours are described by means of a case report and a review of the literature. The close correlation between histological differentiation and prognosis of liposarcoma is underlined. The recommended possibilities of treating these rare soft tissue tumours are discussed.

Adipose Tissue↗
PubMed1986

[Retroperitoneal liposarcoma with various histological figures].

A case of retroperitoneal liposarcoma consisting of three large nodules with three different types of histologic findings is presented. A 69-year-old man was diagnosed as having a malignant tumor in the retroperitoneum and underwent successful tumor extirpation. The resected tumor had three different type of nodules, 18 X 15 X 7.0 cm, 8 X 15 X 4.0 cm, 15 X 10 X 2.5 cm in size, respectively. The histologic examination revealed myxoid, well-differentiated fibrosing and lipoma-like liposarcoma type, respectively. Chemotherapy was undertaken postoperatively, and there is no evidence of recurrence two years after surgery.

Aged↗
PubMed1986

Enhanced levels of insulin-like growth factor messenger RNA in human colon carcinomas and liposarcomas.

The insulin-like growth factors I and II (IGF-I and -II) are proteins which stimulate cell proliferation and are important in normal human growth and development. They are coded for by separate genes and bind to specific cell surface receptors, eliciting a mitogenic response. IGFs are secreted by several cell lines derived from adult tumors. We have examined a number of human adult tumors for IGF messenger RNA (mRNA) expression and found IGF-II mRNA levels were consistently elevated in two types, colon carcinoma and liposarcoma. Adult colonic mucosa contains low levels of IGF-I and -II mRNA while several colon tumors, particularly of rectal and rectosigmoid origin, contained significantly elevated levels of IGF-II message. Over 90% of liposarcomas examined contained greatly elevated levels of IGF-II mRNA while control tissue (adipose) contained very low or undetectable IGF mRNA levels. Many of these tumors also contained elevated IGF-I mRNA levels. Northern analysis of these RNAs revealed differences in the abundance and sizes of IGF transcripts compared to other normal and malignant tissues known to express IGF.

Carcinoma↗
PubMed1985

[An extremely rare autopsy case of cardiac liposarcoma and Brenner tumor].

A 79-year-old woman with primary liposarcoma of the heart, an extremely rare malignancy, coexistent with Brenner tumor was reported. The histological features of the sarcoma on the routine histological slides were so varied that it was necessary to differentiate the histology from that of malignant fibrous histiocytoma or pleomorphic rhabdomyosarcoma. Most of the tumor cells including fibroblastic and bizarre giant cells, however, were stained intensely with histochemical methods for lipids and consequently diagnosed as pleomorphic liposarcoma originated from the epicardium. Electron microscopically, lipid droplets were demonstrated in the cytoplasm of the tumor cells, supporting the histological diagnosis. No distant or nodal metastases were noted.

Aged↗
PubMed1979

[Liposarcoma of the pancreas. Study of a case including ultrastructure].

The authors report a case of polymorphous liposarcoma situated in the pancreas. Ultrastructural study of proliferation demonstrated two cell contingents which appeared to represent stages of varied differentiation in the elaboration of adipose cells. The marked preponderance in the case studied of clear and little organised cells would appear to justify the histological classification of the polymorphous liposarcoma as a relatively undifferentiated tumour. Furthermore, this study emphasised the value of electron microscopy in the diagnosis of neoplasms which are complex from a morphological standpoint.

Adult↗
PubMed1980

Liposarcoma of the lower extremity.

Twenty patients with primary liposarcoma of the lower extremity were treated over a 25-year period. The adequacy of the initial surgical procedure and histological grade of malignancy both influenced survival rates. In addition local recurrence was noted only in patients who had undergone "inadequate" initial excision. Inguinal lymph nodes were uninvolved by tumor in all cases. In general, patients with liposarcomas of myxoid and/or round cell type survived for long periods of time. However, even patients with myxoid lesions occasionally exhibited evidence of early blood-borne metastases. This study suggests an important relationship between an inadequate primary resection, local recurrence, and eventual retroperitoneal spread. In the majority of cases, this may have resulted from failure to control the primary distal extremity tumor, with subsequent contiguous spread of metastases into the ipsilateral retroperitoneal space. If feasible, radical soft part resection should be performed as the primary surgical therapy of these neoplasms. Tumors contiguous to the knee or ankle joint should be treated by primary amputation. Failure to control local disease may result in blood-borne dissemination or local spread along musculoaponeurotic planes to involve proximal groin or retroperitoneal space.

Histiocytoma, Benign Fibrous↗
PubMed1982

Liposarcoma complicating neurofibromatosis. Report of two cases.

Liposarcoma complicating neurofibromatosis is a rare entity. Until now, only two cases have been reported in the literature. The authors present two new cases of liposarcoma arising in generalized neurofibromatosis with detailed microscopic findings. Other neoplasms associated with neurofibromatosis are also discussed.

Adolescent↗
PubMed1983

Primary liposarcoma of bone. Case report and review of the literature.

Although liposarcoma is a common tumor of the soft tissues of the body, it rarely occurs as a primary neoplasm of bone. An extensive review of the literature from 1930-1980 uncovered fewer than 35 cases. The authors discuss the diagnosis and treatment of a case of primary liposarcoma of bone in the right femur of a 34-year-old Bedouin man.

Adult↗