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At least 739 records · Page 41Linked to original sources
PubMed1979

Inhibition of the evoked release of acetylcholine by the porphyrin precursor delta-aminolevulinic acid.

The effect of delta-aminolevulinic acid (ALA) on neuromuscular transmission were studied. High concentrations (0.6 to 18 mM) of ALA caused significant reductions in the amplitudes of curarized end-plate potentials (epps). Changing the ratio of calcium to magnesium in the bathing solution allowed the quantal content of the epps to be directly measured. Under these conditions, ALA reduced the quantal content of epps without affecting the depolarization produced by a single quantum of acetylcholine. It was concluded that ALA, in high concentrations, inhibits the release of acetylcholine evoked by a nerve impulse but is unlikely to be the cause of the neurological defects of acute porphyria.

Acetylcholine↗
PubMed1975

The effect of porphyrin precursors on monosynaptic reflex activity in the isolated hemisected frog spinal cord.

The porphyrin precursors beta-aminolevulinic acid (beta-ALA) and porphobilinogen (PBG) which accumulate, and are excreted in the urine in increased amounts during acute attacks of porphyria, were tested for their effects on reflex activity in the isolated hemisected spinal cords of Xenopus laevis. The two compounds were found to exert an inhibitory effect on monosynaptic ventral root responses, as well as on dorsal root responses (DRR) and dorsal root potentials (DRP). The latent period for inhibition of the monosynaptic response was longer than that for the DRR and DRP. The sensitivity of the preparations to the effect of the porphyrin precursors was subject to some seasonal variation. BETA-ALA and PBG did not effect conduction in isolated sciatic nerves at a concentration of 1 mg/ml.

Aminolevulinic Acid↗
PubMed1986

13C-NMR evidence of bacteriochlorophyll a formation by the C5 pathway in Chromatium.

The 13C-NMR spectra of bacteriochlorophyll a formed in the presence of L-[1-13C]glutamate and [2-13C]glycine in Chromatium vinosum strain D were analyzed. The isotope in the glutamate was specifically incorporated into eight carbon atoms in the tetrapyrrole macrocycle derived from the C-5 of 5-aminolevulinic acid (ALA), and the 13C in glycine was incorporated into the methyl carbon of the methoxycarbonyl group attached to the isocyclic ring of bacteriochlorophyll a. These labeling patterns provide evidence for the exclusive operation of the C5 pathway in ALA biosynthesis in the bacterium. The 13C chemical shifts of two quaternary carbons (C-9 and C-16) of bacteriochlorophyll a were reassigned in the present study.

Aminolevulinic Acid↗