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PubMedDate not supplied

Correlation of blood groups with congenital disorders and gastro intestinal diseases.

Blood group studies were conducted in 330 patients suffering from gastro intestinal disorders and 180 patients with congenital malformations and compared with normal subjects. Statistical analysis has shown that (a) there is significant correlation between B group and thalassaemia, (b) congenital malformations show higher incidence in B and O groups. It would be pertinent to draw attention to the fact that B group was found to be significantly correlated to duodenal ulcer from the present study contrary to the early reports. In addition, these observations show that blood groups are linked with diseases.

ABO Blood-Group System↗
PubMed1986

Polyethylene glycol polymers of low molecular weight as probes of intestinal permeability. II. Application to infants and children with intestinal disease.

We used a mixture of low molecular weight polymers of polyethylene glycol (PEG) to study intestinal permeability in children with chronic diarrhea. After an oral load, urinary recovery of the longer chain, higher molecular weight polymers was significantly decreased compared with that in healthy adults and infants without disease of the gastrointestinal mucosa. A correlation was observed between clinical severity of disease, histopathologic condition of the small bowel mucosa, and PEG scores. These results indicate that intestinal permeability in children can be studied by noninvasive means and that an assessment of mucosal integrity can be obtained.

Adolescent↗
PubMed1977

Estriol concentrations in urine and serum in patients with various intestinal diseases.

Pregnant women with ulcerative colitis shows frequently low estriol values in both serum and urine. 18 patients with ulcerative colitis, 4 patien;s with mb. Crohn, and 3 patients with a by-pass operation were examined. Low estriol concentrations were seen only in the patients with ulcerative colitis especially in patients, where an operation has been performed. In one patient with severe diarrhea the estriol concentration in serum was low until the intestinal function normalised and the estriol concentration went up exactly when the diarrhea stopped. However, no unequivocal connection between low estriol concentrations and diarrhea could be demonstrated.

Colitis, Ulcerative↗
PubMed1993

[Carcinoma in non-specific inflammatory intestinal diseases-- epidemiology, clinical aspects, dispensarization].

Idiopathic proctocolitis and Crohn's disease are important precancerous conditions in particular in patients with the onset of the disease at a young age. The causes of colorectal carcinoma in these diseases remain hypothetical. The risk must not be underrated but it is not high enough to justify prophylactic colectomy. The fundamental contribution to dispensary programmes was the discovery of dysplasia, i. e. precancerous changes of the intestinal epithelia. The main method of dispensarization is coloscopy with multiple biopsies of different segments of the colon and rectum. It is recommended to initiate dispensary programmes 10 years after the onset of the disease. Dysplasia is not an ideal marker of the increased risk of carcinoma and other indicators of malignant transformation in intestinal biopsies are intensely sought. The further development of dispensary programmes depends on these efforts and the results of cost-benefit analyses.

Humans↗
PubMed1999

Diagnosis and management of small intestinal diseases.

Advances in the diagnosis and management of small bowel diseases are the subject of this review. Topics covered include improving the specificity of breath tests for bacterial overgrowth; small bowel enteroscopy; early diagnosis of mesenteric ischemia; the use of polymerase chain reaction for diagnosing central nervous system involvement in Whipple's disease; progress in defining the cause and pathogenesis of chronic idiopathic intestinal pseudoobstruction and the Peutz-Jeghers syndrome; defining the role of gut barrier function in health and disease; the therapeutic role for bile acid-binding resins in diarrhea after refeeding in critically ill patients; use of genetic techniques and topical steroid therapy in treating graft-versus-host disease; and the beneficial effects of combination hormonal therapy in occult gastrointestinal blood loss resulting from angiodysplasia.

Journal Article↗
PubMed1983

[Colorectal biopsy in inflammatory intestinal diseases].

Meticulous attention to the techniques of taking and processing both rectal and colonic biopsies is emphasised because this makes interpretation easier for the pathologist and more productive of useful information. The biopsy appearances of ulcerative colitis are described and distinguished from those seen in Crohn's disease and the various types of infective colitis. Comparison of sequential biopsies gives valuable information about the histology of the different phases of the disease in response to treatment. The criteria are described for distinguishing between active colitis, resolving colitis and ulcerative colitis in remission. Reference is also made to the development of epithelial dysplasia in patients with longstanding disease. The histological criteria for the diagnosis of Crohn's disease and the various types of infective colitis are summarised. Attention is drawn to the important condition known as "the solitary ulcer syndrome of the rectum" because this is a common condition not widely recognised by pathologists. Disorders of the mesenteric circulation can produce mucosal changes in the colon or rectum which mimick inflammatory bowel disease. The biopsy appearances are distinctive and can be distinguished from other causes of colitis. The increasing use of fibreoptic endoscopic biopsy is providing pathologists with a valuable opportunity to contribute to the differential diagnosis of colorectal disease.

Biopsy↗
PubMed1997

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells.

BACKGROUND & AIMS: Cell-mediated immunity is a feature of Crohn's disease (CD). The heterodimer interleukin (IL)-12, produced by phagocytes, induces T-cell cytokines, primarily interferon (IFN)-gamma. This study examined whether CD lamina propria mononuclear cells (LPMCs) express and release bioactive IL-12. METHODS: LPMCs were isolated from 13 patients with CD, 9 with ulcerative colitis (UC), and 13 controls. Messenger RNA for p40 and p35 IL-12 subunits was evaluated by reverse-transcription polymerase chain reaction. IL-12 was measured by enzyme-linked immunosorbent assay in LPMC culture supernatants. The INF-gamma-inducing effect of unstimulated LPMC supernatants was evaluated. RESULTS: Messenger RNA for both IL-12 subunits was detected in LPMCs of 11 of 13 patients with CD, 1 of 9 patients with UC, and 1 of 13 controls (P < 0.001). IL-12 was measured (10.5 +/- 2 pg/mL at 24 hours) in unstimulated CD LPMCs and was enhanced by pokeweed mitogen, lipopolysaccharide, and staphylococcal enterotoxin B. No IL-12 was detectable in 8 of 9 patients with UC and 12 of 13 control-unstimulated LPMCs. IL-12 induced by pokeweed mitogen and staphylococcal enterotoxin B in UC was lower than in CD and did not differ from controls. An IFN-gamma-inducing effect was restricted to unstimulated CD LPMC supernatants and was inhibited by an anti-IL-12 antibody in a dose-dependent fashion. CONCLUSIONS: IL-12 transcripts are expressed in CD intestinal tissues. CD LPMCs are up-regulated in their capability of releasing bioactive IL-12. Expression and release of bioactive IL-12 seem to differentiate CD from UC.

Blood Cells↗