Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Helicobacter”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 739 records · Page 41Linked to original sources
PubMedDate not supplied

Comparative study of modified-release clarithromycin and immediate-release clarithromycin in the treatment of Helicobacter pylori-associated peptic ulcer disease.

BACKGROUND/AIMS: Proton pump inhibitor-based triple therapy containing immediate-release clarithromycin is an important regimen for the eradication of Helicobacter pylori (H. pylori). However, the efficacy of modified-release clarithromycin for the treatment of H. pylori-associated peptic ulcer disease is still unknown. The aims of the study were to compare the efficacy of modified-release clarithromycin and immediate-release clarithromycin on the rates of ulcer healing and eradication of H. pylori. METHODOLOGY: One hundred and sixty-one patients with Helicobacter pylori-associated peptic ulcer were randomized to receive one-week triple therapy with either modified-release clarithromycin 1000mg once daily (AECMR) or immediate-release clarithromycin 500mg twice daily (AECIR) in combination with amoxicillin 1,000mg twice daily (A) and esomeprazole 40mg once daily (E). Post-treatment ulcer healing status and Helicobacter pylori status was determined by endoscopy and 13C urea-breath test at 16 weeks and 8 weeks after completion of triple therapy, respectively. RESULTS: Helicobacter pylori eradication rates were 87.5% and 87.7% for AECMR and AECIR, respectively, in the intent-to-treat analysis. Eradication rates in the per-protocol groups were 90.3% and 91.4% for AECMR and AECIR, respectively. In both the intent-to-treat and per-protocol analyses, the eradication rates were comparable in the AECMR and AECIR groups (p= 1.0 and 1.0, respectively). Ulcer healing rates in the intention-to-treat analysis were 81.3% and 77.8% for AECMR and AECIR, respectively. Ulcer healing rates in the per-protocol analysis were 90.3% and 90.0% for AECMR and AECIR groups, respectively. In both the intention-to-treat and per-protocol analyses, the ulcer healing rates were comparable in the AECMR and AECIR groups (p=0.645 and 0.584, respectively). CONCLUSIONS: Modified-release clarithromycin 1000mg once daily can be used as an alternative to immediate-release clarithromycin 500mg twice daily for the treatment of Helicobacter pylori-associated peptic ulcer disease.

Amoxicillin↗
PubMed2006

[The role of helicobacter pylori infection in carcinoma of the larynx].

INTRODUCTION: Helicobacter pylori causes different chronic infections that has been linked to the development of malignant disease of the aerodigestive tract. The larynx as a part of upper aerodigestive tract could be infected with this bacteria, mostly by gastroesophageal reflux. MATERIAL AND METHODS: In our study rapid urease tests were performed on the tissue samples of 80 patients with laryngeal squamous cell carcinoma and 34 control with benign laryngeal pathology. RESULTS: In the evaluation of 80 specimens with laryngeal cancer in 62.5% we recorded a positive urease test reaction pointing for coexisting Helicobacter pylori infection and in 37.8% of cases the negative reaction. In the control group a positive reaction was in 47.3% of cases and negative in 52.7% of cases. CONCLUSIONS: Inflammation inducted by Helicobacter pylori would cause epithelial cell proliferation and could follow to development of laryngeal cancer. Thus, laryngeal tissue can be colonized by some other agents containing a urease enzyme other than Helicobacter pylori an additional tests may be performed. In our future investigation we are trying to estimate the Helicobacter pylori infection in pathologic tissue using a polymerase chain reaction (PCR).

Biopsy↗
PubMedDate not supplied

[Isolation of helicobacter pylori in dental plaque in patients with gastritis at "Angamos" clinic].

OBJECTIVE: Detect the presence of (Helicobacter pylori) in dental plaque among patients with gastritis diagnosed by biopsy at Angamos Surquillo Hospital. MATERIALS AND METHODS TYPE OF STUDY: Analytical Observation. POPULATION: 115 patients scheduled for endoscopy at the Gastroenterological Department of said hospital. The methodology employed for the biopsy of the antrum and fundus of the stomach was by means of a gastroscope. Once the sample was collected it was processed and stained with hematoxilin-eosin for the histological diagnosis of gastritis by observation of Helicobacter pylori. Dental plaque samples were obtained by scraping the supragingival area and were transported in a conservation medium for culture of the bacteria in a selective medium and incubated in microaerophilia for 5 to 10 days;suspected colonies were stained and compared to a patron strain. Urease and oxidase tests confirmed the diagnosis. RESULTS: In total, 66 cases of gastritis associated with H.p. were found by biopsy. In 4 of these cases, H.p from dental plaque were also isolated. In another group of 49 fases of gastritis not associated with H.p., no H.p. was found in the dental plaque of 45 of these cases while H.p. was isolated from dental plaque in 4 clases. CONCLUSION: The results show a direct relation between the cases of gastritis and the finding of Helicobacter pylori in dental plaque, which would indicate a relation between the patients and the bacteria in these cases, as they act as a reservoir for said bacteria; as compared with the cases in which there is no H.p presence in gastritis without Helicobacter, except in four cases. The cases of gastritis with Helicobacter pylori and negative dental plaque are not significant, in these cases the bacteria entered with the food.

Adult↗
PubMed1990

Specific cellular immune response in patients with Helicobacter pylori infection.

The leukocyte migration inhibition test was performed in 39 patients with Helicobacter pylori infection and in 38 patients without such infection. The culture of Helicobacter pylori was used as antigen. A highly significant inhibitory effect on leukocyte migration was found in patients with Helicobacter pylori infection. The results can be taken as proof of a systemic immune response to helicobacters at the cellular level in patients with Helicobacter pylori infection.

Adult↗
PubMedDate not supplied

Are perforated gastroduodenal ulcers related to Helicobacter pylori infection?

The prevalence of Helicobacter pylori gastritis in 36 patients with a perforated ulcer undergoing endoscopy prior to or at least 2 months after perforation was 56%, intermediate between that of age and sex matched healthy blood donors (36%) who had measurement of circulating antibodies to Helicobacter pylori and of ulcer patients without perforation matched for age, sex and ulcer location (86%). In the 20 patients with Helicobacter pylori gastritis, 8 had a history of peptic ulcer and 7 of 9 patients with a follow-up of at least 12 months and no preventive treatment had a symptomatic relapse. The group of patients without infection included 6 young patients (< 40) who did not use non steroidal anti-inflammatory drugs and 10 older patients (> 60): 9 used non steroidal anti-inflammatory drugs and seven had a normal gastric mucosa on biopsy. One patient without Helicobacter pylori had a second perforation, the only relapse in this group. We conclude that patients with perforated ulcers are a heterogeneous group with a recurrent ulcer disease mainly in patients with Helicobacter pylori.

Adult↗
PubMedDate not supplied

Serological diagnosis of infection by Helicobacter pylori in chronic ulcer disease.

The authors estimated the frequency of occurrence of the infection by Helicobacter pylori in the long term gastroduodenal ulcer disease. The serological diagnosis (ELISA test) was carried out in 175 patients, suffering from this disease for at least two years, to reveal the existence of specific IgG against Helicobacter pylori. The study confirmed the frequent occurrence of infection by Helicobacter pylori in the gastro-duodenal ulcer disease of the stomach (59.2%) and the duodenum (83.7%). It was found that mainly in men the existence of specific IgG against Helicobacter pylori (in the ulcer of the stomach 63.3% and in the ulcer of the duodenum 89.9%!). The results indicate the necessity of taking into consideration the infection by Helicobacter pylori in the treatment of perennial gastro-duodenal ulcer disease.

Antibodies, Bacterial↗
PubMed1993

Serum levels of pepsinogen I and gastrin in gastric carcinoma: the influence of Helicobacter pylori infection and tumor characteristics.

The influence of Helicobacter pylori infection on serum levels of pepsinogen I and gastrin in gastric carcinoma was investigated by simultaneous determination of serum pepsinogen I, gastrin, and IgG antibodies against Helicobacter pylori in 100 patients with gastric carcinoma, and in another 100 age- and sex-matched healthy controls. Serum pepsinogen I level was significantly lower in gastric carcinoma than in controls (55.5 +/- 28.1 vs. 76.9 +/- 25.1 ng/ml, p < 0.005), but there was no difference in serum gastrin between them (63.2 +/- 30.2 vs. 57.4 +/- 28.5 pg/ml, p = 0.16). Helicobacter pylori infection caused a significant increase in serum PGI level in advanced, intestinal type, and non-cardia gastric carcinoma. The serum gastrin level was affected by neither Helicobacter pylori infection nor any of the tumor characteristics. It is concluded that pepsinogen I, rather than gastrin, in the serum is greatly influenced by Helicobacter pylori infection and tumor characteristics in gastric carcinoma.

Adult↗
PubMed1994

Helicobacter pylori: incidence and comparison of three diagnostic methods in 196 Saudi patients with dyspepsia.

One hundred and ninety-six symptomatic Saudi patients with dyspepsia underwent gastroscopy, and multiple biopsies were taken from the antrum of the stomach for identification of Helicobacter pylori. Three methods were studied for diagnosis of Helicobacter pylori, including urease test, culture and histopathology. The commonest gastroscopic findings were gastritis in 82 patients (41.84%) and duodenal ulcer in 40 patients (20.41%). Among the 196 patients, Helicobacter pylori was identified by histopathology in 145 patients (73.98%), the urease test was positive in 126 patients (64.29%), and a positive culture was obtained in 102 patients (52.04%). These results show that there is a high incidence of Helicobacter infection among Saudi patients with peptic ulcer disease or non-ulcer dyspepsia. Helicobacter pylori identification was more successful by histopathology than by the urease test or culture.

Biopsy, Needle↗
PubMedDate not supplied

Evaluation of Helicobacter pylori sensitivity to amoxycillin and metronidazole in dyspeptic patients.

We evaluated the "in vitro" sensitivity to amoxycillin and metronidazole of 193 Helicobacter pylori strains isolated from the gastric mucosa of dyspeptic patients. Susceptibility was determined by disc diffusion on agar plates. All the isolates were found to be sensitive to amoxycillin. On the contrary, 12% of the strains isolated from patients never treated for Helicobacter pylori infection and 73% of those isolated from patients who had previously received unsuccessful treatment for Helicobacter pylori infection were found to be resistant to metronidazole. Resistance was more common in women (17%) than in men (4%: p < 0.01) and was not correlated with age. The occurrence of Helicobacter pylori resistance to metronidazole is relatively common in Italy. In vitro testing of Helicobacter pylori sensitivity seems to be important before embarking on treatments aimed at eradicating the bacterium.

Adult↗
PubMedDate not supplied

Tissue staining for Helicobacter pylori in intestinal metaplasia: correlation with its extension and histochemical subtypes.

The role played by Helicobacter pylori (Hp) infection in the occurrence of non-cardial gastric adenocarcinoma is suggestive but still debated. This study aimed to evaluate: a) the prevalence of Helicobacter-like organisms in antral bioptic specimens of 291 patients with chronic gastritis with antral atrophy and different subtypes of intestinal metaplasia (IM); b) the presence of a possible different positive tissue staining for the bacteria in the complete and incomplete intestinal metaplasia. Of the 291 patients, 222 cases (76.3%) showed type I IM, 28 cases (9.6%) type II IM and 41 cases (14.1%) type III IM. Helicobacter-like organisms were found in 42.9% of cases and positive tissue staining rate appeared to be inversely related to the extension of IM (58.7% in IM extended in less than 30% of specimens, 30.2% in IM extended between 30% and 60%, 2.7% in IM exceeding 60% of the biopsed area). The inverse correlation between lower positive tissue staining for Helicobacter-like organisms and greater extension of IM was statistically significant (p < 0.001). Incomplete metaplasia appeared to be unrelated to age and associated with a lower positive tissue staining for Helicobacter-like organisms; among patients with type I metaplasia, 118/222 showed Hp-positive bioptic specimens, vs 7/69 of types II and III (p < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMedDate not supplied

Helicobacter pylori infection and gastric cancer: usefulness of screening high risk groups.

The presence of Helicobacter pylori is associated with approximately an 8 fold increase risk of developing gastric cancer. Helicobacter pylori is easy to diagnose non-invasively and effectively treated with antibiotics. More research into the natural history of Helicobacter pylori associated premalignant lesions, e.g. the reversibility of types 1 and 2 intestinal metaplasia, is necessary before a screening strategy can be developed. It also remains to be seen whether specific strains of H. pylori are associated with gastric cancer and whether differences in the host response to Helicobacter pylori infection affect the clinical outcome. When these issues are clarified it will be possible to identify individuals who are at high risk of developing gastric cancer and who will benefit from eradication. It is inevitable that asymptomatic individuals at high risk will be screened for the presence of Helicobacter pylori infection.

Female↗
PubMed1996

Helicobacter pylori from duodenal ulcer patients expresses inducible nitric oxide synthase immunoreactivity in vivo and in vitro.

Helicobacter pylori is a major pathogenic factor in gastritis, ulcer disease and gastric cancer. Helicobacter pylori associated gastritis is of complex pathogenesis which is only partially elucidated. In the present study we investigated by immunohistochemical BSA method the expression of inducible nitric oxide synthase in the gastric wall and in vitro in Helicobacter pylori. In the gastric wall nitric oxide synthase immunoreactivity was found in macrophages, in endothelial cells and in neural elements. In Helicobacter pylori nitric oxide synthase was also expressed. In conclusion, we postulate a possibility of a direct toxic effect of Helicobacter pylori to gastric epithelial cells through the nitric oxide radical.

Adult↗
PubMed1996

Value of serology (ELISA) for the diagnosis of Helicobacter pylori infection: evaluation in patients attending endoscopy and in those with fundic atrophic gastritis.

In the present study we assessed the diagnostic accuracy of four commercial IgG enzyme-linked immunosorbent assay (ELISA) kits (Autoplate, H.pylori-EIA-Well, Enzygnost, Helori-test) and evaluated the performance of these tests in patients with fundic atrophic gastritis. Serum antibodies to Helicobacter pylori were measured in 70 out-patients attending endoscopy for dyspepsia and 43 patients with non-autoimmune fundic atrophic gastritis. Using the cut-off values recommended by the manufacturers, and comparing serological findings with gastric biopsy results of dyspeptic out-patients attending endoscopy, the four kits showed a sensitivity and specificity, respectively, of 91% and 96%, for Autoplate, 67% and 100% for H.pylori-EIA-Well, 79% and 100% for Enzygnost, and 81% and 96% for Helori-test. Evaluation in patients with atrophic gastritis revealed a high prevalence of antibodies to Helicobacter pylori (84%) and it demonstrated that patients with and those without gastric colonization by this microorganism had a similar rate of seropositivity (76-84% vs 50-78%). In conclusion, our data demonstrate that: a) this assay is a reliable and valid method to detect gastric colonization by Helicobacter pylori; b) positive serum antibody associated with a negative detection of Helicobacter pylori in the gastric mucosa suggests mucosal atrophy; c) patients with fundic atrophic gastritis should be excluded from studies investigating the value of serology in diagnosing Helicobacter pylori infection.

Adult↗
PubMedDate not supplied

[Eradication of Helicobacter pylori in patients with recurrent abdominal pain using a triple drug treatment].

BACKGROUND: Different antibiotics, antagonist H2 and others have been used for elimination and/or eradication of Helicobacter pylori. AIMS: Evaluate elimination of Helicobacter pylori with amoxicillin, bismuth subsalicylate and ranitidine; and the improvement of recurrent abdominal pain. METHOD: 20 children with recurrent abdominal pain associated to gastritis and histologic identification of Helicobacter pylori were studied under a period of 18 months (January 1992 to June 1993), at Instituto Nacional de Pediatría, México, D.F. All children were treated simultaneously with: Amoxicillin, 15 days, plus ranitidine and bismuth subsalicylate for one month. RESULTS: Helicobacter pylori was eliminated in 14 of 20 children studied. All these children had an important improvement of recurrent abdominal pain. CONCLUSION: Elimination of Helicobacter pylori and clinical improvement was present in 14 of 20 children studied (70%).

Abdominal Pain↗
PubMedDate not supplied

Histological spectrum of lymphoid follicles and aggregates in Helicobacter pylori gastritis.

Seventy three patients of non ulcer dyspepsia underwent upper gastrointestinal endoscopy with biopsy from antrum and body of stomach. The tissue was stained with hematoxylin eosin and warthin starry stain. The severity of gastritis was correlated with the presence of Helicobacter pylori and lymphoid follicles and aggregates. The incidence of chronic atrophic gastritis and Helicobacter pylori were found to be 97% and 64.1% respectively. Lymphoid follicles and aggregates were seen in 32.9% of chronic atrophic gastritis. Severity of gastritis with activity correlates with Helicobacter pylori colonisation and the presence of lymphoid follicles and aggregates. We have found that there is no difference between presence of lymphoid follicles and aggregates in Helicobacter pylori positive and negative gastritis. The development of lymphoid follicles probably represents an immune response to the colonisation of gastric mucosa by Helicobacter pylori.

Adult↗
PubMed1996

[Elimination of Helicobacter pylori in patients with recurrent abdominal pain with simultaneous administration of ranitidine, bismuth subsalicylate and clarithromycin].

OBJECTIVE: Elimination of Helicobacter pylori with Chlaritromicin, Bismuth subsalicylate and Ranitidine; and improvement of recurrent abdominal pain. ANTECEDENT: Different antibiotics, antagonist H2 and others has been used for elimination and, or eradication of Helicobacter pylori. METHOD: 22 children with recurrent abdominal pain associated to gastritis and histologic identification of Helicobacter pylori were studied under a period of 18 months (january 1992 to june 1993), at Instituto Nacional de Pediatría, México, D:F: All children were treated simultaneously with: Chlaritromicin, 15 days, Plus ranitidine and bismuth subsalicylate for one month. RESULTS: Helicobacter pylori was eliminate in 14 of 22 children studied. All these children had an important improvement of recurrent abdominal pain. CONCLUSION: Elimination of Helicobacter pylori and clinical improvement was present in 14 of 22 children studied (63.7%).

Abdominal Pain↗
PubMed1997

[Five cases of peptic ulcer of gastric tube after radical esophagectomy for esophageal carcinoma and analysis of Helicobacter pylori infection at gastric tube].

The peptic ulcer of gastric tube using for esophageal reconstruction is rare. We report herein five cases of peptic ulcer of gastric tube used for esophageal reconstruction after esophagectomy for esophageal carcinoma. The reconstructive route, in all cases, was posterior mediastinum. In one case, 10 days after esophagectomy, he had high grade fever and pneumonia of right lower lobe of lung. Endoscopic examination revealed a deep ulcerative lesion on anterior wall of gastric tube and fistula formation on membranous part of trachea. The partial resection of gastric tube was performed for closing to tracheo-gastro fistula. In other four cases, the location of ulcer was middle or lower third of gastric tube. One had multiple peptic ulcer and other had single. Two cases of four underwent post irradiation therapy. One case of then, the Helicobacter infection detected using by rapid urease test and histological examination. We analyzed of Helicobacter pylori infection and serum gastrin level of gastric tube in outpatients who have used gastric tube for esophageal reconstruction after radical esophagectomy. Helicobacter pylori infection was positive at 56% (9/16) of all patients. The serum gastrin level of patients who was positive of Helicobacter pylori infection is not significantly higher than that of patients who was negative. We consider that post operative irradiation therapy and Helicobacter infection might play in development of peptic ulcer of gastric tube.

Aged↗
PubMed1997

Regression of a primary gastric MALT lymphoma with extensive antrum lesions by Helicobacter pylori eradication.

Some studies have suggested that low-grade MALT lymphoma may regress after eradication of Helicobacter pylori infection. This case report describes a Helicobacter pylori-positive patient with very extensive ulcerated polypoid lesions involving gastric antrum and prepyloric region, diagnosed by histology, pathological analysis and staging procedures as low-grade MALT lymphoma of EI1 stage. The patient received eradication therapy with a one-week course of omeprazole plus amoxicillin plus clarithromycin and was seen at follow-up after 3, 6 and 15 months. At follow-up, Helicobacter pylori eradication appeared to be in resolution of the macroscopic and histological features of the lymphoma, as confirmed by endoscopic, histological and molecular findings. Until now, only a few cases with a large gastric MALT lymphoma has successful treatment of Helicobacter pylori resulted in regression. Although additional follow-up is needed, it would appear that Helicobacter pylori infection cure may be effective also for large low-grade stage EI1 MALT lymphoma.

Aged↗