[Stress and coping with stress in the aged].
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Psychological reactions and their 'hierarchies' regarding the own health status were analysed in a sample of 81 survivors of the Bonn Longitudinal Study on Aging and in different clinical samples (patients suffering from hemophilia, renal failure, heart infarction, stroke, and schizophrenia). The longitudinal analysis of the health-related response hierarchy points to a high degree of consistency of these reactions over time. Comparing the response hierarchies of the aged sample as related to different areas of life stress (such as housing, income, family, health problems), the author finds a high degree of discriminative competence in coping with stress. The same is true for the response hierarchies of the patient groups. This high degree of situation-specific selectivity in patterns of responses to chronical disease should be studied more intensively from theoretical as well as clinical-practical points of view.
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Starting from the consideration that the assumed disturbances of the limbic system in psychiatric patients must lead, among other things, to functional autonomic disorders, the physiological reactions of previously untreated depressive and schizophrenic patients to short-lasting experimental stress situations were compared with those of healthy subjects. Whereas the plasma catecholamine levels and the autonomic functions of healthy subjects were easily foreseeable and reacted adequately to the situation, the two groups of patients showed a high degree of general unspecific activation even, eg in resting situations, associated with a relatively slight reaction to stress situations. How far these findings are of significance in the clarification of therapeutic methods in those patients exposed to increased stress is discussed.
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The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with 2 days of mild restraint and was maximal (93% less damage; p less than 0.0005) when the animal was mildly restrained for 10 days. Pretreatment with indomethacin abolished the protection afforded by chronic mild restraint, suggesting a mechanism involving endogenous prostaglandin synthesis. Chronic mild restraint significantly (p less than 0.05) reduced the injury to the gastric mucosa caused by cold-restraint stress. This model of mild restraint may prove useful in future studies on the mechanism of stress-induced and other gastric mucosal lesions.
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