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PubMed1980

William Halsted and Rudolph Matas: their unique alliance.

William Halsted and Rudolph Matas were two of the most distinguished surgeons in American medicine. Although their personalities were completely opposite, they enjoyed a long and devoted friendship. This is of historical interest in that Halsted opened his nonprofessional life to a very few other men. During their relationship a fairly continuous corresponsence was maintained. This paper will examine their friendship through an analysis of their personal letters, the majority of which have never been published. Their contents reveal a unique alliance, and provide futher information on the world of American surgery as it existed during the first part of this centrury.

General Surgery↗
PubMed1995

Frank.

In medical school we are taught that the 'proper' relationship between doctor and patient is one where the doctor remains aloof and objective. Because of the nature of general practice we often form friendships with our patients. These friendships enrich our professional lives without detracting from the doctor-patient relationship.

Family Practice↗
PubMed1997

Gender role influences on Turkish adolescents' self-identity.

This study investigated gender role influences on Turkish adolescents' self-identity process as part of the International Self-Identity Research Project. A total of 154 male and 119 female adolescents ages 14 through 17 from urban and rural areas of Turkey were surveyed through a questionnaire. The results indicated that "family" was the dominant source of belongingness for both males and females, followed by "friendships" and "school." Friendships and education were valued more by females than by males. Symbolic items (e.g., relationships, happiness) influenced females' self-identity more than they did males, while males tended to place greater importance on material items (e.g., home, TV, sports equipment). Athletic activities were highly important in males' self-validation process while females were oriented more toward the artistic and creative. General affective attributes (e.g., honesty, respect, thoughtfulness) were similarly valued by males and females as important criteria for self-evaluation. Finally, males were more religious, patriotic, and felt stronger ties to ancestors while females appeared to be more altruistic and placed high importance on social relations.

Adolescent↗
PubMed1998

Stability and continuity of child-caregiver and child-peer relationships.

We examined the relationship quality of 55 (27 girls) 9-year-old children with their mothers, teachers, and friends as rated by teachers and by the children themselves. The goal of this longitudinal study was to examine stability and continuity in the quality of children's relationships between infancy and 9 years of age. At age 9, children's perception of their relationships with their teachers was associated with their current teachers' ratings of their relationships with the children. Children's perceptions of their relationships with their mothers were consistent with earlier ratings of attachment security. Children's perceptions of their relationships with teachers were predicted by the quality of their attachment relationships with their first teachers. Children's perceptions of their friendship quality was predicted by preschool teacher ratings of friendship quality and the quality of their attachment relationships with their first teachers.

Child↗
PubMed2001

Spinocerebellar ataxia type 1 in China: molecular analysis and genotype-phenotype correlation in 5 families.

BACKGROUND: Twelve genetic types of autosomal dominant hereditary ataxia have been recently identified and the genes responsible for most of them cloned. Molecular identification of the type of ataxia is important to determine the disease prevalence and its natural history in various populations. OBJECTIVES: To perform molecular analysis of 75 Chinese families affected with spinocerebellar ataxia (SCA) and to evaluate the spectrum of mutations in these genes and the correlation between genotypes and phenotypes in Chinese patients. SETTING: Neurogenetics Unit, China-Japan Friendship Hospital, Beijing, China. METHODS: One hundred nine patients from 75 kindreds diagnosed as having autosomal dominant SCA, 16 patients with sporadic SCA or spastic paraplegia, 280 control chromosomes of the Chinese population, and 120 control chromosomes of the Sakha population were selected for this study. We conducted detailed mutational analysis by direct sequencing of polymerase chain reaction products amplified from genomic DNA. RESULTS: Spinocerebellar ataxia type 1 (SCA1) was identified in 5 families with 12 studied patients. All affected family members were heterozygous for a CAG repeat expansion in the SCA1 gene containing 51 to 64 trinucleotide repeats. Normal alleles had 26 to 35 repeats. Spinocerebellar ataxia type 1 accounted for 7% of the studied Chinese families with ataxia. In addition, we determined the frequency of a single vs double CAT interruption in 120 control chromosomes of the Siberian Sakha population, which has the highest known prevalence of SCA1, and compared this with 280 control chromosomes from the Chinese populations. The results show that 64.7% of the Siberian normal alleles contain a single CAT interruption, whereas 92% of the Chinese had more than 1 interruption. CONCLUSIONS: Spinocerebellar ataxia type 1 is responsible for 7% of affected families in the Chinese population. A correlation between the prevalence of SCA1 and the number of CAT interruptions in the trinucleotide chain suggests that a CAT-to-CAG substitution may have been the initial event contributing to the generation of expanded alleles and influencing relative prevalence of SCA1.

Adult↗
PubMed1990

Affective syndromes, psychotic features, and prognosis. II. Mania.

Fifty-six patients with mania and psychotic features and 14 with schizoaffective disorder, manic type, were followed up with biannual assessments during a 5-year period. Results were treated as they were in an analogous follow-up of patients with psychotic major depression or schizoaffective disorder, depressed type. Patients with schizoaffective mania experienced more morbidity during follow-up than did patients with psychotic mania. Among patients with schizoaffective mania, those with a chronic subtype did far worse than did the others, while the mainly schizophrenic--mainly affective distinction was not predictive. When depressed and manic groups were combined (n = 173), the following baseline variables were significant independent predictors of a sustained delusional outcome: longer duration of the index episode, temporal dissociation between psychotic features and affective symptoms, and impaired adolescent friendship pattern.

Adult↗
PubMed1998

Some psychosocial aspects of nonlethal chondrodysplasias: I. Assessment using a Life-Styles Questionnaire.

Studies concerning the psychosocial aspects of skeletal dysplasias that cause disproportionate short stature have been few and have usually involved small numbers of patients. As part of a study involving patients with chondrodysplasias and their families, an assessment battery of standardised instruments designed to measure depression, anxiety, self-esteem, personal support networks, marital adjustment, and family structure were completed by patients and, in many cases, their sibs, spouses, and/or parents. This first in a series of six papers reports the results of a Life-Styles Questionnaire which provides some insights into the levels of satisfaction with various aspects of life, including friendships, employment, the use of some substances and services, and the impact of the skeletal dysplasia on career, marriage, and childbearing. Results are presented for patients and the unaffected parents of patients. Overall, the study has shown a high level of satisfaction with many aspects of life. However, there are important differences in attitudes between the married and unmarried patients, and in some cases the unaffected parents, in a number of areas including health, overall satisfaction with life, and concerns surrounding child bearing and employment.

Adolescent↗
PubMed1996

R.D. Lawrence, H.G. Wells, G.B. Shaw: a vignette.

Among the unpublished autobiographical notes of Dr R.D. Lawrence are numerous references to his contacts and friendship with the author H.G. Wells, who was to become the first President of the (British) Diabetic Association. Wells was responsible for Lawrence being called in for consultation by George Bernard Shaw, a meeting which was to have surprising consequences.

Diabetes Mellitus↗
PubMed1996

Essential and reactive alcoholism: a review.

Methodological characteristics and substantive findings of investigations of essential and reactive alcoholics were reviewed. The data base was comprised of approximately 12 studies published between 1951-1992, most of which employed small samples of hospitalized male alcoholics. Psychometric properties of the Essential-Reactive Alcoholism Questionnaire, the instrument generally used to assess the essential-reactive dimensions, rarely were examined. The weight of the evidence suggests that essential alcoholics have earlier onset and greater severity of alcoholism, lower levels of occupational and educational achievement, more interpersonal conflict, fewer long-term friendships, more antisocial attitudes and conduct, greater density of familial alcoholism, more impaired neuropsychological functioning, and lower resting blood pressure than do reactive alcoholics. Research is needed to assess the prognostic utility of the essential-reactive typology and the degree to which the distinction may facilitate patient-treatment matching.

Alcoholism↗
PubMed1999

Social support, social adjustment, and recovery status in bulimia nervosa.

OBJECTIVE: To examine recovery status in bulimia nervosa (BN) and its relation to social support and social adjustment. METHOD: Using a cross-sectional design, we administered the modified Social Support Questionnaire and the Social Adjustment Scale-Self-Report (SAS-SR) to 40 women, each of whom was actively bulimic (ABN), was in remission from BN (RBN), or had no history of eating disturbance (comparison). RESULTS: In terms of social support, relative to RBN and comparison subjects, the ABN group had significantly fewer persons in their friendship and kinship networks available to provide emotional support, although the groups were equivalent in number of persons available to provide things and advice. Relative to the comparison group, both bulimic groups were significantly dissatisfied with the quality of emotional support provided by relatives. On the SAS-SR, women in the ABN group displayed the poorest overall social functioning. The RBN group was functioning significantly better than the ABN group, but significantly more poorly than the comparison group. DISCUSSION: Our results suggest that the social functioning of RBN women lies between ABN women and non-eating-disordered women, indicating both gains relative to the active phase and residual deficits.

Adult↗
PubMed1999

Female dominance and female social relationships among yellow baboons (Papio hamadryas cynocephalus).

Adult females in a female-bonded, cercopithecine species such as baboons are characterized by hierarchically ranked matrilines, i.e., female offspring assume rankings just beneath those of their mothers. In this system of closely ranked matrilines, a female should engage in significantly more affiliative interactions with those individuals who are closely ranked to herself than with those individuals who are more distantly ranked. We examine the hypothesis that females in this troop of feral yellow baboons (Papio hamadryas cynocephalus) who are closely ranked will also show close social affiliation. We collected focal data on 23 feral, adult female subjects (253 possible dyads) over approximately 1 year at the Tana River National Primate Reserve, Kenya. Following Bramblett's [Behav Brain Sci 4: 435, 1981] method of dominance tabulation and utilizing a modified version of Smuts' [Sex and friendship in baboons, Hawthorne: Aldine Publishing Co., 1985] preferred partner index, we describe and compare the dominance matrix and hierarchy, preferred proximity partner and grooming partner sociograms, and the social networks of these 23 focal females. Over 1,400 interactions were utilized in the dominance tabulations, 41 statistically significant proximity partner preferences were documented, and 100 grooming dyads were recorded. We examine both partners' ranks and the presence of an infant as possible factors influencing proximity and grooming partner preferences. We find that in this population there is no direct correspondence between females' ranks and their affiliation partners. Neither proximity nor grooming preferences are consistently predictable from partners' ranks. While proximity preferences were not significantly influenced by the presence of an infant, grooming partner preferences were. Females with infants had more grooming partners and were more often involved in unidirectional grooming relationships as the recipients than were females without infants. We conclude that females' dominance rankings are not good predictors of either proximity partner or grooming partner preferences and that the presence of an infant does have a significant impact on grooming partner preferences in this population.

Animals↗
PubMed1997

Social relationships in later life: a review of the research literature.

This review examines the contribution of sociological perspectives to the study of relationships in later life. Three main areas are analysed: first, the family life of older people, second, marital relationships; third, friendship in later life. The article concludes with an assessment of the changes affecting the social lives of different groups of older people.

Aged↗
PubMed2000

Electrochemical processes in electrospray ionization mass spectrometry

Editorial Comment Last month we presented, as a Special Feature, a set of five articles that constituted a Commentary on the fundamentals and mechanism of electrospray ionization (ESI). These articles produced some lively discussion among the authors on the role of electrochemistry in ESI. Six authors participated in a detailed exchange of views on this topic, the final results of which constitute this month's Special Feature. We particularly hope that younger scientists will find value in this month's Special Feature, not only for the science that it teaches but also what it reveals about the processes by which scientific conclusions are drawn. To a degree, the contributions part the curtains on these processes and show science in action. We sincerely thank the contributors to this discussion. The give and take of intellectual debate is not always easy, and to a remarkable extent this set of authors has maintained good humor and friendships, even when disagreeing strongly on substance. Graham Cooks and Richard Caprioli Copyright 2000 John Wiley & Sons, Ltd.

Journal Article↗
PubMed1993

The Save our Sisters Project. A social network strategy for reaching rural black women.

Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target population is 2600 black women 50-74 years of age residing in the county. To assist these women to obtain annual mammograms, SOS has recruited and trained 64 black women who are "natural helpers" to serve as lay health advisors. The lay health advisors reach older black women through their existing kin, friendship, and job networks. Responses from 14 focus group interviews found that when it is a matter of older black women's health concerns, women turn to certain women for social support. Responses revealed factors related to the individual woman and her social network that influence rural black women's seeking breast cancer screening. These results were applied to the Social Change model for designing the training and three network intervention strategies: (1) providing social support (information and referrals, emotional caring, and tangible assistance) through interpersonal counseling with women in their social networks; (2) working as a group, planning and implementing breast cancer control and prevention activities through community-based organizations to which advisors belong (e.g., church groups, civic groups, and social groups); and (3) establishing themselves as a non-profit, community-based SOS Association to sustain project interventions after the funding period. The SOS Community Advisory Group and the advisors developed innovative methods of recruitment, implementation, and follow-up. The community programs they have initiated are: (1) the Adopt-A-Sister Program, which assists black women who cannot afford the cost of a mammogram; (2) a committee on understanding the health care system, which assists women in negotiating regulations and using health care providers; (3) a training committee, which recruits and trains additional advisors; (4) a support group for black women with diagnoses of breast cancer; and (5) a speakers bureau, which has produced a 10-minute video, brochure, and tee-shirts as community education materials.

Black or African American↗
PubMed2006

Possible roles of consolation in captive chimpanzees (Pan troglodytes).

Empathy is a necessary prerequisite for the occurrence of consolation. The term "consolation" contains a hypothesis about function, which is distress alleviation. The present study aims to confirm the occurrence of consolation in captive chimpanzees via the post-conflict/matched-control method (PC-MC) and to suggest its possible roles. We collected 273 PC-MC pairs in the group of Pan troglodytes housed in the ZooParc de Beauval (France). We confirmed the presence of consolatory contacts (mean level of consolation, 49.5% +/- 22.3% SEM) in the colony. Consolation rates were significantly higher than reconciliation levels (mean level of reconciliation, 28.9% +/- 16.8% SEM). The level of consolation was greater in the absence of reconciliation than in the presence of it, suggesting that consolation might be an alternative behavior. As friendship and relatedness did not influence the occurrence of consolation, they did not seem to be the best prerequisites for this behavioral mechanism, at least in this chimpanzee colony. Affinitive contacts with third parties were significantly more frequent when the victim called attention to itself during severe aggressions by screaming. These high-pitched sounds seem to be useful in eliciting aid from conspecifics, as occurs in young humans. The occurrence of consolation reduced the likelihood of further attacks among group-members. From this perspective, both victims and consolers most likely gain potential advantages by interacting with each other when aggression is particularly severe, reconciliation is not immediate, and consequently social stress reaches high levels.

Animals↗
PubMed2005

Educational and social late effects of childhood cancer and related clinical, personal, and familial characteristics.

BACKGROUND: The objectives of this study were to compare educational and social outcomes for young survivors of childhood cancer with a population control group of individuals who were never diagnosed with cancer and to identify risk and protective factors for these outcomes. METHODS: In this multicenter, Canadian, retrospective cohort study, 800 survivors age 17 years or younger were matched by age and gender with a group of 923 control participants. Using a mailed survey that was completed by parents, educational outcomes were assessed with questions about the child's enrollment in disability or special-education programs, repeating a grade, and academic or other school problems. Using friendships was the measure of social outcomes. RESULTS: Based on parental reports, significantly more survivors than controls repeated a grade (21% vs. 9%), attended learning-disability (19% vs. 7%) or special-education programs (20% vs. 8%), had educational or other school problems (46% vs. 23%), had no close friends (19% vs. 8%), and were less likely to use friends as confidants (58% vs. 67%). Survivors of central nervous system (CNS) tumors reportedly were more likely than controls to have educational problems and no close friends, followed by survivors of leukemia, and survivors of neuroblastoma. Among survivors, cranial radiation increased the likelihood of having educational difficulties and having no close friends compared with survivors who did not receive cranial radiation. Survivors who reportedly had high self-esteem and whose parents had postsecondary education had fewer educational and social problems. CONCLUSIONS: Children and adolescents who survived cancer, particularly those who had CNS tumors, leukemia, and neuroblastoma, required close monitoring for early educational and social difficulties, and such children should be offered educational rehabilitation and social skills training to maximize their academic and social success.

Adolescent↗
PubMed2002

Beyond shape and weight: exploring the relationship between nonbody determinants of self-esteem and eating disorder symptoms in adolescent females.

OBJECTIVE: Recent research using the Shape and Weight-Based Self-Esteem (SAWBS) Inventory has shown that basing self-esteem on shape and weight is related to eating disorder and psychiatric symptoms. This study examined the relationship between other determinants of self-esteem assessed in the SAWBS Inventory (e.g., friendships, intimate relationships, school/work competence) and eating disorder and psychological health variables. METHOD: Female high school adolescents (N = 235) participated in this study. The relative contribution of the self-esteem dimensions to eating disorder and self-esteem was examined. RESULTS: In addition to shape and weight, basing self-esteem on intimate relationships was also related to higher eating disorder symptoms and lower body and global self-esteem. The only protective factors to emerge in this study were basing self-esteem on competence at school and other activities. DISCUSSION: Basing self-esteem on intimate relationships was associated with similar physical and health problems to basing self-esteem on shape and weight. The implications of these findings with regard to healthy adolescent development are addressed.

Adolescent↗
PubMed1983

Estimation of the daily intake of nitrates and nitrites which children one to six years old, who attend State Nurseries in the City of Havanna, may consume.

The knowledge of the amounts of nitrates and nitrites consumed by the child population is of great importance due to three fundamental aspects: Reduction of nitrates to nitrites. Relation of these to methemoglobinemia. Carcinogenicity of the N-nitroso compounds, of which nitrites are the precursors. In the present article information is given as to the estimated amounts of nitrates and nitrites, which about 10 000 children between one and six years of age, who attend State Nurseries in the City of Havanna, may consume through the daily intake of food, milk and water offered by the Centralized Kitchen "Cuba-Finland Friendship". The method of analysis used to determine nitrates and nitrites is that reported by the Mixed Committee FAO/OMS in 1976, using a reducing column containing cadmium described by FOLLET et al. in 1963. The statistical method employed is the t-Test of the comparison of media. Estimated quantities of nitrates and nitrites, which these children may consume according to the offer of food, milk and water they receive, are: 25.6 mg of NaNO3 and 1.04 mg of NaNO2 for children one to three years of age, and 36.1 mg of NaNO3 and 1.48 mg of NaNO2 for children four to six. These values lie under those recommended as admissible daily intake reported by the Mixed Committee FAO/OMS. Therefore, there does not seem to exist a risk to health through consumption of nitrates and nitrites by the population under investigation.

Animals↗