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Results for “FLUORIDE POISONING”

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At least 739 records · Page 41Linked to original sources
PubMed2006

[Contrast analysis on two air fluorine content measurement methods].

OBJECTIVE: To take the two kinds of sampling and measurement methods of air fluorine content in the endemic fluorosis area to carry on the comparison, understanding their difference and inside relation. METHODS: Sampled 22 households random on the scene in the disease area with two samplers by two methods, at the position of which, at the same time, equidistance, same highness, as close as possible, but not produce interactive effect, to collect 34 of the air sample, and then gained the results by their respective methods of laboratory analysis and statistical analysis. RESULTS: The test of significance between two methods was P > 0.05, the coefficient of correlation was r = 0.7752, the test of significance was P < 0.01, the equation of linear regression between the GB method (X) and the manual method (Y) was Y = 1.1623X + 0.0008, the test of significance of coefficient of regression was P < 0.01. CONCLUSION: Two kinds of methods had no significant differences. They preset the medium degree positive correlation and a linear regression. The air fluoride in different granularity of suspended particles was not the same. The GB method was more applicable to research of synthesis damage towards the exposing crowd in burning coal fluorine, and manual method was more applicable to research of the damage resulting from the exposing crowd in burning coal fluorine through the breath system. Generally speaking, the results of the manual method was higher than the GB method.

Air Pollutants↗
PubMed1991

[Magnetic resonance imaging of fluorosis and stress fractures due to fluoride].

Osteocondensation of the spine and stress fractures of the appendicular bones are observed under treatment with sodium fluoride or after long-term drinking of Vichy Saint-Yorre spring water. Five patients with a mean total dose of fluoride intake of 24.7 g (9-66) were studied with MR imaging. Two of them had a diffuse osteocondensation; MRI showed a low signal intensity in the vertebrae on T1 and T2-weighted images. MRI was performed in an asymptomatic patient who was being treated with sodium fluoride for 16 months; it revealed a heterogenous low signal intensity in the pelvis and femoral metaphysis. Two patients experienced stress fractures; MRI demonstrated a linear area of very low signal intensity surrounded by an area of decreased signal intensity on T1-weighted images and high signal intensity on T2-weighted images. MRI of fluorosis shows a non specific low signal intensity linked to a densifying image on the standard radiograph or an area of high technetium-99m intake on bone scan.

Aged↗
PubMed1991

[An experimental study of inhibition on lactation in fluorosis rats].

The effect of fluorosis on lactation, lactotroph function and ultrastructure were studied in lactating rats. The results were as follows: 1) Inhibition of lactation in lactating rats with chronic fluorosis was assessed by stunting growth of pups and decrease in the amount of milk suckled by pups in 30 min. Metoclopramide, a blocker of dopamine receptor, could improve lactation in these rats. 2) During chronic fluorosis serum PRL level was decreased, however, PRL content in pituitary was increased. Electronmicroscopic examination showed accumulation of large mature secretory granules and appearance of extremely large abnormal secretory granules in lactotroph cytoplasma. These findings indicate that hormone release of pituitary lactotrophs is obstructed in lactating rats with fluorosis, and the toxic effect of fluoride is mediated by an enhanced function of dopaminergic system in hypothalamus.

Animals↗
PubMed1991

[The treatment of occupational fluorosis by acupuncture reflexotherapy].

The article contains the electrodiagnostic data on 26 auricular points in 24 fluorosis-affected patients. It was established that the greatest electrical polarity asymmetry was found in points 13, 25, 28, 31, 54, 37, 39 and 40. Palpation of the auricular and corporal points also showed unfavorable conditions in the respective painful point of the organ. Basing on the results of the acupuncture procedures, needle therapies of 80 occupational fluorosis cases were performed. The therapeutic patterns elaborated by the author were also proposed, which proved perfect results at different stages of the disease.

Acupuncture Points↗
PubMed1991

Red cell membrane alterations in human chronic fluoride toxicity.

Red cells from humans exposed chronically to toxic levels of fluoride through drinking water showed significant increase in lipid peroxidation and membranous cholesterol and phospholipids. Additionally, electrophoretic patterns of ghost membrane proteins revealed the presence of a new band in the range of congruent to 66 Kd and increase in the high molecular weight protein and predominance of bands with a molecular weight of congruent to 93 Kd and congruent to 20 Kd. The activities of total, Na(+)-K(+)-, Mg(2+)- and Ca(2+)-ATPases were significantly decreased in the red cell ghosts of fluorotic patients.

Adenosine Triphosphatases↗
PubMed1991

[An experimental study of blood biochemical diagnostic indices for chronic fluorosis].

Mild and severe chronic fluorosis were produced in Wistar rats by feeding them with water containing 10 ppm and 30 ppm fluoride respectively for eight months. There were some different changes in the eighteen blood biochemical indices between mild and severe chronic fluorosis. GSH-px, K+, Ca2+, p2-, Apr and cAMP from these blood biochemical indices were chosen to set up a diagnostic function discriminant of mild and severe chronic fluorosis by the computer.

Animals↗
PubMed1990

[A study of left ventricular function of workers exposed to fluorine].

The left ventricular function of 26 workers exposed to fluorine was investigated. The results demonstrated that the LVET in the higher urine fluorine group (greater than 1.5 mg/L) was significantly shorter than the control group (P less than 0.01), the PEP was much longer than the control group (P less than 0.05), and the rate of PEP/LVET compared with the control group was increased. The difference was statistically significant (P less than 0.01). In the lower urine fluorine group (less than 1.5 mg/L) the time of LVET and PEP and the rate of PEP/LVET was not significantly different from the control group. The results showed that excessive fluorine ion in the body could cause decrease of myocardial contraction. The reason may be, that the fluorine ion inhibits the activities of certain enzymes in the body, thereby producing inhibition of ATP supply and utilization.

Adult↗
PubMed1990

[Epidemiological survey of endemic fluorosis in Xiou Shan and Bao Jing areas].

It may be affirmed that Mushan in Bao Jing county is a light fluorosis area and Yan Tian in Xiou Shan county is a middle fluorosis area with the help of following investigations: fluoride levels in inhalatable dust, food, drinking water, soil, coal, biological effects of fluoride on habitants and the burden of fluoride in the body of habitants. It is demonstrated that the cause of fluorosis is above areas is essentially the oral intake of excess fluoride through the foods, mainly maize, polluted by burning coal fly ash containing fluoride.

Air Pollution↗
PubMed1990

Histopathological changes in rabbit testes during experimental fluorosis.

The aim of the study was to evaluate relationship between infertility and the histological structure of the testes following the subcutaneous administration of different doses of sodium fluoride (5, 10, 20 and 50 mg/kg/day), for 100 days, to groups of six male albino rabbits; the six control animals were given 1 cc distilled water/kg b.w./day for the same length of time. Deficient maturation and differentiation of the spermatocytes and an increase in the amount of interstitial tissue were found in the experimental animals. In the higher dosage groups, spermatogenesis stopped and the seminiferous tubules became necrotic. The study thus established the existence of a definite relationship between fluorosis and testicular damage.

Animals↗
PubMed1990

[Early diagnosis and classification of occupational fluorosis].

On the basis of evaluating the clinical course and supplementary method of examination carried out in 132 patients suffering of professional fluorosis and in 200 workers in the premorbid state the author proposes criteria of early diagnosis. Considering Zislin's classification of professional fluorosis, literature data and own findings the author introduces 2 new criteria in the classification, namely, content of fluorine in the urine and length of work in this profession.

Air Pollutants, Occupational↗
PubMed1990

Lack of effect of fluoride on reproductive performance and development in Shetland sheepdogs.

A 10-y history of high rates of perinatal deaths and congenital anomalies in dogs in a Shetland Sheepdog kennel prompted investigations into the cause(s). Skeletal fluorosis (mottled teeth in pups, bony exostoses in adults) followed use of a commercial dog food later found to contain 460 ppm fluoride (F) from rock phosphate added as a mineral source. The effects of the water source and fluoride in dog food on female reproduction and teratogenicity were investigated in a 2-y, 2-way factorial study in the kennel. Twenty adult shelties of proven fertility were brought into the kennel and randomized into 4 treatment groups, each consisting of 4 females and 1 male. Treatments were: Group A, high F (460 ppm) dog food, well water; Group B, high F dog food, distilled water; Group C, low F (55ppm) dog food, well water; Group D, low F dog food, distilled water. Only Group C produced as many pups as expected. Overall the missed pregnancy rate (44%) in study bitches and perinatal death rate (50%) in 48 study pups paralleled the problems in shelties resident in the kennel. Higher rates for both variables in the high F and the distilled water groups seemed likely due to chance. The only major anomaly was in Group D; minor anomalies appeared in all groups. Although 460 ppm F in dog food did produce bony exostoses, we did not find convincing evidence that it adversely affected reproduction in shelties. The cause of the reproductive problems was apparently not the dog food, water, foliage, genetic factors, or infectious disease and currently remains undetermined.

Abnormalities, Drug-Induced↗
PubMed1990

Histopathological changes in rabbit ovary during experimental fluorosis.

Albino rabbits were injected sodium fluoride solutions in the concentration of 5, 10, 20 and 50 mg/kg body weight/day subcutaneously for 100 days. The control rabbits were given 1 cc of distilled water for the same period and sacrificed. The ovary was examined for histopathological changes. Animals in control and 5 mg fluoride treated groups displayed normal follicles with oocytes and interstitial tissue in ovaries. In animals treated with 10 and 20 mg fluoride, ovary exhibited congested oocytes in the follicles, necrosis of follicle cells and interstitial oedema. The degenerative changes were most pronounced in animals treated with 50 mg fluoride, in which complete atrophy of follicles along with oocyte disintegration and marked necrosis of cells accompanied by infiltration of monocytes, lymphocytes and histiocytes in interstitial tissue occurred. The data indicate that the structural alterations in the ovary were more pronounced with the concomitant increase in the dose of fluoride.

Acute Disease↗
PubMed1989

[Magnification radiography with Circlex 0.1 mm ultra-microfocus].

929 magnification radiographies of different rates of magnification were taken in 719 patients and 39 animals with the Japanese Circlex 0.1 mm ultra-microfocus tube. According to IEC 336/1982 documentation, tests on focus size, resolution, filtration effect of penumbra, filtration effect of contrast, background dispersion and space effect were done. The results showed that 0.1 mm ultra-microfocus could produce images of high quality.

Animals↗
PubMed1989

[Hazards of development of occupational fluorosis in manufacture of phosphorus-containing mineral products].

Complex studies pertaining to the production of phosphorus-containing mineral products detected no cases of occupational fluorosis among workers. The reasons for fluorosis absence in fluorine-exposed workers were analyzed. The total fluorine load was calculated in workers of the main professions. It was demonstrated that fluorine annual intake of 2-4 g corresponding to the mean-shift concentration of 1-2 mg/m3 (critical levels) required various activities aimed at prevention of occupational fluorosis.

Absenteeism↗