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[Clinico-radiometric studies of the eye in radioactive contamination].

The aim of the study was assessment of local and remote effects of radioactive substances on ocular media and development of measures to remove radionuclides from the eye. Radioactive substances getting into the eye in the form of aerosols, dust, or gaseous mixtures are unevenly distributed in it. The highest radioactivity was found on the skin of the eyelids and orbit, particularly so on the eyelashes and eyebrows, the least one on the cornea and in the conjunctival cavity. A follow-up of 8 to 17 years showed that timely removal of radionuclides from ocular surface prevented the development of specific symptoms and trophic changes of ocular media, of radiation cataracts among other things. The suggested method for washing the skin of the eyelids and orbital area from radioactive contaminants did not induce skin irritation, maceration, sense of discomfort, and is recommended for practice.

Accidents, Aviation↗

[Achromial pityriasis versicolor of the eyelid].

A 40-year-old man developed a white lesion of the eye, lid with fail of the eyelashes. The lesions are caused by Pityrosporum Orbiculare, a very common commensal of hair follicules. The hyphal forms are seen among the keratin.

Adult↗

The "pluck and sew" technique of individual hair follicle placement.

A novel and simple approach to single hair follicle transplantation for alopecia is a hair threaded on a curved needle with the follicle attached. It is the best aesthetically acceptable procedure in certain areas, namely the eyebrow, the sideburn, the hair margin, areas requiring precise grafting following face lift procedures, and the eyelash. The presented technique simplifies the precise, oriented placement of single hair grafts and has been time-tested by the senior author for the last 20 years.

Female↗

Computer-assisted corneal topography: accuracy and reproducibility of the topographic modeling system.

BACKGROUND: Assessment of the efficacy and stability of novel refractive surgery techniques and comparative studies require accurate and reproducible corneal mapping technology, ideally to +/- 0.25 D. A vertically mounted Topographic Modeling System (TMS) system was evaluated. MATERIALS AND METHODS: Six calibrated PMMA spheres (30.00, 35.00, 43.00, 50.00, 55.00, and 60.00 D) were used. Two examiners performed three measurements on each test sphere and compared appropriate data with a previously tested and calibrated digital auto-keratometer (SK-1, precision < 0.25 D). The accuracy and reproducibility of all 25 rings of the TMS were studied as a function of focus (250 to 500 microns), centering (100 to 300 microns), and integrity of the inner and outer reflected placido images to mimic tear breaks at the corneal apex and peripheral vignetting and shadows produced by eyelids and eyelashes. RESULTS: The accuracy of the 25 rings decreased from the center to the periphery. The deviation scores (mean difference of three readings between measured and calibrated surface powers) of rings 3 through 25 were 100% within +/- 0.25 D only for the 43.00-diopter sphere. They were 56%, 68%, 43%, 13%, and 17% within +/- 0.25 D respectively for the 30.00-, 35.00-, 50.00-, 55.00-, and 60.00-diopter spheres. For 500 microns of defocusing, we observed a mean deviation of 0.35 D for the flattest sphere to 2.30 D for the 60.00-diopter sphere. For the same amount of defocusing, the error produced by the TMS increased progressively with the sphere dioptric power. Masking the first four and six rings, one by one, showed topographic maps to be valid only when all four central placido images were fully read by the computer. CONCLUSIONS: The TMS clinical performance could be improved by 1) increasing focus depth of field, 2) blocking data processing when central rings are incomplete or missing, 3) increasing the accuracy over the 30.00- to 60.00-diopter range, and 4) providing the user with calibration spheres.

Artifacts↗

[AIDS and the eye].

We are observing a patient who is HIV positive since 1987 and in 1992 he got sick of AIDS. The first ophthalmologist symptom of the illness was a blurred disc margin of the optic nervehead with minor peripapillary hemorrhages and reduction of his visual acuity. After two months the condition of the fundus has improved but on the eyelash in the nasal half a Kaposi sarcoma is emerging. After six month of being sick of AIDS we are observing a reduction of visual acuity on the left eye and we diagnosed a Cytomegalic viral retinitis which is also confirmed serologically. Inspite of the treatment by Gancyclovir his condition is not improving and minor hemorrhages as well as microaneurysms are emerging also in macular area of the right eye.

AIDS-Related Opportunistic Infections↗

Treatment of dry eye by moving the lacrimal punctum to dry dock.

Several methods for occluding the lacrimal canaliculi to prevent spontaneous drainage have been described for the treatment of dry eye. These techniques have been either of short duration or irreversible. We have developed a technique in which the vertical portion of the lacrimal canaliculus is transferred anteriorly, and the lacrimal punctum is placed between the eyelashes, where it is out of the lacrimal meniscus and therefore nonfunctional. If the quantity of lacrimal secretion improves, the vertical portion of the lacrimal canaliculus may be returned to its original site, allowing normal lacrimal flow. The technique was successful in 12 puncta of seven patients with more than 5 years of follow up. The operation was easily reversed in the two puncta of one patient who complained of epiphora after lacrimal secretion had improved, allowing spontaneous tear drainage.

Dry Eye Syndromes↗

The East Asian eyelid-open technique.

Creation of a dynamic levator aponeurosis fold or double eye adds to the beauty of the East Asian. The eyes are larger and less puffy, and the eyelashes appear longer and curve up and out instead of down. The distance from the ciliary border to the eyebrow is decreased and more in proportion. The Mongolian trait is preserved.

Anthropometry↗

Keratosis follicularis spinulosa decalvans: report of a new pedigree.

Keratosis follicularis spinulosa decalvans is a rare, X-linked genodermatosis characterized by follicular hyperkeratosis, scarring alopecia of the scalp, eyebrows and eyelashes, corneal dystrophy and photophobia. We describe two cases from a large family, the first with keratosis follicularis spinulosa decalvans to be reported in the U.K.

Adult↗

Recognizing the allergic person.

Recognition of the allergic individual is facilitated by an awareness of certain characteristic actions and various facial lesions which may be clues to other allergic problems. A gaping expression, clearing of the throat and rubbing or mashing of the eyes and nose may indicate significant rhinitis. Dark circles and bags under the eyes, long, silky eyelashes and injected conjunctivas are other signs. Bruxism and malocclusion may also be related to an allergic diathesis.

Adolescent↗

[Treatment of eyelid carcinomas of 2 cmm or less by contact radiotherapy].

PURPOSE: Analysis of a series of 50 patients treated by contact x-ray for an eyelid carcinoma. METHODS: From 1980 to 1991, a series of 50 patients with 52 lesions has been included in a protocol of contact x ray for eyelid carcinoma. Median age: 69 years; male: 25; female: 25. Histological or cytological diagnosis showed: basocell carcinoma: 47; squamous cell carcinoma: 5. The site was: lower eyelid; 31, inner canther: 10; outer canther: 5; upper eyelid: 6. Stade was (UICC 1987): T1 (< or = 2 cm): 44; post excision: 8. Treatment was performed on an ambulatory basis with the PHILIPS RT 50 x-ray contact machine (50 KV - 0.5 mm A1). The diameter of the localized was 10 mm: 22; 15 or 20 mm: 30. The standard treatment delivered 42 Gy/7 fractions/4 weeks (1 or 2 fractions of 6 Gy for week). RESULTS: There was no death due to cancer. A complete response was seen 2 months after the end of treatment in 43/44 cases. A long-term local control was obtained in 47 patients. Loss of eyelash was seen in the irradiated area with a supple and no necroses of the tarsal cartilage. The irradiated skin is slightly depigmented. Stenoses of the lower lacrimal duct is unusual and was seen only if it was in the field of irradiation. No cataract was observed. The cosmetic and functional results appeared excellent in the large majority of patients. One local relapse occurred in the irradiated area and two just outside the irradiated area. These 3 relapses were salvaged, two by surgical excision and one by a subsequent irradiation. CONCLUSION: Contact x-ray is a simple technique which requires no hospitalization, neither general anesthesia. It gives excellent local control and good cosmetic results in these small eyelid carcinomas.

Adult↗

Focal facial dermal dysplasia: report of a case with associated cardiac defects.

Focal facial dermal dysplasia is characterized by congenital scar-like depressions on both temples and a wide spectrum of associated facial abnormalities. We report a 2-month-old white boy who presented with bitemporal defects, laterally deficient eyebrows, absent lower eyelashes, periorbital puffiness, a bulbous nasal tip with prominent sebaceous hyperplasia, and down-turned corners of the mouth. In addition, he had tetralogy of Fallot, an association which previously has not been described.

Abnormalities, Multiple↗

[Syphilis in an HIV-infected patient].

We report the case of a 28-year-old female prostitute, intravenous drug user, seropositive for human immunodeficiency virus and with unusual manifestations of lues infection. The presence of plantar keratoderma, alopecia of the scalp, total loss of hair eyebrows and eyelashes with bilateral chorioretinitis is emphasised. Non-treponemal and treponemal tests for syphilis showed reactivity, but with abnormal serologic expression. The possible relationship between H.I.V. infection and the natural course of syphilis is discussed.

AIDS-Related Opportunistic Infections↗

Electroconvulsive therapy and intraocular pressure.

Psychiatric patients receiving phenothiazine, tricyclic antidepressant and antiparkinsonian drugs for prolonged periods, occasionally develop mydriasis and angle closure glaucoma. Suxamethonium, usually given to modify the convulsion of electroconvulsive therapy (ECT) increases intraocular pressure (IOP) by about 7-8 mmHg, the increase being maximal and having returned to baseline 2 min and 6 mins after injection, respectively. We studied the effects on IOP of an electrically induced convulsion following induction of anesthesia using methohexitone 1 mg.kg(-1) and suxamethonium 0.5 mg.kg(-1) in 21 consecutive cooperative psychiatric patients, all receiving antipsychotropic drugs. IOP was recorded sequentially from before induction of anesthesia to after resumption of spontaneous respiration. Their mean IOP was 15.3 (SD 3.7) mmHg prior to induction of anesthesia, 13.5 (SD 3.5) mmHg after loss of eyelash reflex following injection of methohexitone, 16.1 (SD 2.4) mmHg after cessation of muscle fasciculations induced by suxamethonium, 19.2 (SD 5.6) mmHg after cessation of convulsion and 15.5 (SD 4.4) mmHg following resumption of regular spontaneous respiration. The successive stepwise changes in the mean IOP were all statistically significant (p < 0.001 each change compared with the preceding pressure; paired 't' tests). These data reveal that the reduction in IOP produced by methohexitone is reversed by the increase in IOP produced by suxamethonium. Collated with the time course of the effects of barbiturates and suxamethomium on IOP, the increase in IOP observed following the induced convulsion was not greater than that expected after suxamethonium alone, suggesting that the induced convulsion during ECT does not pose an ocular hazard to psychiatric patients receiving medications which have iatrogenic glaucomatous potential.

Adult↗

Hepatitis and bone destruction as uncommon manifestations of early syphilis. Report of a case.

We describe a patient with a painful lytic lesion of the clavicle and a granuloma of the liver in late secondary syphilis. The classic "moth-eaten" alopecia of the scalp as well as eyebrows and eyelashes suggested syphilis, although an initial false-negative VDRL test for syphilis (prozone phenomenon) caused a delay in diagnosis. Bone as well as liver involvement in early syphilis may be more common than previously recognized.

Adult↗

Wiedemann-Rautenstrauch syndrome. A case report and review of the literature.

In 1977 Rautenstrauch and Snigula reported on two sisters with a previously undescribed, progeria-like syndrome. Two years later Wiedemann described two unrelated males with the same condition. Since than only a few published cases appeared in the literature. We had the opportunity to study a boy affected by this extremely rare condition. This boy was born after intrauterine growth retardation. At birth two natal teeth were present. OFC was normal despite apparent macrocephaly. During infancy a progeroid appearance was noted with sparse hair, prominent scalp veins, greatly widened anterior fontanelles, malar hypoplasia, and generalized lipoatrophy. The face was triangular with a small maxilla and a protuding chin, the eyes were low-set, the eyebrows and eyelashes were scanty. At the age of 3.5 years there was striking general deficiency of subcutaneous fatty tissue apart from accumulation of adipose tissue on the buttocks and flanks, growth was retarded, mental development was at the low borderline of normal. Cholesterolemia was at the upper range of normal, there was an increase of triglycerides: 3.31 mmol/L (Normal < 1 mmol/L). Other progeroid syndromes such as Hutchinson-Guilford, Berardinelli-Seip, De Barsy, leprechaunism, Cockayne and Hallerman-Streiff could be excluded as well as the CDG syndrome. This condition is most probably inherited as an autosomal recessive trait.

Abnormalities, Multiple↗

[Electrolytic eye-lash epilation with the operating microscope (author's transl)].

A modified technique of epilation by electrolysis is reported. Epilation is hereby performed under the operating microscope. Contrary to the original method, with this technique the eyelash is firstly removed and then the hair canal is sounded with a fine wire under corresponding magnification. After the circuit is closed, white foam is formed and subsequently the hair papilla and the hair follicle are destroyed. The technique has several advantages compared to the original method: 1. It is relatively harmless to tissue. 2. Larger areas of abberant cilia may be epilated in one session as confluent necroses do not occur. 3. The risk of cilia again growing is reduced as the hair follicle and hair papilla are destroyed with high certainty.

Electrolysis↗

Clinical ocular study in leprosy patients at a sanitary dermatological hospital in Brazil.

This study is based upon the observation f 363 leprosy patients having different types of the disease. At the time of the examination, we did not have any previous knowledge about the type of leprosy the patients were having. Thus, the eye examination was done without the knowledge of clinical diagnosis. The ocular examination protocol covered the following: visual activity, facial muscle function, eyebrows, eyelashes, lacrimal system, pupil, eye motility, corneal sensitivity, Schirmir's test and study of the anterior segment of the ocular bulb with a slit-lamp. The study patients included 275 cases of lepromatous leprosy, 57 tuberculoid, 29 indeterminate and two dimorphous cases. The age of the patients ranged between 18 and 82 years, and 229 of them were males. Among those patients, 183 were whites, 23 were black and 157 were mulatto.

Adolescent↗

Rapp-Hodgkin syndrome with palmoplantar keratoderma, glossy tongue, congenital absence of lingual frenum and of sublingual caruncles: newly recognized findings.

We report on a boy with Rapp-Hodgkin syndrome (RHS) or Rapp-Hodgkin ectodermal dysplasia. He had sparse, wiry, slow growing and uncombable hair, but no pili torti or pili canaliculi characteristic of RHS. He also had sparse eyelashes and eyebrows, and obstructed lacrimal puncta and epiphora. Bilateral bony external auditory canal stenosis led to hearing loss. The mouth was small with repaired bilateral cleft lip and palate. Oral manifestations included hypodontia, microdontia, unerupted mandibular premolars with well formed roots, large dental pulp spaces, enamel hypoplasia, multiple caries, glossy tongue, and congenital absence of lingual frenum and of sublingual caruncles including submandibular and sublingual salivary duct openings. Palmo-plantar keratoderma, unerupted premolars, congenital absence of lingual frenum, sublingual caruncles, glossy tongue, and pili canaliculi seen in the patient are newly recognized findings of this syndrome. Overlapping findings of RHS ectrodactyly-ectodermal dysplasia-clefting syndrome (EEC), and ankyloblepharon-ectodermal defects-cleft lip and palate syndrome (AEC) are discussed.

Carbuncle↗