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Hormonal enhancement of technetium-99m pertechnetate uptake in experimental Meckel's diverticulum.

A canine model simulating Meckel's diverticulum was used to evaluate the effects of pentagastrin, glucagon, and a combination of the two hormones on the gastrointestinal localization of 99mTc. Pentagastrin produced accelerated uptake of the radionuclide in both the stomach and the ectopic gastric mucosa but resulted in early visualization of the duodenum and a "washout" effect on the radioisotope within the Meckel's diverticulum. Glucagon provided prolonged retention of the radionuclide in the stomach and ectopic mucosa and prevented duodenal visualization. A combination of both hormones produced increased activity in the stomach and experimental Meckel's and decreased duodenal filling. This enhanced target to background contrast and provided improved visualization of the ectopic gastric mucosa.

Animals↗

Congenital diverticulum of the left ventricle.

A case of a 7-mo old male infant with a diverticulum of the left ventricle is reported. The diverticulum has been successfully resected and the defect of the diaphragm closed. Repair of the associated huge ventral hernia has been postponed to be done in stages.

Diverticulum↗

Hemoperitoneum from perforated Meckel's diverticulum.

Approximately 4% of patients with Meckel's diverticulum will experience complication, the most common of which are intestinal obstruction, gastrointestinal bleeding, acute inflammation, and perforation. We report an extremely rare complication of perforated Meckel's diverticulum which presented as hemoperitoneum.

Child↗

A case of split notochord syndrome: presence of dorsal enteric diverticulum adjacent to the dorsal enteric fistula.

Like umblical enteric remnants (eg, umblical sinus and omphalomesenteric fistula), enteric remnants can be seen on the dorsal aspect of the body (dorsal enteric sinus, dorsal enteric fistula IDEF], dorsal enteric diverticulum) in conjunction with complete cleft of the vertebral column. Complete cleft of the vertebral column associated with gastrointestinal tract and central nervous system anomalies is known as "split notochord syndrome" (SNS). The authors present an unreported variant of SNS having dorsal enteric diverticulum adjacent to the DEF. The patient died 17 days after surgical repair.

Abnormalities, Multiple↗

Endoscopic treatment of tracheal diverticulum after primary repair of esophageal atresia and tracheoesophageal fistula.

Two cases of recurrent and persistent respiratory symptoms after primary repair of esophageal atresia and tracheoesophageal fistula are described. The diagnostic workup included barium swallow examination, radionuclide study for gastroesophageal reflux, and bronchoscopy. The tracheal diverticulum was detected on bronchoscopy. Treatment consisted of endoscopic cauterization of the mucosa of the diverticulum and its orifice using electrocoagulation in case 1 and the Nd:YAG laser in case 2. Electrocoagulation produced tracheal edema, which caused severe respiratory distress necessitating temporary tracheostomy. Cauterization with the Nd:YAG laser was safe, effective, and uncomplicated.

Bronchoscopy↗

Bronchogastric fistula, pulmonary sequestration, malrotation of the intestine, and Meckel's diverticulum--a new association.

Two female children, each who had a bronchogastric fistula and pulmonary sequestration (communicating bronchopulmonary foregut malformation, CBPFM) and associated malrotation of the intestine and Meckel's diverticulum are presented. Each child also presented with severe gastroesophageal reflux. The association of malrotation of the intestine and Meckel's diverticulum with a CBPFM never has been reported as a distinct entity. The concept of association of anomalies is discussed briefly.

Abnormalities, Multiple↗

Experience with the management of urethral diverticulum in 63 women.

The presentation and management are reviewed of 63 women with urethral diverticulum seen at a single institution in 10 years. Of the women 36 (61.9%) had urinary incontinence as a presenting symptom and 20 (31.7%) had incontinence as the only presenting complaint. Diverticula were suspected in 57 cases (90.5%) based on the presence of a periurethral mass during pelvic examination. Investigations included voiding cystourethrogram, excretory urogram, urodynamic studies and recently transvaginal ultrasound. Voiding cystourethrography adequately demonstrated the diverticulum in 60 of the 63 women (95.2%). Urodynamic studies performed in 58 women revealed abnormal findings in 36 (62%), including genuine stress urinary incontinence in 28 (48.3%). The location/number/size/configuration, communication, continence classification was used to define the characteristics of the diverticula. Seven women either refused operation or had small asymptomatic diverticula not requiring treatment. Transvaginal diverticulectomy was performed using a 3-layer closure in 56 women. Concomitant bladder neck suspension was performed in 27 women with documented stress urinary incontinence and/or urethral hypermobility. With a mean followup of 70 months (range 6 to 136) 48 women (85.7%) were completely relieved of the presenting complaint. Complications of diverticulectomy included 2 small distal recurrent diverticula, 1 urethrovaginal fistula and 6 transient early urinary tract infections. None of the women had urethral stricture or recurrent urinary tract infection. Six women (22.2%) who underwent diverticulectomy and bladder neck suspension, and 3 (10.3%) treated with diverticulectomy alone had minimal urinary incontinence requiring less than 2 pads a day.

Adult↗

Spontaneous rupture of a bladder diverticulum: ultrasonographic diagnosis.

We report a rare case of spontaneous rupture of a large bladder diverticulum that was diagnosed accurately and promptly using abdominal ultrasonography. Instillation of saline and air into the bladder on ultrasonography demonstrated jetting from the wall of the bladder diverticulum. We recommend this useful imaging technique, which can be performed easily in the emergency room, in all suspected cases of bladder rupture.

Aged↗

Pubovaginal sling for treatment of female stress urinary incontinence complicated by urethral diverticulum.

To evaluate the practicality of combining urethral diverticulectomy with a procedure for stress urinary incontinence, the records of 14 patients who underwent urethrodiverticulectomy during a 3-year period were reviewed. Noteworthy was that 10 patients (71%) had urinary incontinence as the chief complaint, while 8 (57%) had symptoms of stress urinary incontinence and underwent fluoroscopic urodynamic testing and the others had post-void dribbling. Of the latter 8 patients 7 (50%) demonstrated type II or type III stress urinary incontinence and 1 had a normal study. The 7 women then underwent transvaginal diverticulectomy with a concomitant pubovaginal sling. Of the diverticula 4 (57%) were true diverticula and 3 (43%) appeared to be pseudodiverticula or traction diverticula related to a previous urethral suspension. At 3 to 21 months (mean 17) all patients were cured of stress urinary incontinence. One patient exhibited detrusor instability postoperatively, which was ultimately treated with an Ingelman-Sundberg procedure. Postoperatively, 1 diverticulum recurred, for a recurrence rate of 14%. We conclude that the presence of a urethral diverticulum does not compromise successful repair of associated stress urinary incontinence when the pubovaginal sling procedure is used.

Adult↗

Diverticulum of the female urethral roof managed endoscopically.

We report a rare case of a diverticulum located along and draining into the roof of the urethra in a woman. This diverticulum was managed successfully endoscopically with a pediatric resectoscope. The pathophysiology of this unusual lesion is discussed, as is the rationale for endoscopic management.

Diverticulum↗

Urethral diverticulum in male subjects: report of 5 cases.

We present 5 cases of urethral diverticulum in male subjects, of which 2 were congenital and 3 were acquired. Of these diverticula 4 were in the anterior urethra, while 1 was in the posterior urethra. One congenital diverticulum contained multiple calculi.

Adolescent↗

Giant urethral diverticulum after free full thickness skin graft urethroplasty.

A case of a giant urethral diverticulum, developing as a complication of a free skin graft urethroplasty 2 years previously, is reported. The incidence of diverticulum formation in reported series of free skin graft urethroplasty is small. The degree of dilatation present in this case has not been reported in the recent literature and its management is discussed.

Aged↗

Acquired male urethral diverticulum.

Four cases of acquired urethral diverticula in male subjects are reviewed. All patients presented with complications such as urinary tract infection, urethral fistulas and stone or sequestrum formation in the diverticulum. The recommended treatment is excision of the diverticulum and repair of the urethra. The relevant literature has been reviewed.

Adolescent↗

The clinical significance of renal caliceal diverticulum in children: relation to vesicoureteral reflux.

Of 250 children with vesicoureteral reflux, 23 had a renal caliceal diverticulum in one or both kidneys. In a third of these 23 children this was the only renal change noted and in the remaining two-thirds other changes of chronic pyelonephritis were seen. The presence of a caliceal diverticulum is evidence that renal damage of some degree is associated with reflux and urinary tract infection, and should be added to existing criteria for investigation of reflux in a child.

Adult↗

Anterior urethral diverticulum in the female: diagnosis and surgical approach.

BACKGROUND: Despite an incidence of 3-40% in different populations, a diagnosis of urethral diverticulum in female patients is often delayed or missed. CASE: A 49-year-old multiparous woman presented complaining of severe, refractory urinary urgency and frequency and urge incontinence, in addition to dysuria and pelvic pain for several years. The diagnosis of an anterior urethral diverticulum was made based on findings at magnetic resonance imaging. Surgical management was accomplished vaginally without significant urethral disruption. At 5 months postoperatively, the patient was markedly improved. CONCLUSION: Lower urinary tract pathology can create a diagnostic and surgical dilemma, which necessitates a thorough evaluation and careful management to achieve a satisfactory outcome.

Diverticulum↗

Clear cell adenocarcinoma of the urinary bladder within a diverticulum.

A rare case of clear cell adenocarcinoma within a bladder diverticulum is presented. A 69-year-old man presented to our institution with gross hematuria. Workup, including computed tomography and cystoscopy, revealed a papillary bladder mass within a bladder diverticulum near the right ureteral orifice. Biopsy of the tumor was performed, and the pathologic examination revealed clear cell adenocarcinoma. He underwent bladder diverticulectomy and remained disease free at 1 year of follow-up. The clinicopathologic characteristics of this entity compared with its most difficult pathologic differential diagnosis, nephrogenic adenoma, are reviewed.

Adenocarcinoma, Clear Cell↗

Carcinosarcoma in a bladder diverticulum.

A 47-year-old man presented with hematuria and dysuria. He was found to have a carcinosarcoma originating from a bladder diverticulum. He underwent a partial cystectomy and received postoperative chemotherapy. One year later, he presented with a large local recurrence and died shortly afterward. We believe this to be the second case of a carcinosarcoma originating in a bladder diverticulum.

Carcinosarcoma↗