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PubMed1992

Computer program for planning and evaluating microplate experiments.

A microcomputer program is described for planning and statistically evaluating microplate and other similar experiments. This program is written in BASIC and can be run on any PC XT/AT compatible computer under DOS. The first part of the program writes the protocol of the experiment into a disk file and sends it to a printer and also prints specifications for the addition of ingredients. The second part of the program calculates means and standard deviations of the values measured for all groups of samples. It is also possible for the program to calculate activation coefficients, coefficients of modulation and percentages of suppression for special groups. Inputting the required data can be performed manually from the keyboard or automatically from disk files.

Data Interpretation, Statistical↗
PubMed2000

[Promoting reading and spelling in children with computer programs].

OBJECTIVES AND METHODS: Sixteen students trained their reading and spelling skills with the computer programmes Budenberg 1 and 2 and the Comles Package for 1000 minutes over a one-month period. RESULTS: Following one month of computer training, reading test scores had improved for seven of the 16, and spelling test scores for three children whose basic performance had been poor. Three and a half months of school instruction later, the reading test scores had improved for nine children, while there was no effect upon the spelling scores for most of the students.

Child↗
PubMed2004

[Drug interaction computer programs: which choice?].

Adverse drug reactions represent a partly preventable cause of morbidity. Computer-based tools may be useful for the prevention of those events resulting from drug interactions. While several such tools are currently available to practitioners, they have rarely been compared regarding their performances and limits. This article presents a benchmark evaluation of seven drug interaction databases which may be elected by physicians or pharmacists as an aid to prescription on a regular basis. None of the databases tested appears to be perfect, and the systems vary in their overall completeness and ease of use.

Adverse Drug Reaction Reporting Systems↗
PubMed1995

A computer program to determine a protein sequence from an amino acid analysis.

We have developed a computational method for analyzing the proteolytic products of a protein, knowing its sequence and the amino acid percentages of its products. For all fragments, amino acid percentages are calculated and compared to the experimental results (calculating the error within the experiment). The program keeps the best fitted fragment using a least squared method. This program was written to determine the sequence of the proteolytic products that appeared during the purification of annexin I domain 2. The reliability of the method was verified in this case. However the latter depends on the length and on the amino acid composition of the entire protein and of its fragments. This program may be suitable for analyzing the sequence of the products in any protease digestion, whether designed or accidental.

Amino Acid Sequence↗
PubMed2001

MicroMeasure: a new computer program for the collection and analysis of cytogenetic data.

The ability to identify individual chromosomes in cytological preparations is an essential component of many investigations. While several computer software applications have been used to facilitate such quantitative karyotype analysis, most of these programs are limited by design for specific types of analyses, or can be used only with specific hardware configurations. MicroMeasure is a new image analysis application that may be used to collect data for a wide variety of chromosomal parameters from electronically captured or scanned images. Unlike similar applications, MicroMeasure may be individually configured by the end user to suit a wide variety of research needs. This program can be used with most common personal computers, and requires no unusual or specific hardware. MicroMeasure is made available to the research community without cost by the Department of Biology at Colorado State University via the World Wide Web at http://www.biology.colostate.edu/MicroMeasure.

Chromosome Banding↗
PubMed1990

GLUCOPAGE: a computer program for managing diabetic pregnancy.

The microcomputer is an invaluable aid in the management of diabetes mellitus because of its ability to manipulate, summarise, and produce graphical displays from blood glucose data in such a way that new trends, or the effects of changes in therapy, are more readily apparent to the clinician. Currently available software however, while adequate for most purposes, has not been written to cope with the unique problems presented by diabetic pregnancy in which large amounts of data are generated over short periods of time, insulin requirements may change rapidly, and blood glucose control must be extremely tight. We have produced a new program, GLUCOPAGE, specifically for use in the management of diabetic pregnancy. GLUCOPAGE operates in conjunction with the Ames Memory Glucometer, from which it can download data either directly or telemetrically via a modern into the host IBM PC or compatible microcomputer. Large amounts of data can be summarised in various tabular and graphical formats on screen or in printed form. A single A4-size printout, the Glucopage, provides tabular and graphical summaries of a full week's blood glucose data. Copies of the Glucopage may conveniently be filed in the case notes, given to the patient or distributed to other medical staff.

Blood Glucose Self-Monitoring↗
PubMed1984

Extension of a flexible computer program for handling DNA sequence data.

Our previously (Nucl. Acids Res. 10, 229 (1982] described program is largely extended. Maintaining the program architecture we are now able to present the same program with a highly increased comfort. The number of nucleotides per line is variable and the option for calculating restriction enzyme fragments is included. A four digit code guides through the program. The program is selfdefining and may be used without any prior computer experience. Copies are available on request.

Base Sequence↗
PubMed1977

[Computer programming for radiocardiography and radiocyclography].

Digital radiocardiography with linear programming, on the ALGOL language, by means of an ODRA-1204 computer is described. Determination of cardiac dynamical parameters of patients in rest and under load was carried out. Radioisotopic methods were combined with conventional cardiologic examinations, particularly the microcatheterization.

Computers↗
PubMed1990

Computer program for the reservoir model of metabolic crossroads.

A program containing 344 sentences, written in BASIC and adapted to run in personal computers (PC) has been developed to simulate the reservoir model of metabolic crossroads. The program draws the holes of the reservoir with shapes reflecting the Vmax, Km (S0.5) and cooperativity coefficients (n) of the enzymes and calculates both the actual velocities and the percentage of contribution of every enzyme to the overall removal of their common substrate.

Computer Simulation↗
PubMed2000

Ethics in the classroom: a reflection on integrating ethical discussions in an introductory course in computer programming.

In this paper, we describe our recent approaches to introducing students in a beginning computer science class to the study of ethical issues related to computer science and technology. This consists of three components: lectures on ethics and technology, in-class discussion of ethical scenarios, and a reflective paper on a topic related to ethics or the impact of technology on society. We give both student reactions to these aspects, and instructor perspective on the difficulties and benefits in exposing students to these ideas.

California↗
PubMed1992

A computer program (DCN) for numerical convolution and deconvolution of pharmacokinetic functions.

A program adapted for use on microcomputers (DCN) has been developed which permits one to perform operations of numerical convolution and deconvolution using polyexponential functions, that are often implemented in pharmacokinetic analysis. The program is written in Microsoft GWBASIC and can be used in personal computers with no modification. The user supplies information relating to the coefficients and exponentials defining the polyexponential equation of the response and weighting functions and the program performs the deconvolution operation by numerical integration using trapezoidal rule and provides numerical and graphic information concerning the input function. The program can be applied to the deconvolution of many linear pharmacokinetic systems and allows one to solve problems related to drug release, absorption, distribution, as well as others. Additionally, the program is able to perform the convolution operation if information about the input and weighting functions and is also able to simulate pharmacokinetic processes. The efficacy of the program was evaluated by comparison with several deconvolution algorithms, in particular that proposed by Veng-Pedersen and Iga.

Algorithms↗