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PubMed1995

Tomographic (pQCT) and biomechanical effects of hPTH(1-38) on chronically immobilized or overloaded rat femurs.

Six-month old rats chronically submitted to right hindlimb immobilization (IM) with mechanical overload (OL) of the left leg were treated 1 month later with 200 micrograms/kg/d of hPTH(1-38) for 15 or 75 days. Peripheral quantitative computed tomography (pQCT) scans and bending tests showed that hPTH increased cortical mass and volumetric BMD (vCtBMD) in both legs. However, elastic modulus of cortical bone and diaphyseal load-bearing capacity were improved only in OL bones. Improvement of diaphyseal strength was attributable to that of cortical bone quality, yet a stronger mechanostatic response of cortical modeling to bone material quality was also observed in treated OL bones. Data support hPTH(1-38) use for improving cortical bone mass and strength and point out a physical activity interaction with therapeutic results.

Analysis of Variance↗
PubMed1995

Perspectives of pQCT technology associated to biomechanical studies in skeletal research employing rat models.

Assessment of bone material quality and architectural indicators by means of peripheral quantitative computed tomography (pQCT) offers a wide perspective for skeletal research employing noninvasive procedures. Some mechanically-validated examples of these pQCT applications in animal models are described. They concern (a) the analysis of bone mechanostatical interrelationships as shown by experimental "distribution/quality" curves, and (b) the noninvasive determination of bone strength. An attractive attempt to extrapolate the latter to human bone studies is also discussed.

Absorptiometry, Photon↗
PubMed1996

Mechanical validation of a tomographic (pQCT) index for noninvasive estimation of rat femur bending strength.

Cross-sectional moment of inertia (CSMI) and volumetric cortical bone mineral density (vCtBMD) were assessed by peripheral quantitative computed tomography (pQCT) at femur midshafts from 103 Wistar female rats receiving 0 (n = 12) or 15-1000 mu g/kg/day sc of dexamethasone (n = 46) from 5 to 9 weeks of age, or 0 or 80 mg/kg 3/wk of AI(OH)(3) IP (n = 23,22) from 4 to 10 months of age. A bone strength index (BSI), calculated as the product CSMI x vCtBMD, was found to closely correlate (r = 0.94, R(2) = 0.89, p < 0.001) with the actual, mechanically tested bending breaking force of all bones. Correlation and determination coefficients obtained were higher than those usually reported employing different long-bone strength predictive formulae. The curve approached the origin and was linear throughout the wide range of CSMI, vCtBMD and BSI achieved because of age- and treatment-induced differences, showing a very low standard error of the estimate. Instead, different curve slopes and/or intercepts were found in separate analysis between data from each of the experiments when breaking force was correlated with CSMI or vCtBMD alone, or with the DEXA-assessed BMD of the mechanically assayed bone portion. Results suggest that noninvasive assessment of the BSI by means of pQCT technology provides an original tool for a precise and accurate estimation of long-bone bending strength that can be advantageously applied in crosssectional as well as longitudinal, in vivo studies employing animal models.

Analysis of Variance↗
PubMed2005

3D elastic registration of vessel structures from IVUS data on biplane angiography.

RATIONALE AND OBJECTIVES: Planar angiograms and intravascular ultrasound (IVUS) imaging provide important insight for the evaluation of atherosclerotic diseases and blood flow abnormalities. The construction of realistic three-dimensional models is essential to efficiently follow the progression of arterial plaque. This requires an explicit localization of IVUS frames from angiograms. Because of the difficulties encountered when trying to track the position of an IVUS transducer, we propose an elastic registration approach that relies on a virtual catheter path. MATERIALS AND METHODS: Deformable surface models of the lumen and external wall are constructed from segmented IVUS contours. A crude registration is obtained using a three-dimensional vessel centerline, reconstructed from two calibrated angiograms. Robust optimization of the virtual catheter path, position, absolute orientation, and regulation of the external wall shape is performed until near-perfect alignment of the back-projected silhouettes on image edges is reached. RESULTS: Visual assessment of the reconstructed vessels showed a good superposition of virtual models on the angiograms. We measured a 0.4-mm residual error value. A preliminary study of convergence properties on 15 datasets showed that initial absolute orientation may affect the solution. However, for follow-ups, coherent solutions were found among datasets. CONCLUSION: The advantages of the virtual catheter path approach are demonstrated. Future work will look at ways to single out the true solution with a better use of the available information in both modalities and additional validation studies on improved datasets.

Algorithms↗
PubMed2006

Comparing electronic-keypad responses to paper-and-pencil questionnaires in group assessments of alcohol consumption and related attitudes.

Electronic versions of questionnaires have the potential to improve research and interventions in the addictions. Administering questionnaires electronically to groups, however, has proven difficult without a multitude of computers, but gathering data electronically from a group could make for easy assessment and quick feedback. Using a sample of 107 college students, we examined the validity of wireless keypad survey responses by comparing them to traditional paper-and-pencil questionnaires. The two formats led to almost identical responses that did not differ significantly from each other (all effect sizes less than g=.15) and high correlations between formats. The wireless, handheld keypad procedure appears to generate data that are as valid as questionnaire responses and permit rapid feedback to groups, as well as easy, human error-free data entry for analysis.

Adult↗
PubMedDate not supplied

Spine bone mineral density and vertebral body height are altered by alcohol consumption in growing male and female rats.

Alcohol, consumed for extended periods by growing male and female rats, impairs osteogenesis and reduces bone size and mass. The skeletal sites of experimental animals commonly chosen for an evaluation of bone mechanical characteristics and architectural properties, bone matrix gene expression, tissue concentrations of growth factors, and bone mineral density (BMD) have been the tibiae and femora. Far less attention has been focused on the spine and the effects of alcohol on vertebral BMD and vertebral body height. Fifteen male and 15 female Sprague-Dawley rats (aged 30 days) were divided into three groups: an alcohol-fed group, matched to a pair-fed non-alcohol isocaloric-fed control group with animals of the same sex, and an ad libitum-fed control group. Alcohol-fed animals received a Lieber-DeCarli liquid diet containing 36% of caloric intake as alcohol; isocaloric pair-fed rats received the same diet without alcohol. After 45 days of feeding, the lumbar spine was removed. The fourth lumbar vertebra from each spine was dissected, and the vertebral body height was measured. Lumbar vertebral body height was significantly reduced by alcohol consumption in both male and female rats compared with findings for either control group. Cancellous and cortical BMD of the vertebral body was determined by peripheral quantitative computed tomography (pQCT). Male and female rats (aged 75 days) in the ad libitum-fed group had similar vertebral body cortical and cancellous BMD, with cortical BMD being greater than cancellous BMD. Lumbar vertebral body cancellous and cortical BMD declined for both male and female rats in response to alcohol consumption for 45 days compared with findings for either control group. More BMD loss occurred from cancellous than from cortical bone in both sexes after chronic alcohol consumption. Chronic alcohol consumption by growing rats results in vertebral growth reduction and vertebral osteopenia.

Alcohol Drinking↗
PubMed2006

A novel mouse model for the study of the inhibitory effects of chronic ethanol exposure on direct bone formation.

Excessive alcohol consumption has been reported to interfere with human bone homeostasis and repair in multiple ways. Previous studies have demonstrated that chronic ethanol exposure in the rat via an intragastric dietary delivery system inhibits direct bone formation during distraction osteogenesis (DO, limb lengthening). The opportunity to extend the rat ethanol studies to mice is now possible due to the development of mouse models of DO. This study employed a novel combination of liquid ethanol diet delivery and a murine DO model to test the hypothesis that chronic ethanol exposure would result in deficits in direct bone formation during DO in contrast to the pair-fed controls. Twenty-eight 12-month-old C57BL/6 male mice were acclimated to the Lieber-DeCarli liquid control diet #710027 (Dyets Inc.) over a 1-week period. The mice were separated into two diet groups (n=14/group): pair-fed control and ethanol (diet #710260). After being on diet for 82 days, all mice underwent placement of an external fixator and osteotomy on the left tibia. Following a 6-day latency period, distraction began at a rate of 0.075 mm twice a day (b.i.d.) for 14 days. The weight changes were equivalent for both groups. The hypothesis that chronic ethanol exposure would inhibit direct bone formation and produce skeletal toxicity was supported by radiographic (P=.011) and histologic (P=.002) analyses of the % new bone formation in the DO gaps, by peripheral quantitative computed tomography analysis of the total volumetric bone mineral density of the contralateral proximal tibias (P<.001) and contralateral femoral necks (P=.012), by three-point bending on the contralateral tibias (P<.001 energy to break), by pin site bone formation measures (P<.001), and by ethanol-associated increased adipocyte area (adjacent to the gap) percentages (P<.002). We conclude that this model can be used to study the mechanisms underlying inhibition of bone formation by chronic ethanol exposure and to test preclinical interventions.

Absorptiometry, Photon↗
PubMed2003

Development of non-keyboard input device checklists through assessments.

An assessment of non-keyboard input devices (NKID) was conducted to identify factors for good design in relation to operation, performance and comfort. Twenty-seven NKID users, working in health and safety, evaluated eight devices that included mice, trackballs and a joystick mouse. The factors considered important for good design were: (1) comfortable hand and finger position, (2) adequate control, (3) intuitive and easy to use, (4) ease of device, button and trackball movement, (5) good interaction with software, (6) provision of suitable accessories. Mice were rated more favourably than trackballs or the joystick mouse. The design of the standard 2-button mouse (D4) was considered most desirable to use; the 3-button mouse (D1) and 3-button curved mouse (D8) were also favoured. Assessment data and comments were drawn together with previously published research to produce useful tools for NKID purchasing (i.e. Device Purchasing Checklist) and assessment (i.e. Device Assessment Checklist).

Adult↗
PubMed2004

Left-handed versus right-handed computer mouse use: effect on upper-extremity posture.

Alternatives to reduce postural constraints have to be sought in order to reduce musculoskeletal complaints related to computer work. This study aimed at documenting the impact of using the mouse on the left side of a standard keyboard (with a right numeric keypad) on upper-extremity posture. A simulated computer task was performed by 27 subjects in a laboratory before and 1 month after ergonomics training. Shoulder flexion and abduction, as well as wrist extension were reduced with left-handed mouse use. Sixteen of the 27 subjects truly converted to using the mouse with the left hand. After a month of using the mouse with the left hand, the time required to perform the same task reduced, the perceived difficulty and discomfort improved, though the time to perform the task was still longer than when using the mouse with the right hand. For work involving both keyboard and mouse use, and without the need of the numeric keypad, it would probably be preferable to use a keyboard without the numeric keypad if the mouse is to be used on the right-hand side. If such keyboards are unavailable, an interesting alternative would be to use the mouse on the left side provided sufficient time is allowed to get accustomed to it.

Adult↗
PubMed2005

Developing an observational instrument to evaluate personal computer keyboarding style.

While computer use is considered to be a risk factor for musculoskeletal disorders of the upper extremity (MSD-UE), there is currently little information on how the fingers, hand and thumb are used during keyboarding, and no means to document their postures and motions. A computer keyboarding observational instrument, termed the Personal Computer Keyboarding Style (PeCKS), is being developed to meet this need. The goal of this paper is to describe the process by which the PeCKS was developed. Literature on MSD-UE was reviewed and discussions were held with content experts to develop criterion-based items considered to be potential risk factors for MSD-UE during keyboard use. These items were systematically reviewed and rated by seven experts using the Delphi technique. These ratings were used to determine which items to retain and which to discard, resulting in 19 items to define keyboarding style. The PeCKS, when further psychometric testing is completed, will be useful to document and assess keyboarding to identify those individuals who may be at risk for MSD-UE.

Computer Peripherals↗
PubMed2006

Effects of a vertical keyboard design on typing performance, user comfort and muscle tension.

To circumvent the awkward pronated hand position inherent to conventional horizontal keyboards, a vertical, split keyboard was designed with flexible cushions supporting the wrists, allowing relaxed hand and arm postures. During eight twice-weekly 30-min training sessions, the performance and subjective comfort of nine experienced typists were tested. Typing speed and error percentage, and surface electromyographic activity of six forearm muscles and two postural muscles were recorded in separate sessions at the end of each week. Typing speed rapidly recovered to the preset rate of 300 keystrokes/min and error percentages were similar for the two keyboards. The vertical keyboard caused lower muscular activity in especially finger extensor muscles, did not increase postural muscle activity, and self-reported comfort was higher. Thus, the vertical keyboard was easily mastered, was experienced as comfortable, and caused less stress on muscles sensitive to repetitive strain injuries.

Adolescent↗
PubMed2006

The effect of six keyboard designs on wrist and forearm postures.

There is increasing evidence that alternative geometry keyboards may prevent or reduce arm pain or disorders, and presumably the mechanism is by reducing awkward arm postures. However, the effect of alternative keyboards, especially the new designs, on wrist and arm postures are not well known. In this laboratory study, the wrist and forearm postures of 100 subjects were measured with a motion analysis system while they typed on 6 different keyboard configurations. There were significant differences in wrist extension, ulnar deviation, and forearm pronation between keyboards. When considering all 6 wrists and forearm postures together, the keyboard with an opening angle of 12 degrees , a gable angle of 14 degrees , and a slope of 0 degrees appears to provide the most neutral posture among the keyboards tested. Subjects most preferred this keyboard or a similar keyboard with a gable angle of 8 degrees and they least preferred the keyboard on a conventional laptop computer. These findings may assist in recommendations regarding the selection of keyboards for computer usage.

Adult↗
PubMed2004

A randomized, prospective study of the effects of Tai Chi Chun exercise on bone mineral density in postmenopausal women.

OBJECTIVE: To evaluate the potential benefits of programmed Tai Chi Chun (TCC) exercise on the weight-bearing bones of early postmenopausal women. DESIGN: Age-matched and randomized prospective intervention. SETTING: University medical school. PARTICIPANTS: One hundred thirty-two healthy postmenopausal women (mean age, 54.0+/-3.5y) within 10 years of menopause onset were recruited and randomized into the TCC exercise group (n=67) or the sedentary control group (n=65). INTERVENTION: Supervised TCC exercise was performed by the TCC group for 45 minutes a day, 5 days a week, for 12 months; control subjects retained a sedentary life style. Main outcome measures Bone mineral density (BMD) was measured in the lumbar spine and proximal femur by using dual-energy x-ray absorptiometry and in the distal tibia by using multislice peripheral quantitative computed tomography (pQCT). All BMD measurements were repeated after 12 months in both groups. Fracture rate was also documented. RESULTS: Baseline measurements showed homogeneity in age, anthropometric variables, and menstruation status between the TCC and control groups. Exactly 81.6% of the subjects in the TCC group and 83.1% of subjects in the control group completed the 12-month follow-up study. BMD measurements revealed a general bone loss in both TCC and sedentary control subjects at all measured skeletal sites, but with a reportedly slower rate in the TCC group. A significant 2.6- to 3.6-fold retardation of bone loss (P<.01) was found in both trabecular and cortical compartments of the distal tibia in the TCC group as compared with the controls, as measured by pQCT. A total of 4 fracture cases were documented during follow-up, including 3 subjects in the control group and 1 in the TCC group. CONCLUSIONS: This is the first prospective and randomized study to show that a programmed TCC exercise intervention is beneficial for retarding bone loss in weight-bearing bones in early postmenopausal women. Long-term follow-up is needed to substantiate the role of TCC exercise in the prevention of osteoporosis and its related fracture.

Asian People↗
PubMedDate not supplied

The new fabrication method of standard surface sources.

We developed a new fabrication method for standard surface sources by using an inkjet printer with inks in which a radioactive material is mixed to print on a sheet of paper. Three printed test patterns have been prepared: (1) 100mm x 100mm uniformity-test patterns, (2) positional-resolution test patterns with different widths and intervals of straight lines, and (3) logarithmic intensity test patterns with different radioactive intensities. The results revealed that the fabricated standard surface sources had high uniformity, high positional resolution, arbitrary shapes and a broad intensity range.

Calibration↗
PubMed2004

Variations in glenoid rim anatomy: implications regarding anchor insertion.

PURPOSE: The purpose of this study was to investigate normal bony anatomy of the glenoid rim and to define the angles for successful anchor placement for anterior and posterior labral repairs. TYPE OF STUDY: An anatomic study using cadaveric shoulder specimens. METHODS: Soft tissue was dissected from 20 cadaveric shoulders, and the glenoids were isolated. The glenoid specimens were scanned to obtain cross-sectional images using peripheral quantitative computed tomography (pQCT) in 4 different planes. Glenoid rim angles were measured from the cross-sectional pQCT images of the glenoids at 5 positions: the 3-o'clock, 4:30-, 6-, 7:30-, and 9-o'clock positions. Glenoid morphology was noted for each position. RESULTS: The glenoid rim angles from the 3-o'clock to the 9-o'clock positions were 53 degrees +/- 5 degrees, 45 degrees +/- 7 degrees, 80 degrees +/- 10 degrees, 61 degrees +/- 10 degrees, 49 degrees +/- 4 degrees, respectively. Asymmetric morphology of the glenoid was noted with an almost straight line extending medially from the rim at the 3-o'clock position, whereas a concave morphology was noted at the 9-o'clock position. Similarly at the 4:30-o'clock position, the scapular bony surface did not curve toward the base as markedly as it did at the corresponding posterior 7:30-o'clock position. CONCLUSIONS: The available bone mass for the anchor insertion was found to vary depending on the position of the glenoid rim. Both rim angle and glenoid morphology for each position must be considered when selecting the ideal anchor insertion angle for labral repair.

Aged↗
PubMed2004

Cell micropatterning using photopolymerization with a liquid crystal device commercial projector.

Photopolymerization has been widely used for surface micropatterning. The technique often requires photomasks and light sources with appropriate energies or filters. For rapid prototyping of surface photo-micropatterning, we have developed a novel device by modifying a commercially available liquid crystal device projector. In place of the image expansion unit of the projector, we attached an image reduction unit, an adjustable stage, and an optical monitoring unit. The device projected computer-generated images onto surfaces and subjected these patterns to photopolymerization. Micropatterned images can be easily prepared with various software run on personal computers. With the developed photopolymerization device, micropatterning of poly(ethylene glycol) (PEG) was achieved with PEG-diacrylate and a visible light photopolymerization initiator, camphorquinone. Selective cell adhesion control was also achieved on the micropatterned surfaces.

Animals↗
PubMed2004

Inkjet printing for high-throughput cell patterning.

The adaptation of inkjet printing technology to the complex fields of tissue engineering and biomaterial development presents the potential to increase progress in these emerging technologies through the implementation of this high-throughput capability via automated processes to enable precise control and repeatability. In this paper, a method of applying high-throughput inkjet printing to control cellular attachment and proliferation by precise, automated deposition of collagen is presented. The results indicate that commercial inkjet printing technology can be used to create viable cellular patterns with a resolution of 350 microm through the deposition of biologically active proteins. This method demonstrates a combination of off-the-shelf inkjet printing and biomaterials and has potential to be adapted to tissue engineering and colony patterning applications. Adapting this method into the three-dimensional construction of cellular structures for eventual high-throughput tissue engineering using a bottom-up approach is possible.

Animals↗
PubMed2005

Inkjet printing of viable mammalian cells.

The purpose of this study was to explore the use of a commercial thermal printer to deposit Chinese Hamster Ovary (CHO) and embryonic motoneuron cells into pre-defined patterns. These experiments were undertaken to verify the biocompatibility of thermal inkjet printing of mammalian cells and the ability to assemble them into viable constructs. Using a modified Hewlett Packard (HP) 550C computer printer and an HP 51626a ink cartridge, CHO cells and rat embryonic motoneurons were suspended separately in a concentrated phosphate buffered saline solution (3 x). The cells were subsequently printed as a kind of "ink" onto several "bio-papers" made from soy agar and collagen gel. The appearance of the CHO cells and motoneurons on the bio-papers indicated an healthy cell morphology. Furthermore, the analyses of the CHO cell viability showed that less than 8% of the cells were lysed during printing. These data indicate that mammalian cells can be effectively delivered by a modified thermal inkjet printer onto biological substrates and that they retain their ability to function. The computer-aided inkjet printing of viable mammalian cells holds potential for creating living tissue analogs, and may eventually lead to the construction of engineered human organs.

Animals↗