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At least 739 records · Page 41Linked to original sources
PubMed1975

Inhibition by 2,4-dinitrophenol of 9,10-dimethyl-1,2-benzanthracene carcinogenesis in the hamster cheek pouch.

After topical treatment of cheek pouches of 10 hamsters with 9,10-dimethyl-1,2-benzanthracene and 2,4-dinitrophenol for 10 weeks no carcinomas developed in any of the animals. After treatment of 10 animals with the carcinogen only, there were 49 carcinomas in the 8 survivors. Inhibition of chemical carcinogenesis by dinitrophenol was tentatively attributed to suppression of ATP synthesis and to activation of ATPase by dinitrophenol.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1984

The microvasculature of the hamster cheek pouch as a model for studying acute immune-complex-induced inflammatory reactions (with 1 color plate).

The acute microvascular reactions induced by immune complexes were studied. Hamster cheek pouch preparations of ovalbumin (OA)-immunized animals were topically exposed to different doses of OA (0.1, 1, 10 or 100 micrograms/ml). Fluorescein-isothiocyanate-labelled dextran (FITC-dextran, molecular weight 150,000) was injected intravenously as a macromolecular tracer. The microvascular alterations observed upon exposure to OA ranged, in a dose dependent way, from a mild vasoconstriction and reversible vascular leakage from postcapillary venules exhibited by 0.1 micrograms/ml OA, to a severe long-lasting vasoconstriction, platelet aggregation, stasis, leukocyte accumulation in venules and prolonged vascular leakage from venules seen after exposure to 100 micrograms/ml OA. Exposure of immunized animals to 100 micrograms/ml fluorescein-labelled OA (FITC-OA) resulted in deposition of FITC-OA at the walls of small venules, indicating immune complex formation at these sites. A more diffuse pattern of FITC-OA localization at venules was seen with 10 micrograms/ml FITC-OA, which may possibly indicate formation of smaller more soluble immune complexes with lower doses of OA. The intravital model used in this study forms a basis for studying immunologically induced acute inflammatory reactions at the microvascular level.

Animals↗
PubMed1988

Angiotensin reactivity in the cheek pouch of the renovascular hypertensive hamster.

Increased reactivity to vasoconstrictor agents and decreased arteriolar luminal diameter have been implicated in the maintenance of hypertension. The same hamster cheek pouch microvessels were tested for angiotensin I (Ang I) and angiotensin II (Ang II) reactivity before and 10 to 14 days after Grollman (two-kidney, one figure-8) or sham operation. Microvascular geometric parameters were measured before and after a maximal vasodilator dose of adenosine. Then maximal vasoconstrictions to Ang I or Ang II were measured: Ang I and Ang II were applied adjacent to arterioles (10(-2)-10(0) pmol) and venules (10(-1) pmol) in 10-microliter aliquots for 1 minute. Blood pressure (178 +/- 11/133 +/- 8 mm Hg) of renovascular hypertensive hamsters was elevated significantly over blood pressure of sham-operated hamsters (120 +/- 11/97 +/- 10 mm Hg). No change was observed in venular geometry or reactivity in renovascular hypertensive hamsters. Arteriolar luminal diameter, wall thickness, wall/lumen ratio, and wall area were not altered in hypertensive hamsters in the normal or vasodilated state; vasodilator capacity was the same in all groups. Conversion of Ang I to Ang II (response to Ang I divided by response to Ang II) for first-order and Third-order arterioles and third-order venules was 74 +/- 5, 79 +/- 3, and 72 +/- 6%, respectively, and was unaltered in renovascular hypertensive hamsters. Although vessel geometry was not altered, there was a significant shift to the left of the Ang I and Ang II dose-response curves of first-order and third-order arterioles, indicating increased sensitivity to these vasoconstrictors.(ABSTRACT TRUNCATED AT 250 WORDS)

Adenosine↗
PubMed1991

Hamster cheek-pouch testing of dental soft polymers.

The hamster cheek pouch provides a suitable model system for the mucous-membrane irritation testing of dental materials. Poor retention of materials or difficulties in histopathological interpretation caused by surgical artifacts have been reported in published techniques. We describe a new "pouch-in-pouch" technique for mucous membrane irritation tests. The retention rate of polymer discs was 97% and 87% at 14 and 35 days, respectively. Clear differentiation was obtained between the tissue reaction to the test materials and the surgical procedure. Polymer discs containing dibutyltin diacetate (DBTD) or dibutyl phthalate (DBP) as plasticizer resulted in epithelial changes, including epithelial atypia, early papillomas, and areas resembling dysplasia. The potentially pre-malignant nature of these changes requires further investigation.

Animals↗
PubMed2003

Geographical variation of skull morphology and its functional significances in the red-cheeked squirrel.

Skulls of the red-cheeked squirrel (Dremomys rufigenis) from various geographical locations: Malaysia (peninsular area), Vietnam (south district)-Laos, and Thailand (north district) were osteometrically examined. The skull size of the squirrels in the southern (Malaysia) population was fundamentally larger than that in the northern (Vietnam, Laos and Thailand) populations. The proportion indices indicated that the splanchnocranium was relatively longer in the Malaysia population, and that the interorbital space was narrower in Vietnam-Laos, and Thailand populations. We suggest that the long nose and laterally-oriented orbits in the skull may be better adapted for terrestrial-insectivorous life in the Malaysia population and the binocular sense facilitated by rostrally-oriented eyes contributes to the arboreal-fruit eating behavior in the two northern populations. The Malaysia population was clearly distinguished from the other populations by the principal component analysis. We suggest that the geographical barrier of the Isthmus of Kra influences the morphological variation of the skull among the squirrel populations.

Adaptation, Biological↗
PubMed1978

Histological study on the prenatal development of the cheek-teeth of rabbits (Oryctolagus cuniculus).

The prenatal development of cheek-teeth of rabbits was studied by histological methods. Females from 15 to 30 days of gestation were sacrificed and their fetuses were collected and decapitated. The heads were fixed in buffered neutral formalin and paraffin embedded. Sagittal and frontal sections of 7 mu were obtained and stained with hematoxylin-eosin. The first tooth-germs observed were the m3 and m3, in the animal of 16 days of fetal life. One day after the m4 and m4 are observed in the bud stage. The last teeth to initiate development in the fetal rabbits are the M3 and M3 at 30 days. Only the m3, m4, m3 and m4 start cementogenesis in the prenatal stage.

Animals↗
PubMed2000

Equine dental disease part 4: a long-term study of 400 cases: apical infections of cheek teeth.

Of 400 horses referred because of equine dental disease, 162 suffered from primary apical infections of their cheek teeth (CT), including 92 with maxillary CT infections and 70 with mandibular CT infections. Maxillary swellings and sinus tracts were more common (82 and 26% incidence, respectively) with infections of the rostral 3 maxillary CT, than with infections of the caudal 3 maxillary CT (39 and 5% incidence, respectively). Nasal discharge was more commonly present with caudal (95%) than rostral (23%) maxillary CT infections. Mandibular CT apical infections commonly had mandibular swellings (91%) and mandibular sinus tracts (59%) and these infections were closely related to eruption of the affected CT. A variety of treatments, including medical treatment, apical curettage, repulsion and oral extraction of affected teeth were utilised in these cases, with oral extraction appearing to be most satisfactory. Infections of caudal maxillary CT with a secondary paranasal sinusitis were most refractory to treatment, with a complete response to the initial treatment achieved in just 33% of these cases. Most other cases responded fully to their initial treatment. The long-term response to treatment was good in most cases.

Animals↗
PubMed2005

Supernumerary cheek teeth (n = 24): clinical features, diagnosis, treatment and outcome in 15 horses.

REASONS FOR PERFORMING STUDY: There are few reports of case series of horses with supernumerary cheek teeth (SCT) that document clinical findings, treatment and long-term outcome. OBJECTIVES: To review the clinical and ancillary diagnostic findings and responses to different treatments in horses with SCT. METHODS: The case records of 15 horses were reviewed and long-term outcomes obtained by telephone interview. RESULTS: Fifteen horses with a total of 24 SCT were identified. Two SCT were incidental findings and were not treated. Clinical signs were improved or resolved in 11 of 13 of the teeth treated conservatively and all 6 treated by extraction had a favourable outcome. Four horses were subjected to euthanasia within a short period of diagnosis, either due to a poor prognosis at the outset or failure to respond to initial conservative treatment. CONCLUSIONS: Some SCT are chance findings and do not cause clinical signs. In those instances where clinical signs of dental disease are mild, conservative treatment including the management of diastema and reduction of overgrowths is often effective. Horses with severe clinical signs attributable to an SCT are likely to require extraction of the offending tooth. POTENTIAL RELEVANCE: An SCT is an uncommon dental anomaly but should be considered in the differential diagnosis of cases with signs of severe dental disease. The preferred management for SCT is very variable and determined by the severity of the associated changes, but ranges from conservative measures through forceps extraction per os to major facial flap surgery.

Animals↗
PubMed2003

Slapped cheek disease. How it affects children and pregnant women.

BACKGROUND: Slapped cheek disease, otherwise known as erythema infectiosum (EI) or 'fifth disease', is a common cause of fever and rash in children. OBJECTIVE: The clinical features in children, and the implications for pregnant contacts will be discussed in this article. DISCUSSION: Erythema infectiosum is usually a mild self limiting illness in children. Patients are unlikely to be infectious after the rash and other symptoms are present, and children do not need to be excluded from school or childcare. Infection in pregnant women under 20 weeks gestation can lead to miscarriage or hydrops, but in 50% of cases the fetus is unaffected. Pregnant women who are IgM positive require appropriate specialist referral and serial ultrasounds.

Child↗
PubMed2000

[Histologic study on impeding leukoplakia carcinogenesis of golden hamster cheek pouch about Erigeron breviscapus (Vant) Hand-Mazz].

OBJECTIVE: To observe the effect of Erigeron breviscapus (Vant) Hand Mazz (HEr) in impeding oral leukoplakia carcinogenesis, and to seek effective Chinese herb medicine that can impede precarcinoma of oral mucosas. METHODS: 132 golden hamsters were randomly divided into model group (60 animals), HEr group (60 animals), and control group 12 animals. Salley's leukoplakia carcinogenesis model of golden hamster cheek pouch was used in this study. HEr was injected into the stomach to impede evolution of carcinogenesis. Pathological specimens were observed via naked eye and light microscope between model group and HEr group. Results were compared. RESULTS: Observation via naked-eye showed that leukoplakia rate of HEr group (18.2%) was lower than that of model group (27.3%). Observation via light microscope showed that carcinogenesis rate descended one fold and displasia rate descended 0.4 fold in HEr group. CONCLUSION: HEr has exact effect in impeding leukoplakia carcinogenesis.

English Abstract↗
PubMed1998

[Flow cytometry dynamic study binding to bromodeoxyuridine in golden hamster cheek pouch premalignancy]

OBJECTIVE:In order to study cellular dynamicfeatures in carcinoma and premalignancy originated inepithelial tissue. METHODS: The golden hamster pouch premalignant model with dimethylbenzanthracence(DMBA) smeared was established by Salley and detected with flow cytometry(FCM) binding to bromodeoxyuridine(BRDU),30 Syrian golden hamsters were grouped and done contrast study. RESULTS: The cellular lesions were aggravated gradually along with extention of smeared DMBA microstopically,FCM detective results demonstrated that the detective rate of Sporiod cell between contrast and smeared group had significant difference. Even though mild dysplsia presented microscopically FCM detective result and significant difference. CONCLUSION: The study suggests that golden hamster cheek pouch premalignancy has cellular dynamicfeatures of dysplasia.

Journal Article↗
PubMed1998

[Developmental carcinogenesis in the cheek pouch of the hamster induced by DMBA using on light microscope]

OBJECTIVE:In this study that the DMBA was applicated to induce the premalignantal changes of the cheek pouches of 89 hamsters in various stage,the result was shown that the slight epithelial displasia was occured 3 weeks later,the medium displasia was occured 5 weeks later,and the severe displasia or the carcinoma in situ was occured 6-9 weeks later.It is suggested that the suitable experimental period of the hamster's carcinogenesis is during 1-3 weeks.

Journal Article↗
PubMedDate not supplied

Plexiform neurofibroma of the cheek mucosa. A case report.

The case reported deals with a solitary plexiform neurofibroma affecting the cheek submucosa. Neurofibroma is an uncommon tumor which rarely appears in oral cavity but it represents the most common neurogenic tumor. Furthermore, plexiform variety is less frequent. Clinically, oral neurofibromas usually appears as anodyne and asintomatic lesions. Sometimes, they produce nervous compression. In this case, tumor is big but asintomatic. There is no definitive radiologic image. It has association with polyglandular syndromes and phacomatosis. The treatment of choice is excision. There are doubts of the surgical results so that some authors are looking for new non-surgical treatments. The clinical characteristics, epidemiology, diagnosis and treatment are described as soon as a bibliographic revisión.

Aged↗
PubMed1997

[The study of influencing cellular dynamics of gynostemma pentaphyllum on golden hamster cheek pouch premalignancy]

Studying premalignancy is an important field of conquering cancer.The aim to study the mechanics of oral mucosal premalignant formation and seek effective drug which could prevent and block cancer,Gynostemma Pentaphyllum(GP) was applies to block carcinomatous conversion of golden hamster cheek pouch by Salley's way.Using light microscopic observation and proliferating cell nuclear antigen(PCNA) as well as bromodeoxyuridine(BrdU)(PCNA AND BrdU are immunohistochemistry techniques),GPs effect was observed dynamically.We found that GP could delay the presence of leukoplakia and decrease the rate of presence as well as cancer-causing rate. The positive cells of taking drug group PCNA and BrdU were lower than model group significantly and in a lower condition all the time.It is illustrated that GP has the effect of preventing cancer and inhibiting cellular dysplasia.

Journal Article↗
PubMed1991

[An infant with short stature and red cheeks (Rothmund-Thomson syndrome)].

An infant with short stature and progressive skin lesions of cheeks and dorsum of the hands is described. Further problems such as recurrent diarrhoea and respiratory infections suggested zinc-deficiency, malabsorption-syndrome, Bloom syndrome and early Lupus Erythematosus respectively. Finally Rothmund-Thomson syndrome was diagnosed. This rare genetic disorder is characterized by variable expression of typical cutaneous changes, cataracts, skeletal anomalies, short stature, abnormal hair growth and defective nails and teeth, mental retardation, hypogonadism and a typical facial appearance.

Diagnosis, Differential↗
PubMed1991

Alloplastic cheek augmentation.

Alloplastic cheek augmentation can achieve an attractive malar prominence that is in balance and harmony with the other facial features. To reach this goal, the surgeon must first identify the proper candidate and then determine the type of malar deficiency. A vertical line through the lateral canthus allows the malar deficiency to be classified as anterior-medial, posterior-lateral, or combined. The proper implant is selected on the basis of the type of the defect and the degree of the deficiency. Different techniques are described that help the surgeon locate the site of the ideal malar eminence. Once that site is located, the surgeon outlines the proposed pocket for the implant. Both silicone and Proplast implants are successful. The insertion may be through the intraoral route, blepharoplasty approach, or under the face lift flap. The possible complications are discussed, but the complication rate is minimal.

Humans↗
PubMed1977

Effects of adenosine and guanosine cyclic phosphates and their corresponding nucleotides and nucleosides on vitamin A-induced epidermal tumor promotion and growth in hamster cheek pouch.

Adenosine and guanosine cyclic monophosphates (cAMP and cGMP) exerted opposite effects at similar concentration and similar effects at markedly different concentrations on the yields of tumors promoted by vitamin A in hamster cheek pouch. Increasing the concentration of cAMP between 10(-5) M and 10(-3) M was associated with increases in tumor yield and diameter which partially or completely overcame the net tumor promotion inhibitory effects which were sometimes seen at 10(-5) M cAMP. In contrast, increasing the concentration of cGMP between 10(-5) M and 10(-3) M caused the net effects to change from increases to decreases in tumor yield without much change in diameter. The relative magnitudes of the tumor yield increasing and decreasing effects of the cyclic nucleotides varied substantially between experiments at constant concentration of cyclic nucleotide. Adenosine-5'-monophosphate (AMP) showed simultaneous tumor promotion inhibitory and growth stimulatory effects, the former effect being similar to that of cAMP but tumor yield decreased rather than increased as concentration of AMP was increased whereas the opposite occured with cAMP. Guanosine-5'-monophosphate (GMP) showed the tumor yield increasing effect of low concentraitons of cGMP but not the yield decreasing effect of high concentrations of cGMP. Adenosine (10(-3) M) showed a significant tumor yield increasing effect similar to that of 10(-3) M cAMP. Guanosine showed no significant effects at either 10(-3) M or 10(-5) M concentrations.

9,10-Dimethyl-1,2-benzanthracene↗