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PubMedDate not supplied

Structure and software tools of AIDA.

AIDA consists of a set of software tools to allow for fast development and easy-to-maintain Medical Information Systems. AIDA supports all aspects of such a system both during development and operation. It contains tools to build and maintain forms for interactive data entry and on-line input validation, a database management system including a data dictionary and a set of run-time routines for database access, and routines for querying the database and output formatting. Unlike an application generator, the user of AIDA may select parts of the tools to fulfill his needs and program other subsystems not developed with AIDA. The AIDA software uses as host language the ANSI-standard programming language MUMPS, an interpreted language embedded in an integrated database and programming environment. This greatly facilitates the portability of AIDA applications. The database facilities supported by AIDA are based on a relational data model. This data model is built on top of the MUMPS database, the so-called global structure. This relational model overcomes the restrictions of the global structure regarding string length. The global structure is especially powerful for sorting purposes. Using MUMPS as a host language allows the user an easy interface between user-defined data validation checks or other user-defined code and the AIDA tools. AIDA has been designed primarily for prototyping and for the construction of Medical Information Systems in a research environment which requires a flexible approach. The prototyping facility of AIDA operates terminal independent and is even to a great extent multi-lingual. Most of these features are table-driven; this allows on-line changes in the use of terminal type and language, but also causes overhead. AIDA has a set of optimizing tools by which it is possible to build a faster, but (of course) less flexible code from these table definitions. By separating the AIDA software in a source and a run-time version, one is able to write implementation-specific code which can be selected and loaded by a special source loader, being part of the AIDA software. This feature is also accessible for maintaining software on different sites and on different installations.

Database Management Systems↗
PubMedDate not supplied

An examination of adolescents who were and were not exposed to "Teens Stopping AIDS": reaching the hard-to-reach.

Teens Stopping AIDS (TSA) was an HIV prevention project in Sacramento, California, that involved coalitions of volunteers in designing and launching a social marketing intervention. Mounted in 15 zip codes where teen sexually transmitted disease (STD) and pregnancy rates were high, TSA delivered HIV prevention messages for one year through various communication channels (e.g., radio spots, posters, skills-building workshops). Sixty-seven percent of 521 sexually active adolescents surveyed in a random sample phone interview reported exposure to TSA. To inform future refinements in the intervention, logistic regression was used to identify factors associated with exposure to the program. Eighteen-year-olds were less likely than their younger counterparts to report exposure to TSA (OR [odds ratio] = .54, p <.05). Adolescents living in zip codes where a concentrated effort had been made to hold workshops, display posters, and organize peer outreach were more likely than adolescents living outside of these zip codes to report any program exposure (OR= 2.57, p <.01). Adolescents traditionally viewed as "hard to reach" (i.e., males, minorities, and those with a history of high-risk behavior) were no less likely than other adolescents to report exposure to TSA. Characterizing the members of the unexposed segment of the target audience made it possible to offer practical suggestions for expanding the reach of the program.

Adolescent↗
PubMed2002

How rehabilitation therapists gather, evaluate, and implement new knowledge.

INTRODUCTION: Rehabilitation therapists are strongly encouraged to apply research to their practices, but relatively little is known about the processes therapists use for continuing their education. This study examines the strategies used by a sample of therapists to gather new knowledge, evaluate its appropriateness to their clinical problems, and implement new learning into their practices. METHODS: Twenty-four randomly selected occupational therapists and physical therapists from a large metropolitan area participated in in-depth interviews. Descriptive codes within interview transcripts described participants' individual approaches to continuing education (CE). Themes derived from comparative analysis across interviews were interpreted, building on prior understandings and suggesting strategies for CE research and programs. RESULTS: Participants valued formal CE highly and expressed frustration concerning its limited availability. Most participants relied on informal consultations with peers as their first educational resource. Peers also supported participants' evaluation and implementation of new knowledge. Although seven participants reported use of systematic methods to access, evaluate, and implement new knowledge, others described more haphazard approaches toward evaluation and application of their learning. Participants identified economic, administrative, and interprofessional barriers to integration of new knowledge into their practices. DISCUSSION: There is a need to develop and incorporate guidelines for evaluating and implementing learning within formal and informal CE programs. The appeal of formal CE suggests that more efficient strategies for continuing rehabilitation are required. Therapists' heavy reliance on peers suggests that educationally influential therapists may be effective media for informal CE interventions. CE targeted to policy makers should focus on promoting organizational change to enhance therapists' translation of research into practice.

Canada↗
PubMed1984

Identification of diethylene glycol in sera from Egyptian children by frequency-pulsed electron-capture gas-liquid chromatography.

Sera taken from fifteen patients (from Kerdasa village near Cairo, Egypt) infected with Schistosoma haematobium, with eggs present in the urine, were studied by frequency-pulsed electron-capture gas-liquid chromatography (FPEC-GLC). Some of the patients were treated with metrifonate and again studied by FPEC-GLC. Diethylene glycol was detected in the sera of untreated patients infected with S. haematobium. This compound was identified by negative chemical ionization and electron-impact mass spectrometry. Initially we suspected that the build-up of diethylene glycol in these patients was caused by schistosomiasis infection. However, in a follow-up blind-coded study using FPEC-GLC, which included 37 sera from Kerdasa and Tamooh villages near Cairo, Egypt, we detected diethylene glycol in eleven samples, four of which were controls from the villages. These latter findings indicate that the source of diethylene glycol might be the environment or foodstuffs, but the specific source has not been determined. Regardless of the source, diethylene glycol could affect the health of these Egyptian children by causing a narcotic effect, increased bladder stones, and increased numbers of bladder tumours.

Adolescent↗
PubMed2004

Building protein interaction maps for Down's syndrome.

Now that the complete sequences for human chromosome 21 and the orthologous mouse genomic regions are known, reasonably complete, conserved, protein-coding gene catalogues are also available. The central issue now facing Down's syndrome researchers is the correlation of increased expression of specific, normal, chromosome 21 genes with the development of specific deficits in learning and memory. Because of the number of candidate genes involved, the number of alternative splice variants of individual genes and the number of pathways in which these genes function, a pathway analysis approach will be critical to success. Here, three examples, both gene specific and pathway related, that would benefit from pathway analysis are discussed: (1) the potential roles of eight chromosome 21 proteins in RNA processing pathways; (2) the chromosome 21 protein intersectin 1 and its domain composition, alternative splicing, protein interactions and functions; and (3) the interactions of ten chromosome 21 proteins with components of the mitogen-activated protein kinase and the calcineurin signalling pathways. A productive approach to developing gene-phenotype correlations in Down's syndrome will make use of known and predicted functions and interactions of chromosome 21 genes to predict pathways that may be perturbed by their increased levels of expression. Investigations may then be targeted in animal models to specific interactions, intermediate steps or end-points of such pathways and the downstream - perhaps amplified - consequences of gene dosage directly assessed. Once pathway perturbations have been identified, the potential for rational design of therapeutics becomes practical.

Animals↗
PubMed1998

Shielding design calculation for SPring-8 beamlines using STAC8.

The beamlines of SPring-8 are classified by synchrotron radiation source into undulator, wiggler and bending-magnet beamlines for safety analysis. The shielding design calculations for synchrotron radiation are performed with a new shielding design code, STAC8, taking into consideration the linear-polarization effect, the slant length of the shield hutch wall and the build-up effect as functions of scattering angle and azimuthal angle.

Journal Article↗
PubMedDate not supplied

Profile of psychiatric emergency patients.

From this mass of data, one can assemble a statistical composite profile of the psychiatric emergency patient. This patient is young, unmarried, female, living near the emergency department, poor, diagnosed as psychotic, exhibiting some acutely disruptive or life-threatening behavior, having a history of prior contact with the psychiatric system, arriving at night by herself, and at risk for medical illness or substance abuse. Such a composite profile is misleading, however, for it is unlikely that there is a homogeneous population seeking help in psychiatric emergency services. Rather it seems likely that the composite data conceals a number of demographic and clinical subgroups: the young unmarried borderline woman, the chronically psychotic deinstitutionalized single young male, the middle-aged alcoholic, and the other depressed and organically-impaired patient are examples of such subgroups. When these groups are lumped together in overall figures, salient features and differences are obscured. Studies of these subgroups are needed. Secondly, there is substantial variation between the different studies reported above. Thus, while this summary can give some general guidance for clinical and administrative planning, it is crucial for every psychiatric emergency service to monitor its own utilization statistics. Where the profile of emergency service users does not match that of the underlying census data or that of those persons most at risk for serious psychiatric illness, administrators must raise the question of over- or under-utilization. Finally, there is a need for further studies to build on this preliminary data. Such studies must use uniform diagnostic criteria such as DSM III, prospective blind design, and better coding of the data to facilitate retrieval and processing of relevant information.

Adult↗
PubMed1998

The cell wall structure: developments in diagnosis and treatment of candidiasis.

Candidiasis are among the fungal infections the most difficult to diagnose and treat. Research focused on specific fungal components which are absent in the host, such as the cell wall has lead to a better understanding of Candida albicans pathogenicity and clinical impact. The cell wall is responsible for antigenic expression and primary interaction with the host. It is composed mainly of beta-glucans, chitin and mannoproteins, which account for the rigidity of the wall and for the fungal morphology. Of these components, mannoproteins might carry a "morphogenetic code" which might modulate the molecular architecture of the cell wall. The features of specific cell wall proteins as part of building blocks to form this structure is revised, and the usefulness of monoclonal antibodies obtained against cell wall components to study those processes, together with their clinical applicability, is discussed.

Antibodies, Monoclonal↗
PubMed2005

Therapist alliance-building behavior within a cognitive-behavioral treatment for anxiety in youth.

Explored the specific behavior of therapists contributing to a child client's perception of a therapeutic alliance with youth (n = 56) who received a manualized cognitive-behavioral treatment for anxiety disorders. The first 3 sessions were coded for 11 therapist behaviors hypothesized to predict ratings of alliance. Child, therapist, and observer alliance ratings were gathered after the 3rd and 7th therapy sessions. "Collaboration" positively predicted early child ratings of alliance, and "finding common ground" and "pushing the child to talk" negatively predicted early child ratings of alliance. Although no coded therapist behaviors predicted early therapist ratings of alliance, "collaboration" and "not being overly formal" positively predicted therapist alliance ratings by Session 7. Child, observer, and therapist ratings of alliance were significantly correlated. Results are discussed with regard to the identified behavior of the therapist as a step toward the identification of empirically supported strategies for building a stronger child-therapist alliance.

Adolescent↗
PubMed1993

Problems and priorities in epidemiologic research on human health effects related to wiring code and electric and magnetic fields.

Because of a reported excess of cancers among children living near power lines, there is some concern that electric and magnetic fields (EMFs) induced by electric power sources may affect human health, and this possibility has provoked considerable controversy. The scientific question of whether there are such health effects is far from resolved. Building upon a set of detailed reviews of the available evidence, this paper proposes research priorities and places particular emphasis on epidemiologic research. The most pressing need is to verify the validity of the claim that childhood cancer risk is affected by the type of wiring code in the vicinity of the household. More useful work can be done to verify this in the areas in which such studies have already been carried out, and additional studies should be done elsewhere. Methodological investigation of the interrelationships among different measures and proxies for EMF is needed, and this could feed back to influence the type of EMF measures used in epidemiologic studies. Studies of cancer among adults in relation to EMFs in the work place are needed. Of lower priority are studies of adverse reproductive outcomes in relation to parental EMF exposure and studies of the neurobehavioral impact of chronic EMF exposure. This article also discusses the structural impediments of conducting environmental epidemiology research and argues that bold, large-scale epidemiologic monitoring systems are needed. There is a discussion of the interface between epidemiology and public policy in a topic area as controversial as EMFs.

Adult↗
PubMed2000

Peeling by binding or twisting by cranking: models for promoter opening and transcription initiation by RNA polymerase II.

The precise, sequence-specific regulation of RNA synthesis is the primary mechanism underlying differential gene expression. This general statement applies to both prokaryotic and eukaryotic organisms, as well as to their viral pathogens. Thus, it is not surprising that genomes use a substantial portion of their protein-coding content to regulate the process of RNA synthesis. Transcriptional regulation in bacterial systems is particularly well understood. In this essay, we build on this knowledge and propose two opposing models to describe promoter opening and transcription initiation in the eukaryotic RNA polymerase II system. Promoter opening in the "twisting by cranking" model is based on changes in the trajectory of DNA. In contrast, invasion of single-stranded DNA-binding proteins between the DNA strands drives the reaction in the "peeling by binding" model.

Adenosine Triphosphate↗
PubMed2002

How best to geo-reference farms? A case study from Cornwall, England.

The commonest way of geo-referencing farms as single points is using the location of the farmhouse as either read off a map or approximated by its postcode. While these two methods may be adequate for small farms, they are unlikely to be satisfactory for large ones, or alternatively when they are comprised of several discrete units or holdings. In order to investigate the best representation of the total farm polygon(s) by a single point, we undertook a study using nearly 500 actual farm boundaries in the county of Cornwall, England. For each farm, the farm boundaries were digitised, and its area and centroid determined using ArcView 3.2. A variety of point geo-referencing systems were tested to find the best single point location for a farm, as judged by the proportion of farm area captured. Whilst the centroid was found to capture the largest area, the main farm building was judged to be the best geo-referencing method for practical purposes. In contrast, the various systems of geo-coding using the farm postal address performed relatively poorly. Where there are separate parcels of land managed together in a single parish, they may be identified as a single unit, but if there are separate parcels in different parishes they should be identified as separate units.The implications of these results for Great Britain's national animal health information system (VETNET) are discussed.

Agriculture↗
PubMed2004

The biopsychosocial domains and the functions of the medical interview in primary care: construct validity of the Verona Medical Interview Classification System.

Factor analysis (FA) is a powerful method of testing the construct validity of coding systems of the medical interview. The study uses FA to test the underlying assumptions of the Verona Medical Interview Classification System (VR-MICS). The relationship between factor scores and patient characteristics was also examined. The VR-MICS coding categories consider the three domains of the biopsychosocial model and the main functions of the medical interview-data gathering, relationship building and patient education. FA was performed on the frequencies of the VR-MICS categories based on 238 medical interviews. Seven factors (62.5% of variance explained) distinguished different strategies patients and physicians use to exchange information, build a relationship and negotiate treatment within the domains of the biopsychosocial model. Three factors, Psychological, Social Inquiry and Management of Patient Agenda, were related to patient data: sociodemographic (female gender, age and employment), social (stressful events), clinical (GHQ-12 score), personality (chance external health locus of control) and clinical characteristics (psychiatric history, chronic illness, attributed presence of emotional distress).

Adolescent↗
PubMed2003

Targeting RNA: new opportunities to address drugless targets.

Historically, pharmaceutical industries have focussed on the discovery of compounds that target the protein products of genes. The intermediary product between gene and protein, consisting of RNA, has remained largely unexplored. Several drugs targeting the rRNA of bacteria have been, however, in clinical use for over half a century. One of these drug classes, the aminoglycoside antibiotics, also targets human rRNA, and have been developed as therapeutics for genetic disorders. Targeting at the RNA level is an economical approach to address non-drugable proteins and targets that have failed to give leads by hits in HTS, as it can build on biological knowledge gathered over years. RNA also offers entirely new opportunities for drug development, such as targeting of non-coding RNA sequences.

Aminoglycosides↗
PubMed2002

Measuring information spatial densities.

A novel definition of the stimulus-specific information is presented, which is particularly useful when the stimuli constitute a continuous and metric set, as, for example, position in space. The approach allows one to build the spatial information distribution of a given neural response. The method is applied to the investigation of putative differences in the coding of position in hippocampus and lateral septum.

Animals↗
PubMed2001

Integration of nursing assessment concepts into the medical entities dictionary using the LOINC semantic structure as a terminology model.

Recent investigations have tested the applicability of various terminology models for the representing nursing concepts including those related to nursing diagnoses, nursing interventions, and standardized nursing assessments as a prerequisite for building a reference terminology that supports the nursing domain. We used the semantic structure of Clinical LOINC (Logical Observations, Identifiers, Names, and Codes) as a reference terminology model to support the integration of standardized assessment terms from two nursing terminologies into the Medical Entities Dictionary (MED), the concept-oriented, metadata dictionary at New York Presbyterian Hospital. Although the LOINC semantic structure was used previously to represent laboratory terms in the MED, selected hierarchies and semantic slots required revisions in order to incorporate the nursing assessment concepts. This project was an initial step in integrating nursing assessment concepts into the MED in a manner consistent with evolving standards for reference terminology models. Moreover, the revisions provide the foundation for adding other types of standardized assessments to the MED.

Dictionaries, Medical as Topic↗
PubMed2006

[The expression of enhanced green fluorescent protein gene on cultured human fetal retinal progenitor cells].

PURPOSE: To investigate the transfer efficiency and transient expression of plasmid vector coding enhanced green fluorescent protein (EGFP)gene pEGFP-N1 which was transferred into primary cultured human fetal retinal progenitor cells. To build up a tracking method for study of retinal progenitor cells transplantation. METHODS: pEGFP-N1 plasmid was amplified in E.coli, primary cultured human fetal retinal progenitor cells transferred with pEGFP-N1 by means of CaCl2. The transfer efficiency was evaluated by flow cytometry. Transient expression in vitro was observed by fluorescent microscope and laser scanning confocal microscope. RESULTS: The transfer efficiency of pEGFP-N1 into primary cultured human fetal retinal progenitor cells could maximumly reach to 32.45% during 48 hours. There was obvious expression of pEGFP-N1 in vitro at 48th hour after transferring. CONCLUSION: pEGFP-N1 is an ideal transient expression vector for primary cultured human fetal retinal progenitor cells in vitro. It is a useful tracer for transplantation of retinal progenitor cells.

Cells, Cultured↗
PubMed2004

Consequence modeling using the fire dynamics simulator.

The use of Computational Fluid Dynamics (CFD) and in particular Large Eddy Simulation (LES) codes to model fires provides an efficient tool for the prediction of large-scale effects that include plume characteristics, combustion product dispersion, and heat effects to adjacent objects. This paper illustrates the strengths of the Fire Dynamics Simulator (FDS), an LES code developed by the National Institute of Standards and Technology (NIST), through several small and large-scale validation runs and process safety applications. The paper presents two fire experiments--a small room fire and a large (15 m diameter) pool fire. The model results are compared to experimental data and demonstrate good agreement between the models and data. The validation work is then extended to demonstrate applicability to process safety concerns by detailing a model of a tank farm fire and a model of the ignition of a gaseous fuel in a confined space. In this simulation, a room was filled with propane, given time to disperse, and was then ignited. The model yields accurate results of the dispersion of the gas throughout the space. This information can be used to determine flammability and explosive limits in a space and can be used in subsequent models to determine the pressure and temperature waves that would result from an explosion. The model dispersion results were compared to an experiment performed by Factory Mutual. Using the above examples, this paper will demonstrate that FDS is ideally suited to build realistic models of process geometries in which large scale explosion and fire failure risks can be evaluated with several distinct advantages over more traditional CFD codes. Namely transient solutions to fire and explosion growth can be produced with less sophisticated hardware (lower cost) than needed for traditional CFD codes (PC type computer verses UNIX workstation) and can be solved for longer time histories (on the order of hundreds of seconds of computed time) with minimal computer resources and length of model run. Additionally results that are produced can be analyzed, viewed, and tabulated during and following a model run within a PC environment. There are some tradeoffs, however, as rapid computations in PC's may require a sacrifice in the grid resolution or in the sub-grid modeling, depending on the size of the geometry modeled.

Computer Simulation↗