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Predicting dentists' perceived occupational risk for HIV infection.

This study posed two questions: what is the level of perceived occupational risk among American general practice dentists (GPDs)? What factors influence perception of occupational risk for HIV infection among GPDs? In data obtained from a national mail survey of 1351 GPDs (response rate, 88%) 31% of American GPDs expressed disagreement with the statement that HIV+ individuals can be safely treated in their office settings. Of the 16 variables entered into a multiple regression equation, 9 variables had a statistically significant influence on dentists' assessment of occupational risk. In order of their influence they were (1) concern re the economic viability of the practice, (2) ethical obligation to treat patients at risk, (3) certainty of having treated patients with HIV infection, (4) risk attributed to four accidental occupational exposures, (5) concern re treatment of homosexuals, (6) relevant continuing education exposure, (7) personal worry re transmission of HIV infection from patients, (8) implementation of infection control behaviors, (9) number of patients seen per week. Statistically nonsignificant predictors of interest included age, knowledge level re HIV transmission routes, practice location in a high prevalence area, and perceived effectiveness of infection control behaviors. Results argue for intervention programs with less focus on delivery of factual information regarding the transmission of the disease and the effectiveness of infection control techniques, and more emphasis on the themes of practice economic viability, professional ethics, and structured educational encounters involving dentists' knowing exposure to HIV-infected patients.

Acquired Immunodeficiency Syndrome↗

Neural control of behavioral responses in the nudibranch mollusc Phestilla sibogae.

The tropical aeoliacean nudibranch Phestilla sibogae, has a number of large and reidentifiable neurons in its centrally located cerebral-pedal-pleural ganglion complex. In studies involving nearly intact animal preparations, neurons were identified which control specific movements of the dorsal cerata, the oral veil tentacles, and the margins of the foot. Responses of neurons to mechanical vibrations in the environment, and responses to light not mediated by the eyes are described. Finally, a pair of large cerebral neurons are identified that are superficially similar in structure, location, and function to the metacerebral giants found in several other opisthobranchs. These neurons are electrically coupled and control stereotyped movements of the mouth. These anatomical and neurophysiological features, when coupled with the fact that the generation time of Phestilla (30 days) is comparable to that of Drosophila suggests that this nudibranch may prove useful in combined studies of neurophysiology, behavior and genetics.

Animals↗

Remote control of behavior through genetically targeted photostimulation of neurons.

Optically gated ion channels were expressed in circumscribed groups of neurons in the Drosophila CNS so that broad illumination of flies evoked action potentials only in genetically designated target cells. Flies harboring the "phototriggers" in different sets of neurons responded to laser light with behaviors specific to the sites of phototrigger expression. Photostimulation of neurons in the giant fiber system elicited the characteristic escape behaviors of jumping, wing beating, and flight; photostimulation of dopaminergic neurons caused changes in locomotor activity and locomotor patterns. These responses reflected the direct optical activation of central neuronal targets rather than confounding visual input, as they persisted unabated in carriers of a mutation that eliminates phototransduction. Encodable phototriggers provide noninvasive control interfaces for studying the connectivity and dynamics of neural circuits, for assigning behavioral content to neurons and their activity patterns, and, potentially, for restoring information corrupted by injury or disease.

Action Potentials↗

Conflicting processes in the extinction of conditioned taste aversion: behavioral and molecular aspects of latency, apparent stagnation, and spontaneous recovery.

The study of experimental extinction and of the spontaneous recovery of the extinguished memory could cast light on neurobiological mechanisms by which internal representations compete to control behavior. In this work, we use a combination of behavioral and molecular methods to dissect subprocesses of experimental extinction of conditioned taste aversion (CTA). Extinction of CTA becomes apparent only 90 min after the extinction trial. This latency is insensitive to muscarinic and beta-adrenergic modulation and to protein synthesis inhibition in the insular cortex (IC). Immediately afterwards, however, the extinguishing trace becomes sensitive to beta-adrenergic blockade and protein synthesis inhibition. The subsequent kinetics and magnitude of extinction depend on whether a spaced or massed extinction protocol is used. A massed protocol is highly effective in the short run, but results in apparent stagnation of extinction in the long-run, which conceals fast spontaneous recovery of the preextinguished trace. This recovery can be truncated by a beta-adrenergic agonist or a cAMP analog in the insular cortex, suggesting that spontaneous overtaking of the behavioral control by the original association is regulated at least in part by beta-adrenergic input, probably operating via the cAMP cascade, long after the offset of the conditioned stimulus. Hence, the performance of the subject in experimental extinction is the sum total of multiple, sometimes conflicting, time-dependent processes.

Animals↗

[Effectiveness of typical and atypical neuroleptics in the control of behavioral and psychopathological symptoms of dementia. Results of a retrospective study].

INTRODUCTION: Presence of disruptive behavioural and psychological symptoms in dementia (BPSD) is highly prevalent and, as a consequence, neuroleptics are frequently used in these patients to control BPSD. Several reviews have shown the clinical equivalence of different classes of neuroleptics in BPSD control, although that equivalence has been only indirectly assessed by comparing the combined results of different types of active drugs versus placebo. Thus, little is known on the comparative effectiveness, head to head, of different neuroleptics on BPSD. The aim of this study was to gather preliminary information on the effectiveness of typical (haloperidol, thioridazine) and atypical (olanzapine, risperidone) neuroleptics on BPSD. METHODS: Multicenter, observational and retrospective study using chart reviews of patients with dementia to assess neuroleptic prescriptions and clinical outcomes at 12 weeks on treatment. RESULTS: No significant differences on BPSD improvement were found by type of neuroleptic (n=78; Kruskal- Wallis exact test; p=0.47). There also were no differences by neuroleptics when the analysis was stratified by levels of cognitive decline (Kruskal-Wallis exact test; p=0.86 and 0.87 for moderate and severe levels of deterioration, respectively). Recorded side effects were worse in the haloperidol group (n=19) regarding rigidity (Fisher's exact; p=0.01), tremor (Fisher's exact p=0.03) and akathisia (Fisher's exact; p=0.03). CONCLUSIONS: Our findings support the equivalence in effectiveness of several classes of neuroleptics commonly used to treat BPSD. Nevertheless these results need to be confirmed by adequately powered randomized trials and further pharmacoepidemiological studies to assess their safety.

Aged↗

Physical aggression and control in heterosexual relationships: the effect of sampling.

This study investigated the proposition by Johnson (1995) that there are distinct patterns of physical aggression within relationships, characterized as common couple violence and patriarchal terrorism. The present samples comprised students (N = 113), women from a domestic violence refuge (N = 44), and male prisoners (N = 108). Participants completed measures of physical aggression, controlling behavior, fear of injuries, and injuries. Reports of these measures were entered into a Discriminant Function Analysis (DFA). With the exception of self-reported use of controlling behavior, the variables showed univariately significant differences between the groups. The DFA produced two significant functions which together correctly classified 75% of cases. These results support the view that there are distinct patterns of aggressive relationships corresponding to those identified by Johnson (1995).

Aggression↗

Use of classical conditioning procedures to control aggressive behaviors in children: a preliminary report.

This experiment tested the effectiveness of classical conditioning procedures in reducing children's aggressive behaviors in a classroom setting. As hypothesized, 11 boys and 14 girls who were shown pictures of aggressive scenes paired with the presentation of negatively evaluated words subsequently displayed significantly fewer aggressive responses than controls who had not experienced these conditioning procedures. A significant teacher/classroom effect was also found, which appeared to be a function of the level of the 3 teachers' permissiveness. Specifically, children's aggressive behaviors occurred more frequently in the classroom where a permissive atmosphere prevailed than in the classroom where a more restrictive atmosphere was maintained. In those classrooms where a permissive atmosphere prevailed, the children who were the same sex as their teacher tended to display more aggressive responses than those children who were the opposite sex from their teacher.

Adolescent↗

Predicting intentions to use condoms among African-American adolescents: the theory of planned behavior as a model of HIV risk-associated behavior.

The relation of attitudes, subjective norms, and perceived behavioral control to intentions to use condoms was examined among 179 adolescents who completed a confidential self-administered questionnaire prior to participating in a minority youth health conference. Approximately 72% of the adolescents were African Americans. Hierarchical multiple regression analyses revealed that attitudes and subjective norms predicted intentions to use condoms and that, consistent with the theory of planned behavior, perceived behavioral control added a significant increment to the squared multiple correlation. Although adolescents' perceptions of their friends' approval of condom use was unrelated to their condom-use intentions, adolescents' behavioral beliefs about the effects of condoms on sexual enjoyment, normative beliefs regarding partners' and mothers' approval, and control beliefs regarding technical skill at using condoms were associated with such intentions. These results suggest the utility of the theory of planned behavior as a model of condom use among adolescents. Implications for HIV risk-reduction interventions are discussed.

Adolescent↗

Applying the Theory of Planned Behavior to healthy eating behaviors in urban Native American youth.

BACKGROUND: To investigate the efficacy of the Theory of Planned Behavior (TPB) to predict healthy eating behavior in a group of urban Native American youth. METHODS: Native American boys and girls (n = 139), ages 9-18 years old, were given a self-administered survey to assess eating behavior using the TBP constructs (intention, attitude, subjective norm, barriers, self-efficacy, and perceived behavioral control). Youth were also measured for height and weight and body mass index (BMI) was calculated. Bivariate correlations and stepwise regression analyses of TBP model were performed with SPSS software. RESULTS: No association was found between intention and healthy eating behavior. However, independently healthy eating behavior was correlated with barriers (0.46), attitude (0.44), perceived behavioral control (0.35), and subjective norm (0.34). The most predictive barriers to eating healthy included the availability and taste of foods. Boys' eating behavior was most predicted by subjective norm, while girls' eating behavior was most predicted by barriers. CONCLUSION: Lack of association between intention and healthy eating behavior suggests that factors other than intentions may drive healthy eating behaviors in urban Native American youth. Results indicate that programs promoting healthy eating to youth might focus on collaborating with families to make healthy foods more appealing to youth.

Journal Article↗

Relationships between drinking motives and drinking restraint.

Relationships between drinking motives (self-perceived reasons for drinking alcohol) and drinking restraint (preoccupation with controlling alcohol intake) were examined in a nonclinical young adult sample. Ninety-seven undergraduate university drinkers completed the Temptation and Restraint Inventory (Collins & Lapp, 1992), the Drinking Motives Questionnaire (Cooper, Russell, Skinner, & Windle, 1992), and measures of demographics (age and gender) and social desirability. Results indicated that after accounting for the influences of demographic and social desirability information, Coping Motives and Enhancement Motives scores from the Drinking Motives Questionnaire were significant predictors of Cognitive and Emotional Preoccupation scores on the Temptation and Restraint Inventory, and Coping Motives scores were a significant predictor of Cognitive and Behavioral Control scores on the Temptation and Restraint Inventory. Social Motives scores on the Drinking Motives Questionnaire did not significantly predict either Cognitive and Emotional Preoccupation or Cognitive and Behavioral Control scores. Further analyses suggested that actual behavioral attempts at alcohol restriction on the Temptation and Restraint Inventory were predicted by Enhancement Motives scores, whereas cognitive concerns about drinking were predicted by Coping Motives scores. Results are discussed in terms of implications for risk for excessive and problem drinking in enhancement and coping-motivated young adult drinkers.

Adaptation, Psychological↗

Interaction between sleep and thermoregulation: an aspect of the control of behavioral states.

Studies on the interaction between sleep and thermoregulation are reviewed with regard to the processes underlying the ultradian evolution of behavioral states. The experimental evidence shows that thermoregulatory mechanisms influence the waking-sleeping cycle in both the absence or the presence of a thermal load. Such a control appears to be a functional necessity to maintain physiological homeostasis.

Activity Cycles↗

Summation of excitatory and inhibitory control produced by traditional tone-shock contingencies and autocontingencies.

Previous research has demonstrated that rats can be unsignaled shock to predict subsequent periods free from shock. This shock-no shock stimulus arrangement, termed an autocontingency, has appeared less likely to exert behavioral control when a traditional tone-shock contingency was simultaneously available. The present research examined the generality of CS-US contingency dominance in a conditioned suppression paradigm by using a summation test in which "probe" stimuli derived from tone-shock contingencies were superimposed upon responding maintained by an autocontingency. In experiment 1, an inhibitory CS accelerated responding only when responding was normally suppressed by the autocontingency. In experiment 2, an excitatory CS failed to yield conditioned suppression during an inhibitory (accelerative) period produced by the autocontingency. Unlike our previous findings (e.g., Davis, Memmott & Hurwitz, 1975), these results do not support a general notion of tone-shock contingency dominance over autocontingencies. Behavioral control by autocontingencies appears robust and "holds its own" in summation with both excitatory and inhibitory CSs derived from traditional contingencies.

Animals↗

Genome-wide expression analysis in Drosophila reveals genes controlling circadian behavior.

In Drosophila, a number of key processes such as emergence from the pupal case, locomotor activity, feeding, olfaction, and aspects of mating behavior are under circadian regulation. Although we have a basic understanding of how the molecular oscillations take place, a clear link between gene regulation and downstream biological processes is still missing. To identify clock-controlled output genes, we have used an oligonucleotide-based high-density array that interrogates gene expression changes on a whole genome level. We found genes regulating various physiological processes to be under circadian transcriptional regulation, ranging from protein stability and degradation, signal transduction, heme metabolism, detoxification, and immunity. By comparing rhythmically expressed genes in the fly head and body, we found that the clock has adapted its output functions to the needs of each particular tissue, implying that tissue-specific regulation is superimposed on clock control of gene expression. Finally, taking full advantage of the fly as a model system, we have identified and characterized a cycling potassium channel protein as a key step in linking the transcriptional feedback loop to rhythmic locomotor behavior.

Animals↗

Self-efficacy theory and the theory of planned behavior: teaching physically active physical education classes.

The purpose of our investigation was to examine determinants of teachers' intentions to teach physically active physical education classes (i.e., spend at least 50% of class time with the students engaged in moderate to vigorous physical activity). Based on the theory of planned behavior, a model was examined hypothesizing that teachers' intentions were determined by subjective norm, attitude, and perceived behavioral control. Grounded in self-efficacy theory, it was hypothesized that program goal importance and hierarchical and barrier self-efficacy would also predict intention. Using a series of hierarchical regression analyses, the theory of planned behavior was supported by accounting for 59% of the variance in intention due to attitude, perceived behavioral control, and subjective norm. Self-efficacy theory based variables received minimal support.

Adult↗