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[Changes in the phagocytic activity of the peritoneal macrophages of white mice caused by alcoholic intoxication].

Observations made on white mice showed that doses of alcohol had a stimulating effect on the indices of macrophage acitivity (pagocytic number and phagocytic index), while longer administration of 40% ethyl alcohol solution (in doses of 0,1 ml for 21--30 days) suppressed the functional activity of macrophages. In vitro experiments in which macrophages were subjected to the action of ethyl alcohol showed that alcohol, depending on its concentration, had a direct effect on the cells of the microphage system.

Alcoholic Intoxication↗

[Benzodiazepines in blood samples of alcohol intoxicated drivers].

1,000 blood samples from drivers tested for alcohol were screened specifically for active constituents and metabolites of medicines of the benzodiazepine class. 42 blood samples contained benzodiazepines and a total of eight different active constituents were detected. The active constituents of Valium, Vegesan or Tranxilium, Lexotanil and Seresta have to be dealt with primarily. In addition to benzodiazepine 35 samples showed an alcohol level of over 0.08%. This raised the question of whether the benzodiazepine level measured in the blood samples would intensify the effect of the alcohol. Four categories were formed in order to be able to compare the levels of the various benzodiazepines. According to this categorisation the benzodiazepine concentration was classed as very high in 4 cases, high in 7 cases, moderate in 26 cases and low in 10 cases.

Adult↗

[Acute alcoholic intoxication and accidents].

Many studies have shown the role of alcohol intake, even in low quantities, as a risk factor in accidents, mainly road accidents, but also in accidents occurring in the home and at the workplace. For a blood alcohol level of 0.5 g per litre, the risk of accident is already two-fold. Accidents occur more often to persons who drink occasionally than to those who are alcohol-dependent. For a subject of average body weight, it is accepted that one glass of an alcohol-containing drink can raise the blood alcohol level by approximately 0.2 g per litre. One to two hours is required to eliminate this quantity of alcohol.

Accidents, Traffic↗

[Test performance with minimal alcoholic intoxication].

Driving ability of 34 males under minor influence of alcohol was tested at the ART 90 test unit of the Austrian Road Safety Board. Furthermore, 22 males not under the influence of alcohol, formed part of the sober control group. Some months previously, all volunteers had completed a driver aptitude test consisting of identical tests for all participants. Therefore a before-and-after analysis as well as a comparison of the different groups could be carried out by means of MANOVA. A high motivational level was guaranteed in the first tests as all test persons' driver qualification depended on the results of their driver aptitude tests. Months later they were invited to participate in this study on a voluntary basis. The second tests took place immediately after a social evening at which 8 volunteers were present at any one time. To create conditions as near to reality as possible, only alcohol that would be readily available to the public was served. An entertainer ensured an equally cheerful and relaxed atmosphere in both the experimental and control groups. Alcohol levels were measured by means of the Siemens breathalyser. Results show that as early as an average alcohol level of 0.67/1000 performance is significantly impaired: three times more errors in concentration tests, twice as many errors in reaction tests, twice as many observation errors in visual structuring and a considerable reduction of reactive stress tolerance. On the other hand quantitative dimensions of performance such as reaction time are not significantly impaired. In addition, the readiness to take risks increases with alcohol consumption as is shown by means of questionnaire.

Adolescent↗